{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:59:55Z","timestamp":1791352795433,"version":"4.3.1"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370818"],"award-info":[{"award-number":["82370818"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270862"],"award-info":[{"award-number":["82270862"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010096","name":"Southern Medical University","doi-asserted-by":"publisher","award":["202312121031"],"award-info":[{"award-number":["202312121031"]}],"id":[{"id":"10.13039\/501100010096","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010096","name":"Southern Medical University","doi-asserted-by":"publisher","award":["S202312121167"],"award-info":[{"award-number":["S202312121167"]}],"id":[{"id":"10.13039\/501100010096","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2024A1515220024"],"award-info":[{"award-number":["2024A1515220024"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2024A1515012744"],"award-info":[{"award-number":["2024A1515012744"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004000","name":"Guangzhou Municipal Science and Technology Program key projects","doi-asserted-by":"publisher","award":["2024A04J5098"],"award-info":[{"award-number":["2024A04J5098"]}],"id":[{"id":"10.13039\/501100004000","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004000","name":"Guangzhou Municipal Science and Technology Program key projects","doi-asserted-by":"publisher","award":["2025A04J3541"],"award-info":[{"award-number":["2025A04J3541"]}],"id":[{"id":"10.13039\/501100004000","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Affective Disorders"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.jad.2025.119429","type":"journal-article","created":{"date-parts":[[2025,5,18]],"date-time":"2025-05-18T17:53:05Z","timestamp":1747590785000},"page":"119429","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Association between depressive symptoms and mortality in patients with Cardiovascular-Kidney-Metabolic syndrome: The mediating role of inflammatory biomarkers"],"prefix":"10.1016","volume":"386","author":[{"given":"Geningyue","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yichuan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aomiao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingyuan","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuotong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinran","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuyu","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaoming","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijie","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongji","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jad.2025.119429_bb0005","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.jad.2024.05.157","article-title":"Relationship between metabolic syndrome and depression: a study based on Rafsanjan Youth Cohort Study","volume":"361","author":"Abbasifard","year":"2024","journal-title":"J. Affect Disorders"},{"key":"10.1016\/j.jad.2025.119429_bb0010","doi-asserted-by":"crossref","first-page":"2455","DOI":"10.1007\/s40620-024-01998-5","article-title":"Global prevalence of depression in chronic kidney disease: a systematic review and meta-analysis","volume":"37","author":"Adejumo","year":"2024","journal-title":"J. Nephrol."},{"key":"10.1016\/j.jad.2025.119429_bb0015","article-title":"Inflammation and cardiovascular disease: from mechanisms to therapeutics","volume":"4","author":"Alfaddagh","year":"2020","journal-title":"Am. J. Prevent. Cardiol."},{"key":"10.1016\/j.jad.2025.119429_bb0020","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1093\/ndt\/gfad240","article-title":"Mental health and addiction service utilization among people living with chronic kidney disease","volume":"39","author":"Bhasin","year":"2024","journal-title":"Nephrol. Dial. Transpl."},{"key":"10.1016\/j.jad.2025.119429_bb0025","doi-asserted-by":"crossref","DOI":"10.2337\/db23-688-P","article-title":"Severity of type 2 diabetes and the risk of depression-a nationwide population-based study","volume":"72","author":"Cho","year":"2023","journal-title":"Diabetes"},{"key":"10.1016\/j.jad.2025.119429_bb0030","doi-asserted-by":"crossref","first-page":"2152","DOI":"10.1093\/ndt\/gfad021","article-title":"High rates of psychological distress, mental health diagnoses and suicide attempts in people with chronic kidney disease in Ireland","volume":"38","author":"Cogley","year":"2023","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.jad.2025.119429_bb0035","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.biopsych.2009.09.033","article-title":"A meta-analysis of cytokines in major depression","volume":"67","author":"Dowlati","year":"2010","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jad.2025.119429_bb0040","doi-asserted-by":"crossref","DOI":"10.3389\/fpubh.2021.605651","article-title":"Depression and associated factors in Chinese patients with chronic kidney disease without dialysis: a cross-sectional study","volume":"9","author":"Duan","year":"2021","journal-title":"Front. Public Health"},{"key":"10.1016\/j.jad.2025.119429_bb0045","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1093\/eurheartj\/ehad188","article-title":"Psychological therapies for depression and cardiovascular risk: evidence from national healthcare records in England","volume":"44","author":"El Baou","year":"2023","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.jad.2025.119429_bb0050","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1003954","article-title":"Symptom burden and health-related quality of life in chronic kidney disease: a global systematic review and meta-analysis","volume":"19","author":"Fletcher","year":"2022","journal-title":"PLoS Med."},{"key":"10.1016\/j.jad.2025.119429_bb0055","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1111\/joim.12406","article-title":"Inflammation and plaque vulnerability","volume":"278","author":"Hansson","year":"2015","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.jad.2025.119429_bb0060","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1093\/eurheartj\/eht462","article-title":"Depression and cardiovascular disease: a clinical review","volume":"35","author":"Hare","year":"2014","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.jad.2025.119429_bb0065","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.1001\/jama.2020.23068","article-title":"Association between depressive symptoms and incident cardiovascular diseases","volume":"324","author":"Harshfield","year":"2020","journal-title":"Jama-J. Am. Med. Assoc."},{"key":"10.1016\/j.jad.2025.119429_bb0070","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1001\/jama.2010.619","article-title":"Association between major depressive episodes in patients with chronic kidney disease and initiation of dialysis, hospitalization, or death","volume":"303","author":"Hedayati","year":"2010","journal-title":"Jama"},{"key":"10.1016\/j.jad.2025.119429_bb0075","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232112906","article-title":"The role of inflammation in cardiovascular disease","volume":"23","author":"Henein","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jad.2025.119429_bb0080","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/S0140-6736(21)02141-3","article-title":"Time for united action on depression: a-world psychiatric association commission","volume":"399","author":"Herrman","year":"2022","journal-title":"Lancet"},{"key":"10.1016\/j.jad.2025.119429_bb0085","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1038\/s44161-021-00011-7","article-title":"Low depression frequency is associated with decreased risk of cardiometabolic disease","volume":"1","author":"Honigberg","year":"2022","journal-title":"Nature Cardiovascular Research"},{"key":"10.1016\/j.jad.2025.119429_bb0090","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1097\/PSY.0000000000000289","article-title":"The predictive value of depressive symptoms for all-cause mortality: findings from the PRIME Belfast study examining the role of inflammation and cardiovascular risk markers","volume":"78","author":"Hughes","year":"2016","journal-title":"Psychosom. Med."},{"key":"10.1016\/j.jad.2025.119429_bb0095","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1111\/dom.14829","article-title":"Interconnection between cardiovascular, renal and metabolic disorders: a narrative review with a focus on Japan","volume":"24","author":"Kadowaki","year":"2022","journal-title":"Diabetes Obes. Metab."},{"key":"10.1016\/j.jad.2025.119429_bb0100","doi-asserted-by":"crossref","first-page":"10741","DOI":"10.1073\/pnas.1308814110","article-title":"Revised microcalcification hypothesis for fibrous cap rupture in human coronary arteries","volume":"110","author":"Kelly-Arnold","year":"2013","journal-title":"P. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jad.2025.119429_bb0105","doi-asserted-by":"crossref","DOI":"10.2337\/dci23-0035","article-title":"Diabetes and multiple long-term conditions: a review of our current global health challenge","volume":"46","author":"Khunti","year":"2023","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jad.2025.119429_bb0110","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1111\/acps.12698","article-title":"Peripheral cytokine and chemokine alterations in depression: a meta-analysis of 82 studies","volume":"135","author":"K\u00f6hler","year":"2017","journal-title":"Acta Psychiat. Scand."},{"key":"10.1016\/j.jad.2025.119429_bb0115","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1177\/2047487316649493","article-title":"The association of depressive symptoms with cardiovascular and all-cause mortality in central and Eastern Europe: prospective results of the HAPIEE study","volume":"23","author":"Kozela","year":"2016","journal-title":"Eur. J. Prev. Cardiol."},{"key":"10.1016\/j.jad.2025.119429_bb0120","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1046\/j.1525-1497.2001.016009606.x","article-title":"The PHQ-9: validity of a brief depression severity measure","volume":"16","author":"Kroenke","year":"2001","journal-title":"J. Gen. Intern. Med."},{"key":"10.1016\/j.jad.2025.119429_bb0125","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.122.028332","article-title":"Association of depression and poor mental health with cardiovascular disease and suboptimal cardiovascular health among young adults in the United States","volume":"12","author":"Kwapong","year":"2023","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.jad.2025.119429_bb0130","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S2215-0366(21)00395-3","volume":"9","year":"2022","journal-title":"Lancet Psychiatry"},{"issue":"21","key":"10.1016\/j.jad.2025.119429_bb0135","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.1001\/jama.2023.22276","article-title":"Here's what to know about cardiovascular-kidney-metabolic syndrome, newly defined by the AHA","volume":"330","author":"Larkin","year":"2023","journal-title":"Jama-J. Am. Med. Assoc."},{"key":"10.1016\/j.jad.2025.119429_bb0140","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1161\/ATVBAHA.108.179705","article-title":"Inflammation in atherosclerosis","volume":"32","author":"Libby","year":"2012","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.jad.2025.119429_bb0145","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.jad.2011.08.003","article-title":"Interleukin (IL)-6, tumour necrosis factor alpha (TNF-\u03b1) and soluble interleukin-2 receptors (sIL-2R) are elevated in patients with major depressive disorder: a meta-analysis and meta-regression","volume":"139","author":"Liu","year":"2012","journal-title":"J. Affect. Disord."},{"issue":"2","key":"10.1016\/j.jad.2025.119429_bb0150","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.biopsych.2019.11.017","article-title":"Peripheral blood cell-stratified subgroups of inflamed depression","volume":"88","author":"Lynall","year":"2020","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jad.2025.119429_bb0155","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s11011-008-9118-1","article-title":"The inflammatory & neurodegenerative (I&ND) hypothesis of depression: leads for future research and new drug developments in depression","volume":"24","author":"Maes","year":"2009","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.jad.2025.119429_bb0160","doi-asserted-by":"crossref","DOI":"10.1186\/s12933-023-01937-x","article-title":"The cardio-renal-metabolic connection: a review of the evidence","volume":"22","author":"Marassi","year":"2023","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.jad.2025.119429_bb0165","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2019.21043","article-title":"Association of depression with all-cause and cardiovascular disease mortality among adults in China","volume":"3","author":"Meng","year":"2020","journal-title":"JAMA Netw. Open."},{"issue":"20","key":"10.1016\/j.jad.2025.119429_bb0170","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1161\/CIR.0000000000001186","article-title":"A synopsis of the evidence for the science and clinical management of cardiovascular-kidney-metabolic (CKM) syndrome: a scientific statement from the American Heart Association","volume":"148","author":"Ndumele","year":"2023","journal-title":"Circulation"},{"issue":"20","key":"10.1016\/j.jad.2025.119429_bb0175","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1161\/CIR.0000000000001184","article-title":"Cardiovascular-kidney-metabolic health: a presidential advisory from the American Heart Association","volume":"148","author":"Ndumele","year":"2023","journal-title":"Circulation"},{"key":"10.1016\/j.jad.2025.119429_bb0180","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1001\/jamacardio.2023.3241","article-title":"Prevalence and overlap of cardiac, renal, and metabolic conditions in US adults, 1999-2020","volume":"8","author":"Ostrominski","year":"2023","journal-title":"JAMA Cardiol."},{"key":"10.1016\/j.jad.2025.119429_bb0185","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.euroneuro.2017.04.001","article-title":"Why are depressed patients inflamed? A reflection on 20 years of research on depression, glucocorticoid resistance and inflammation","volume":"27","author":"Pariante","year":"2017","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.jad.2025.119429_bb0190","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1016\/S0140-6736(18)31612-X","article-title":"The Lancet Commission on global mental health and sustainable development","volume":"392","author":"Patel","year":"2018","journal-title":"The Lancet"},{"key":"10.1016\/j.jad.2025.119429_bb0195","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.122.027610","article-title":"Depression and anxiety are associated with cardiovascular health in young adults","volume":"11","author":"Patterson","year":"2022","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.jad.2025.119429_bb0200","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1001\/archpsyc.58.3.221","article-title":"Depression and cardiac mortality: results from a community-based longitudinal study","volume":"58","author":"Penninx","year":"2001","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.jad.2025.119429_bb0205","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1111\/jgs.15731","article-title":"Depression increases the risk of death independently from vascular events in elderly individuals: the three-city study","volume":"67","author":"P\u00e9quignot","year":"2019","journal-title":"J. Am. Geriatr. Soc."},{"key":"10.1016\/j.jad.2025.119429_bb0210","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1001\/jamapsychiatry.2020.1351","article-title":"Association of symptoms of depression with cardiovascular disease and mortality in low-, middle-, and high-income countries","volume":"77","author":"Rajan","year":"2020","journal-title":"JAMA Psychiat."},{"key":"10.1016\/j.jad.2025.119429_bb0215","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1097\/00006842-199511000-00008","article-title":"Lymphocyte subsets associated with major depression and dysthymia: modification by antidepressant treatment","volume":"57","author":"Ravindran","year":"1995","journal-title":"Psychosom. Med."},{"key":"10.1016\/j.jad.2025.119429_bb0220","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1016\/S0140-6736(21)02143-7","article-title":"Global prevalence and burden of depressive and anxiety disorders in 204 countries and territories in 2020 due to the COVID-19 pandemic","volume":"398","author":"Santomauro","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.jad.2025.119429_bb0225","doi-asserted-by":"crossref","first-page":"S31","DOI":"10.5551\/jat.21_Sup.1-S31","article-title":"Metabolic syndrome and cardiovascular diseases in Korea","volume":"21","author":"Suh","year":"2014","journal-title":"J. Atheroscler. Thromb."},{"key":"10.1016\/j.jad.2025.119429_bb0230","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.kint.2022.05.012","article-title":"Molecular mechanisms and therapeutic targets for diabetic kidney disease","volume":"102","author":"Tuttle","year":"2022","journal-title":"Kidney Int."},{"key":"10.1016\/j.jad.2025.119429_bb0235","doi-asserted-by":"crossref","DOI":"10.1038\/s41398-022-01911-3","article-title":"Depressive disorders are associated with increased peripheral blood cell deformability: a cross-sectional case-control study (Mood-Morph)","volume":"12","author":"Walther","year":"2022","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.jad.2025.119429_bb0240","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.3945\/ajcn.2010.29885","article-title":"Specific metabolic rates of major organs and tissues across adulthood: evaluation by mechanistic model of resting energy expenditure","volume":"92","author":"Wang","year":"2010","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.jad.2025.119429_bb0245","doi-asserted-by":"crossref","DOI":"10.1242\/dmm.050799","article-title":"Biological resilience in health and disease","volume":"17","author":"Weavers","year":"2024","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.jad.2025.119429_bb0250","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2023.37011","article-title":"Depressive symptoms and mortality among US adults","volume":"6","author":"Zhang","year":"2023","journal-title":"JAMA Netw. Open."}],"container-title":["Journal of Affective Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032725008651?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032725008651?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T05:54:49Z","timestamp":1778565289000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165032725008651"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":50,"alternative-id":["S0165032725008651"],"URL":"https:\/\/doi.org\/10.1016\/j.jad.2025.119429","relation":{},"ISSN":["0165-0327"],"issn-type":[{"value":"0165-0327","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association between depressive symptoms and mortality in patients with Cardiovascular-Kidney-Metabolic syndrome: The mediating role of inflammatory biomarkers","name":"articletitle","label":"Article Title"},{"value":"Journal of Affective Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jad.2025.119429","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"119429"}}