{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T17:16:24Z","timestamp":1792602984879,"version":"4.5.0"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003453","name":"Guangdong Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2022A1515011658"],"award-info":[{"award-number":["2022A1515011658"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Guangdong Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2023A1515012235"],"award-info":[{"award-number":["2023A1515012235"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Affective Disorders"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.jad.2024.10.091","type":"journal-article","created":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T07:09:45Z","timestamp":1729580985000},"page":"1064-1070","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Exploring causal association between functional\/structural connectivity and major depression disorder: A bidirectional Mendelian randomization study"],"prefix":"10.1016","volume":"369","author":[{"given":"Huacong","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyi","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumeng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoxing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowen","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengtao","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junqi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.jad.2024.10.091_bb0005","doi-asserted-by":"crossref","DOI":"10.1002\/brb3.1365","article-title":"Parcellation-based tractographic modeling of the dorsal attention network [journal article]","volume":"9","author":"Allan","year":"2019","journal-title":"Brain Behav."},{"issue":"1","key":"10.1016\/j.jad.2024.10.091_bb0010","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.pscychresns.2012.07.010","article-title":"Fronto-limbic microstructure and structural connectivity in remission from major depression [Journal Article; Research Support, Non-U.S. Gov\u2019t]","volume":"204","author":"Arnold","year":"2012","journal-title":"Psychiatry Res."},{"issue":"6","key":"10.1016\/j.jad.2024.10.091_bb0015","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1097\/WCO.0000000000000396","article-title":"Brain connectivity and neurological disorders after stroke [journal article; review]","volume":"29","author":"Baldassarre","year":"2016","journal-title":"Curr. Opin. Neurol."},{"issue":"2","key":"10.1016\/j.jad.2024.10.091_bb0020","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1093\/ije\/dyv080","article-title":"Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression [Journal Article; Research Support, Non-U.S. Gov\u2019t]","volume":"44","author":"Bowden","year":"2015","journal-title":"Int. J. Epidemiol."},{"issue":"3","key":"10.1016\/j.jad.2024.10.091_bb0025","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1111\/acer.14782","article-title":"Large-scale brain network activation during emotional inhibitory control: associations with alcohol misuse in college freshmen [Journal Article; Research Support, N.I.H., Extramural]","volume":"46","author":"Cohen-Gilbert","year":"2022","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.jad.2024.10.091_bb0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.nicl.2019.101710","article-title":"White matter abnormalities in depression: a categorical and phenotypic diffusion MRI study [Journal Article; Research Support, Non-U.S. Gov\u2019t]","volume":"22","author":"Coloigner","year":"2019","journal-title":"Neuroimage-Clin."},{"issue":"19","key":"10.1016\/j.jad.2024.10.091_bb0035","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1001\/jama.2017.17219","article-title":"Mendelian randomization [journal article; review]","volume":"318","author":"Emdin","year":"2017","journal-title":"J. Am. Med. Assoc."},{"key":"10.1016\/j.jad.2024.10.091_bb0040","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.jad.2023.03.080","article-title":"Decreased dorsal attention network homogeneity as a potential neuroimaging biomarker for major depressive disorder [journal article; research support, non-U.S. Gov\u2019t]","volume":"332","author":"Gao","year":"2023","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2024.10.091_bb2000","doi-asserted-by":"crossref","unstructured":"GBD 2019 Diseases and Injuries Collaborators. Global burden of 369 diseases and injuries in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019 [published correction appears in Lancet. 2020 Nov 14;396(10262):1562. doi: 10.1016\/S0140-6736(20)32226-1]. Lancet. 2020;396(10258):1204-1222. doi:10.1016\/S0140-6736(20)30925-9.","DOI":"10.1016\/S0140-6736(20)30925-9"},{"issue":"3","key":"10.1016\/j.jad.2024.10.091_bb0045","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.biopsych.2014.08.009","article-title":"Depression, neuroimaging and connectomics: a selective overview [Journal Article; Research Support, Non-U.S. Gov't; Review]","volume":"77","author":"Gong","year":"2015","journal-title":"Biol. Psychiatry"},{"issue":"4","key":"10.1016\/j.jad.2024.10.091_bb0050","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.biopsych.2011.02.003","article-title":"Default-mode and task-positive network activity in major depressive disorder: implications for adaptive and maladaptive rumination [Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov\u2019t]","volume":"70","author":"Hamilton","year":"2011","journal-title":"Biol. Psychiatry"},{"issue":"6","key":"10.1016\/j.jad.2024.10.091_bb0055","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1038\/mp.2011.23","article-title":"Discovering imaging endophenotypes for major depression [journal article; review]","volume":"16","author":"Hasler","year":"2011","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jad.2024.10.091_bb0060","doi-asserted-by":"crossref","first-page":"508","DOI":"10.3389\/fnhum.2018.00508","article-title":"Within-network connectivity in the salience network after attention Bias modification training in residual depression: report from a preregistered clinical trial [journal article]","volume":"12","author":"Hilland","year":"2018","journal-title":"Front. Hum. Neurosci."},{"issue":"1","key":"10.1016\/j.jad.2024.10.091_bb0065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.tins.2010.10.004","article-title":"Stuck in a rut: rethinking depression and its treatment [Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov\u2019t]","volume":"34","author":"Holtzheimer","year":"2011","journal-title":"Trends Neurosci."},{"issue":"1","key":"10.1016\/j.jad.2024.10.091_bb0070","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/s41398-021-01619-w","article-title":"Altered resting-state functional connectome in major depressive disorder: a mega-analysis from the PsyMRI consortium [Journal Article; Research Support, Non-U.S. Gov\u2019t]","volume":"11","author":"Javaheripour","year":"2021","journal-title":"Transl. Psychiatry"},{"issue":"1","key":"10.1016\/j.jad.2024.10.091_bb0075","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/s41398-023-02540-0","article-title":"Altered brain dynamic in major depressive disorder: state and trait features [Journal Article; Research Support, Non-U.S. Gov\u2019t]","volume":"13","author":"Javaheripour","year":"2023","journal-title":"Transl. Psychiatry"},{"issue":"6","key":"10.1016\/j.jad.2024.10.091_bb0080","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1001\/jamapsychiatry.2015.0071","article-title":"Large-scale network dysfunction in major depressive disorder: a meta-analysis of resting-state functional connectivity [Journal Article; Meta-Analysis; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov\u2019t]","volume":"72","author":"Kaiser","year":"2015","journal-title":"Jama Psychiatry"},{"key":"10.1016\/j.jad.2024.10.091_bb0085","first-page":"49","article-title":"Affective network and default mode network in depressive adolescents with disruptive behaviors [journal article]","volume":"12","author":"Kim","year":"2016","journal-title":"Neuropsychiatr. Dis. Treat."},{"issue":"1","key":"10.1016\/j.jad.2024.10.091_bb0095","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s12868-019-0508-6","article-title":"Abnormal resting-state cerebral-limbic functional connectivity in bipolar depression and unipolar depression [Journal Article; Research Support, Non-U.S. Gov't]","volume":"20","author":"Liu","year":"2019","journal-title":"Bmc Neurosci."},{"issue":"5","key":"10.1016\/j.jad.2024.10.091_bb0100","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1001\/jamapsychiatry.2023.0131","article-title":"Association between the Fronto-limbic network and cognitive and emotional functioning in individuals with bipolar disorder: a systematic review and Meta-analysis [journal article; meta-analysis; systematic review]","volume":"80","author":"Mesbah","year":"2023","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.jad.2024.10.091_bb0105","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.jad.2017.11.018","article-title":"Insular subdivisions functional connectivity dysfunction within major depressive disorder [journal article; research support, non-U.S. Gov\u2019t]","volume":"227","author":"Peng","year":"2018","journal-title":"J. Affect. Disord."},{"issue":"9","key":"10.1016\/j.jad.2024.10.091_bb0110","doi-asserted-by":"crossref","first-page":"3001","DOI":"10.1007\/s00429-019-01945-2","article-title":"The cingulate cortex and limbic systems for emotion, action, and memory [journal article; review]","volume":"224","author":"Rolls","year":"2019","journal-title":"Brain Struct. Funct."},{"issue":"5","key":"10.1016\/j.jad.2024.10.091_bb0115","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.neubiorev.2009.01.004","article-title":"Bipolar and major depressive disorder: neuroimaging the developmental-degenerative divide [journal article; review]","volume":"33","author":"Savitz","year":"2009","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"1","key":"10.1016\/j.jad.2024.10.091_bb0120","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1162\/netn_a_00056","article-title":"Global connectivity of the fronto-parietal cognitive control network is related to depression symptoms in the general population [journal article]","volume":"3","author":"Schultz","year":"2019","journal-title":"Network Neurosci."},{"issue":"11","key":"10.1016\/j.jad.2024.10.091_bb0125","doi-asserted-by":"crossref","first-page":"3253","DOI":"10.1681\/ASN.2016010098","article-title":"Mendelian randomization as an approach to assess causality using observational data [journal article; review]","volume":"27","author":"Sekula","year":"2016","journal-title":"J. Am. Soc. Nephrol."},{"issue":"24","key":"10.1016\/j.jad.2024.10.091_bb0130","doi-asserted-by":"crossref","first-page":"11020","DOI":"10.1073\/pnas.1000446107","article-title":"Resting-state functional MRI in depression unmasks increased connectivity between networks via the dorsal nexus [Journal Article; Research Support, N.I.H., Extramural]","volume":"107","author":"Sheline","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"4","key":"10.1016\/j.jad.2024.10.091_bb0135","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0242-22.2023","article-title":"The genetic architectures of functional and structural connectivity properties within cerebral resting-state Networks [Journal Article; Research Support, Non-U.S. Gov\u2019t]","volume":"10","author":"Tissink","year":"2023","journal-title":"Eneuro"},{"issue":"5","key":"10.1016\/j.jad.2024.10.091_bb0140","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/s41588-018-0099-7","article-title":"Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases [Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov\u2019t]","volume":"50","author":"Verbanck","year":"2018","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jad.2024.10.091_bb0145","article-title":"Systemic inflammatory regulators and risk of acute-on-chronic liver failure: a bidirectional mendelian-randomization study [journal article]","volume":"11","author":"Wang","year":"2023","journal-title":"Front. Cell Dev. Biol."},{"issue":"6","key":"10.1016\/j.jad.2024.10.091_bb0150","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines11061575","article-title":"Causal associations between functional\/structural connectivity and stroke: a bidirectional mendelian randomization study [journal article]","volume":"11","author":"Wang","year":"2023","journal-title":"Biomedicines"},{"key":"10.1016\/j.jad.2024.10.091_bb0155","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.clinph.2024.02.004","article-title":"Distinct MRI-based functional and structural connectivity for antidepressant response prediction in major depressive disorder [journal article]","volume":"160","author":"Wang","year":"2024","journal-title":"Clin. Neurophysiol."},{"issue":"18","key":"10.1016\/j.jad.2024.10.091_bb0160","doi-asserted-by":"crossref","first-page":"9078","DOI":"10.1073\/pnas.1900390116","article-title":"Reduced default mode network functional connectivity in patients with recurrent major depressive disorder [Journal Article; Research Support, Non-U.S. Gov\u2019t]","volume":"116","author":"Yan","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jad.2024.10.091_bb0165","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.neuroimage.2017.11.010","volume":"167","author":"Yoo","year":"2018","journal-title":"Neuroimage"},{"issue":"17","key":"10.1016\/j.jad.2024.10.091_bb0170","doi-asserted-by":"crossref","first-page":"8582","DOI":"10.1073\/pnas.1900801116","article-title":"Childhood trauma history is linked to abnormal brain connectivity in major depression [Journal Article; Research Support, N.I.H., Extramural]","volume":"116","author":"Yu","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"4","key":"10.1016\/j.jad.2024.10.091_bb0175","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/bdi.13336","article-title":"Common and unique alterations of functional connectivity in major depressive disorder and bipolar disorder [Journal Article; Research Support, Non-U.S. Gov\u2019t]","volume":"25","author":"Yu","year":"2023","journal-title":"Bipolar Disord."},{"issue":"1","key":"10.1016\/j.jad.2024.10.091_bb0180","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/s41398-023-02492-5","article-title":"Dissecting the causal association between social or physical inactivity and depression: a bidirectional two-sample Mendelian randomization study [journal article]","volume":"13","author":"Zhao","year":"2023","journal-title":"Transl. Psychiatry"}],"container-title":["Journal of Affective Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032724017919?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032724017919?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,6]],"date-time":"2024-12-06T14:17:15Z","timestamp":1733494635000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165032724017919"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":36,"alternative-id":["S0165032724017919"],"URL":"https:\/\/doi.org\/10.1016\/j.jad.2024.10.091","relation":{},"ISSN":["0165-0327"],"issn-type":[{"value":"0165-0327","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exploring causal association between functional\/structural connectivity and major depression disorder: A bidirectional Mendelian randomization study","name":"articletitle","label":"Article Title"},{"value":"Journal of Affective Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jad.2024.10.091","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}