{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:05:14Z","timestamp":1787069114211,"version":"build-2736575974"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T00:00:00Z","timestamp":1724716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006483","name":"AbbVie Inc","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006483","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Affective Disorders"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.jad.2024.08.119","type":"journal-article","created":{"date-parts":[[2024,8,24]],"date-time":"2024-08-24T07:09:05Z","timestamp":1724483345000},"page":"136-145","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Full-spectrum efficacy of cariprazine across manic and depressive symptoms of bipolar I disorder in patients experiencing mood episodes: Post hoc analysis of pooled randomized controlled trial data"],"prefix":"10.1016","volume":"366","author":[{"given":"Eduard","family":"Vieta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger S.","family":"McIntyre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren C.","family":"Aronin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Kramer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huy-Binh","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jad.2024.08.119_bb0005","unstructured":"APA 2000, American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition), American Psychiatric Association. Text Revision. Washington DC (2000)."},{"key":"10.1016\/j.jad.2024.08.119_bb0010","doi-asserted-by":"crossref","unstructured":"APA 2013, American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders (Fifth Edition), American Psychiatric Association, Arlington, VA (2013).","DOI":"10.1176\/appi.books.9780890425596"},{"key":"10.1016\/j.jad.2024.08.119_bb0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.euroneuro.2023.04.013","article-title":"A systematic review of manic\/hypomanic and depressive switches in patients with bipolar disorder in naturalistic settings: the role of antidepressant and antipsychotic drugs","volume":"73","author":"Barbuti","year":"2023","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.jad.2024.08.119_bb0020","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0165-0327(02)00265-3","article-title":"Mixed depressive features predict maniform switch during treatment of depression in bipolar I disorder","volume":"78","author":"Bottlender","year":"2004","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2024.08.119_bb0025","doi-asserted-by":"crossref","first-page":"284","DOI":"10.4088\/JCP.14m09081","article-title":"Efficacy and safety of low- and high-dose cariprazine in acute and mixed mania associated with bipolar I disorder: a double-blind, placebo-controlled study","volume":"76","author":"Calabrese","year":"2015","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.jad.2024.08.119_bb0030","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1176\/appi.ajp.2015.15020164","article-title":"An 8-week randomized, double-blind, placebo-controlled evaluation of the safety and efficacy of Cariprazine in patients with bipolar I depression","volume":"173","author":"Durgam","year":"2016","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jad.2024.08.119_bb0035","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1111\/bdi.12238","article-title":"The efficacy and tolerability of cariprazine in acute mania associated with bipolar I disorder: a phase II trial","volume":"17","author":"Durgam","year":"2015","journal-title":"Bipolar Disord."},{"key":"10.1016\/j.jad.2024.08.119_bb0040","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1176\/appi.ajp.2018.18070824","article-title":"Cariprazine treatment of bipolar depression: a randomized double-blind placebo-controlled phase 3 study","volume":"176","author":"Earley","year":"2019","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jad.2024.08.119_bb0045","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.jad.2017.03.032","article-title":"Tolerability of cariprazine in the treatment of acute bipolar I mania: a pooled post hoc analysis of 3 phase II\/III studies","volume":"215","author":"Earley","year":"2017","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2024.08.119_bb0050","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.jad.2019.11.098","article-title":"A pooled post hoc analysis evaluating the safety and tolerability of cariprazine in bipolar depression","volume":"263","author":"Earley","year":"2020","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2024.08.119_bb0055","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1111\/bdi.12852","article-title":"Efficacy and safety of cariprazine in bipolar I depression: a double-blind, placebo-controlled phase 3 study","volume":"22","author":"Earley","year":"2020","journal-title":"Bipolar Disord."},{"key":"10.1016\/j.jad.2024.08.119_bb0060","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1111\/bdi.12612","article-title":"Incidence, prevalence and clinical correlates of antidepressant-emergent mania in bipolar depression: a systematic review and meta-analysis","volume":"20","author":"Fornaro","year":"2018","journal-title":"Bipolar Disord."},{"key":"10.1016\/j.jad.2024.08.119_bb0065","first-page":"180","article-title":"The International College of Neuro-Psychopharmacology (CINP) treatment guidelines for bipolar disorder in adults (CINP-BD-2017), part 3: the clinical guidelines","volume":"20","author":"Fountoulakis","year":"2017","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.jad.2024.08.119_bb0070","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.euroneuro.2023.03.009","article-title":"Antidepressant efficacy of cariprazine in bipolar disorder and the role of its pharmacodynamic properties: a hypothesis based on data","volume":"72","author":"Fountoulakis","year":"2023","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.jad.2024.08.119_bb0075","first-page":"121","article-title":"The International College of Neuro-Psychopharmacology (CINP) treatment guidelines for bipolar disorder in adults (CINP-BD-2017), part 2: review, grading of the evidence, and a precise algorithm","volume":"20","author":"Fountoulakis","year":"2017","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.jad.2024.08.119_bb0080","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s40345-018-0133-9","article-title":"Antidepressants in bipolar depression: an enduring controversy","volume":"6","author":"Gitlin","year":"2018","journal-title":"Int. J. Bipolar Disord."},{"key":"10.1016\/j.jad.2024.08.119_bb0085","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.jad.2012.07.038","article-title":"Lower rate of depressive switch following antimanic treatment with second-generation antipsychotics versus haloperidol","volume":"144","author":"Goikolea","year":"2013","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2024.08.119_bb0090","first-page":"218","article-title":"The clinical global impression severity and improvement scales. ECDEU assessment manual for psychopharmacology. US Department of Health, education, and welfare publication (ADM). 76-338. Rockville","volume":"1976","author":"Guy","year":"1976","journal-title":"MD: National Institute of Mental Health"},{"key":"10.1016\/j.jad.2024.08.119_bb0095","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1136\/jnnp.23.1.56","article-title":"A rating scale for depression","volume":"23","author":"Hamilton","year":"1960","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.jad.2024.08.119_bb0100","doi-asserted-by":"crossref","DOI":"10.4088\/JCP.19m12896","article-title":"Predictors of depressive switch in patients with bipolar I disorder who initiated or changed pharmacologic treatment for mania or mixed-mania: a prospective observational study","volume":"81","author":"Maccariello","year":"2020","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.jad.2024.08.119_bb0105","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1176\/appi.ajp.159.10.1711","article-title":"The prognostic significance of \u201cswitching\u201d in patients with bipolar disorder: a 10-year prospective follow-up study","volume":"159","author":"Maj","year":"2002","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jad.2024.08.119_bb0110","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.jad.2019.07.020","article-title":"Cariprazine for the treatment of bipolar mania with mixed features: a post hoc pooled analysis of 3 trials","volume":"257","author":"McIntyre","year":"2019","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2024.08.119_bb0115","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.jad.2014.09.026","article-title":"The prevalence and illness characteristics of DSM-5-defined \u201cmixed feature specifier\u201d in adults with major depressive disorder and bipolar disorder: results from the international mood disorders collaborative project","volume":"172","author":"McIntyre","year":"2015","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2024.08.119_bb0120","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1017\/S1092852919001287","article-title":"Cariprazine efficacy in bipolar I depression with and without concurrent manic symptoms: post hoc analysis of 3 randomized, placebo-controlled studies","volume":"25","author":"McIntyre","year":"2020","journal-title":"CNS Spectr."},{"key":"10.1016\/j.jad.2024.08.119_bb0125","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1192\/bjp.134.4.382","article-title":"A new depression scale designed to be sensitive to change","volume":"134","author":"Montgomery","year":"1979","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.jad.2024.08.119_bb0130","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.jad.2018.04.097","article-title":"Does recent mania affect response to antidepressants in bipolar disorder? A re-analysis of STEP-BD data","volume":"236","author":"Mousavi","year":"2018","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2024.08.119_bb0135","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0165-0327(02)00120-9","article-title":"Differentiating moderate and severe depression using the Montgomery-Asberg depression rating scale (MADRS)","volume":"77","author":"Muller","year":"2003","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2024.08.119_bb0140","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1176\/appi.ajp.2013.13020185","article-title":"The International Society for Bipolar Disorders (ISBD) task force report on antidepressant use in bipolar disorders","volume":"170","author":"Pacchiarotti","year":"2013","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jad.2024.08.119_bb0145","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.jad.2014.11.018","article-title":"Cariprazine in the treatment of acute mania in bipolar I disorder: a double-blind, placebo-controlled, phase III trial","volume":"174","author":"Sachs","year":"2015","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2024.08.119_bb0150","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.4088\/JCP.09r05259gre","article-title":"The neurobiology of the switch process in bipolar disorder: a review","volume":"71","author":"Salvadore","year":"2010","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.jad.2024.08.119_bb0155","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1176\/appi.ajp.2012.12030301","article-title":"Bipolar mixed states: an international society for bipolar disorders task force report of symptom structure, course of illness, and diagnosis","volume":"170","author":"Swann","year":"2013","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jad.2024.08.119_bb0160","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.jad.2021.02.043","article-title":"Evaluation of MADRS severity thresholds in patients with bipolar depression","volume":"286","author":"Thase","year":"2021","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2024.08.119_bb0165","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1111\/j.1399-5618.2009.00726.x","article-title":"The International Society for Bipolar Disorders (ISBD) task force report on the nomenclature of course and outcome in bipolar disorders","volume":"11","author":"Tohen","year":"2009","journal-title":"Bipolar Disord."},{"key":"10.1016\/j.jad.2024.08.119_bb0170","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1176\/appi.ajp.160.12.2099","article-title":"The McLean-Harvard first-episode mania study: prediction of recovery and first recurrence","volume":"160","author":"Tohen","year":"2003","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jad.2024.08.119_bb0175","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.4088\/JCP.v68n1002","article-title":"Self-reported history of manic\/hypomanic switch associated with antidepressant use: data from the systematic treatment enhancement program for bipolar disorder (STEP-BD)","volume":"68","author":"Truman","year":"2007","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.jad.2024.08.119_bb0180","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.eurpsy.2004.12.002","article-title":"The treatment of mixed states and the risk of switching to depression","volume":"20","author":"Vieta","year":"2005","journal-title":"Eur. Psychiatry"},{"key":"10.1016\/j.jad.2024.08.119_bb0185","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.jad.2009.02.007","article-title":"Predictors of switching from mania to depression in a large observational study across Europe (EMBLEM)","volume":"118","author":"Vieta","year":"2009","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2024.08.119_bb0190","doi-asserted-by":"crossref","DOI":"10.1038\/nrdp.2018.8","article-title":"Bipolar disorders","volume":"4","author":"Vieta","year":"2018","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.jad.2024.08.119_bb0195","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.1016\/j.euroneuro.2015.08.020","article-title":"Effect of cariprazine across the symptoms of mania in bipolar I disorder: analyses of pooled data from phase II\/III trials","volume":"25","author":"Vieta","year":"2015","journal-title":"Eur. Neuropsychopharmacol."},{"issue":"Suppl. 4","key":"10.1016\/j.jad.2024.08.119_bb0200","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/j.1399-5618.2005.00212.x","article-title":"Atypical antipsychotics: newer options for mania and maintenance therapy","volume":"7","author":"Vieta","year":"2005","journal-title":"Bipolar Disord."},{"key":"10.1016\/j.jad.2024.08.119_bb0205","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1176\/appi.ajp.2014.13111501","article-title":"The risk of switch to mania in patients with bipolar disorder during treatment with an antidepressant alone and in combination with a mood stabilizer","volume":"171","author":"Viktorin","year":"2014","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jad.2024.08.119_bb0210","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/bdi.12609","article-title":"Canadian network for mood and anxiety treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) 2018 guidelines for the management of patients with bipolar disorder","volume":"20","author":"Yatham","year":"2018","journal-title":"Bipolar Disord."},{"key":"10.1016\/j.jad.2024.08.119_bb0215","doi-asserted-by":"crossref","DOI":"10.4088\/PCC.20m02611","article-title":"Broad efficacy of cariprazine on depressive symptoms in bipolar disorder and the clinical implications","volume":"22","author":"Yatham","year":"2020","journal-title":"Prim. Care Companion CNS Disord."},{"key":"10.1016\/j.jad.2024.08.119_bb0220","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1192\/bjp.133.5.429","article-title":"A rating scale for mania: reliability, validity and sensitivity","volume":"133","author":"Young","year":"1978","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.jad.2024.08.119_bb0225","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1176\/appi.ajp.158.9.1524","article-title":"Cycling into depression from a first episode of mania: a case-comparison study","volume":"158","author":"Zarate","year":"2001","journal-title":"Am. J. Psychiatry"}],"container-title":["Journal of Affective Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032724013533?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032724013533?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,9,14]],"date-time":"2024-09-14T10:43:12Z","timestamp":1726310592000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165032724013533"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":45,"alternative-id":["S0165032724013533"],"URL":"https:\/\/doi.org\/10.1016\/j.jad.2024.08.119","relation":{},"ISSN":["0165-0327"],"issn-type":[{"value":"0165-0327","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Full-spectrum efficacy of cariprazine across manic and depressive symptoms of bipolar I disorder in patients experiencing mood episodes: Post hoc analysis of pooled randomized controlled trial data","name":"articletitle","label":"Article Title"},{"value":"Journal of Affective Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jad.2024.08.119","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}