{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T04:15:31Z","timestamp":1787890531723,"version":"build-2784847793"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Affective Disorders"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.jad.2025.120215","type":"journal-article","created":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T23:20:16Z","timestamp":1756855216000},"page":"120215","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"PA","title":["Temperament and morbidity in bipolar disorder: A latent profile analysis of the TEMPS-A scale and its impact on the long-term illness course"],"prefix":"10.1016","volume":"393","author":[{"given":"Carolin","family":"Schneider","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice Mai Ly","family":"Dingelstadt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niklas","family":"Ortelbach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"Rote","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Quinlivan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana","family":"Fiebig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"K\u00f6nig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Simhandl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Bauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Pfennig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J.","family":"Stamm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace","family":"O'Malley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jad.2025.120215_bb0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jad.2004.12.003","article-title":"TEMPS: temperament evaluation of Memphis, Pisa, Paris and San Diego","volume":"85","author":"Akiskal","year":"2005","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2025.120215_bb0010","series-title":"Bipolar Disorders: 100 Years after Manic-Depressive Insanity","first-page":"37","article-title":"The soft bipolar spectrum: Footnotes to Kraepelin on the interface of hypomania, temperament and depression","author":"Akiskal","year":"2000"},{"issue":"Suppl. 1","key":"10.1016\/j.jad.2025.120215_bb0015","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S0165-0327(00)00203-2","article-title":"Re-evaluating the prevalence of and diagnostic composition within the broad clinical spectrum of bipolar disorders","volume":"59","author":"Akiskal","year":"2000","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2025.120215_bb0020","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1007\/s00115-001-1230-y","article-title":"Temperament and affective disorders. The TEMPS-A scale as a convergence of European and US-American concepts","volume":"73","author":"Akiskal","year":"2002","journal-title":"Nervenarzt"},{"key":"10.1016\/j.jad.2025.120215_bb0025","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jad.2004.12.001","article-title":"TEMPS-A: progress towards validation of a self-rated clinical version of the temperament evaluation of the Memphis, Pisa, Paris, and San Diego autoquestionnaire","volume":"85","author":"Akiskal","year":"2005","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2025.120215_bb0030","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jad.2003.10.012","article-title":"TEMPS-A: validation of a short version of a self-rated instrument designed to measure variations in temperament","volume":"85","author":"Akiskal","year":"2005","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2025.120215_bb0035","series-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"American Psychiatric Association","year":"2000"},{"key":"10.1016\/j.jad.2025.120215_bb0040","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1192\/bjp.2021.184","article-title":"Latent subtypes of manic and\/or irritable episode symptoms in two population-based cohorts","volume":"221","author":"Arathimos","year":"2022","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.jad.2025.120215_bb0045","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1111\/bdi.12967","article-title":"Latent class analysis of bipolar disorder symptoms and suicidal ideation and behaviors","volume":"23","author":"Au","year":"2021","journal-title":"Bipolar Disord."},{"key":"10.1016\/j.jad.2025.120215_bb0050","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1034\/j.1600-0447.2003.02057.x","article-title":"Does prophylaxis-delay in bipolar disorder influence outcome? Results from a long-term study of 147 patients","volume":"107","author":"Baethge","year":"2003","journal-title":"Acta Psychiatr. Scand."},{"key":"10.1016\/j.jad.2025.120215_bb0055","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0165-0327(03)00101-0","article-title":"Factorial structure and internal consistency of the German TEMPS-A scale: validation against the NEO-FFI questionnaire","volume":"85","author":"Bl\u00f6ink","year":"2005","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2025.120215_bb0060","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s40345-021-00241-5","article-title":"Mania and bipolar depression: complementing not opposing poles-a post-hoc analysis of mixed features in manic and hypomanic episodes","volume":"9","author":"Born","year":"2021","journal-title":"Int J Bipolar Disord."},{"key":"10.1016\/j.jad.2025.120215_bb0065","series-title":"Applied Multiple Regression\/Correlation Analysis for the Behavioral Sciences","author":"Cohen","year":"2003"},{"key":"10.1016\/j.jad.2025.120215_bb0070","series-title":"Latent Class and Latent Transition Analysis","author":"Collins","year":"2009"},{"key":"10.1016\/j.jad.2025.120215_bb0075","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1037\/dev0000382","article-title":"Latent profile and cluster analysis of infant temperament: comparisons across person-centered approaches","volume":"53","author":"Gartstein","year":"2017","journal-title":"Dev. Psychol."},{"key":"10.1016\/j.jad.2025.120215_bb0080","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1111\/j.2044-8260.1967.tb00530.x","article-title":"Development of a rating scale for primary depressive illness","volume":"6","author":"Hamilton","year":"1967","journal-title":"Br. J. Soc. Clin. Psychol."},{"key":"10.1016\/j.jad.2025.120215_bb0085","doi-asserted-by":"crossref","first-page":"31","DOI":"10.31887\/DCNS.2015.17.1\/phoff","article-title":"The Kraepelinian tradition","volume":"17","author":"Hoff","year":"2015","journal-title":"Dialogues Clin. Neurosci."},{"key":"10.1016\/j.jad.2025.120215_bb0090","doi-asserted-by":"crossref","first-page":"601","DOI":"10.30773\/pi.2023.0444","article-title":"Distinguishing affective temperament profiles in major depressive disorder and bipolar disorder through the short version of TEMPS-A: cross-sectional study using latent profile analysis","volume":"21","author":"Jang","year":"2024","journal-title":"Psychiatry Investig."},{"key":"10.1016\/j.jad.2025.120215_bb0095","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0165-0327(03)00111-3","article-title":"Psychotherapy of bipolar disorder: a review","volume":"80","author":"Jones","year":"2004","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2025.120215_bb0100","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.jad.2012.12.023","article-title":"The relation between affective temperament and resilience in depression: a controlled study","volume":"148","author":"Kesebir","year":"2013","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2025.120215_bb0105","series-title":"Manic-Depressive Insanity and Paranoia","first-page":"117","author":"Kraepelin","year":"1921"},{"key":"10.1016\/j.jad.2025.120215_bb0110","article-title":"Affective temperaments and illness severity in patients with bipolar disorder","volume":"57","author":"Luciano","year":"2021","journal-title":"Medicina (Kaunas)"},{"key":"10.1016\/j.jad.2025.120215_bb0115","doi-asserted-by":"crossref","first-page":"398","DOI":"10.4088\/JCP.14m09410","article-title":"Lurasidone in the treatment of bipolar depression with mixed (subsyndromal hypomanic) features: post hoc analysis of a randomized placebo-controlled trial","volume":"76","author":"McIntyre","year":"2015","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.jad.2025.120215_bb0120","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0232459","article-title":"Utility of TEMPS-A in differentiation between major depressive disorder, bipolar I disorder, and bipolar II disorder","volume":"15","author":"Morishita","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.jad.2025.120215_bb0125","series-title":"Mplus user\u2019s guide","author":"Muth\u00e9n","year":"2015"},{"key":"10.1016\/j.jad.2025.120215_bb0130","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1080\/10705510701575396","article-title":"Deciding on the number of classes in latent class analysis and growth mixture modeling: a Monte Carlo simulation study","volume":"14","author":"Nylund","year":"2007","journal-title":"Struct. Equ. Model."},{"key":"10.1016\/j.jad.2025.120215_bb0135","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40345-021-00248-y","article-title":"The big five model in bipolar disorder: a latent profile analysis and its impact on longterm illness severity","volume":"10","author":"Ortelbach","year":"2022","journal-title":"Int J Bipolar Disord."},{"key":"10.1016\/j.jad.2025.120215_bb0140","doi-asserted-by":"crossref","DOI":"10.1186\/1741-7015-11-132","article-title":"Personalized medicine in psychiatry: problems and promises","volume":"11","author":"Ozomaro","year":"2013","journal-title":"BMC Med."},{"key":"10.1016\/j.jad.2025.120215_bb0145","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1177\/0004867418783062","article-title":"Impulsivity predicts illness severity in long-term course of bipolar disorder: a prospective approach","volume":"52","author":"Rote","year":"2018","journal-title":"Australian & New Zealand Journal of Psychiatry."},{"key":"10.1016\/j.jad.2025.120215_bb0150","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.jad.2020.01.079","article-title":"Resilience and insight in euthymic patients with bipolar disorder","volume":"266","author":"\u015eenormanc\u0131","year":"2020","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2025.120215_bb0155","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1080\/10705511.2013.824781","article-title":"Statistical power to detect the correct number of classes in latent profile analysis","volume":"20","author":"Tein","year":"2013","journal-title":"Struct. Equ. Model."},{"key":"10.1016\/j.jad.2025.120215_bb0160","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1037\/abn0000045","article-title":"A 3-year longitudinal study of risk for bipolar Spectrum psychopathology","volume":"124","author":"Walsh","year":"2015","journal-title":"J. Abnorm. Psychol."},{"key":"10.1016\/j.jad.2025.120215_bb0165","series-title":"SKID. Strukturiertes Klinisches Interview f\u00fcr DSM-IV. Achse I und Achse II. Handanweisung","author":"Wittchen","year":"1997"},{"key":"10.1016\/j.jad.2025.120215_bb0170","author":"World Health Organization, W.H.O"},{"issue":"20","key":"10.1016\/j.jad.2025.120215_bb2170","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1001\/jama.2013.281053","article-title":"World Medical Association Declaration of Helsinki: Ethical principles for medical research involving human subjects","volume":"310","author":"World Medical Association","year":"2013","journal-title":"JAMA"},{"key":"10.1016\/j.jad.2025.120215_bb0175","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1192\/bjp.133.5.429","article-title":"A rating scale for mania: reliability, validity and sensitivity","volume":"133","author":"Young","year":"1978","journal-title":"Br. J. Psychiatry"}],"container-title":["Journal of Affective Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016503272501657X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016503272501657X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T04:56:48Z","timestamp":1780635408000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S016503272501657X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":36,"alternative-id":["S016503272501657X"],"URL":"https:\/\/doi.org\/10.1016\/j.jad.2025.120215","relation":{},"ISSN":["0165-0327"],"issn-type":[{"value":"0165-0327","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Temperament and morbidity in bipolar disorder: A latent profile analysis of the TEMPS-A scale and its impact on the long-term illness course","name":"articletitle","label":"Article Title"},{"value":"Journal of Affective Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jad.2025.120215","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"120215"}}