{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T14:15:48Z","timestamp":1781014548714,"version":"3.54.1"},"reference-count":77,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Affective Disorders"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.jad.2024.12.011","type":"journal-article","created":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T17:37:41Z","timestamp":1733333861000},"page":"160-172","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Effects of Fzd6 on intestinal flora and neuroinflammation in lipopolysaccharide-induced depression-like mice"],"prefix":"10.1016","volume":"372","author":[{"given":"Wenlu","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoru","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaona","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiyan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaotang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoqiang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guohua","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jad.2024.12.011_bb0005","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1126\/science.abi6087","article-title":"Signaling inflammation across the gut-brain axis","volume":"374","author":"Agirman","year":"2021","journal-title":"Science (New York, N.Y.)"},{"key":"10.1016\/j.jad.2024.12.011_bb0010","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1002\/glia.23343","article-title":"Genetic deletion of xCT attenuates peripheral and central inflammation and mitigates LPS-induced sickness and depressive-like behavior in mice","volume":"66","author":"Albertini","year":"2018","journal-title":"Glia"},{"key":"10.1016\/j.jad.2024.12.011_bb0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.sjbs.2022.103311","article-title":"Genetic and epigenetic factors associated with depression: an updated overview","volume":"29","author":"Alshaya","year":"2022","journal-title":"Saudi journal of biological sciences"},{"key":"10.1016\/j.jad.2024.12.011_bb0020","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1006\/phrs.2000.0672","article-title":"Decreased body temperature dependent appearance of behavioral despair in the forced swimming test in mice","volume":"42","author":"Arai","year":"2000","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.jad.2024.12.011_bb0025","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/j.drudis.2016.01.013","article-title":"The glucagon-like peptide 1 (GLP) receptor as a therapeutic target in Parkinson\u2019s disease: mechanisms of action","volume":"21","author":"Athauda","year":"2016","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.jad.2024.12.011_bb0030","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1038\/s41398-020-01130-8","article-title":"CD36 deficiency affects depressive-like behaviors possibly by modifying gut microbiota and the inflammasome pathway in mice","volume":"11","author":"Bai","year":"2021","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.jad.2024.12.011_bb0035","first-page":"541","article-title":"Altered composition of gut microbiota in depression: a systematic review","volume":"11","author":"Barandouzi","year":"2020","journal-title":"Front. Psychol."},{"key":"10.1016\/j.jad.2024.12.011_bb0040","first-page":"e3769","article-title":"The tail suspension test","volume":"59","author":"Can","year":"2012","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.jad.2024.12.011_bb0045","doi-asserted-by":"crossref","first-page":"155","DOI":"10.2174\/1570159X14666151204122017","article-title":"LPS-induced murine neuroinflammation model: main features and suitability for pre-clinical assessment of nutraceuticals","volume":"14","author":"Catorce","year":"2016","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.jad.2024.12.011_bb0050","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1007\/s00213-022-06285-4","article-title":"Lipopolysaccharide-induced endotoxaemia during adolescence promotes stress vulnerability in adult mice via deregulation of nuclear factor erythroid 2-related factor 2 in the medial prefrontal cortex","volume":"240","author":"Chen","year":"2023","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.jad.2024.12.011_bb0055","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/s41398-023-02416-3","article-title":"Leveraging the microbiome to understand clinical heterogeneity in depression: findings from the T-RAD study","volume":"13","author":"Chin Fatt","year":"2023","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.jad.2024.12.011_bb0060","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/bs.pmbts.2022.06.025","article-title":"Frizzled receptors and SFRP5 in lipid metabolism: current findings and potential applications","volume":"194","author":"Chu","year":"2023","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"key":"10.1016\/j.jad.2024.12.011_bb0065","doi-asserted-by":"crossref","DOI":"10.1002\/brb3.711","article-title":"Long noncoding RNA expression in peripheral blood mononuclear cells and suicide risk in Chinese patients with major depressive disorder","volume":"7","author":"Cui","year":"2017","journal-title":"Brain and behavior"},{"key":"10.1016\/j.jad.2024.12.011_bb0070","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.jad.2022.10.045","article-title":"Gut microbiota mediated inflammation, neuroendocrine and neurotrophic functions involved in the antidepressant-like effects of diosgenin in chronic restraint stress","volume":"321","author":"Cui","year":"2023","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2024.12.011_bb0075","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1007\/s43440-021-00274-8","article-title":"Insights into a possible role of glucagon-like peptide-1 receptor agonists in the treatment of depression","volume":"73","author":"Detka","year":"2021","journal-title":"Pharmacological reports : PR"},{"key":"10.1016\/j.jad.2024.12.011_bb0080","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.1008249","article-title":"The role and mechanism of NLRP3 inflammasome-mediated astrocyte activation in dehydrocorydaline against CUMS-induced depression","volume":"13","author":"Fang","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jad.2024.12.011_bb0085","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1193053","article-title":"Roles of microglia in adult hippocampal neurogenesis in depression and their therapeutics","volume":"14","author":"Fang","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jad.2024.12.011_bb0090","first-page":"25","article-title":"Effects of probiotics on intestinal flora, inflammation and degree of liver cirrhosis in rats with liver cirrhosis by regulating Wnt\/\u03b2-catenin signaling pathway","volume":"35","author":"Feng","year":"2021","journal-title":"J. Biol. Regul. Homeost. Agents"},{"key":"10.1016\/j.jad.2024.12.011_bb0095","doi-asserted-by":"crossref","first-page":"S130","DOI":"10.1080\/10408398.2018.1542587","article-title":"Nondigestible carbohydrates, butyrate, and butyrate-producing bacteria","volume":"59","author":"Fu","year":"2019","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.jad.2024.12.011_bb0100","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1038\/s41398-024-02846-7","article-title":"Down-regulation of MKP-1 in hippocampus protects against stress-induced depression-like behaviors and neuroinflammation","volume":"14","author":"Geng","year":"2024","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.jad.2024.12.011_bb0105","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1002\/da.21939","article-title":"The importance of anxiety in both major depression and bipolar disorder","volume":"29","author":"Goldberg","year":"2012","journal-title":"Depress. Anxiety"},{"key":"10.1016\/j.jad.2024.12.011_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.117217","article-title":"The regulatory effect of Angelicae Sinensis Radix on neuroendocrine-immune network and sphingolipid metabolism in CUMS-induced model of depression","volume":"319","author":"Gong","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jad.2024.12.011_bb0115","doi-asserted-by":"crossref","DOI":"10.3390\/ijms231911245","article-title":"The microbiota-gut-brain axis in psychiatric disorders","volume":"23","author":"G\u00f3ralczyk-Bi\u0144kowska","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jad.2024.12.011_bb0120","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/omi.12322","article-title":"A double-edged sword: role of butyrate in the oral cavity and the gut","volume":"36","author":"Guan","year":"2021","journal-title":"Mol Oral Microbiol"},{"key":"10.1016\/j.jad.2024.12.011_bb0125","article-title":"Glucagon-like peptide 1 improves insulin resistance in vitro through anti-inflammation of macrophages","volume":"49","author":"Guo","year":"2016","journal-title":"Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas"},{"key":"10.1016\/j.jad.2024.12.011_bb0130","first-page":"16","article-title":"Hospitalization costs and financial burden on families with children with depression: a cross-section study in Shandong Province, China","author":"Guo","year":"2019","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.jad.2024.12.011_bb0135","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.jad.2020.03.131","article-title":"Major depression accompanied with inflammation and multiple cytokines alterations: evidences from clinical patients to macaca fascicularis and LPS-induced depressive mice model","volume":"271","author":"He","year":"2020","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2024.12.011_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2023.106717","article-title":"Protective effect of Nr4a2 (Nurr1) against LPS-induced depressive-like behaviors via regulating activity of microglia and CamkII neurons in anterior cingulate cortex","volume":"191","author":"He","year":"2023","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.jad.2024.12.011_bb0145","doi-asserted-by":"crossref","first-page":"12368","DOI":"10.1111\/jne.12368","article-title":"Hypothalamic Wnt signalling and its role in energy balance regulation","volume":"28","author":"Helfer","year":"2016","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.jad.2024.12.011_bb0150","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1186\/s12974-015-0332-6","article-title":"Systemic inflammation and microglial activation: systematic review of animal experiments","volume":"12","author":"Hoogland","year":"2015","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.jad.2024.12.011_bb0155","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.bbr.2017.12.025","article-title":"Understanding the pathophysiology of depression: from monoamines to the neurogenesis hypothesis model - are we there yet?","volume":"341","author":"Jesulola","year":"2018","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.jad.2024.12.011_bb0160","doi-asserted-by":"crossref","DOI":"10.1002\/brb3.2177","article-title":"Gut microbiota variations in patients diagnosed with major depressive disorder-a systematic review","volume":"11","author":"Knudsen","year":"2021","journal-title":"Brain and behavior"},{"key":"10.1016\/j.jad.2024.12.011_bb0165","doi-asserted-by":"crossref","unstructured":"Komada, M., Takao, K., Miyakawa, T., 2008. Elevated plus maze for mice. Journal of visualized experiments : JoVE.","DOI":"10.3791\/1088-v"},{"key":"10.1016\/j.jad.2024.12.011_bb0170","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/978-1-4939-8994-2_9","article-title":"The open field test for measuring locomotor activity and anxiety-like behavior","volume":"1916","author":"Kraeuter","year":"2019","journal-title":"Methods in molecular biology (Clifton, N.J.)"},{"key":"10.1016\/j.jad.2024.12.011_bb0175","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.ctrv.2017.11.002","article-title":"Targeting the Wnt\/beta-catenin pathway in cancer: update on effectors and inhibitors","volume":"62","author":"Krishnamurthy","year":"2018","journal-title":"Cancer Treat. Rev."},{"key":"10.1016\/j.jad.2024.12.011_bb0180","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1002\/ame2.12033","article-title":"The intestinal microbiome and Alzheimer\u2019s disease: a review","volume":"1","author":"Li","year":"2018","journal-title":"Animal models and experimental medicine"},{"key":"10.1016\/j.jad.2024.12.011_bb0185","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1186\/s12906-022-03652-8","article-title":"Luteolin alleviates inflammation and autophagy of hippocampus induced by cerebral ischemia\/reperfusion by activating PPAR gamma in rats","volume":"22","author":"Li","year":"2022","journal-title":"BMC complementary medicine and therapies"},{"key":"10.1016\/j.jad.2024.12.011_bb0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.nut.2022.111837","article-title":"Maternal vitamin D deficiency aggravates the dysbiosis of gut microbiota by affecting intestinal barrier function and inflammation in obese male offspring mice","volume":"105","author":"Li","year":"2023","journal-title":"Nutrition (Burbank, Los Angeles County, Calif.)"},{"key":"10.1016\/j.jad.2024.12.011_bb0195","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.bbrc.2019.08.032","article-title":"Protein arginine methyltransferase-1 deficiency restrains depression-like behavior of mice by inhibiting inflammation and oxidative stress via Nrf-2","volume":"518","author":"Liu","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jad.2024.12.011_bb0200","article-title":"Toward a deeper understanding of gut microbiome in depression: the promise of clinical applicability","volume":"9","author":"Liu","year":"2022","journal-title":"Advanced science (Weinheim, Baden-Wurttemberg, Germany)"},{"key":"10.1016\/j.jad.2024.12.011_bb0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2023.175828","article-title":"Anti-depression-like effect of Mogroside V is related to the inhibition of inflammatory and oxidative stress pathways","volume":"955","author":"Liu","year":"2023","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jad.2024.12.011_bb0210","article-title":"Electroacupuncture and manual acupuncture at LR3 and ST36 have attenuating effects on hypertension and subsequent cognitive dysfunction in spontaneously hypertensive rats: a preliminary resting-state functional magnetic resonance imaging study","volume":"17","author":"Liu","year":"2023","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.jad.2024.12.011_bb0215","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s10787-016-0283-2","article-title":"LPS and neuroinflammation: a matter of timing","volume":"24","author":"Lopes","year":"2016","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.jad.2024.12.011_bb0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114167","article-title":"A combination of cecum microbiome and metabolome in CUMS depressed rats reveals the antidepressant mechanism of traditional Chinese medicines: a case study of Xiaoyaosan","volume":"276","author":"Lv","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jad.2024.12.011_bb0225","doi-asserted-by":"crossref","DOI":"10.1016\/j.pbb.2023.173640","article-title":"Fluoxetine combined with swimming exercise synergistically reduces lipopolysaccharide-induced depressive-like behavior by normalizing the HPA axis and brain inflammation in mice","volume":"232","author":"Mahdirejei","year":"2023","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.jad.2024.12.011_bb0230","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s13041-016-0209-3","article-title":"Frizzled-1 receptor regulates adult hippocampal neurogenesis","volume":"9","author":"Mardones","year":"2016","journal-title":"Mol. Brain"},{"key":"10.1016\/j.jad.2024.12.011_bb0235","doi-asserted-by":"crossref","first-page":"15490","DOI":"10.1523\/JNEUROSCI.3299-14.2014","article-title":"Gut microbes and the brain: paradigm shift in neuroscience","volume":"34","author":"Mayer","year":"2014","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jad.2024.12.011_bb0240","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.tcb.2019.10.003","article-title":"Wnt signaling in 3D: recent advances in the applications of intestinal organoids","volume":"30","author":"Merenda","year":"2020","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.jad.2024.12.011_bb0245","doi-asserted-by":"crossref","first-page":"e468","DOI":"10.1097\/MJT.0000000000001235","article-title":"Common pathways for pain and depression-implications for practice","volume":"27","author":"Mihailescu-Marin","year":"2020","journal-title":"Am. J. Ther."},{"key":"10.1016\/j.jad.2024.12.011_bb0250","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.neuroscience.2018.12.008","article-title":"The sex-specific effects of LPS on depressive-like behavior and oxidative stress in the hippocampus of the mouse","volume":"399","author":"Millett","year":"2019","journal-title":"Neuroscience"},{"key":"10.1016\/j.jad.2024.12.011_bb0255","first-page":"11","article-title":"Urinary citrate and butyric acid as early biomarkers for diagnosing post stroke depression in T2dM","volume":"70","author":"Mp","year":"2022","journal-title":"J. Assoc. Physicians India"},{"key":"10.1016\/j.jad.2024.12.011_bb0260","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.bbi.2019.06.016","article-title":"Probiotic consumption during puberty mitigates LPS-induced immune responses and protects against stress-induced depression- and anxiety-like behaviors in adulthood in a sex-specific manner","volume":"81","author":"Murray","year":"2019","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.jad.2024.12.011_bb0265","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19010026","article-title":"Effects of glucagon-like Peptide-1 on oxidative stress and Nrf2 signaling","volume":"19","author":"Oh","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jad.2024.12.011_bb0270","article-title":"Exploring the role of inflammation in major depressive disorder: beyond the monoamine hypothesis","volume":"17","author":"Pastis","year":"2023","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.jad.2024.12.011_bb0275","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.coph.2019.11.009","article-title":"Adult hippocampal neurogenesis and antidepressants effects","volume":"50","author":"Planchez","year":"2020","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.jad.2024.12.011_bb0280","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.3390\/ejihpe13080110","article-title":"Metabolic adverse effects of psychotropic drug therapy: a systematic review","volume":"13","author":"Sep\u00falveda-Lizcano","year":"2023","journal-title":"European journal of investigation in health, psychology and education"},{"key":"10.1016\/j.jad.2024.12.011_bb0285","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.1044375","article-title":"Gastrodin ameliorates the lipopolysaccharide-induced neuroinflammation in mice by downregulating miR-107-3p","volume":"13","author":"Song","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jad.2024.12.011_bb0290","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.neuint.2016.06.011","article-title":"The neuropharmacology of butyrate: the bread and butter of the microbiota-gut-brain axis?","volume":"99","author":"Stilling","year":"2016","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.jad.2024.12.011_bb0295","first-page":"369","article-title":"Dynamic change of the expression of glucocorticoid receptor in the hippocampus of rat model of depression by chronic unpredictable mild stress","volume":"26","author":"Sun","year":"2016","journal-title":"Journal of Jiangsu University (Medicine Edition)"},{"key":"10.1016\/j.jad.2024.12.011_bb0300","doi-asserted-by":"crossref","first-page":"8415","DOI":"10.1021\/acs.jafc.8b02462","article-title":"Clostridium butyricum attenuates chronic unpredictable mild stress-induced depressive-like behavior in mice via the gut-brain Axis","volume":"66","author":"Sun","year":"2018","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jad.2024.12.011_bb0305","doi-asserted-by":"crossref","first-page":"721","DOI":"10.7150\/thno.31562","article-title":"Fto deficiency reduces anxiety- and depression-like behaviors in mice via alterations in gut microbiota","volume":"9","author":"Sun","year":"2019","journal-title":"Theranostics"},{"key":"10.1016\/j.jad.2024.12.011_bb0310","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.jad.2023.10.072","article-title":"TGR5 deficiency-induced anxiety and depression-like behaviors: the role of gut microbiota dysbiosis","volume":"344","author":"Tao","year":"2024","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2024.12.011_bb0315","first-page":"417","article-title":"Time and dose effects of lipopolysaccharide on release of inflammatory factors in N9 microglia","volume":"30","author":"Wang","year":"2013","journal-title":"Journal of Xinxiang Medical University"},{"key":"10.1016\/j.jad.2024.12.011_bb0320","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.brainresbull.2013.11.002","article-title":"Inactivation of \u03b2-catenin results in the reduction of postnatal body weight gain","volume":"100","author":"Wang","year":"2014","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.jad.2024.12.011_bb0325","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21186969","article-title":"Clinical evidence of antidepressant effects of insulin and anti-hyperglycemic agents and implications for the pathophysiology of depression-a literature review","volume":"21","author":"Woo","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jad.2024.12.011_bb0330","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2021.627608","article-title":"Gut microbiota mediates the preventive effects of dietary capsaicin against depression-like behavior induced by lipopolysaccharide in mice","volume":"11","author":"Xia","year":"2021","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.jad.2024.12.011_bb0335","doi-asserted-by":"crossref","first-page":"9575","DOI":"10.1007\/s11033-022-07848-6","article-title":"Construction of Fzd6(Q152E )mice through CRISPR\/Cas9 technology and their reproduction and identification","volume":"49","author":"Yan","year":"2022","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.jad.2024.12.011_bb0340","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2023.175996","article-title":"Frizzled 6 mutation regulates reserpine-induced depression-like behavior and Wnt signaling pathway in mice","volume":"957","author":"Yan","year":"2023","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jad.2024.12.011_bb0345","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1181973","article-title":"Lipopolysaccharide-induced depression-like model in mice: meta-analysis and systematic evaluation","volume":"14","author":"Yin","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jad.2024.12.011_bb0350","doi-asserted-by":"crossref","first-page":"19013","DOI":"10.18632\/aging.203351","article-title":"Glucagon-like peptide-1 attenuated carboxymethyl lysine induced neuronal apoptosis via peroxisome proliferation activated receptor-\u03b3","volume":"13","author":"Zhang","year":"2021","journal-title":"Aging"},{"key":"10.1016\/j.jad.2024.12.011_bb0355","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2022.2046246","article-title":"Lacticaseibacillus paracasei sh2020 induced antitumor immunity and synergized with anti-programmed cell death 1 to reduce tumor burden in mice","volume":"14","author":"Zhang","year":"2022","journal-title":"Gut Microbes"},{"key":"10.1016\/j.jad.2024.12.011_bb0360","article-title":"The relationship between gut microbiota and inflammatory response, learning and memory in mice by sleep deprivation","volume":"13","author":"Zhang","year":"2023","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.jad.2024.12.011_bb0365","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.tibtech.2008.11.007","article-title":"Tipping the balance: modulating the Wnt pathway for tissue repair","volume":"27","author":"Zhao","year":"2009","journal-title":"Trends Biotechnol."},{"key":"10.1016\/j.jad.2024.12.011_bb0370","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1186\/s12974-016-0728-y","article-title":"The antidepressant-like effects of pioglitazone in a chronic mild stress mouse model are associated with PPAR\u03b3-mediated alteration of microglial activation phenotypes","volume":"13","author":"Zhao","year":"2016","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.jad.2024.12.011_bb0375","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.jad.2019.05.065","article-title":"Depression comorbid with hyperalgesia: different roles of neuroinflammation induced by chronic stress and hypercortisolism","volume":"256","author":"Zhao","year":"2019","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2024.12.011_bb0380","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.bbr.2017.05.064","article-title":"Behavioral, inflammatory and neurochemical disturbances in LPS and UCMS-induced mouse models of depression","volume":"364","author":"Zhao","year":"2019","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.jad.2024.12.011_bb0385","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2023.114573","article-title":"Corrigendum to \u201cBehavioral, inflammatory and neurochemical disturbances in LPS and UCMS-induced mouse models of depression\u201d [Behav. Brain Res. 64 (2019) 494-502]","volume":"452","author":"Zhao","year":"2023","journal-title":"Behav. Brain Res."}],"container-title":["Journal of Affective Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032724019906?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032724019906?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T13:56:24Z","timestamp":1740059784000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165032724019906"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":77,"alternative-id":["S0165032724019906"],"URL":"https:\/\/doi.org\/10.1016\/j.jad.2024.12.011","relation":{},"ISSN":["0165-0327"],"issn-type":[{"value":"0165-0327","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of Fzd6 on intestinal flora and neuroinflammation in lipopolysaccharide-induced depression-like mice","name":"articletitle","label":"Article Title"},{"value":"Journal of Affective Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jad.2024.12.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}