{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T18:41:47Z","timestamp":1788633707631,"version":"build-2803163510"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T00:00:00Z","timestamp":1738886400000},"content-version":"am","delay-in-days":312,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Affective Disorders"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1016\/j.jad.2024.01.232","type":"journal-article","created":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T23:38:30Z","timestamp":1706830710000},"page":"661-670","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Genetic evidence strengthens the bidirectional connection between oral health status and psychiatric disorders: A two-sample Mendelian randomization study"],"prefix":"10.1016","volume":"351","author":[{"given":"Yangyang","family":"Pi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziming","family":"Jiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luning","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxuan","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjuan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faxuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jad.2024.01.232_bb0005","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1016\/j.euroneuro.2019.10.011","article-title":"Nutritional psychiatry: towards improving mental health by what you eat","volume":"29","author":"Adan","year":"2019","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.jad.2024.01.232_bb0010","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyt.2022.810008","article-title":"The Oral-microbiome-brain Axis and neuropsychiatric disorders: an anthropological perspective","volume":"13","author":"Bowland","year":"2022","journal-title":"Front. Psychiatry"},{"key":"10.1016\/j.jad.2024.01.232_bb0015","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1093\/aje\/kwu283","article-title":"Multivariable Mendelian randomization: the use of pleiotropic genetic variants to estimate causal effects","volume":"181","author":"Burgess","year":"2015","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.jad.2024.01.232_bb0020","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1002\/gepi.21758","article-title":"Mendelian randomization analysis with multiple genetic variants using summarized data","volume":"37","author":"Burgess","year":"2013","journal-title":"Genet. Epidemiol."},{"key":"10.1016\/j.jad.2024.01.232_bb0025","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.eurpsy.2011.10.004","article-title":"European Psychiatric Association (EPA) guidance on prevention of mental disorders","volume":"27","author":"Campion","year":"2012","journal-title":"Eur. Psychiatry"},{"key":"10.1016\/j.jad.2024.01.232_bb0030","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.jad.2017.07.037","article-title":"Oral health impacts of medications used to treat mental illness","volume":"223","author":"Cockburn","year":"2017","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2024.01.232_bb0035","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1001\/jama.2017.17219","article-title":"Mendelian randomization","volume":"318","author":"Emdin","year":"2017","journal-title":"JAMA"},{"key":"10.1016\/j.jad.2024.01.232_bb0040","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1016\/S0140-6736(18)32279-7","article-title":"Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017","volume":"392","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.jad.2024.01.232_bb0045","first-page":"41","article-title":"Bipolar disorder. Dialogues","volume":"1","author":"Goodwin","year":"1999","journal-title":"Clin. Neurosci."},{"key":"10.1016\/j.jad.2024.01.232_bb0050","doi-asserted-by":"crossref","first-page":"605","DOI":"10.3126\/nje.v6i4.17254","article-title":"Necessity of oral health intervention in schizophrenic patients - a review","volume":"6","author":"Gupta","year":"2016","journal-title":"Nepal J. Epidemiol."},{"key":"10.1016\/j.jad.2024.01.232_bb0055","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1111\/odi.12428","article-title":"Global burden of oral diseases: emerging concepts, management and interplay with systemic health","volume":"22","author":"Jin","year":"2016","journal-title":"Oral Dis."},{"key":"10.1016\/j.jad.2024.01.232_bb0060","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1177\/00220345221120510","article-title":"Mental disorders and Oral diseases: future research directions","volume":"102","author":"Joury","year":"2023","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.jad.2024.01.232_bb0065","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1177\/00220345231171108","article-title":"Mental health and Oral health in a nationally representative cohort","volume":"102","author":"Kalaigian","year":"2023","journal-title":"J. Dent. Res."},{"issue":"87","key":"10.1016\/j.jad.2024.01.232_bb0070","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/prd.12398","article-title":"Oral health\u2019s inextricable connection to systemic health: special populations bring to bear multimodal relationships and factors connecting periodontal disease to systemic diseases and conditions","volume":"2000","author":"Kapila","year":"2021","journal-title":"Periodontol"},{"key":"10.1016\/j.jad.2024.01.232_bb0075","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD008802.pub2","article-title":"Oral health advice for people with serious mental illness","volume":"11","author":"Khokhar","year":"2011","journal-title":"Cochrane Data. Syst. Rev."},{"issue":"25","key":"10.1016\/j.jad.2024.01.232_bb0080","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1034\/j.1600-0757.2001.22250102.x","article-title":"Causation and pathogenesis of periodontal disease","volume":"2000","author":"Kinane","year":"2001","journal-title":"Periodontol"},{"key":"10.1016\/j.jad.2024.01.232_bb0085","doi-asserted-by":"crossref","first-page":"17038","DOI":"10.1038\/nrdp.2017.38","article-title":"Periodontal diseases","volume":"3","author":"Kinane","year":"2017","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.jad.2024.01.232_bb0090","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1097\/PSY.0000000000000135","article-title":"A systematic review and meta-analysis of the association between poor oral health and severe mental illness","volume":"77","author":"Kisely","year":"2015","journal-title":"Psychosom. Med."},{"key":"10.1016\/j.jad.2024.01.232_bb0095","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.jad.2016.04.040","article-title":"The oral health of people with anxiety and depressive disorders - a systematic review and meta-analysis","volume":"200","author":"Kisely","year":"2016","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2024.01.232_bb0100","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.cell.2014.02.042","article-title":"Psychiatric disorders: diagnosis to therapy","volume":"157","author":"Krystal","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.jad.2024.01.232_bb0105","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1111\/jcpe.13536","article-title":"Multimorbid disease trajectories for people with periodontitis","volume":"48","author":"Larvin","year":"2021","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/j.jad.2024.01.232_bb0110","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/s41588-018-0307-5","article-title":"Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use","volume":"51","author":"Liu","year":"2019","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jad.2024.01.232_bb0115","series-title":"Did the Brain and Oral Microbiota Talk to each Other?","first-page":"9","author":"Maitre","year":"2020"},{"key":"10.1016\/j.jad.2024.01.232_bb0120","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1111\/jcpe.13420","article-title":"Periodontal diseases and depression: A pre-clinical in vivo study","volume":"48","author":"Martinez","year":"2021","journal-title":"J. Clin. Perio- dontol."},{"key":"10.1016\/j.jad.2024.01.232_bb0125","article-title":"The role of the Oral microbiota related to periodontal diseases in anxiety, mood and trauma- and stress-related disorders","volume":"12","author":"Martinez","year":"2021","journal-title":"Front. Psychiatry"},{"key":"10.1016\/j.jad.2024.01.232_bb0130","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1111\/jcpe.13780","article-title":"Neuroinflammation related to the blood-brain barrier and sphingosine-1-phosphate in a pre-clinical model of periodontal diseases and depression in rats","volume":"50","author":"Martin-Hernandez","year":"2023","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/j.jad.2024.01.232_bb0135","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1001\/jamapsychiatry.2019.1119","article-title":"Genetic variants associated with anxiety and stress-related disorders: a genome-wide association study and mouse-model study","volume":"76","author":"Meier","year":"2019","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.jad.2024.01.232_bb0140","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1038\/s41588-021-00857-4","article-title":"Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology","volume":"53","author":"Mullins","year":"2021","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jad.2024.01.232_bb0145","first-page":"13","article-title":"No bidirectional relationship between depression and periodontitis: a genetic correlation and Mendelian randomization study","author":"Nolde","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jad.2024.01.232_bb0150","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/s41582-019-0174-4","article-title":"Immunoneuropsychiatry \u2014 novel perspectives on brain disorders","volume":"15","author":"Pape","year":"2019","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.jad.2024.01.232_bb0155","doi-asserted-by":"crossref","first-page":"E16","DOI":"10.1038\/sj.bdj.2012.989","article-title":"Prevalence of oral diseases and oral-health-related quality of life in people with severe mental illness undertaking community-based psychiatric care","volume":"213","author":"Patel","year":"2012","journal-title":"Br. Dent. J."},{"key":"10.1016\/j.jad.2024.01.232_bb0160","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0140-6736(19)31146-8","article-title":"Oral diseases: a global public health challenge","volume":"394","author":"Peres","year":"2019","journal-title":"Lancet"},{"key":"10.1016\/j.jad.2024.01.232_bb0165","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.bbi.2021.07.009","article-title":"Associations of immunological proteins\/traits with schizophrenia, major depression and bipolar disorder: a bi-directional two-sample mendelian randomization study","volume":"97","author":"Perry","year":"2021","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.jad.2024.01.232_bb0170","first-page":"661","article-title":"The global burden of oral diseases and risks to oral health","volume":"83","author":"Petersen","year":"2005","journal-title":"Bull. World Health Organ."},{"key":"10.1016\/j.jad.2024.01.232_bb0175","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1093\/ije\/dyq151","article-title":"Power and instrument strength requirements for Mendelian randomization studies using multiple genetic variants","volume":"40","author":"Pierce","year":"2011","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.jad.2024.01.232_bb0180","article-title":"Gingival pain: an unusual side effect of ziprasidone","volume":"2013","author":"Raghunath","year":"2013","journal-title":"BMJ Case Rep."},{"key":"10.1016\/j.jad.2024.01.232_bb0185","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1111\/j.1469-0691.2007.01802.x","article-title":"Oral infections and systemic disease--an emerging problem in medicine","volume":"13","author":"Rautemaa","year":"2007","journal-title":"Clin. Microbiol. Infect."},{"key":"10.1016\/j.jad.2024.01.232_bb0190","first-page":"12","article-title":"Mendelian randomization: concepts and scope","author":"Richmond","year":"2022","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.jad.2024.01.232_bb0195","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1056\/NEJMcp054630","article-title":"Clinical practice","volume":"355","author":"Scully","year":"2006","journal-title":"Aphthous ulceration. N. Engl. J. Med."},{"key":"10.1016\/j.jad.2024.01.232_bb0200","doi-asserted-by":"crossref","first-page":"3253","DOI":"10.1681\/ASN.2016010098","article-title":"Mendelian randomization as an approach to assess causality using observational data","volume":"27","author":"Sekula","year":"2016","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.jad.2024.01.232_bb0205","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0140-6736(07)60031-2","article-title":"Dental caries","volume":"369","author":"Selwitz","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.jad.2024.01.232_bb0210","doi-asserted-by":"crossref","first-page":"2773","DOI":"10.1038\/s41467-019-10630-1","article-title":"Genome-wide analysis of dental caries and periodontitis combining clinical and self-reported data","volume":"10","author":"Shungin","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jad.2024.01.232_bb0215","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1001\/jama.2021.18236","article-title":"Strengthening the reporting of observational studies in epidemiology using Mendelian randomization: the STROBE-MR statement","volume":"326","author":"Skrivankova","year":"2021","journal-title":"JAMA"},{"key":"10.1016\/j.jad.2024.01.232_bb0220","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/ije\/dyg070","article-title":"'Mendelian randomization': can genetic epidemiology contribute to understanding environmental determinants of disease?","volume":"32","author":"Smith","year":"2003","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.jad.2024.01.232_bb0225","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1097\/01.yco.0000194146.81024.5a","article-title":"Anxiety states: a review of conceptual and treatment issues","volume":"19","author":"Starcevic","year":"2006","journal-title":"Curr. Opin. Psychiatry"},{"key":"10.1016\/j.jad.2024.01.232_bb0230","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1093\/ije\/dyw088","article-title":"Selecting instruments for Mendelian randomization in the wake of genome-wide association studies","volume":"45","author":"Swerdlow","year":"2016","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.jad.2024.01.232_bb0235","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1038\/s41586-022-04434-5","article-title":"Mapping genomic loci implicates genes and synaptic biology in schizophrenia","volume":"604","author":"Trubetskoy","year":"2022","journal-title":"Nature"},{"issue":"Suppl","key":"10.1016\/j.jad.2024.01.232_bb0240","doi-asserted-by":"crossref","first-page":"15S","DOI":"10.14219\/jada.archive.2007.0358","article-title":"Dry mouth and its effects on the oral health of elderly people","volume":"138","author":"Turner","year":"2007","journal-title":"J. Am. Dent. Assoc."},{"key":"10.1016\/j.jad.2024.01.232_bb0245","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2020.608630","article-title":"Exploring the relationship between Psychiatric traits and the risk of mouth ulcers using bi-directional Mendelian Randomi- zation","volume":"11","author":"Wang","year":"2020","journal-title":"Front. Genet."},{"key":"10.1016\/j.jad.2024.01.232_bb0250","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1038\/s41588-018-0090-3","article-title":"Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression","volume":"50","author":"Wray","year":"2018","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jad.2024.01.232_bb0255","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1186\/s12903-018-0696-y","article-title":"Psychological problems and quality of life of patients with oral mucosal diseases: a preliminary study in Chinese population","volume":"18","author":"Yang","year":"2018","journal-title":"BMC Oral Health"}],"container-title":["Journal of Affective Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032724002520?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032724002520?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T02:53:20Z","timestamp":1720061600000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165032724002520"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":51,"alternative-id":["S0165032724002520"],"URL":"https:\/\/doi.org\/10.1016\/j.jad.2024.01.232","relation":{},"ISSN":["0165-0327"],"issn-type":[{"value":"0165-0327","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genetic evidence strengthens the bidirectional connection between oral health status and psychiatric disorders: A two-sample Mendelian randomization study","name":"articletitle","label":"Article Title"},{"value":"Journal of Affective Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jad.2024.01.232","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}