{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T20:51:03Z","timestamp":1781297463868,"version":"3.54.1"},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012232","name":"National Key Clinical Specialty Discipline Construction Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012232","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Affective Disorders"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.jad.2025.119989","type":"journal-article","created":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T23:22:16Z","timestamp":1753744936000},"page":"119989","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Sleep disorders and aging: Mendelian randomization analysis of epigenetic and frailty markers"],"prefix":"10.1016","volume":"391","author":[{"given":"Zheng","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongjia","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haitang","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinghua","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangyou","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenggang","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jad.2025.119989_bb0005","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.ejca.2017.01.014","article-title":"DNA methylome analysis identifies accelerated epigenetic ageing associated with postmenopausal breast cancer susceptibility","volume":"75","author":"Ambatipudi","year":"2017","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.jad.2025.119989_bb0010","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13459","article-title":"A genome-wide association study of the frailty index highlights brain pathways in ageing","volume":"20","author":"Atkins","year":"2021","journal-title":"Aging Cell"},{"key":"10.1016\/j.jad.2025.119989_bb0015","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0014821","article-title":"Epigenetic predictor of age","volume":"6","author":"Bocklandt","year":"2011","journal-title":"PloS One"},{"key":"10.1016\/j.jad.2025.119989_bb0020","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1093\/ije\/dyv080","article-title":"Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression","volume":"44","author":"Bowden","year":"2015","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.jad.2025.119989_bb0025","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1002\/gepi.21965","article-title":"Consistent estimation in Mendelian randomization with some invalid instruments using a weighted Median estimator","volume":"40","author":"Bowden","year":"2016","journal-title":"Genet. Epidemiol."},{"key":"10.1016\/j.jad.2025.119989_bb0030","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/s41467-019-14156-4","article-title":"A robust and efficient method for Mendelian randomization with hundreds of genetic variants","volume":"11","author":"Burgess","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jad.2025.119989_bb0035","doi-asserted-by":"crossref","DOI":"10.1093\/sleep\/zsac308","article-title":"Discovery of genomic loci associated with sleep apnea risk through multi-trait GWAS analysis with snoring","volume":"46","author":"Campos","year":"2023","journal-title":"Sleep"},{"key":"10.1016\/j.jad.2025.119989_bb0040","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.biopsych.2016.07.008","article-title":"Epigenetic aging and immune senescence in women with insomnia symptoms: findings from the women\u2019s health initiative study","volume":"81","author":"Carroll","year":"2017","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jad.2025.119989_bb0045","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.sleh.2021.02.002","article-title":"Postpartum sleep loss and accelerated epigenetic aging","volume":"7","author":"Carroll","year":"2021","journal-title":"Sleep Health"},{"key":"10.1016\/j.jad.2025.119989_bb0050","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/s40520-022-02310-w","article-title":"The impact of insomnia on frailty and the hallmarks of aging","volume":"35","author":"Carvalhas-Almeida","year":"2023","journal-title":"Aging Clin. Exp. Res."},{"key":"10.1016\/j.jad.2025.119989_bb0055","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.cell.2020.12.028","article-title":"Telomeres: history, health, and hallmarks of aging","volume":"184","author":"Chakravarti","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.jad.2025.119989_bb0060","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1038\/cr.2015.36","article-title":"Three-dimensional human facial morphologies as robust aging markers","volume":"25","author":"Chen","year":"2015","journal-title":"Cell Res."},{"key":"10.1016\/j.jad.2025.119989_bb0065","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.sleep.2021.04.014","article-title":"The prevalence of sleep problems among children in mainland China: a meta-analysis and systemic-analysis","volume":"83","author":"Chen","year":"2021","journal-title":"Sleep Med."},{"key":"10.1016\/j.jad.2025.119989_bb0070","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1038\/s41588-021-00944-6","article-title":"Polygenic basis and biomedical consequences of telomere length variation","volume":"53","author":"Codd","year":"2021","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jad.2025.119989_bb0075","doi-asserted-by":"crossref","DOI":"10.3389\/fpubh.2024.1381482","article-title":"Causality between sleep traits and the risk of frailty: a mendelian randomization study","volume":"12","author":"Deng","year":"2024","journal-title":"Front. Public Health"},{"key":"10.1016\/j.jad.2025.119989_bb0080","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/s12916-023-02780-3","article-title":"Circulating levels of micronutrients and risk of infections: a Mendelian randomization study","volume":"21","author":"Flatby","year":"2023","journal-title":"BMC Med."},{"key":"10.1016\/j.jad.2025.119989_bb0085","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1146\/annurev-publhealth-040119-094412","article-title":"Sleep health: an opportunity for public health to address health equity","volume":"41","author":"Hale","year":"2020","journal-title":"Annu. Rev. Public Health"},{"key":"10.1016\/j.jad.2025.119989_bb0090","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1196\/annals.1395.001","article-title":"Biological aging is no longer an unsolved problem","volume":"1100","author":"Hayflick","year":"2007","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.jad.2025.119989_bb0095","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.34408","article-title":"The MR-Base platform supports systematic causal inference across the human phenome","volume":"7","author":"Hemani","year":"2018","journal-title":"eLife"},{"key":"10.1016\/j.jad.2025.119989_bb0100","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1016\/S0140-6736(19)31786-6","article-title":"Frailty: implications for clinical practice and public health","volume":"394","author":"Hoogendijk","year":"2019","journal-title":"Lancet"},{"key":"10.1016\/j.jad.2025.119989_bb0105","doi-asserted-by":"crossref","first-page":"R115","DOI":"10.1186\/gb-2013-14-10-r115","article-title":"DNA methylation age of human tissues and cell types","volume":"14","author":"Horvath","year":"2013","journal-title":"Genome Biol."},{"key":"10.1016\/j.jad.2025.119989_bb0110","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1038\/s41576-018-0004-3","article-title":"DNA methylation-based biomarkers and the epigenetic clock theory of ageing","volume":"19","author":"Horvath","year":"2018","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.jad.2025.119989_bb0115","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.18632\/aging.100859","article-title":"Increased epigenetic age and granulocyte counts in the blood of Parkinson\u2019s disease patients","volume":"7","author":"Horvath","year":"2015","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.jad.2025.119989_bb0120","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1002\/lary.28900","article-title":"Prevalence of sleep disorders and association with mortality: results from the NHANES 2009-2010","volume":"131","author":"Huyett","year":"2021","journal-title":"Laryngoscope"},{"key":"10.1016\/j.jad.2025.119989_bb0125","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1038\/s41588-021-00954-4","article-title":"A generalized linear mixed model association tool for biobank-scale data","volume":"53","author":"Jiang","year":"2021","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jad.2025.119989_bb0130","doi-asserted-by":"crossref","first-page":"S204","DOI":"10.1542\/peds.2019-2056I","article-title":"Sleep disorders in adolescents","volume":"145","author":"Kansagra","year":"2020","journal-title":"Pediatrics"},{"key":"10.1016\/j.jad.2025.119989_bb0135","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1097\/PSY.0000000000001243","article-title":"Short sleep and insomnia are associated with accelerated epigenetic age","volume":"86","author":"Kusters","year":"2024","journal-title":"Psychosom. Med."},{"key":"10.1016\/j.jad.2025.119989_bb0140","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/s41588-019-0361-7","article-title":"Biological and clinical insights from genetics of insomnia symptoms","volume":"51","author":"Lane","year":"2019","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jad.2025.119989_bb0145","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1038\/s41588-018-0147-3","article-title":"Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals","volume":"50","author":"Lee","year":"2018","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jad.2025.119989_bb0150","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.sleep.2021.11.011","article-title":"\u201cYou look sleepy\u2026\u201d The impact of sleep restriction on skin parameters and facial appearance of 24 women","volume":"89","author":"L\u00e9ger","year":"2022","journal-title":"Sleep Med."},{"key":"10.1016\/j.jad.2025.119989_bb0155","doi-asserted-by":"crossref","first-page":"690","DOI":"10.18632\/aging.100809","article-title":"DNA methylation age of blood predicts future onset of lung cancer in the women\u2019s health initiative","volume":"7","author":"Levine","year":"2015","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.jad.2025.119989_bb0160","doi-asserted-by":"crossref","first-page":"573","DOI":"10.18632\/aging.101414","article-title":"An epigenetic biomarker of aging for lifespan and healthspan","volume":"10","author":"Levine","year":"2018","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.jad.2025.119989_bb0165","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1111\/joim.13533","article-title":"Epigenetic aging: biological age prediction and informing a mechanistic theory of aging","volume":"292","author":"Li","year":"2022","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.jad.2025.119989_bb0170","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1007\/s11357-022-00714-0","article-title":"Cardiovascular correlates of epigenetic aging across the adult lifespan: a population-based study","volume":"45","author":"Liu","year":"2023","journal-title":"GeroScience"},{"key":"10.1016\/j.jad.2025.119989_bb0175","doi-asserted-by":"crossref","first-page":"303","DOI":"10.18632\/aging.101684","article-title":"DNA methylation GrimAge strongly predicts lifespan and healthspan","volume":"11","author":"Lu","year":"2019","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.jad.2025.119989_bb0180","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s10433-024-00804-2","article-title":"The causal relationship between sleep disturbances and the risk of frailty: a two-sample Mendelian randomization study","volume":"21","author":"Lu","year":"2024","journal-title":"Eur. J. Ageing"},{"key":"10.1016\/j.jad.2025.119989_bb0185","doi-asserted-by":"crossref","first-page":"3555","DOI":"10.1093\/bioinformatics\/btv402","article-title":"LDlink: a web-based application for exploring population-specific haplotype structure and linking correlated alleles of possible functional variants","volume":"31","author":"Machiela","year":"2015","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jad.2025.119989_bb0190","doi-asserted-by":"crossref","DOI":"10.1186\/s13059-021-02398-9","article-title":"Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging","volume":"22","author":"McCartney","year":"2021","journal-title":"Genome Biol."},{"key":"10.1016\/j.jad.2025.119989_bb0195","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.jsmc.2022.03.003","article-title":"Epidemiology of insomnia: prevalence, course, risk factors, and public health burden","volume":"17","author":"Morin","year":"2022","journal-title":"Sleep Med. Clin."},{"key":"10.1016\/j.jad.2025.119989_bb0200","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s13148-016-0301-7","article-title":"Obesity accelerates epigenetic aging in middle-aged but not in elderly individuals","volume":"9","author":"Nevalainen","year":"2017","journal-title":"Clin. Epigenetics"},{"key":"10.1016\/j.jad.2025.119989_bb0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2021.101314","article-title":"DNA methylation-based age clocks: from age prediction to age reversion","volume":"68","author":"Noroozi","year":"2021","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.jad.2025.119989_bb0210","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.amjmed.2018.09.021","article-title":"Sleep disorders","volume":"132","author":"Pavlova","year":"2019","journal-title":"Am. J. Med."},{"key":"10.1016\/j.jad.2025.119989_bb0215","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a040501","article-title":"Mendelian randomization: concepts and scope","volume":"12","author":"Richmond","year":"2022","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.jad.2025.119989_bb0220","series-title":"MRC IEU UK Biobank GWAS pipeline version 2 [WWW Document]. data.bris","author":"Ruth Mitchell","year":"2019"},{"key":"10.1016\/j.jad.2025.119989_bb0225","doi-asserted-by":"crossref","first-page":"2152","DOI":"10.1093\/gerona\/glad174","article-title":"Discordant biological and chronological age: implications for cognitive decline and frailty","volume":"78","author":"Shaaban","year":"2023","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"10.1016\/j.jad.2025.119989_bb0230","doi-asserted-by":"crossref","first-page":"4587","DOI":"10.1002\/cam4.4015","article-title":"A modifiable risk factors atlas of lung cancer: a Mendelian randomization study","volume":"10","author":"Shen","year":"2021","journal-title":"Cancer Med."},{"key":"10.1016\/j.jad.2025.119989_bb0235","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.5665\/sleep.2964","article-title":"Cues of fatigue: effects of sleep deprivation on facial appearance","volume":"36","author":"Sundelin","year":"2013","journal-title":"Sleep"},{"key":"10.1016\/j.jad.2025.119989_bb0240","doi-asserted-by":"crossref","DOI":"10.1093\/ageing\/afad221","article-title":"How to construct a frailty index from an existing dataset in 10 steps","volume":"52","author":"Theou","year":"2023","journal-title":"Age Ageing"},{"key":"10.1016\/j.jad.2025.119989_bb0245","doi-asserted-by":"crossref","first-page":"2400","DOI":"10.1681\/ASN.2020121760","article-title":"Mendelian randomization analysis as a tool to gain insights into causes of diseases: a primer","volume":"32","author":"Tin","year":"2021","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.jad.2025.119989_bb0250","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/s41588-018-0099-7","article-title":"Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases","volume":"50","author":"Verbanck","year":"2018","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jad.2025.119989_bb0255","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.ajhg.2017.06.005","article-title":"10 years of GWAS discovery: biology, function, and translation","volume":"101","author":"Visscher","year":"2017","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.jad.2025.119989_bb0260","doi-asserted-by":"crossref","first-page":"3503","DOI":"10.1038\/s41467-019-11456-7","article-title":"Genome-wide association analysis of self-reported daytime sleepiness identifies 42 loci that suggest biological subtypes","volume":"10","author":"Wang","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jad.2025.119989_bb0265","doi-asserted-by":"crossref","DOI":"10.7189\/jogh.13.04071","article-title":"Prevalence of sleep disturbances and associated factors among Chinese residents: a web-based empirical survey of 2019","volume":"13","author":"Wang","year":"2023","journal-title":"J. Glob. Health"},{"key":"10.1016\/j.jad.2025.119989_bb0270","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1093\/ajcn\/nqaa069","article-title":"Application and interpretation of Mendelian randomization approaches in exploring the causality between folate and coronary artery disease","volume":"111","author":"Wu","year":"2020","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.jad.2025.119989_bb0275","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1093\/ije\/dyx034","article-title":"MendelianRandomization: an R package for performing Mendelian randomization analyses using summarized data","volume":"46","author":"Yavorska","year":"2017","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.jad.2025.119989_bb0280","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1007\/s00415-020-10119-8","article-title":"An atlas on risk factors for multiple sclerosis: a Mendelian randomization study","volume":"268","author":"Yuan","year":"2021","journal-title":"J. Neurol."},{"key":"10.1016\/j.jad.2025.119989_bb0285","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1007\/s11357-020-00283-0","article-title":"Association between genetically predicted telomere length and facial skin aging in the UK Biobank: a Mendelian randomization study","volume":"43","author":"Zhan","year":"2020","journal-title":"GeroScience"},{"key":"10.1016\/j.jad.2025.119989_bb0290","doi-asserted-by":"crossref","DOI":"10.1186\/s12916-022-02557-0","article-title":"Maintaining healthy sleep patterns and frailty transitions: a prospective Chinese study","volume":"20","author":"Zhu","year":"2022","journal-title":"BMC Med."}],"container-title":["Journal of Affective Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032725014314?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032725014314?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T04:55:53Z","timestamp":1779857753000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165032725014314"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":58,"alternative-id":["S0165032725014314"],"URL":"https:\/\/doi.org\/10.1016\/j.jad.2025.119989","relation":{},"ISSN":["0165-0327"],"issn-type":[{"value":"0165-0327","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sleep disorders and aging: Mendelian randomization analysis of epigenetic and frailty markers","name":"articletitle","label":"Article Title"},{"value":"Journal of Affective Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jad.2025.119989","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"119989"}}