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Disord."},{"key":"10.1016\/j.jad.2025.119648_bb0295","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.jad.2022.06.073","article-title":"The association between overweight\/obesity and poor cognitive function is mediated by inflammation in patients with major depressive disorder","volume":"313","author":"Lan","year":"2022","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2025.119648_bb0300","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.bbi.2021.12.027","article-title":"Longitudinal associations between adolescents\u2019 individualised risk for depression and inflammation in a UK cohort study","volume":"101","author":"Latham","year":"2022","journal-title":"Brain Behav. 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Disord."},{"issue":"7","key":"10.1016\/j.jad.2025.119648_bb0355","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.3390\/nu15071752","article-title":"Dysbiosis of the gut microbiota and kynurenine (Kyn) pathway activity as potential biomarkers in patients with major depressive disorder","volume":"15","author":"Lin","year":"2023","journal-title":"Nutrients"},{"issue":"6209","key":"10.1016\/j.jad.2025.119648_bb0360","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1126\/science.1254403","article-title":"Human Cognitive Aging: Corriger la Fortune?","volume":"346","author":"Lindenberger","year":"2014","journal-title":"Science (N. Y.)."},{"issue":"3","key":"10.1016\/j.jad.2025.119648_bb0365","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1002261","article-title":"Age-related cognitive decline and associations with sex, education and apolipoprotein E genotype across ethnocultural groups and geographic regions: a collaborative cohort study","volume":"14","author":"Lipnicki","year":"2017","journal-title":"PLoS Med."},{"key":"10.1016\/j.jad.2025.119648_bb0370","article-title":"Gut microbiome composition linked to inflammatory factors and cognitive functions in first-episode, drug-naive major depressive disorder patients","volume":"15","author":"Liu","year":"2021","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.jad.2025.119648_bb0375","doi-asserted-by":"crossref","first-page":"1242367","DOI":"10.3389\/fpsyt.2023.1242367","article-title":"The role of IL-33 in depression: A systematic review and meta-analysis","volume":"14","author":"Liu","year":"2023","journal-title":"Front. 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Psychiatr. Res."},{"issue":"3","key":"10.1016\/j.jad.2025.119648_bb0405","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.neubiorev.2008.10.005","article-title":"Evidence for a cytokine model of cognitive function","volume":"33","author":"McAfoose","year":"2009","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"9","key":"10.1016\/j.jad.2025.119648_bb0410","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/j.biopsych.2008.11.029","article-title":"Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression","volume":"65","author":"Miller","year":"2009","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jad.2025.119648_bb0415","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.jad.2018.12.083","article-title":"Neurognitive function and symptom remission 2 years after ECT in major depressive disorders","volume":"246","author":"Mohn","year":"2019","journal-title":"J. Affect. 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(Sao Paulo, Brazil: 1999)"},{"issue":"7","key":"10.1016\/j.jad.2025.119648_bb0530","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1002\/hipo.20542","article-title":"The effects of IL-1 receptor antagonist on beta amyloid mediated depression of LTP in the rat CA1 in vivo","volume":"19","author":"Schmid","year":"2009","journal-title":"Hippocampus"},{"issue":"1","key":"10.1016\/j.jad.2025.119648_bb0535","doi-asserted-by":"crossref","first-page":"E23","DOI":"10.1503\/jpn.220117","article-title":"Effect of short-term, high-dose probiotic supplementation on cognition, related brain functions and BDNF in patients with depression: A secondary analysis of a randomized controlled trial","volume":"48","author":"Schneider","year":"2023","journal-title":"Journal of Psychiatry & Neuroscience: JPN"},{"issue":"2","key":"10.1016\/j.jad.2025.119648_bb0540","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1099\/ijsem.0.000817","article-title":"Sellimonas intestinalis gen. Nov., sp. 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