{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T11:55:29Z","timestamp":1785412529611,"version":"3.56.0"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["NCD\/ad-hoc\/15\/2020-21"],"award-info":[{"award-number":["NCD\/ad-hoc\/15\/2020-21"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Affective Disorders"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.jad.2025.119891","type":"journal-article","created":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T11:37:31Z","timestamp":1752579451000},"page":"119891","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Comparative efficacy of antidepressant augmentation with amantadine vs pramipexole in treatment-resistant unipolar depression: A randomised controlled trial"],"prefix":"10.1016","volume":"390","author":[{"given":"Biswa Ranjan","family":"Mishra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debadatta","family":"Mohapatra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tathagata","family":"Biswas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Archana","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahadeb","family":"Panigrahi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rituparna","family":"Maiti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jad.2025.119891_bb0005","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.4088\/JCP.v68n0810","article-title":"Pramipexole in psychiatry: a systematic review of the literature","volume":"68","author":"Aiken","year":"2007","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.jad.2025.119891_bb0010","first-page":"28","article-title":"The Clinical Global Impressions Scale","volume":"4","author":"Busner","year":"2007","journal-title":"Psychiatry Edgmont"},{"key":"10.1016\/j.jad.2025.119891_bb0015","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/S0006-3223(01)01083-6","article-title":"Increased hippocampal BDNF immunoreactivity in subjects treated with antidepressant medication","volume":"50","author":"Chen","year":"2001","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jad.2025.119891_bb0020","first-page":"925","article-title":"Significantly lower nerve growth factor levels in patients with major depressive disorder than in healthy subjects: a meta-analysis and systematic review","volume":"11","author":"Chen","year":"2015","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"10.1016\/j.jad.2025.119891_bb0025","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1017\/S003329171700068X","article-title":"Backing into the future: pharmacological approaches to the management of resistant depression","volume":"47","author":"Cowen","year":"2017","journal-title":"Psychol. Med."},{"key":"10.1016\/j.jad.2025.119891_bb0030","doi-asserted-by":"crossref","first-page":"e636","DOI":"10.4088\/JCP.12m08093","article-title":"A randomized, double-blind, placebo-controlled trial of pramipexole augmentation in treatment-resistant major depressive disorder","volume":"74","author":"Cusin","year":"2013","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.jad.2025.119891_bb0035","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1080\/13651501.2016.1248852","article-title":"Evidence-based pharmacotherapy of treatment-resistant unipolar depression","volume":"21","author":"Dold","year":"2017","journal-title":"Int. J. Psychiatry Clin. Pract."},{"key":"10.1016\/j.jad.2025.119891_bb0040","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0193-953X(05)70283-5","article-title":"Definition and epidemiology of treatment-resistant depression","volume":"19","author":"Fava","year":"1996","journal-title":"Psychiatr. Clin. North Am."},{"key":"10.1016\/j.jad.2025.119891_bb0045","doi-asserted-by":"crossref","first-page":"57","DOI":"10.64719\/pb.4089","article-title":"A systematic review of augmentation strategies for patients with major depressive disorder","volume":"42","author":"Fleurence","year":"2009","journal-title":"Psychopharmacol. Bull."},{"key":"10.1016\/j.jad.2025.119891_bb0050","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.jad.2013.02.003","article-title":"Combining a dopamine agonist and selective serotonin reuptake inhibitor for the treatment of depression: a double-blind, randomized pilot study","volume":"149","author":"Franco-Chaves","year":"2013","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2025.119891_bb0055","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1016\/S0140-6736(16)31678-6","article-title":"Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990\u20132015: a systematic analysis for the Global Burden of Disease Study 2015","volume":"388","year":"2016","journal-title":"Lancet Lond. Engl."},{"key":"10.1016\/j.jad.2025.119891_bb0060","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1136\/jnnp.23.1.56","article-title":"A rating scale for depression","volume":"23","author":"Hamilton","year":"1960","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.jad.2025.119891_bb0065","doi-asserted-by":"crossref","DOI":"10.1100\/2012\/372474","article-title":"The efficacy of pramipexole, a dopamine receptor agonist, as an adjunctive treatment in treatment-resistant depression: an open-label trial","volume":"2012","author":"Hori","year":"2012","journal-title":"ScientificWorldJournal"},{"key":"10.1016\/j.jad.2025.119891_bb0070","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.neubiorev.2017.12.012","article-title":"The use of quetiapine in the treatment of major depressive disorder: evidence from clinical and experimental studies","volume":"86","author":"Ign\u00e1cio","year":"2018","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.jad.2025.119891_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.psychres.2022.115010","article-title":"The effectiveness of off-label dopamine stimulating agents in depressive disorder: a systematic review and meta-analysis","volume":"319","author":"Jeuring","year":"2023","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.jad.2025.119891_bb0080","doi-asserted-by":"crossref","first-page":"46","DOI":"10.2478\/s13380-013-0103-8","article-title":"The role of neurotrophins in major depressive disorder","volume":"4","author":"Jiang","year":"2013","journal-title":"Transl. Neurosci."},{"key":"10.1016\/j.jad.2025.119891_bb0085","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1093\/ijnp\/pyy094","article-title":"Glutamatergic neurotransmission: pathway to developing novel rapid-acting antidepressant treatments","volume":"22","author":"Kadriu","year":"2018","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.jad.2025.119891_bb0090","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1080\/10401230701675222","article-title":"Treatment resistant depression\u2014advances in somatic therapies","volume":"19","author":"Kennedy","year":"2007","journal-title":"Ann. Clin. Psychiatry Off. J. Am. Acad. Clin. Psychiatr."},{"key":"10.1016\/j.jad.2025.119891_bb0095","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1177\/0706743716664885","article-title":"Systematic review of clinical practice guidelines for failed antidepressant treatment response in major depressive disorder, dysthymia, and subthreshold depression in adults","volume":"62","author":"MacQueen","year":"2017","journal-title":"Can. J. Psychiatry Rev. Can. Psychiatr."},{"key":"10.1016\/j.jad.2025.119891_bb0100","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1002\/da.20275","article-title":"Quetiapine adjunct to selective serotonin reuptake inhibitors or venlafaxine in patients with major depression, comorbid anxiety, and residual depressive symptoms: a randomized, placebo-controlled pilot study","volume":"24","author":"McIntyre","year":"2007","journal-title":"Depress. Anxiety"},{"key":"10.1016\/j.jad.2025.119891_bb0105","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1007\/s12325-023-02700-0","article-title":"Treatment-resistant depression in real-world clinical practice: a systematic literature review of data from 2012 to 2022","volume":"41","author":"Oliveira-Maia","year":"2024","journal-title":"Adv. Ther."},{"issue":"4","key":"10.1016\/j.jad.2025.119891_bb0110","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1590\/1516-4446-2017-2393","article-title":"Potential antidepressant effect of amantadine: a review of preclinical studies and clinical trials","volume":"40","author":"Raupp-Barcaro","year":"2018","journal-title":"Rev. Bras. Psiquiatr."},{"key":"10.1016\/j.jad.2025.119891_bb0115","first-page":"179","article-title":"Antipsychotics as antidepressants","volume":"8","author":"Roberts","year":"2016","journal-title":"Asia-Pac. Psychiatry Off. J. Pac. Rim Coll. Psychiatr."},{"key":"10.1016\/j.jad.2025.119891_bb0120","first-page":"778","article-title":"Amantadine as an additive treatment in patients suffering from drug-resistant unipolar depression","volume":"59","author":"Rog\u00f3z","year":"2007","journal-title":"Pharmacol. Rep. PR"},{"key":"10.1016\/j.jad.2025.119891_bb0125","doi-asserted-by":"crossref","DOI":"10.7573\/dic.212290","article-title":"Antidepressant efficacy and side-effect burden: a quick guide for clinicians","volume":"4","author":"Santarsieri","year":"2015","journal-title":"Drugs Context"},{"key":"10.1016\/j.jad.2025.119891_bb0130","doi-asserted-by":"crossref","first-page":"773","DOI":"10.3390\/jpm13050773","article-title":"Recent developments in pharmacotherapy of depression: bench to bedside","volume":"13","author":"Shad","year":"2023","journal-title":"J. Pers. Med."},{"key":"10.1016\/j.jad.2025.119891_bb0135","doi-asserted-by":"crossref","first-page":"e531","DOI":"10.4088\/JCP.14com09586","article-title":"What are the comparative benefits and harms of augmentation treatments in major depression?","volume":"76","author":"Shelton","year":"2015","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.jad.2025.119891_bb0140","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0924-977X(98)00004-2","article-title":"Treatment resistant depression: methodological overview and operational criteria","volume":"9","author":"Souery","year":"1999","journal-title":"Eur. Neuropsychopharmacol. J. Eur. Coll. Neuropsychopharmacol."},{"key":"10.1016\/j.jad.2025.119891_bb0145","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1097\/00004850-200303000-00005","article-title":"Amantadine as augmentation therapy in the management of treatment-resistant depression","volume":"18","author":"Stryjer","year":"2003","journal-title":"Int. Clin. Psychopharmacol."},{"key":"10.1016\/j.jad.2025.119891_bb0150","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.psychres.2010.12.007","article-title":"Reliability of the Hamilton Rating Scale for Depression: a meta-analysis over a period of 49 years","volume":"189","author":"Trajkovi\u0107","year":"2011","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.jad.2025.119891_bb0155","doi-asserted-by":"crossref","DOI":"10.3390\/life13041043","article-title":"Pramipexole augmentation for treatment-resistant unipolar and bipolar depression in the real world: a systematic review and meta-analysis","volume":"13","author":"Tundo","year":"2023","journal-title":"Life"}],"container-title":["Journal of Affective Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032725013333?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032725013333?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T14:01:38Z","timestamp":1779717698000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165032725013333"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":31,"alternative-id":["S0165032725013333"],"URL":"https:\/\/doi.org\/10.1016\/j.jad.2025.119891","relation":{},"ISSN":["0165-0327"],"issn-type":[{"value":"0165-0327","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparative efficacy of antidepressant augmentation with amantadine vs pramipexole in treatment-resistant unipolar depression: A randomised controlled trial","name":"articletitle","label":"Article Title"},{"value":"Journal of Affective Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jad.2025.119891","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"119891"}}