{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T04:35:46Z","timestamp":1777091746559,"version":"3.51.4"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100013115","name":"Zhejiang Provincial Program for the Cultivation of High-Level Innovative Health Talents","doi-asserted-by":"publisher","award":["2020-18"],"award-info":[{"award-number":["2020-18"]}],"id":[{"id":"10.13039\/501100013115","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["226-2023-00130"],"award-info":[{"award-number":["226-2023-00130"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370557"],"award-info":[{"award-number":["82370557"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Zhejiang Province Natural Science Foundation","doi-asserted-by":"publisher","award":["LR24H030001"],"award-info":[{"award-number":["LR24H030001"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Affective Disorders"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.jad.2025.119420","type":"journal-article","created":{"date-parts":[[2025,5,17]],"date-time":"2025-05-17T06:10:34Z","timestamp":1747462234000},"page":"119420","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Inflammatory bowel disease, age of its onset and incident psychiatric disorders: The role of post-IBD lifestyle and medications"],"prefix":"10.1016","volume":"385","author":[{"given":"Ke","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiqiong","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhihao","family":"Ying","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiayao","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaole","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changling","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangdi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rongpan","family":"Bai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jad.2025.119420_bb0005","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1093\/ecco-jcc\/jjac095","article-title":"Psychiatric disorders in adult and Paediatric patients with inflammatory bowel diseases - a systematic review and Meta-analysis","volume":"16","author":"Arp","year":"2022","journal-title":"J. Crohns Colitis"},{"key":"10.1016\/j.jad.2025.119420_bb0010","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1001\/jama.2021.4001","article-title":"Association between age at diabetes onset and subsequent risk of dementia","volume":"325","author":"Barbiellini Amidei","year":"2021","journal-title":"JAMA"},{"key":"10.1016\/j.jad.2025.119420_bb0015","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1001\/jamapediatrics.2019.2662","article-title":"Association of Childhood-Onset Inflammatory Bowel Disease with Risk of psychiatric disorders and suicide attempt","volume":"173","author":"Butwicka","year":"2019","journal-title":"JAMA Pediatr."},{"key":"10.1016\/j.jad.2025.119420_bb0020","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1093\/ije\/dyac238","article-title":"Lifestyle, genetic risk and incidence of cancer: a prospective cohort study of 13 cancer types","volume":"52","author":"Byrne","year":"2023","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.jad.2025.119420_bb0025","doi-asserted-by":"crossref","first-page":"2652","DOI":"10.1056\/NEJMra2002697","article-title":"Pathophysiology of inflammatory bowel diseases","volume":"383","author":"Chang","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jad.2025.119420_bb0030","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1186\/s12916-023-03019-x","article-title":"The associations of dietary patterns with depressive and anxiety symptoms: a prospective study","volume":"21","author":"Chen","year":"2023","journal-title":"BMC Med."},{"key":"10.1016\/j.jad.2025.119420_bb0035","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/nrn2297","article-title":"From inflammation to sickness and depression: when the immune system subjugates the brain","volume":"9","author":"Dantzer","year":"2008","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.jad.2025.119420_bb0040","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0195002","article-title":"Using data linkage to electronic patient records to assess the validity of selected mental health diagnoses in English hospital episode statistics (HES)","volume":"13","author":"Davis","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.jad.2025.119420_bb0045","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.jad.2024.12.038","article-title":"Modifiable lifestyle factors influencing neurological and psychiatric disorders mediated by structural brain reserve: an observational and Mendelian randomization study","volume":"372","author":"Dong","year":"2025","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2025.119420_bb0050","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1053\/j.gastro.2017.10.034","article-title":"Incidence and treatment of patients diagnosed with inflammatory bowel diseases at 60 years or older in sweden","volume":"154","author":"Everhov","year":"2018","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jad.2025.119420_bb0055","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1001\/jamapsychiatry.2022.4974","article-title":"Role of the gut-brain Axis in the shared genetic etiology between gastrointestinal tract diseases and psychiatric disorders: a genome-wide pleiotropic analysis","volume":"80","author":"Gong","year":"2023","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.jad.2025.119420_bb0060","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1007\/s10620-014-3375-0","article-title":"Treatment with immunosuppressive therapy may improve depressive symptoms in patients with inflammatory bowel disease","volume":"60","author":"Horst","year":"2015","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.jad.2025.119420_bb0065","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1136\/archdischild-2023-325675","article-title":"Psychiatric disorders in paediatric-onset immune-mediated inflammatory diseases: a nationwide Danish study","volume":"108","author":"Jansson","year":"2023","journal-title":"Arch. Dis. Child."},{"key":"10.1016\/j.jad.2025.119420_bb0070","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2020.02.032","article-title":"Pretreatment frailty is independently associated with increased risk of infections after immunosuppression in patients with inflammatory bowel diseases","volume":"158","author":"Kochar","year":"2020","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jad.2025.119420_bb0075","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.crohns.2010.08.004","article-title":"IBD in the elderly population: results from a population-based study in Western Hungary, 1977-2008","volume":"5","author":"Lakatos","year":"2011","journal-title":"J. Crohns Colitis"},{"key":"10.1016\/j.jad.2025.119420_bb0080","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1093\/ecco-jcc\/jjab039","article-title":"Association between inflammatory bowel disease and psychiatric morbidity and suicide: a Swedish Nationwide population-based cohort study with sibling comparisons","volume":"15","author":"Ludvigsson","year":"2021","journal-title":"J. Crohns Colitis"},{"key":"10.1016\/j.jad.2025.119420_bb0085","article-title":"Child maltreatment and incident mental disorders in middle and older ages: a retrospective UK biobank cohort study","volume":"11","author":"Macpherson","year":"2021","journal-title":"Lancet Reg. Health Eur."},{"key":"10.1016\/j.jad.2025.119420_bb0090","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1002\/wps.20723","article-title":"Beyond depression: the expanding role of inflammation in psychiatric disorders","volume":"19","author":"Miller","year":"2020","journal-title":"World Psychiatry"},{"key":"10.1016\/j.jad.2025.119420_bb0095","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S2468-1253(16)30078-4","article-title":"Mercaptopurine versus placebo to prevent recurrence of Crohn's disease after surgical resection (TOPPIC): a multicentre, double-blind, randomised controlled trial","volume":"1","author":"Mowat","year":"2016","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"10.1016\/j.jad.2025.119420_bb0100","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1007\/s10654-023-00992-8","article-title":"Adherence to a healthy lifestyle and brain structural imaging markers","volume":"38","author":"Pan","year":"2023","journal-title":"Eur. J. Epidemiol."},{"key":"10.1016\/j.jad.2025.119420_bb0105","doi-asserted-by":"crossref","first-page":"453","DOI":"10.2174\/1567205018666210929144740","article-title":"The Janus-like association between proton pump inhibitors and dementia","volume":"18","author":"Papazoglou","year":"2021","journal-title":"Curr. Alzheimer Res."},{"key":"10.1016\/j.jad.2025.119420_bb0110","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1192\/bjp.bp.107.046706","article-title":"Tobacco smoking as a risk factor for major depressive disorder: population-based study","volume":"193","author":"Pasco","year":"2008","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.jad.2025.119420_bb0115","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1111\/apt.17119","article-title":"Risk of dementia in patients with inflammatory bowel disease: a Danish population-based study","volume":"56","author":"Ronnow Sand","year":"2022","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.jad.2025.119420_bb0120","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/nrgastro.2013.240","article-title":"IBD across the age spectrum: is it the same disease?","volume":"11","author":"Ruel","year":"2014","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.jad.2025.119420_bb0125","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1176\/appi.ajp.2018.17101167","article-title":"Predicting suicide attempts and suicide deaths following outpatient visits using electronic health records","volume":"175","author":"Simon","year":"2018","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jad.2025.119420_bb0130","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.jalz.2017.06.2637","article-title":"Obesity trajectories and risk of dementia: 28 years of follow-up in the Whitehall II study","volume":"14","author":"Singh-Manoux","year":"2018","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.jad.2025.119420_bb0135","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1001779","article-title":"UK biobank: an open access resource for identifying the causes of a wide range of complex diseases of middle and old age","volume":"12","author":"Sudlow","year":"2015","journal-title":"PLoS Med."},{"key":"10.1016\/j.jad.2025.119420_bb0140","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1093\/ije\/dyz038","article-title":"A systematic review of validated suicide outcome classification in observational studies","volume":"48","author":"Swain","year":"2019","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.jad.2025.119420_bb0145","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1002\/alz.13562","article-title":"Age at cardiovascular disease onset, dementia risk, and the role of lifestyle factors","volume":"20","author":"van Gennip","year":"2024","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.jad.2025.119420_bb0150","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1136\/gutjnl-2018-317610","article-title":"Inflammatory bowel disease and new-onset psychiatric disorders in pregnancy and post partum: a population-based cohort study","volume":"68","author":"Vigod","year":"2019","journal-title":"Gut"},{"key":"10.1016\/j.jad.2025.119420_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.autrev.2023.103498","article-title":"Global, regional, and national burden of inflammatory bowel disease and its associated anemia, 1990 to 2019 and predictions to 2050: an analysis of the global burden of disease study 2019","volume":"23","author":"Wang","year":"2024","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.jad.2025.119420_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106325","article-title":"TNF inhibitors have a protective role in the risk of dementia in patients with ankylosing spondylitis: results from a nationwide study","volume":"182","author":"Watad","year":"2022","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.jad.2025.119420_bb0165","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.jad.2023.01.111","article-title":"Associations of healthy lifestyle with depression and post-depression dementia: a prospective cohort study","volume":"327","author":"Xu","year":"2023","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2025.119420_bb0170","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2023.28798","article-title":"Lifestyle factors in the Association of Shift Work and Depression and anxiety","volume":"6","author":"Xu","year":"2023","journal-title":"JAMA Netw. Open"},{"key":"10.1016\/j.jad.2025.119420_bb0175","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.123.031280","article-title":"Cardiovascular disease, genetic susceptibility, and risk of psychiatric disorders and suicide attempt: a community-based matched cohort study based on the UK biobank","volume":"13","author":"Yang","year":"2024","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.jad.2025.119420_bb0180","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1136\/gutjnl-2020-320789","article-title":"Inflammatory bowel disease is associated with higher dementia risk: a nationwide longitudinal study","volume":"70","author":"Zhang","year":"2021","journal-title":"Gut"},{"key":"10.1016\/j.jad.2025.119420_bb0185","doi-asserted-by":"crossref","first-page":"879","DOI":"10.2147\/PPA.S156883","article-title":"Improvement of psychological status after infliximab treatment in patients with newly diagnosed Crohn\u2019s disease","volume":"12","author":"Zhang","year":"2018","journal-title":"Patient Prefer. Adherence"},{"key":"10.1016\/j.jad.2025.119420_bb0190","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1186\/s12916-022-02478-y","article-title":"Regular proton pump inhibitor use and incident dementia: population-based cohort study","volume":"20","author":"Zhang","year":"2022","journal-title":"BMC Med."}],"container-title":["Journal of Affective Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032725008560?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032725008560?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T05:04:02Z","timestamp":1749099842000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165032725008560"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":38,"alternative-id":["S0165032725008560"],"URL":"https:\/\/doi.org\/10.1016\/j.jad.2025.119420","relation":{},"ISSN":["0165-0327"],"issn-type":[{"value":"0165-0327","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inflammatory bowel disease, age of its onset and incident psychiatric disorders: The role of post-IBD lifestyle and medications","name":"articletitle","label":"Article Title"},{"value":"Journal of Affective Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jad.2025.119420","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"119420"}}