{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T17:46:29Z","timestamp":1789062389057,"version":"build-2803163510"},"reference-count":95,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004688","name":"Universidad del Zulia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004688","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Affective Disorders"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1016\/j.jad.2024.01.228","type":"journal-article","created":{"date-parts":[[2024,1,28]],"date-time":"2024-01-28T13:13:55Z","timestamp":1706447635000},"page":"349-355","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Possible role of metformin as an antidepressant in diabetes"],"prefix":"10.1016","volume":"351","author":[{"given":"Adriana","family":"Pedrea\u00f1ez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yenddy","family":"Carrero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata","family":"Vargas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan P.","family":"Hernandez-Fonseca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1496-5511","authenticated-orcid":false,"given":"Jes\u00fas","family":"Mosquera-Sulbaran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jad.2024.01.228_bb0005","doi-asserted-by":"crossref","first-page":"80","DOI":"10.4103\/japtr.JAPTR_273_18","article-title":"Differential effect of metformin and\/or glyburide on apelin serum levels in patients with type 2 diabetes mellitus: concepts and clinical practice","volume":"9","author":"Al-Kuraishy","year":"2018","journal-title":"J. Adv. Pharm. Technol. Res."},{"key":"10.1016\/j.jad.2024.01.228_bb0010","doi-asserted-by":"crossref","first-page":"142","DOI":"10.4103\/japtr.JAPTR_18_20","article-title":"Metformin and\/or vildagliptin mitigate type II diabetes mellitus induced-oxidative stress: the intriguing effect","volume":"11","author":"Al-Kuraishy","year":"2020","journal-title":"J. Adv. Pharm. Technol. Res."},{"key":"10.1016\/j.jad.2024.01.228_bb0015","first-page":"1","article-title":"Long-term use of metformin and Alzheimer\u2019s disease: beneficial or detrimental effects","volume":"31","author":"Al-Kuraishy","year":"2023","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.jad.2024.01.228_bb0020","doi-asserted-by":"crossref","first-page":"3255","DOI":"10.1007\/s11064-023-03981-1","article-title":"Pathogenic role of fibrinogen in the neuropathology of multiple sclerosis: a tale of sorrows and fears","volume":"48","author":"Alruwaili","year":"2023","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.jad.2024.01.228_bb0025","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0072120","article-title":"Metformin inhibits angiotensin II-induced differentiation of cardiac fibroblasts into myofibroblasts","volume":"8","author":"Bai","year":"2013","journal-title":"PloS One"},{"key":"10.1016\/j.jad.2024.01.228_bb0030","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1007\/s00125-008-1053-5","article-title":"Metformin and the intestine","volume":"51","author":"Bailey","year":"2008","journal-title":"Diabetologia"},{"issue":"69\u201376","key":"10.1016\/j.jad.2024.01.228_bb0035","article-title":"Insulin counter-regulatory factors, fibrinogen and C-reactive protein during olanzapine administration: effects of the antidiabetic metformin","volume":"22","author":"Baptista","year":"2007","journal-title":"Int. Clin. Psychopharmacol."},{"key":"10.1016\/j.jad.2024.01.228_bb0040","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.psyneuen.2016.04.019","article-title":"Symptoms of depression and anxiety in youth with type 1 diabetes: a systematic review and meta-analysis","volume":"70","author":"Buchberger","year":"2016","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.jad.2024.01.228_bb0045","doi-asserted-by":"crossref","first-page":"198","DOI":"10.2337\/dc15-0488","article-title":"The primary glucose-lowering effect of metformin resides in the gut, not the circulation: results from short-term pharmacokinetic and 12-week dose-ranging studies","volume":"39","author":"Buse","year":"2016","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jad.2024.01.228_bb0050","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1161\/CIRCRESAHA.116.308445","article-title":"Anti-inflammatory effects of metformin irrespective of diabetes status","volume":"119","author":"Cameron","year":"2016","journal-title":"Circ. Res."},{"key":"10.1016\/j.jad.2024.01.228_bb0055","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1007\/s11920-010-0165-z","volume":"13","author":"Campayo","year":"2011","journal-title":"Diabetes and depression. Curr. Psychiatry Rep."},{"key":"10.1016\/j.jad.2024.01.228_bb0060","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.2337\/db06-1491","article-title":"Metabolic endotoxemia initiates obesity and insulin resistance","volume":"56","author":"Cani","year":"2007","journal-title":"Diabetes"},{"key":"10.1016\/j.jad.2024.01.228_bb0065","article-title":"Metformin attenuates angiotensin II-induced TGF\u03b21 expression by targeting hepatocyte nuclear factor-4-\u03b1","author":"Chen","year":"2018","journal-title":"Br. J."},{"key":"10.1016\/j.jad.2024.01.228_bb0070","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.1016\/S1098-3597(03)90062-7","article-title":"Insulin as an anti-inflammatory and antiatherosclerotic hormone","volume":"4","author":"Dandona","year":"2003","journal-title":"Clin. Cornerstone"},{"key":"10.1016\/j.jad.2024.01.228_bb0075","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/sj.jhh.1002101","article-title":"Angiotensin II and inflammation: the effect of angiotensin-converting enzyme inhibition and angiotensin II receptor blockade","volume":"21","author":"Dandona","year":"2007","journal-title":"J. Hum. Hypertens."},{"issue":"44","key":"10.1016\/j.jad.2024.01.228_bb0080","article-title":"Chronic kidney disease-induced insulin resistance: current state of the field","volume":"18","author":"Dave","year":"2018","journal-title":"Curr. Diab. Rep."},{"key":"10.1016\/j.jad.2024.01.228_bb0085","series-title":"Metformin Is Associated with the Inhibition of Renal Artery AT1R\/ET-1\/iNOS Axis in a Rat Model of Diabetic Nephropathy with Suppression of Inflammation and Oxidative Stress and Kidney Injury. Biomedicines 10,1644","author":"Dawood","year":"2022"},{"key":"10.1016\/j.jad.2024.01.228_bb0090","doi-asserted-by":"crossref","first-page":"54","DOI":"10.2337\/dc16-1324","article-title":"Metformin is associated with higher relative abundance of mucin-degrading Akkermansia muciniphila and several shortchain fatty acid-producing microbiota in the gut","volume":"40","author":"de la Cuesta-Zuluaga","year":"2017","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jad.2024.01.228_bb0095","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1089\/dia.2006.8.18","article-title":"Anti-inflammatory drugs and their effects on type 2 diabetes","volume":"8","author":"Deans","year":"2006","journal-title":"Diabetes Technol. Ther."},{"key":"10.1016\/j.jad.2024.01.228_bb0100","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1111\/fcp.12825","article-title":"Metformin improves neurobehavioral impairments of streptozotocin-treated and western diet-fed mice: beyond glucose-lowering effects","volume":"37","author":"Delanogare","year":"2023","journal-title":"Fundam. Clin. Pharmacol."},{"key":"10.1016\/j.jad.2024.01.228_bb0105","doi-asserted-by":"crossref","first-page":"2549","DOI":"10.1007\/s00221-020-05911-x","article-title":"Metformin improves depressive-like symptoms in mice via inhibition of peripheral and central NF-\u03baB-NLRP3 inflammation activation","volume":"238","author":"Du","year":"2020","journal-title":"Exp. Brain Res."},{"key":"10.1016\/j.jad.2024.01.228_bb0110","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.3892\/etm.2021.10665","article-title":"Metformin attenuates angiotensin II-induced cardiomyocyte hypertrophy by upregulating the MuRF1 and MAFbx pathway","volume":"22","author":"Du","year":"2021","journal-title":"Exp. Ther. Med."},{"issue":"2140\u20132151","key":"10.1016\/j.jad.2024.01.228_bb0115","article-title":"Activation of AMP-activated protein kinase by metformin ablates angiotensin II-induced endoplasmic reticulum stress and hypertension in mice in vivo","volume":"174","author":"Duan","year":"2017","journal-title":"Br. J. Pharmacol."},{"issue":"5957","key":"10.1016\/j.jad.2024.01.228_bb0120","article-title":"Metformin as a potential agent in the treatment of multiple sclerosis","volume":"21","author":"Dziedzic","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jad.2024.01.228_bb0125","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1586\/erp.12.86","article-title":"Effect of comorbid depression on quality of life in adults with type 2 diabetes","volume":"13","author":"Egede","year":"2013","journal-title":"Expert Rev. Pharmacoecon. Outcomes Res."},{"key":"10.1016\/j.jad.2024.01.228_bb0130","doi-asserted-by":"crossref","first-page":"2328","DOI":"10.2174\/0929867327666200908114902","article-title":"Metformin: a growing journey from glycemic control to the treatment of Alzheimer\u2019s disease and depression","volume":"28","author":"El Massry","year":"2021","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.jad.2024.01.228_bb0135","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.3945\/jn.113.179549","article-title":"Short-chain fatty acids activate AMP-activated protein kinase and ameliorate ethanol-induced intestinal barrier dysfunction in Caco-2 cell monolayers","volume":"143","author":"Elamin","year":"2013","journal-title":"J. Nutr."},{"key":"10.1016\/j.jad.2024.01.228_bb0140","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1517\/13543784.2015.974804","article-title":"Anti-inflammatory agents to treat or prevent type 2 diabetes, metabolic syndrome and cardiovascular disease","volume":"24","author":"Esser","year":"2015","journal-title":"Expert Opin. Investig. Drugs"},{"key":"10.1016\/j.jad.2024.01.228_bb0145","first-page":"409","article-title":"Advanced glycosylation in diabetes mellitus. Occurrence of late complications","volume":"14","author":"Esteves","year":"2001","journal-title":"Acta Med. Port."},{"key":"10.1016\/j.jad.2024.01.228_bb0150","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.biopsych.2005.05.001","article-title":"Mood disorders in the medically ill: scientific review and recommendations","volume":"58","author":"Evans","year":"2005","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jad.2024.01.228_bb0155","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.jad.2019.09.013","article-title":"Metformin ameliorates stress-induced depression-like behaviors via enhancing the expression of BDNF by activating AMPK\/CREB-mediated histone acetylation","volume":"260","author":"Fang","year":"2020","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2024.01.228_bb0160","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.brainresbull.2020.07.015","article-title":"Long-term metformin therapy improves neurobehavioral functions and antioxidative activity after cerebral ischemia\/reperfusion injury in rats","volume":"163","author":"Fatemi","year":"2020","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.jad.2024.01.228_bb0165","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1007\/s12020-014-0323-x","article-title":"The association between diabetes and depression: a very disabling condition","volume":"48","author":"Fiore","year":"2016","journal-title":"Endocrine"},{"key":"10.1016\/j.jad.2024.01.228_bb0170","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/nature15766","article-title":"Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota","volume":"528","author":"Forslund","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.jad.2024.01.228_bb0175","doi-asserted-by":"crossref","first-page":"109720","DOI":"10.1016\/j.pnpbp.2019.109720","article-title":"Association between diabetes and mood disorders and the potential use of anti-hyperglycemic agents as antidepressants","volume":"95","author":"Grigolon","year":"2019","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.jad.2024.01.228_bb0180","article-title":"Metformin for the improvement of comorbid depression symptoms in diabetic patients: a systematic review","volume":"14","author":"Hamal","year":"2022","journal-title":"Cureus"},{"key":"10.1016\/j.jad.2024.01.228_bb0185","doi-asserted-by":"crossref","first-page":"113475","DOI":"10.1016\/j.bbr.2021.113475","article-title":"Metformin reduces oxandrolone- induced depression-like behavior in rats via modulating the expression of IL-1\u03b2, IL-6, IL-10 and TNF-\u03b1","volume":"414","author":"Hammad","year":"2021","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.jad.2024.01.228_bb0190","doi-asserted-by":"crossref","DOI":"10.1155\/2009\/329632","article-title":"Structural and ultrastructural analysis of cerebral cortex, cerebellum, and hypothalamus from diabetic rats","volume":"2009","author":"Hernandez-Fonseca","year":"2009","journal-title":"Exp. Diabetes Res."},{"key":"10.1016\/j.jad.2024.01.228_bb0195","first-page":"13","article-title":"\u201cglucose eater\u201d drug as a therapeutic agent in psychiatry","volume":"51","author":"Howland","year":"2013","journal-title":"J. Psychosoc. Nurs. Ment. Health Serv."},{"key":"10.1016\/j.jad.2024.01.228_bb0200","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1210\/me.2004-0536","article-title":"Pleiotropic AT1 receptor signaling pathways mediating physiological and pathogenic actions of angiotensin II","volume":"20","author":"Hunyady","year":"2006","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.jad.2024.01.228_bb0205","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1177\/1060028020985303","article-title":"Effect of metformin on circulating levels of inflammatory markers in patients with type 2 diabetes: a systematic review and Meta-analysis of randomized controlled trials","volume":"55","author":"Karbalaee-Hasani","year":"2021","journal-title":"Ann. Pharmacother."},{"key":"10.1016\/j.jad.2024.01.228_bb0210","first-page":"591","article-title":"The effect of enalapril and captopril on emotional processes in hypertensive patients","volume":"36","author":"Karwowska-Polecka","year":"2002","journal-title":"Psychiatr. Pol."},{"key":"10.1016\/j.jad.2024.01.228_bb0215","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/s00210-018-1466-8","article-title":"Metformin potentiates cognitive and antidepressant effects of fluoxetine in rats exposed to chronic restraint stress and high fat diet: potential involvement of hippocampal c-Jun repression","volume":"391","author":"Khedr","year":"2018","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"issue":"13\u201326","key":"10.1016\/j.jad.2024.01.228_bb0220","article-title":"Metformin and its therapeutic applications in autoimmune inflammatory rheumatic disease. Korean","volume":"37","author":"Kim","year":"2022","journal-title":"J. Intern. Med."},{"issue":"5935\u20135943","key":"10.1016\/j.jad.2024.01.228_bb0225","article-title":"Effect of metformin on metabolic improvement and gut microbiota","volume":"80","author":"Lee","year":"2014","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.jad.2024.01.228_bb0230","article-title":"Metformin suppresses pro-inflammatory cytokines in vitreous of diabetes patients and human retinal vascular endothelium","volume":"17","author":"Li","year":"2022","journal-title":"PloS One"},{"key":"10.1016\/j.jad.2024.01.228_bb0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2022.113772","article-title":"Metformin alleviates the depression-like behaviors of elderly apoE4 mice via improving glucose metabolism and mitochondrial biogenesis","volume":"423","author":"Lin","year":"2022","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.jad.2024.01.228_bb0240","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.jad.2018.12.112","article-title":"Possible role of GLP-1 in antidepressant effects of metformin and exercise in CUMS mice","volume":"246","author":"Liu","year":"2019","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2024.01.228_bb0245","doi-asserted-by":"crossref","first-page":"3639","DOI":"10.1007\/s11064-023-04012-9","article-title":"Metformin improves comorbid depressive symptoms in mice with allergic rhinitis by reducing olfactory bulb damage","volume":"48","author":"Lv","year":"2023","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.jad.2024.01.228_bb0250","article-title":"Perspective: ACE2, metformin, and COVID-19","volume":"23","author":"Malhotra","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.jad.2024.01.228_bb0255","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.tips.2008.05.003","article-title":"Role of the renin-angiotensin system in vascular inflammation","volume":"29","author":"Marchesi","year":"2008","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.jad.2024.01.228_bb0260","first-page":"1245","article-title":"Insulin resistance and chronic inflammation","volume":"70","author":"Matulewicz","year":"2016","journal-title":"Postepy Hig. Med. Dosw. (Online)"},{"key":"10.1016\/j.jad.2024.01.228_bb0265","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1007\/s10787-022-01043-6","article-title":"Metformin improves depressive-like behavior in experimental Parkinson's disease by inducing autophagy in the substantia nigra and hippocampus","volume":"30","author":"Mendon\u00e7a","year":"2022","journal-title":"Inflammopharmacol"},{"key":"10.1016\/j.jad.2024.01.228_bb0270","doi-asserted-by":"crossref","first-page":"201","DOI":"10.2478\/sjecr-2022-0070","article-title":"Metformin reverses the effects of angiotensin 2 in human mammary arteries by modulating the expression of nitric oxide synthases","volume":"23","author":"Merce","year":"2022","journal-title":"Serbian J. Exp. Clin. Res."},{"key":"10.1016\/j.jad.2024.01.228_bb0275","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/j.biopsych.2008.11.029","article-title":"Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression","volume":"65","author":"Miller","year":"2009","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jad.2024.01.228_bb0280","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1097\/YCO.0000000000000528","article-title":"Depressive symptoms and disorders in type 2 diabetes mellitus","volume":"32","author":"Mukherjee","year":"2019","journal-title":"Curr. Opin. Psychiatry"},{"key":"10.1016\/j.jad.2024.01.228_bb0285","doi-asserted-by":"crossref","first-page":"8005","DOI":"10.4049\/jimmunol.0803563","article-title":"Metformin attenuated the autoimmune disease of the central nervous system in animal models of multiple sclerosis","volume":"182","author":"Nath","year":"2009","journal-title":"J. Immunol."},{"issue":"520\u2013528","key":"10.1016\/j.jad.2024.01.228_bb0290","article-title":"Immunologic effects of metformin and pioglitazone treatment on metabolic syndrome and multiple sclerosis","volume":"73","author":"Negrotto","year":"2016","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.jad.2024.01.228_bb0295","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1146\/annurev-physiol-021909-135846","article-title":"Macrophages, inflammation, and insulin resistance","volume":"72","author":"Olefsky","year":"2010","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.jad.2024.01.228_bb0300","doi-asserted-by":"crossref","first-page":"R311","DOI":"10.1152\/ajpregu.00246.2010","article-title":"Enhanced angiotensin II-mediated central sympathoexcitation in streptozotocin-induced diabetes: role of superoxide anion","volume":"300","author":"Patel","year":"2011","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.jad.2024.01.228_bb0305","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1080\/10253890701476621","article-title":"Chronic administration of an angiotensin II receptor antagonist resets the hypothalamic-pituitary-adrenal (HPA) axis and improves the affect of patients with diabetes mellitus type 2: preliminary results","volume":"11","author":"Pavlatou","year":"2008","journal-title":"Stress"},{"key":"10.1016\/j.jad.2024.01.228_bb0310","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/nature18646","article-title":"Human gut microbes impact host serum metabolome and insulin sensitivity","volume":"535","author":"Pedersen","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.jad.2024.01.228_bb0315","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.brainresbull.2006.07.018","article-title":"Forced swimming test increases superoxide anion positive cells and angiotensin II positive cells in the cerebrum and cerebellum of the rat","volume":"71","author":"Pedreanez","year":"2006","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.jad.2024.01.228_bb0320","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/nature18309","article-title":"Acetate mediates a microbiome-brain-beta-cell axis to promote metabolic syndrome","volume":"534","author":"Perry","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.jad.2024.01.228_bb0325","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/4651031","article-title":"Combined fluoxetine and metformin treatment potentiates antidepressant efficacy increasing IGF2 expression in the dorsal Hippocampus","volume":"2019","author":"Poggini","year":"2019","journal-title":"Neural Plast."},{"key":"10.1016\/j.jad.2024.01.228_bb0330","doi-asserted-by":"crossref","first-page":"958","DOI":"10.2741\/3289","article-title":"The angiotensin II type 2 (AT2) receptor: an enigmatic seven transmembrane receptor","volume":"14","author":"Porrello","year":"2009","journal-title":"Front. Biosci."},{"key":"10.1016\/j.jad.2024.01.228_bb0335","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/nature11450","article-title":"A metagenome-wide association study of gut microbiota in type 2 diabetes","volume":"490","author":"Qin","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.jad.2024.01.228_bb0340","doi-asserted-by":"crossref","DOI":"10.1126\/science.1241214","article-title":"Gut microbiota from twins discordant for obesity modulate metabolism in mice","volume":"341","author":"Ridaura","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.jad.2024.01.228_bb0345","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.diabet.2015.02.003","article-title":"Antidiabetic agents: potential anti-inflammatory activity beyond glucose control","volume":"41","author":"Scheen","year":"2015","journal-title":"Diabetes Metab."},{"key":"10.1016\/j.jad.2024.01.228_bb0350","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1007\/s40265-015-0347-4","article-title":"Depression in type 2 diabetes mellitus: prevalence, impact, and treatment","volume":"75","author":"Semenkovich","year":"2015","journal-title":"Drugs"},{"key":"10.1016\/j.jad.2024.01.228_bb0355","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1136\/gutjnl-2012-303839","article-title":"An increase in the Akkermansia spp. population induced by metformin treatment improves glucose homeostasis in diet-induced obese mice","volume":"63","author":"Shin","year":"2014","journal-title":"Gut"},{"key":"10.1016\/j.jad.2024.01.228_bb0360","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2017.08.019","article-title":"Metformin and ascorbic acid combination therapy ameliorates type 2 diabetes mellitus and comorbid depression in rats","author":"Shivavedi","year":"2017","journal-title":"Brain Res."},{"key":"10.1016\/j.jad.2024.01.228_bb0365","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1007\/s00210-020-01838-w","article-title":"Impact of some oral hypoglycemic agents on type 2 diabetes-associated depression and reserpine-induced depression in rats: the role of brain oxidative stress and inflammation","volume":"393","author":"Soliman","year":"2020","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"10.1016\/j.jad.2024.01.228_bb0370","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1016\/S0140-6736(05)61032-X","article-title":"Type 2 diabetes: principles of pathogenesis and therapy","volume":"365","author":"Stumvoll","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.jad.2024.01.228_bb0375","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.jneuroim.2016.01.014","article-title":"Metformin ameliorates the development of experimental autoimmune encephalomyelitis by regulating T helper 17 and regulatory T cells in mice","volume":"292","author":"Sun","year":"2016","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.jad.2024.01.228_bb0380","article-title":"Depression, inflammation, and the moderating role of metformin: results from the midlife in the United States (MIDUS) study and Sacramento area Latino study on aging (SALSA)","author":"Syed","year":"2023","journal-title":"Psychosom. Med."},{"key":"10.1016\/j.jad.2024.01.228_bb0385","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.jare.2021.12.009","article-title":"Metformin suppresses vascular smooth muscle cell senescence by promoting autophagic flux","volume":"41","author":"Tai","year":"2022","journal-title":"J. Adv, Res."},{"key":"10.1016\/j.jad.2024.01.228_bb0390","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/s41398-022-02234-z","article-title":"Are the antidepressant effects of insulin-sensitizing medications related to improvements in metabolic markers?","volume":"12","author":"Toba-Oluboka","year":"2022","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.jad.2024.01.228_bb0395","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1111\/j.1463-1326.2007.00818.x","article-title":"Effects of insulin resistance on endothelial function: possible mechanisms and clinical implications","volume":"10","author":"Tousoulis","year":"2008","journal-title":"Diabetes Obes. Metab."},{"key":"10.1016\/j.jad.2024.01.228_bb0400","series-title":"Insulin Receptor-Mediated Stimulation Boosts T Cell Immunity during Inflammation and Infection. Cell. Metab","author":"Tsai","year":"2018"},{"key":"10.1016\/j.jad.2024.01.228_bb0405","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1097\/WNR.0000000000001634","article-title":"Protective effect of metformin against ovariectomy induced depressive- and anxiety-like behaviours in rats: role of oxidative stress","volume":"32","author":"Turan","year":"2021","journal-title":"Neuroreport"},{"key":"10.1016\/j.jad.2024.01.228_bb0410","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.brainres.2012.03.021","article-title":"Role of angiotensin II in the brain inflammatory events during experimental diabetes in rats","volume":"1453","author":"Vargas","year":"2012","journal-title":"Brain Res."},{"key":"10.1016\/j.jad.2024.01.228_bb0415","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.2337\/db14-1225","article-title":"Metformin inhibits monocyte-to-macrophage differentiation via AMPK-mediated inhibition of STAT3 activation: potential role in atherosclerosis","volume":"64","author":"Vasamsetti","year":"2015","journal-title":"Diabetes"},{"key":"10.1016\/j.jad.2024.01.228_bb0420","doi-asserted-by":"crossref","first-page":"655","DOI":"10.2217\/epi-2018-0187","article-title":"Metformin exerts antidepressant effects by regulated DNA hydroxymethylation","volume":"11","author":"Wang","year":"2019","journal-title":"Epigenomics"},{"key":"10.1016\/j.jad.2024.01.228_bb0425","doi-asserted-by":"crossref","first-page":"97","DOI":"10.2147\/CIA.S285000","article-title":"Association between systemic immune-inflammation index and diabetic depression","volume":"16","author":"Wang","year":"2021","journal-title":"Clin. Interv. Aging"},{"issue":"104769","key":"10.1016\/j.jad.2024.01.228_bb0430","article-title":"Stress-induced blood brain barrier disruption: molecular mechanisms and signaling pathways","volume":"157","author":"Welcome","year":"2020","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.jad.2024.01.228_bb0435","volume":"13","author":"Wilson","year":"2023","journal-title":"BMJ Open"},{"issue":"49\u201367","key":"10.1016\/j.jad.2024.01.228_bb0440","article-title":"Brain renin-angiotensina new look at an old system","volume":"95","author":"Wright","year":"2011","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.jad.2024.01.228_bb6000","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.pneurobio.2011.07.001","article-title":"Brain renin-angiotensin--a new look at an old system","volume":"95","author":"Wright","year":"2011","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.jad.2024.01.228_bb0445","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1038\/nm.4345","article-title":"Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug","volume":"23","author":"Wu","year":"2017","journal-title":"Nat. Med."},{"key":"10.1016\/j.jad.2024.01.228_bb0450","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1097\/WNR.0000000000001401","article-title":"Effects of metformin on lipopolysaccharide-induced depressive-like behavior in mice and its mechanisms","volume":"31","author":"Yang","year":"2020","journal-title":"Neuroreport"},{"key":"10.1016\/j.jad.2024.01.228_bb0455","doi-asserted-by":"crossref","first-page":"8152","DOI":"10.1002\/jcp.27603","article-title":"Insulin resistance: review of the underlying molecular mechanisms","volume":"234","author":"Yaribeygi","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.jad.2024.01.228_bb0460","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1128\/MCB.00705-08","article-title":"SIRT1 exerts anti-inflammatory effects and improves insulin sensitivity in adipocytes","volume":"29","author":"Yoshizaki","year":"2009","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.jad.2024.01.228_bb0465","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1093\/stmcls\/sxab001","article-title":"Gadd45g, a novel antidepressant target, mediates metformin-induced neuronal differentiation of neural stem cells via DNA demethylation","volume":"40","author":"Zhang","year":"2022","journal-title":"Stem Cells"},{"key":"10.1016\/j.jad.2024.01.228_bb0470","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.ajem.2017.07.070","article-title":"Anti-inflammatory and organ protective effect of insulin in scalded MODS rats without controlling hyperglycemia","volume":"36","author":"Zhu","year":"2018","journal-title":"Am. J. Emerg. Med."}],"container-title":["Journal of Affective Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032724002477?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032724002477?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T02:53:39Z","timestamp":1720061619000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165032724002477"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":95,"alternative-id":["S0165032724002477"],"URL":"https:\/\/doi.org\/10.1016\/j.jad.2024.01.228","relation":{},"ISSN":["0165-0327"],"issn-type":[{"value":"0165-0327","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Possible role of metformin as an antidepressant in diabetes","name":"articletitle","label":"Article Title"},{"value":"Journal of Affective Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jad.2024.01.228","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}