{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T01:36:42Z","timestamp":1777340202683,"version":"3.51.4"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100021953","name":"Arkansas Department of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100021953","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008231","name":"Arkansas Biosciences Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008231","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Affective Disorders"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.jad.2025.01.079","type":"journal-article","created":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T19:18:46Z","timestamp":1737141526000},"page":"579-586","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Empty bottles, rising risks: A case-crossover study on psychotherapeutic medication depletion and suicide triggers"],"prefix":"10.1016","volume":"374","author":[{"given":"Austin","family":"Porter","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allen M.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Srinivasa B.","family":"Gokarakonda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael P.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bradley C.","family":"Martin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jad.2025.01.079_bb0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.ypmed.2019.105796","article-title":"Variation in patterns of health care before suicide: a population case-control study","volume":"127","author":"Ahmedani","year":"2019","journal-title":"Prev. Med."},{"issue":"2","key":"10.1016\/j.jad.2025.01.079_bb0010","first-page":"37","article-title":"Opioid prescription claims among women of reproductive age\u2014United States, 2008\u20132012","volume":"64","author":"Ailes","year":"2015","journal-title":"Morb. Mortal. Wkly Rep."},{"key":"10.1016\/j.jad.2025.01.079_bb0015","unstructured":"Arkansas All-Payer Claims Database. (n.d.). Retrieved April 15, 2023, from https:\/\/www.arkansasapcd.net\/Home\/."},{"issue":"Suppl. 15","key":"10.1016\/j.jad.2025.01.079_bb0025","first-page":"42","article-title":"SSRI safety in overdose","volume":"59","author":"Barbey","year":"1998","journal-title":"J. Clin. Psychiatr."},{"issue":"9","key":"10.1016\/j.jad.2025.01.079_bb0030","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0073973","article-title":"An association between initiation of selective serotonin reuptake inhibitors and suicide\u2014a nationwide register-based case-crossover study","volume":"8","author":"Bj\u00f6rkenstam","year":"2013","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.jad.2025.01.079_bb0035","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.clineuro.2007.08.016","article-title":"Delirium following abrupt discontinuation of fluoxetine","volume":"110","author":"Blum","year":"2008","journal-title":"Clin. Neurol. Neurosurg."},{"issue":"4","key":"10.1016\/j.jad.2025.01.079_bb0040","doi-asserted-by":"crossref","first-page":"273","DOI":"10.2165\/00023210-200216040-00006","article-title":"Discontinuation syndrome in dysthymic patients treated with selective serotonin reuptake inhibitors","volume":"16","author":"Bogetto","year":"2002","journal-title":"CNS Drugs"},{"issue":"6","key":"10.1016\/j.jad.2025.01.079_bb0045","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1176\/appi.ps.20220145","article-title":"Health diagnoses and service utilization in the year before youth and young adult suicide","volume":"74","author":"Braciszewski","year":"2023","journal-title":"Psychiatr. Serv."},{"issue":"1","key":"10.1016\/j.jad.2025.01.079_bb0050","doi-asserted-by":"crossref","first-page":"5","DOI":"10.4103\/IJAM.IJAM_49_17","article-title":"The shortage of psychiatrists and other mental health providers: causes, current state, and potential solutions","volume":"3","author":"Butryn","year":"2017","journal-title":"Int. J. Acad. Med."},{"issue":"11","key":"10.1016\/j.jad.2025.01.079_bb0055","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1007\/s10654-017-0273-8","article-title":"Does air pollution trigger suicide? A case-crossover analysis of suicide deaths over the life span","volume":"32","author":"Casas","year":"2017","journal-title":"Eur. J. Epidemiol."},{"key":"10.1016\/j.jad.2025.01.079_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2021.112159","article-title":"High temperatures trigger suicide mortality in Brussels, Belgium: a case-crossover study (2002\u22122011)","volume":"207","author":"Casas","year":"2022","journal-title":"Environ. Res."},{"issue":"11","key":"10.1016\/j.jad.2025.01.079_bb0065","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1016\/j.mayocp.2015.07.023","article-title":"Patterns of health care usage in the year before suicide: a population-based case-control study","volume":"90","author":"Chock","year":"2015","journal-title":"Mayo Clin. Proc."},{"issue":"Supplement 1","key":"10.1016\/j.jad.2025.01.079_bb0070","doi-asserted-by":"crossref","first-page":"w490","DOI":"10.1377\/hlthaff.28.3.w490","article-title":"Beyond parity: primary care physicians\u2019 perspectives on access to mental health care","volume":"28","author":"Cunningham","year":"2009","journal-title":"Health Aff."},{"issue":"3","key":"10.1016\/j.jad.2025.01.079_bb0075","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/BF00464798","article-title":"Supersensitivity psychosis in schizophrenic patients after sudden clozapine withdrawal","volume":"83","author":"Ekblom","year":"1984","journal-title":"Psychopharmacology"},{"issue":"7488","key":"10.1016\/j.jad.2025.01.079_bb0080","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1136\/bmj.330.7488.396","article-title":"Association between suicide attempts and selective serotonin reuptake inhibitors: systematic review of randomised controlled trials","volume":"330","author":"Fergusson","year":"2005","journal-title":"BMJ"},{"issue":"4","key":"10.1016\/j.jad.2025.01.079_bb0085","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0091936","article-title":"The burden attributable to mental and substance use disorders as risk factors for suicide: findings from the global burden of disease study 2010","volume":"9","author":"Ferrari","year":"2014","journal-title":"PLoS One"},{"issue":"21","key":"10.1016\/j.jad.2025.01.079_bb0090","doi-asserted-by":"crossref","first-page":"E747","DOI":"10.1503\/cmaj.160991","article-title":"Antidepressant discontinuation syndrome","volume":"189","author":"Gabriel","year":"2017","journal-title":"Can. Med. Assoc. J."},{"issue":"2","key":"10.1016\/j.jad.2025.01.079_bb0095","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1001\/archpsyc.62.2.165","article-title":"The relationship between antidepressant medication use and rate of suicide","volume":"62","author":"Gibbons","year":"2005","journal-title":"Arch. Gen. Psychiatry"},{"issue":"1","key":"10.1016\/j.jad.2025.01.079_bb0100","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1186\/s12888-016-0844-3","article-title":"\u2018In my life antidepressants have been\u2026\u2019: a qualitative analysis of users\u2019 diverse experiences with antidepressants","volume":"16","author":"Gibson","year":"2016","journal-title":"BMC Psychiatr."},{"issue":"6","key":"10.1016\/j.jad.2025.01.079_bb0105","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1192\/apt.bp.105.001966","article-title":"Recognising and managing antidepressant discontinuation symptoms","volume":"13","author":"Haddad","year":"2007","journal-title":"Adv. Psychiatr. Treat."},{"issue":"12","key":"10.1016\/j.jad.2025.01.079_bb0110","doi-asserted-by":"crossref","first-page":"2359","DOI":"10.2105\/AJPH.2014.302163","article-title":"Mental health treatment patterns among adults with recent suicide attempts in the United States","volume":"104","author":"Han","year":"2014","journal-title":"Am. J. Public Health"},{"issue":"7","key":"10.1016\/j.jad.2025.01.079_bb0115","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1002\/pds.1579","article-title":"Association between medication and risk of suicide, attempted suicide and death in nationwide cohort of suicidal patients with schizophrenia","volume":"17","author":"Haukka","year":"2008","journal-title":"Pharmacoepidemiol. Drug Saf."},{"issue":"11","key":"10.1016\/j.jad.2025.01.079_bb0120","doi-asserted-by":"crossref","DOI":"10.1002\/brb3.2381","article-title":"Effects of somatic treatments on suicidal ideation and completed suicides","volume":"11","author":"Hawkins","year":"2021","journal-title":"Brain Behav."},{"issue":"1","key":"10.1016\/j.jad.2025.01.079_bb0125","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1192\/bjp.187.1.9","article-title":"Schizophrenia and suicide: systematic review of risk factors","volume":"187","author":"Hawton","year":"2005","journal-title":"Br. J. Psychiatry"},{"issue":"1","key":"10.1016\/j.jad.2025.01.079_bb0130","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.jad.2013.01.004","article-title":"Risk factors for suicide in individuals with depression: a systematic review","volume":"147","author":"Hawton","year":"2013","journal-title":"J. Affect. Disord."},{"issue":"6","key":"10.1016\/j.jad.2025.01.079_bb0135","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1097\/01.mlr.0000127998.89246.ef","article-title":"Chronic medical illness, depression, and use of acute medical services among medicare beneficiaries","volume":"42","author":"Himelhoch","year":"2004","journal-title":"Med. Care"},{"key":"10.1016\/j.jad.2025.01.079_bb0140","author":"Injury Data and Resources\u2014External Cause of Injury Mortality Matrix"},{"issue":"3","key":"10.1016\/j.jad.2025.01.079_bb0145","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1081\/CLT-120037428","article-title":"Relative toxicity of Selective Serotonin Reuptake Inhibitors (SSRIs) in overdose","volume":"42","author":"Isbister","year":"2004","journal-title":"J. Toxicol. Clin. Toxicol."},{"issue":"12","key":"10.1016\/j.jad.2025.01.079_bb0150","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1176\/appi.ajp.2018.18060692","article-title":"When discontinuing SSRI antidepressants is a challenge: management tips","volume":"175","author":"Jha","year":"2018","journal-title":"Am. J. Psychiatry"},{"issue":"6","key":"10.1016\/j.jad.2025.01.079_bb0155","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1111\/j.1524-4733.2009.00543.x","article-title":"Prospective validation of eight different adherence measures for use with administrative claims data among patients with schizophrenia","volume":"12","author":"Karve","year":"2009","journal-title":"Value Health: J. Int. Soc. Pharmacoecon. Outcom. Res."},{"issue":"1","key":"10.1016\/j.jad.2025.01.079_bb0160","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1186\/s12874-021-01408-5","article-title":"A novel weighting method to remove bias from within-subject exposure dependency in case-crossover studies","volume":"21","author":"Kubota","year":"2021","journal-title":"BMC Med. Res. Methodol."},{"key":"10.1016\/j.jad.2025.01.079_bb0165","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.jad.2020.05.071","article-title":"Contacts with health services during the year prior to suicide death and prevalent conditions a nationwide study","volume":"274","author":"Laanani","year":"2020","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2025.01.079_bb0170","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.psychres.2018.10.001","article-title":"Attempting to discontinue antipsychotic medication: withdrawal methods, relapse and success","volume":"270","author":"Larsen-Barr","year":"2018","journal-title":"Psychiatry Res."},{"issue":"5","key":"10.1016\/j.jad.2025.01.079_bb0175","doi-asserted-by":"crossref","first-page":"580","DOI":"10.4088\/JCP.10m06552","article-title":"Antidepressants and risks of suicide and suicide attempts: a 27-year observational study","volume":"72","author":"Leon","year":"2011","journal-title":"J. Clin. Psychiatr."},{"issue":"2","key":"10.1016\/j.jad.2025.01.079_bb0180","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1093\/oxfordjournals.aje.a115853","article-title":"The case-crossover design: a method for studying transient effects on the risk of acute events","volume":"133","author":"Maclure","year":"1991","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.jad.2025.01.079_bb0185","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1146\/annurev.publhealth.21.1.193","article-title":"Should we use a case-crossover design?","volume":"21","author":"Maclure","year":"2000","journal-title":"Annu. Rev. Public Health"},{"issue":"12","key":"10.1016\/j.jad.2025.01.079_bb0190","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2023.48557","article-title":"Benzodiazepine discontinuation and mortality among patients receiving long-term benzodiazepine therapy","volume":"6","author":"Maust","year":"2023","journal-title":"JAMA Netw. Open"},{"issue":"1","key":"10.1016\/j.jad.2025.01.079_bb0195","doi-asserted-by":"crossref","first-page":"33","DOI":"10.4103\/0973-1229.87287","article-title":"Suicide and antidepressants: what current evidence indicates","volume":"10","author":"Nischal","year":"2012","journal-title":"Mens Sana Monogr."},{"issue":"12","key":"10.1016\/j.jad.2025.01.079_bb0200","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1176\/appi.ps.201700070","article-title":"Discontinuing psychiatric medications: a survey of long-term users","volume":"68","author":"Ostrow","year":"2017","journal-title":"Psychiatr. Serv."},{"issue":"4","key":"10.1016\/j.jad.2025.01.079_bb0205","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1177\/104012371502700404","article-title":"The risk of suicide after clozapine discontinuation: cause for concern","volume":"27","author":"Patchan","year":"2015","journal-title":"Ann. Clin. Psychiatry"},{"key":"10.1016\/j.jad.2025.01.079_bb0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.162462","article-title":"Ambient temperature and air pollution associations with suicide and homicide mortality in California: a statewide case-crossover study","volume":"874","author":"Rahman","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.jad.2025.01.079_bb0215","article-title":"Clinical practice guideline recommendations on tapering and discontinuing antidepressants for depression: a systematic review","volume":"12","author":"S\u00f8rensen","year":"2022","journal-title":"Therap. Adv. Psychopharmacol."},{"issue":"3","key":"10.1016\/j.jad.2025.01.079_bb0220","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0165-0327(98)00221-3","article-title":"Mechanism of action of serotonin selective reuptake inhibitors: serotonin receptors and pathways mediate therapeutic effects and side effects","volume":"51","author":"Stahl","year":"1998","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2025.01.079_bb0225","author":"Suicide Data and Statistics | Suicide Prevention | CDC"},{"issue":"12","key":"10.1016\/j.jad.2025.01.079_bb0230","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1007\/s00127-019-01713-x","article-title":"Concurrent use of benzodiazepines, antidepressants, and opioid analgesics with zolpidem and risk for suicide: a case\u2013control and case\u2013crossover study","volume":"54","author":"Sung","year":"2019","journal-title":"Soc. Psychiatry Psychiatr. Epidemiol."},{"issue":"3","key":"10.1016\/j.jad.2025.01.079_bb0235","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/acps.13582","article-title":"Risk of suicide attempt and suicide associated with benzodiazepine: a nationwide case crossover study","volume":"148","author":"Tournier","year":"2023","journal-title":"Acta Psychiatr. Scand."},{"issue":"3","key":"10.1016\/j.jad.2025.01.079_bb0240","first-page":"449","article-title":"Antidepressant discontinuation syndrome","volume":"74","author":"Warner","year":"2006","journal-title":"Am. Fam. Physician"},{"issue":"2","key":"10.1016\/j.jad.2025.01.079_bb0245","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.eurpsy.2011.06.003","article-title":"The European Psychiatric Association (EPA) guidance on suicide treatment and prevention","volume":"27","author":"Wasserman","year":"2012","journal-title":"Eur. Psychiatry"},{"issue":"9","key":"10.1016\/j.jad.2025.01.079_bb0250","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1176\/appi.ps.201800346","article-title":"Diagnosed mental health conditions and risk of suicide mortality","volume":"70","author":"Yeh","year":"2019","journal-title":"Psychiatr. Serv."},{"issue":"7","key":"10.1016\/j.jad.2025.01.079_bb0255","doi-asserted-by":"crossref","first-page":"291","DOI":"10.4088\/JCP.v58n0702","article-title":"Discontinuation symptoms after treatment with serotonin reuptake inhibitors: a literature review","volume":"58","author":"Zajecka","year":"1997","journal-title":"J. Clin. Psychiatr."}],"container-title":["Journal of Affective Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032725000941?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032725000941?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:42:33Z","timestamp":1777336953000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165032725000941"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":50,"alternative-id":["S0165032725000941"],"URL":"https:\/\/doi.org\/10.1016\/j.jad.2025.01.079","relation":{},"ISSN":["0165-0327"],"issn-type":[{"value":"0165-0327","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Empty bottles, rising risks: A case-crossover study on psychotherapeutic medication depletion and suicide triggers","name":"articletitle","label":"Article Title"},{"value":"Journal of Affective Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jad.2025.01.079","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}