{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T17:58:48Z","timestamp":1784829528383,"version":"3.55.0"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100001945","name":"American Psychological Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001945","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Affective Disorders"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1016\/j.jad.2023.11.053","type":"journal-article","created":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T16:05:46Z","timestamp":1700496346000},"page":"39-44","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Intranasal oxytocin as an adjunct treatment among patients with severe major depression with and without comorbid borderline personality disorder"],"prefix":"10.1016","volume":"347","author":[{"given":"Hagai","family":"Maoz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariella","family":"Grossman-Giron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omer","family":"Sedoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uri","family":"Nitzan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Halil","family":"Kashua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maya","family":"Yarmishin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Arad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana","family":"Tzur Bitan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jad.2023.11.053_bb0005","doi-asserted-by":"crossref","DOI":"10.1038\/tp.2013.34","article-title":"Sniffing around oxytocin: review and meta-analyses of trials in healthy and clinical groups with implications for pharmacotherapy","volume":"3","author":"Bakermans-Kranenburg","year":"2013","journal-title":"Transl. Psychiatry"},{"issue":"5","key":"10.1016\/j.jad.2023.11.053_bb0010","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1093\/scan\/nsq085","article-title":"Oxytocin can hinder trust and cooperation in borderline personality disorder","volume":"6","author":"Bartz","year":"2011","journal-title":"Soc. Cogn. Affect. Neurosci."},{"issue":"2","key":"10.1016\/j.jad.2023.11.053_bb0015","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1521\/pedi.18.2.193.32777","article-title":"Childhood maltreatment associated with adult personality disorders: findings from the Collaborative Longitudinal Personality Disorders Study","volume":"18","author":"Battle","year":"2004","journal-title":"J. Personal. Disord."},{"key":"10.1016\/j.jad.2023.11.053_bb0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.psyneuen.2017.01.010","article-title":"Long-term oxytocin administration enhances the experience of attachment","volume":"78","author":"Bernaerts","year":"2017","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.jad.2023.11.053_bb0025","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1007\/7854_2017_26","article-title":"Oxytocin and borderline personality disorder","volume":"35","author":"Bertsch","year":"2018","journal-title":"Curr. Top. Behav. Neurosci."},{"issue":"3","key":"10.1016\/j.jad.2023.11.053_bb0030","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1111\/bjc.12100","article-title":"On the role of oxytocin in borderline personality disorder","volume":"55","author":"Brune","year":"2016","journal-title":"Br. J. Clin. Psychol."},{"issue":"4","key":"10.1016\/j.jad.2023.11.053_bb0035","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.psc.2018.07.010","article-title":"Attachment and borderline personality disorder","volume":"41","author":"Buchheim","year":"2018","journal-title":"Psychiatr. Clin. North Am."},{"key":"10.1016\/j.jad.2023.11.053_bb0040","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.jad.2020.11.111","article-title":"How does borderline personality disorder affect management and treatment response of patients with major depressive disorder? A comprehensive review","volume":"281","author":"Ceresa","year":"2021","journal-title":"J. Affect. Disord."},{"issue":"2\u20133","key":"10.1016\/j.jad.2023.11.053_bb0045","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/0165-0327(95)00091-7","article-title":"Comorbidity of personality disorders and unipolar major depression: a review","volume":"37","author":"Corruble","year":"1996","journal-title":"J. Affect. Disord."},{"issue":"1","key":"10.1016\/j.jad.2023.11.053_bb0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.9758\/cpn.2019.17.1.1","article-title":"The role of intranasal oxytocin in anxiety and depressive disorders: a systematic review of randomized controlled trials","volume":"17","author":"De Cagna","year":"2019","journal-title":"Clin. Psychopharmacol. Neurosci."},{"issue":"1","key":"10.1016\/j.jad.2023.11.053_bb0055","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/bs.3830190102","article-title":"The Hopkins Symptom Checklist (HSCL): a self-report symptom inventory","volume":"19","author":"Derogatis","year":"1974","journal-title":"Behav. Sci."},{"issue":"1","key":"10.1016\/j.jad.2023.11.053_bb0060","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1038\/s41398-019-0658-4","article-title":"Effects of intranasal oxytocin administration on empathy and approach motivation in women with borderline personality disorder: a randomized controlled trial","volume":"9","author":"Domes","year":"2019","journal-title":"Transl. Psychiatry"},{"issue":"4","key":"10.1016\/j.jad.2023.11.053_bb0065","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1080\/17470919.2013.807301","article-title":"Modulation of interpersonal trust in borderline personality disorder by intranasal oxytocin and childhood trauma","volume":"8","author":"Ebert","year":"2013","journal-title":"Soc. Neurosci."},{"issue":"3","key":"10.1016\/j.jad.2023.11.053_bb0070","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.psyneuen.2012.06.016","article-title":"Intranasal oxytocin impedes the ability to ignore task-irrelevant facial expressions of sadness in students with depressive symptoms","volume":"38","author":"Ellenbogen","year":"2013","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.jad.2023.11.053_bb0075","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.yfrne.2018.11.002","article-title":"Menstrual cycle-related fluctuations in oxytocin concentrations: a systematic review and meta-analysis","volume":"52","author":"Engel","year":"2019","journal-title":"Front. Neuroendocrinol."},{"issue":"1","key":"10.1016\/j.jad.2023.11.053_bb0080","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1037\/pas0000038","article-title":"Development and validation of a 6-item working alliance questionnaire for repeated administrations during psychotherapy","volume":"27","author":"Falkenstrom","year":"2015","journal-title":"Psychol. Assess."},{"issue":"12","key":"10.1016\/j.jad.2023.11.053_bb0085","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.4088\/JCP.08m04200gre","article-title":"Personality disorders predict relapse after remission from an episode of major depressive disorder: a 6-year prospective study","volume":"71","author":"Grilo","year":"2010","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.jad.2023.11.053_bb0090","article-title":"Case report: oxytocin and its association with psychotherapy process and outcome","volume":"12","author":"Grossman-Giron","year":"2021","journal-title":"Front. Psychol."},{"key":"10.1016\/j.jad.2023.11.053_bb0095","article-title":"Intranasal oxytocin as add-on treatment for inpatients with severe mental illness: a randomized clinical trial","volume":"1-10","author":"Grossman-Giron","year":"2023","journal-title":"Neuropsychobiology"},{"issue":"6","key":"10.1016\/j.jad.2023.11.053_bb0100","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1037\/amp0000904","article-title":"Summary of the clinical practice guideline for the treatment of depression across three age cohorts","volume":"77","author":"Guideline Development Panel for the Treatment of Depressive, D","year":"2022","journal-title":"Am. Psychol."},{"key":"10.1016\/j.jad.2023.11.053_bb0105","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1136\/jnnp.23.1.56","article-title":"A rating scale for depression","volume":"23","author":"Hamilton","year":"1960","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.jad.2023.11.053_bb0110","series-title":"Introduction to Mediation, Moderation, and Conditional Process Analysis: A Regression-Based Approach","author":"Hayes","year":"2022"},{"key":"10.1016\/j.jad.2023.11.053_bb0115","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neubiorev.2019.10.012","article-title":"Chronic oxytocin administration as a tool for investigation and treatment: a cross-disciplinary systematic review","volume":"108","author":"Horta","year":"2020","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.jad.2023.11.053_bb0120","doi-asserted-by":"crossref","first-page":"125","DOI":"10.3389\/fnhum.2016.00125","article-title":"Lower oxytocin plasma levels in borderline patients with unresolved attachment representations","volume":"10","author":"Jobst","year":"2016","journal-title":"Front. Hum. Neurosci."},{"issue":"4","key":"10.1016\/j.jad.2023.11.053_bb0125","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1002\/(SICI)1099-0879(199612)3:4<249::AID-CPP106>3.0.CO;2-S","article-title":"The reliability and validity of the outcome questionnaire","volume":"3","author":"Lambert","year":"1996","journal-title":"Clin. Psychol. Psychother."},{"issue":"8","key":"10.1016\/j.jad.2023.11.053_bb0130","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1001\/jama.2023.0589","article-title":"Borderline personality disorder: a review","volume":"329","author":"Leichsenring","year":"2023","journal-title":"JAMA"},{"key":"10.1016\/j.jad.2023.11.053_bb0135","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.jad.2021.11.062","article-title":"Intranasal oxytocin administration improves mood in new mothers with moderate low mood but not in mothers with elevated symptoms of postnatal depression: a randomised controlled trial","volume":"300","author":"Lindley Baron-Cohen","year":"2022","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2023.11.053_bb0140","doi-asserted-by":"crossref","first-page":"35","DOI":"10.3389\/fnins.2013.00035","article-title":"Helping oxytocin deliver: considerations in the development of oxytocin-based therapeutics for brain disorders","volume":"7","author":"Macdonald","year":"2013","journal-title":"Front. Neurosci."},{"issue":"8","key":"10.1016\/j.jad.2023.11.053_bb0145","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1016\/j.psyneuen.2011.02.015","article-title":"A review of safety, side-effects and subjective reactions to intranasal oxytocin in human research","volume":"36","author":"MacDonald","year":"2011","journal-title":"Psychoneuroendocrinology"},{"issue":"12","key":"10.1016\/j.jad.2023.11.053_bb0150","doi-asserted-by":"crossref","first-page":"2831","DOI":"10.1016\/j.psyneuen.2013.05.014","article-title":"Oxytocin and psychotherapy: a pilot study of its physiological, behavioral and subjective effects in males with depression","volume":"38","author":"MacDonald","year":"2013","journal-title":"Psychoneuroendocrinology"},{"issue":"10161","key":"10.1016\/j.jad.2023.11.053_bb0155","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.1016\/S0140-6736(18)31948-2","article-title":"Depression","volume":"392","author":"Malhi","year":"2018","journal-title":"Lancet"},{"issue":"6","key":"10.1016\/j.jad.2023.11.053_bb0160","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1007\/s12576-012-0232-9","article-title":"Oxytocin: a therapeutic target for mental disorders","volume":"62","author":"Matsuzaki","year":"2012","journal-title":"J. Physiol. Sci."},{"issue":"4","key":"10.1016\/j.jad.2023.11.053_bb0165","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1521\/pedi_2013_27_070","article-title":"Influence of personality on the outcome of treatment in depression: systematic review and meta-analysis","volume":"28","author":"Newton-Howes","year":"2014","journal-title":"J. Personal. Disord."},{"key":"10.1016\/j.jad.2023.11.053_bb0170","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.jad.2021.12.134","article-title":"Augmentation strategies for treatment resistant major depression: a systematic review and network meta-analysis","volume":"302","author":"Nunez","year":"2022","journal-title":"J. Affect. Disord."},{"issue":"8","key":"10.1016\/j.jad.2023.11.053_bb0175","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1017\/S109285290000047X","article-title":"A psychobiological rationale for oxytocin in the treatment of posttraumatic stress disorder","volume":"15","author":"Olff","year":"2010","journal-title":"CNS Spectr."},{"key":"10.1016\/j.jad.2023.11.053_bb0180","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.neubiorev.2020.04.023","article-title":"Exogenous effects of oxytocin in five psychiatric disorders: a systematic review, meta-analyses and a personalized approach through the lens of the social salience hypothesis","volume":"114","author":"Peled-Avron","year":"2020","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"4","key":"10.1016\/j.jad.2023.11.053_bb0185","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.psc.2018.07.012","article-title":"The neurobiology of borderline personality disorder","volume":"41","author":"Perez-Rodriguez","year":"2018","journal-title":"Psychiatr. Clin. North Am."},{"issue":"6","key":"10.1016\/j.jad.2023.11.053_bb0190","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1177\/1039856219878643","article-title":"Borderline personality disorder and depressive disorder","volume":"27","author":"Rao","year":"2019","journal-title":"Australas. Psychiatry"},{"issue":"1","key":"10.1016\/j.jad.2023.11.053_bb0195","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.eurpsy.2014.08.007","article-title":"Additional intranasal oxytocin to escitalopram improves depressive symptoms in resistant depression: an open trial","volume":"30","author":"Scantamburlo","year":"2015","journal-title":"Eur. Psychiatry"},{"issue":"1","key":"10.1016\/j.jad.2023.11.053_bb0200","doi-asserted-by":"crossref","first-page":"53","DOI":"10.9758\/cpn.2021.19.1.53","article-title":"Selective serotonin reuptake-inhibitors for symptom-based treatment of borderline personality disorders in older adults: an international Delphi study","volume":"19","author":"Schulkens","year":"2021","journal-title":"Clin. Psychopharmacol. Neurosci."},{"issue":"3","key":"10.1016\/j.jad.2023.11.053_bb0205","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.biopsych.2015.07.020","article-title":"The social salience hypothesis of oxytocin","volume":"79","author":"Shamay-Tsoory","year":"2016","journal-title":"Biol. Psychiatry"},{"issue":"5","key":"10.1016\/j.jad.2023.11.053_bb0210","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2018-027574","article-title":"Comparative efficacy and acceptability of antidepressants in the long-term treatment of major depression: protocol for a systematic review and networkmeta-analysis","volume":"9","author":"Shinohara","year":"2019","journal-title":"BMJ Open"},{"issue":"3","key":"10.1016\/j.jad.2023.11.053_bb0215","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1176\/appi.ajp.2010.10050695","article-title":"Relationship of personality disorders to the course of major depressive disorder in a nationally representative sample","volume":"168","author":"Skodol","year":"2011","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jad.2023.11.053_bb0220","series-title":"Manual for the State-Trait Anxiety Inventory, Form Y (\u201cSelf-evaluation Questionnaire\u201d)","author":"Spielberger","year":"1983"},{"key":"10.1016\/j.jad.2023.11.053_bb0225","doi-asserted-by":"crossref","DOI":"10.1016\/j.psyneuen.2023.106074","article-title":"A double-edged hormone: the moderating role of personality and attachment on oxytocin\u2019s treatment facilitation effect","volume":"151","author":"Tzur Bitan","year":"2023","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.jad.2023.11.053_bb0230","doi-asserted-by":"crossref","first-page":"56","DOI":"10.3389\/fnins.2019.00056","article-title":"Oxytocin facilitates social learning by promoting conformity to trusted individuals","volume":"13","author":"Xu","year":"2019","journal-title":"Front. Neurosci."},{"issue":"5","key":"10.1016\/j.jad.2023.11.053_bb0235","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1176\/ajp.2006.163.5.827","article-title":"Prediction of the 10-year course of borderline personality disorder","volume":"163","author":"Zanarini","year":"2006","journal-title":"Am. J. Psychiatry"},{"issue":"4","key":"10.1016\/j.jad.2023.11.053_bb0240","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1037\/cou0000386","article-title":"Oxytocin as a biomarker of the formation of therapeutic alliance in psychotherapy and counseling psychology","volume":"67","author":"Zilcha-Mano","year":"2020","journal-title":"J. Couns. Psychol."}],"container-title":["Journal of Affective Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032723014222?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032723014222?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T04:11:53Z","timestamp":1759032713000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165032723014222"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":48,"alternative-id":["S0165032723014222"],"URL":"https:\/\/doi.org\/10.1016\/j.jad.2023.11.053","relation":{},"ISSN":["0165-0327"],"issn-type":[{"value":"0165-0327","type":"print"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intranasal oxytocin as an adjunct treatment among patients with severe major depression with and without comorbid borderline personality disorder","name":"articletitle","label":"Article Title"},{"value":"Journal of Affective Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jad.2023.11.053","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}