{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T05:02:55Z","timestamp":1772773375208,"version":"3.50.1"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T00:00:00Z","timestamp":1704844800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Affective Disorders"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1016\/j.jad.2024.01.088","type":"journal-article","created":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T02:56:56Z","timestamp":1704855416000},"page":"366-371","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Serum neurofilament light as a potential marker of illness duration in bipolar disorder"],"prefix":"10.1016","volume":"350","author":[{"given":"R.","family":"Queissner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Buchmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Demjaha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Tafrali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Benkert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Kuhle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Jerkovic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Dalkner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Fellendorf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Birner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Platzer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Tmava-Berisha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Maget","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Stross","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Lenger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"H\u00e4ussl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Khalil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Reininghaus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.jad.2024.01.088_bb0005","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.euroneuro.2018.01.001","article-title":"White matter disruptions in patients with bipolar disorder","volume":"28","author":"Abramovic","year":"2018","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.jad.2024.01.088_bb0010","series-title":"Diagnostic and Statistical Manual of Mental Disorders (DSM\u20135)","year":"2013"},{"issue":"8","key":"10.1016\/j.jad.2024.01.088_bb0015","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.1093\/brain\/awy154","article-title":"Serum neurofilament as a predictor of disease worsening and brain and spinal cord atrophy in multiple sclerosis","volume":"141","author":"Barro","year":"2018","journal-title":"Brain"},{"key":"10.1016\/j.jad.2024.01.088_bb0020","first-page":"367","article-title":"Peripheral markers of oxidative stress and antioxidative defense in euthymia of bipolar disorder-gender and obesity effects","volume":"172C","author":"Bengesser","year":"2014","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2024.01.088_bb0025","first-page":"1","article-title":"Is the molecular clock ticking differently in bipolar disorder? Methylation analysis of the clock gene ARNTL","volume":"14","author":"Bengesser","year":"2016","journal-title":"World J. Biol. Psychiatry"},{"key":"10.1016\/j.jad.2024.01.088_bb0030","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.psyneuen.2018.11.009","article-title":"Epigenetics of the molecular clock and bacterial diversity bipolar disorder","volume":"101","author":"Bengesser","year":"2019","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.jad.2024.01.088_bb0035","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/S1474-4422(22)00009-6","article-title":"Serum neurofilament light chain for individual prognostivation of diseaseactivity in people with multiple sclerosis: a retrospective modelling and validation study","volume":"21","author":"Benkert","year":"2022","journal-title":"Lancet Neurol."},{"issue":"3","key":"10.1016\/j.jad.2024.01.088_bb0040","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/S1474-4422(22)00009-6","article-title":"Serum neurofilament light chain for individual prognostication of disease activity in people with multiple sclerosis: a retrospective modelling and validation study","volume":"21","author":"Benkert","year":"2022","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.jad.2024.01.088_bb0045","doi-asserted-by":"crossref","unstructured":"Beumer, W., Drexhage, R., Pont, L., Doorduin, J. & Klein, H. \"Immune theory of psychiatric diseases: a key role for activatedmicroglia and circulating monocytes\", J. Leukoc. Biol., vol. 92, no. 5, pp. 959\u2013975.","DOI":"10.1189\/jlb.0212100"},{"issue":"8","key":"10.1016\/j.jad.2024.01.088_bb0050","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0135313","article-title":"Cerebral white matter lesions and affective episodes correlate in male individuals with bipolar disorder","volume":"10","author":"Birner","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jad.2024.01.088_bb0055","first-page":"438","article-title":"The cytoskeleton in neurodegenerative deseases","volume":"204","author":"Cairns","year":"2004","journal-title":"J Pahtol"},{"issue":"10","key":"10.1016\/j.jad.2024.01.088_bb1000","doi-asserted-by":"crossref","first-page":"3019","DOI":"10.3390\/nu12103019","article-title":"C-reactive protein as a possible predictor of trail-making performance in individuals with psychiatric disorders","volume":"12","author":"Dalkner","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.jad.2024.01.088_bb0060","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1080\/15622975.2018.1487077","article-title":"Branched-chain aminoacids are associated with metabolic parameters in bipolar disorder","volume":"80","author":"Fellendorf","year":"2019","journal-title":"World J. Biol. Psychiatry"},{"key":"10.1016\/j.jad.2024.01.088_bb0065","doi-asserted-by":"crossref","DOI":"10.3390\/antiox10111795","article-title":"Tryptophan metabolism in bipolar disorder in a longitudinal setting","volume":"10","author":"Fellendorf","year":"2021","journal-title":"Antioxidants"},{"key":"10.1016\/j.jad.2024.01.088_bb0070","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/ane.13152","article-title":"Plasma neurofilaments correlate with disability in progressive multiple sclerosis patients","volume":"141","author":"Ferraro","year":"2019","journal-title":"Acta Neurol. Scand."},{"key":"10.1016\/j.jad.2024.01.088_bb0075","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.bbi.2017.05.002","article-title":"Markers of neuroinflammation and neuronal injury in bipolar disorder: relation to prospective clinical outcomes","volume":"65","author":"Isgren","year":"2017","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.jad.2024.01.088_bb0080","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1038\/npp.2014.81","article-title":"Elevated level of the neurofilament light chain in the cerebrospinal fluid of bipolar disorder patients","volume":"39","author":"Jakobsson","year":"2014","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.jad.2024.01.088_bb0085","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/s41582-018-0058-z","article-title":"Neurofilaments as biomarkers in neurological disorders","volume":"14","author":"Khalil","year":"2018","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.jad.2024.01.088_bb0090","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.eurpsy.2013.08.002","article-title":"White matter hyperintensities and cognitive performance in adult patients with bipolar I, bipolar II, and major depressive disorder","volume":"29","author":"Kiesepp\u00e4","year":"2014","journal-title":"Eur. Psychiatry"},{"key":"10.1016\/j.jad.2024.01.088_bb0095","first-page":"1","article-title":"Abdominal obesity is associated with impaired cognitve function in euthyme bipolar individuals","volume":"12","author":"Lackner","year":"2015","journal-title":"World J. Biol. Psychiatry"},{"key":"10.1016\/j.jad.2024.01.088_bb0100","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.jad.2010.05.026","article-title":"Differences in white matter abnormalities between bipolar I and II disorders","volume":"127","author":"Liu","year":"2010","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2024.01.088_bb0105","doi-asserted-by":"crossref","DOI":"10.1001\/archgenpsychiatry.2011.12","article-title":"Prevalence and correlates of bipolar spectrum disorder in the world mental health survey initiative","volume":"68","author":"Merikangas","year":"2011","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.jad.2024.01.088_bb0110","doi-asserted-by":"crossref","first-page":"699","DOI":"10.4088\/JCP.07m03745","article-title":"A longitudinal study of the effects of lithium treatment on prefrontal and subgenual prefrontal grey matter volume in treatment-responsive bipolar disorder patients","volume":"70","author":"Moore","year":"2009","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.jad.2024.01.088_bb0115","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1093\/ijnp\/pyab068","article-title":"Neurofilament light chain is a novel biomarker for major depression and related executive dysfunction","volume":"25","author":"Mu-Hong","year":"2022","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.jad.2024.01.088_bb0120","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.psyneuen.2017.04.015","article-title":"Tryptophan breakdown and cognition in bipolar disorder","volume":"81","author":"Platzer","year":"2017","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.jad.2024.01.088_bb0125","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.jad.2014.12.030","article-title":"Cognitve performances associate with measures of white matter integrity in bipolar disorder","volume":"174","author":"Poletti","year":"2015","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2024.01.088_bb0130","author":"Quanterix"},{"key":"10.1016\/j.jad.2024.01.088_bb0135","author":"Quanterix"},{"key":"10.1016\/j.jad.2024.01.088_bb0140","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.psyneuen.2018.01.024","article-title":"The relationship between inflammatory state and quantity of affective episodes in bipolar disorder","volume":"90","author":"Queissner","year":"2018","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.jad.2024.01.088_bb0145","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.jad.2020.11.063","article-title":"The assoiation between anti-inflammatory effects of longt-term lithium treatment ans illness course in bipolar disorder","volume":"281","author":"Queissner","year":"2021","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2024.01.088_bb0150","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1111\/bdi.12166","article-title":"Tryptophan breakdown is increased in euthymic overweight individuals with bipolar disorder: a preliminary report","volume":"16","author":"Reininghaus","year":"2014","journal-title":"Bipolar Disord."},{"key":"10.1016\/j.jad.2024.01.088_bb0155","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.jad.2014.09.006","article-title":"Weightcycling in bipolar disorder","volume":"117","author":"Reininghaus","year":"2015","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2024.01.088_bb0160","doi-asserted-by":"crossref","DOI":"10.3390\/brainsci7110144","article-title":"Bipolar disorder and immune dysfunction: epidemio- logical findings, proposed patho physiology and clinical implications","volume":"7","author":"Rosenblat","year":"2017","journal-title":"Brain Sci."},{"key":"10.1016\/j.jad.2024.01.088_bb0165","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.pnpbp.2014.01.013","article-title":"Inflamed moods: a review of the interactions between inflammation and mood disorders","volume":"53","author":"Rosenblat","year":"2014","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.jad.2024.01.088_bb0170","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1017\/S0033291716000180","article-title":"Abnormal white matter integrity as a structural endophenotype for bipolar disorder","volume":"46","author":"Saricicek","year":"2016","journal-title":"Psychol. Med."},{"key":"10.1016\/j.jad.2024.01.088_bb0175","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1176\/appi.ajp.2013.12111448","article-title":"Diffusion tensor imaging white matter endopheno- types in patients with schizophrenia or psychotic bipolar disorder and their relatives","volume":"170","author":"Savitz","year":"2013","journal-title":"Am. J. Psychiatry"},{"issue":"2","key":"10.1016\/j.jad.2024.01.088_bb0180","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.jad.2007.06.009","article-title":"Changes in brain metabolism after ECT-positron emission tomography in the assessment of changes in glucose metabolism subsequent to electroconvulsive therapy","volume":"106","author":"Schmidt","year":"2008","journal-title":"J. Affect. Disord."},{"issue":"2","key":"10.1016\/j.jad.2024.01.088_bb0185","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.jad.2007.06.009","article-title":"Changes in brain metabolism after ECT-positron emission tomography in the assessment of changes in glucose metabolism subsequent to electroconvulsive therapy","volume":"106","author":"Schmidt","year":"2008","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2024.01.088_bb0190","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2019.00338","article-title":"Neurofilament light chain as a biomarker in multiple sclerosis","volume":"10","author":"Varhaug","year":"2019","journal-title":"Front. Neurol."},{"key":"10.1016\/j.jad.2024.01.088_bb0195","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.neuroimage.2007.02.049","article-title":"Reproducibility of quantitative tractography methods applied to cerebral white matter","volume":"36","author":"Wakana","year":"2007","journal-title":"Neurimage"}],"container-title":["Journal of Affective Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032724000983?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032724000983?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T15:39:31Z","timestamp":1762789171000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165032724000983"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":40,"alternative-id":["S0165032724000983"],"URL":"https:\/\/doi.org\/10.1016\/j.jad.2024.01.088","relation":{},"ISSN":["0165-0327"],"issn-type":[{"value":"0165-0327","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Serum neurofilament light as a potential marker of illness duration in bipolar disorder","name":"articletitle","label":"Article Title"},{"value":"Journal of Affective Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jad.2024.01.088","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}