{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T16:24:49Z","timestamp":1780331089029,"version":"3.54.1"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002865","name":"Chongqing Science and Technology Commission","doi-asserted-by":"publisher","award":["CSTB2022TIAD-GPX0007"],"award-info":[{"award-number":["CSTB2022TIAD-GPX0007"]}],"id":[{"id":"10.13039\/501100002865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004374","name":"Chongqing Medical University","doi-asserted-by":"publisher","award":["W0198"],"award-info":[{"award-number":["W0198"]}],"id":[{"id":"10.13039\/501100004374","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016834","name":"Chongqing Municipal Health Commission","doi-asserted-by":"publisher","award":["2023DBXM003"],"award-info":[{"award-number":["2023DBXM003"]}],"id":[{"id":"10.13039\/100016834","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Affective Disorders"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.jad.2025.119640","type":"journal-article","created":{"date-parts":[[2025,6,8]],"date-time":"2025-06-08T18:01:51Z","timestamp":1749405711000},"page":"119640","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Increased Kcnq2 in the hippocampal contributes to esketamine-induced long-term cognitive dysfunction in neonatal mice"],"prefix":"10.1016","volume":"389","author":[{"given":"Junjie","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujuan","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haisu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jad.2025.119640_bb0005","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2020.568667","article-title":"The role of Kv7 channels in neural plasticity and behavior","volume":"11","author":"Baculis","year":"2020","journal-title":"Front Physiol."},{"key":"10.1016\/j.jad.2025.119640_bb0010","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1146\/annurev-pharmtox-010617-052912","article-title":"KCNQ-encoded potassium channels as therapeutic targets","volume":"58","author":"Barrese","year":"2018","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.jad.2025.119640_bb0015","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1111\/pan.13391","article-title":"Estimating pediatric general anesthesia exposure: quantifying duration and risk","volume":"28","author":"Bartels","year":"2018","journal-title":"Paediatr. Anaesth."},{"key":"10.1016\/j.jad.2025.119640_bb0020","doi-asserted-by":"crossref","unstructured":"Borsotto, M, Cavarec, L, Bouillot, M, Romey, G, Macciardi, F, Delaye, A. et al PP2A-Bgamma subunit and KCNQ2 K+ channels in bipolar disorder. Pharmacogenom. J., 7, 123-132. 1038\/sj.Tpj.6500400. Chumakov, I.","DOI":"10.1038\/sj.tpj.6500400"},{"key":"10.1016\/j.jad.2025.119640_bb0025","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1097\/ALN.0b013e318221fbbd","article-title":"Developmental stage-dependent persistent impact of propofol anesthesia on dendritic spines in the rat medial prefrontal cortex","volume":"115","author":"Briner","year":"2011","journal-title":"Anesthesiology"},{"key":"10.1016\/j.jad.2025.119640_bb0030","doi-asserted-by":"crossref","DOI":"10.1038\/283673a0","article-title":"Muscarinic suppression of a novel voltage-sensitive K+ current in a vertebrate neurone","volume":"283","author":"Brown","year":"1980","journal-title":"Nature"},{"key":"10.1016\/j.jad.2025.119640_bb0035","doi-asserted-by":"crossref","first-page":"105923","DOI":"10.1016\/j.nbd.2022.105923","article-title":"Neonatal ketamine exposure impairs infrapyramidal bundle pruning and causes lasting increase in excitatory synaptic transmission in hippocampal CA3 neurons","volume":"175","author":"Cabreraa","year":"2022","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.jad.2025.119640_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155043","article-title":"Fucoxanthin, a marine derived carotenoid, attenuates surgery-induced cognitive impairments via activating Akt and ERK pathways in aged mice","volume":"120","author":"Chen","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jad.2025.119640_bb0045","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2020.570588","article-title":"The role of Kv7.2 in neurodevelopment: insights and gaps in our understanding","volume":"11","author":"Dirkx","year":"2020","journal-title":"Front. Physiol."},{"key":"10.1016\/j.jad.2025.119640_bb0050","doi-asserted-by":"crossref","DOI":"10.12688\/f1000research.14344.1","article-title":"Ketamine and rapid-acting antidepressants: a new era in the battle against depression and suicide","volume":"7","author":"Duman","year":"2018","journal-title":"F1000Res"},{"issue":"4","key":"10.1016\/j.jad.2025.119640_bb0055","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s00213-016-4491-7","article-title":"Behavioral alterations of zebrafish larvae after early embryonic exposure to ketamine","volume":"234","author":"F\u00e9lix","year":"2017","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.jad.2025.119640_bb0060","doi-asserted-by":"crossref","DOI":"10.1176\/appi.ajp.2009.08121873","article-title":"Roles of the Akt\/GSK-3 and Wnt signaling pathways in schizophrenia and antipsychotic drug action","volume":"167","author":"Freyberg","year":"2010","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jad.2025.119640_bb0065","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.neubiorev.2020.11.020","article-title":"The effects of ketamine on cognition in treatment-resistant depression: a systematic review and priority avenues for future research","volume":"120","author":"Gill","year":"2021","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.jad.2025.119640_bb0070","doi-asserted-by":"crossref","DOI":"10.1136\/jmg.2007.051938","article-title":"Deletions or duplications in KCNQ2 can cause benign familial neonatal seizures","volume":"44","author":"Heron","year":"2007","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.jad.2025.119640_bb0075","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1002\/ana.23892","article-title":"Cell age-specific vulnerability of neurons to anesthetic toxicity","volume":"73","author":"Hofacer","year":"2013","journal-title":"Ann. Neurol."},{"issue":"6","key":"10.1016\/j.jad.2025.119640_bb0080","doi-asserted-by":"crossref","first-page":"3005","DOI":"10.1007\/s10571-023-01354-4","article-title":"Prenatal exposure to general anesthesia drug Esketamine impaired neurobehavior in offspring","volume":"43","author":"Huang","year":"2023","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.jad.2025.119640_bb0085","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1126\/science.283.5398.70","article-title":"Blockade of NMDA receptors and apoptotic neurodegeneration in the developing brain","volume":"283","author":"Ikonomidou","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.jad.2025.119640_bb0090","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1093\/bja\/aew413","article-title":"Duration of general anaesthetic exposure in early childhood and long-term language and cognitive ability","volume":"119","author":"Ing","year":"2017","journal-title":"Br. J. Anaesth."},{"key":"10.1016\/j.jad.2025.119640_bb0095","doi-asserted-by":"crossref","DOI":"10.1038\/35036198","article-title":"Neuronal KCNQ potassium channels: physiology and role in disease","volume":"1","author":"Jentsch","year":"2000","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.jad.2025.119640_bb0100","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1097\/ALN.0000000000002047","article-title":"Exposure of developing brain to general anesthesia: what is the animal evidence?","volume":"128","author":"Jevtovic-Todorovic","year":"2018","journal-title":"Anesthesiology"},{"key":"10.1016\/j.jad.2025.119640_bb0105","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.neubiorev.2019.10.003","article-title":"General anesthetic neurotoxicity in the young: mechanism and prevention","volume":"107","author":"Ji","year":"2019","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.jad.2025.119640_bb0110","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/j.neuropharm.2007.09.005","article-title":"Effects of fetal exposure to isoflurane on postnatal memory and learning in rats","volume":"53","author":"Li","year":"2007","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.jad.2025.119640_bb0115","doi-asserted-by":"crossref","DOI":"10.2147\/DDDT.S356284","article-title":"Global trends and hotspots in esketamine research: a bibliometric analysis of past and estimation of future trends","volume":"16","author":"Li","year":"2022","journal-title":"Drug Des Devel Ther."},{"key":"10.1016\/j.jad.2025.119640_bb0120","doi-asserted-by":"crossref","first-page":"106145","DOI":"10.1016\/j.phrs.2022.106145","article-title":"Stress induced microglial activation contributes to depression","volume":"179","author":"Li","year":"2022","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.jad.2025.119640_bb0125","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1016\/j.neuron.2022.05.001","article-title":"Ketamine exerts its sustained antidepressant effects via cell-type-specific regulation of Kcnq2","volume":"110","author":"Lopez","year":"2022","journal-title":"Neuron"},{"key":"10.1016\/j.jad.2025.119640_bb0130","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-022-33420-8","article-title":"Structural basis for the activity regulation of a potassium channel AKT1 from Arabidopsis","volume":"13","author":"Lu","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jad.2025.119640_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2017.01.035","article-title":"Up-regulation of SIRT6 in the hippocampus induced rats with depression-like behavior via the block Akt\/GSK3\u03b2 signaling pathway","volume":"323","author":"Mao","year":"2017","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.jad.2025.119640_bb0140","doi-asserted-by":"crossref","first-page":"e751","DOI":"10.1542\/peds.2012-0973","article-title":"Infantile postoperative encephalopathy: perioperative factors as a cause for concern","volume":"133","author":"McCann","year":"2014","journal-title":"Pediatrics"},{"key":"10.1016\/j.jad.2025.119640_bb0145","doi-asserted-by":"crossref","DOI":"10.1146\/annurev.neuro.22.1.105","article-title":"Stress and hippocampal plasticity","volume":"22","author":"McEwen","year":"1999","journal-title":"Annu. Rev. Neurosci."},{"issue":"10","key":"10.1016\/j.jad.2025.119640_bb0150","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1111\/dmcn.14182","article-title":"Early environmental influences on the development of children\u2019s brain structure and function","volume":"61","author":"Miguel","year":"2019","journal-title":"Dev. Med. Child Neurol."},{"key":"10.1016\/j.jad.2025.119640_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2022.175382","article-title":"S-ketamine exerts sex- and dose-dependent anti-compulsive-like effect as monotherapy or in augmentation to fluoxetine","volume":"937","author":"Mori Ayub","year":"2022","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jad.2025.119640_bb0160","doi-asserted-by":"crossref","DOI":"10.1038\/nn1506","article-title":"Distinct triggering and expression mechanisms underlie LTD of AMPA and NMDA synaptic responses","volume":"8","author":"Morishita","year":"2005","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.jad.2025.119640_bb0165","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-540-74806-9_7","article-title":"General anesthetics and long-term neurotoxicity","author":"Perouansky","year":"2008","journal-title":"Handb. Exp. Pharmacol."},{"key":"10.1016\/j.jad.2025.119640_bb0170","doi-asserted-by":"crossref","DOI":"10.1038\/nature01640","article-title":"GSK-3alpha regulates production of Alzheimer\u2019s disease amyloid-beta peptides","volume":"423","author":"Phiel","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.jad.2025.119640_bb0175","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/8957541","article-title":"Serum metabolomics of early postoperative cognitive dysfunction in elderly patients using liquid chromatography and Q-TOF mass spectrometry","volume":"2020","author":"Qian","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.jad.2025.119640_bb0180","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1097\/ALN.0000000000000851","article-title":"Multiple anesthetic exposure in infant monkeys alters emotional reactivity to an acute stressor","volume":"123","author":"Raper","year":"2015","journal-title":"Anesthesiology"},{"key":"10.1016\/j.jad.2025.119640_bb0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2020.12.010","article-title":"Targeted activation of hippocampal place cells drives memory-guided spatial behavior","volume":"183","author":"Robinson","year":"2020","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.jad.2025.119640_bb0190","first-page":"231","article-title":"Anesthesia exposure in the young child and long-term cognition: an integrated review","volume":"87","author":"Rosenblatt","year":"2019","journal-title":"AANA J."},{"key":"10.1016\/j.jad.2025.119640_bb0195","first-page":"106","article-title":"Brain development in rodents and humans: identifying benchmarks of maturation and vulnerability to injury across species","author":"Semple","year":"2013","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.jad.2025.119640_bb0200","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1126\/science.346.6214.1161","article-title":"Researchers struggle to gauge risks of childhood anesthesia","volume":"346","author":"Servick","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.jad.2025.119640_bb0205","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1038\/nature05028","article-title":"NMDA-receptor-mediated, cell-specific integration of new neurons in adult dentate gyrus","volume":"442","author":"Tashiro","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.jad.2025.119640_bb0210","author":"US Food and Drug Administration"},{"issue":"11","key":"10.1016\/j.jad.2025.119640_bb0215","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1038\/nrn.2016.128","article-title":"Lasting impact of general anaesthesia on the brain: mechanisms and relevance","volume":"17","author":"Vutskits","year":"2016","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.jad.2025.119640_bb0220","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.jad.2022.03.072","article-title":"Esketamine alleviates postoperative depression-like behavior through anti-inflammatory actions in mouse prefrontal cortex","volume":"307","author":"Wang","year":"2022","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2025.119640_bb0225","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1097\/ALN.0000000000002232","article-title":"Neuropsychological and behavioral outcomes after exposure of young children to procedures requiring general anesthesia: the Mayo Anesthesia Safety in Kids (MASK) study","volume":"129","author":"Warner","year":"2018","journal-title":"Anesthesiology"},{"key":"10.1016\/j.jad.2025.119640_bb0230","article-title":"A novel dual serotonin transporter and M-channel inhibitor D01 for antidepression and cognitive improvement","volume":"14","author":"Wei","year":"2023","journal-title":"Acta Pharm. Sin. B."},{"key":"10.1016\/j.jad.2025.119640_bb0235","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1097\/01.anes.0000344728.34332.5d","article-title":"Early exposure to anesthesia and learning disabilities in a population-based birth cohort","volume":"110","author":"Wilder","year":"2009","journal-title":"Anesthesiology"},{"key":"10.1016\/j.jad.2025.119640_bb0240","doi-asserted-by":"crossref","DOI":"10.3389\/fsurg.2023.1131137","article-title":"Safety and efficacy of esketamine for postoperative analgesia in pediatric patients with hypospadias","volume":"10","author":"Xu","year":"2023","journal-title":"Front. Surg."},{"key":"10.1016\/j.jad.2025.119640_bb0245","doi-asserted-by":"crossref","DOI":"10.1177\/01926233211046933","article-title":"Comparative milestones in rodent and human postnatal central nervous system development","volume":"49","author":"Zeiss","year":"2021","journal-title":"Toxicol. Pathol."}],"container-title":["Journal of Affective Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032725010821?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032725010821?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T04:59:46Z","timestamp":1776920386000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165032725010821"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":49,"alternative-id":["S0165032725010821"],"URL":"https:\/\/doi.org\/10.1016\/j.jad.2025.119640","relation":{},"ISSN":["0165-0327"],"issn-type":[{"value":"0165-0327","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Increased Kcnq2 in the hippocampal contributes to esketamine-induced long-term cognitive dysfunction in neonatal mice","name":"articletitle","label":"Article Title"},{"value":"Journal of Affective Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jad.2025.119640","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"119640"}}