{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T09:02:22Z","timestamp":1777798942129,"version":"3.51.4"},"reference-count":68,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["LBH- Q21193"],"award-info":[{"award-number":["LBH- Q21193"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81803999"],"award-info":[{"award-number":["81803999"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82204957"],"award-info":[{"award-number":["82204957"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Affective Disorders"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.jad.2025.120630","type":"journal-article","created":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T15:43:47Z","timestamp":1762703027000},"page":"120630","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"PB","title":["Xiaoyaosan alleviates CUMS rat by promoting hippocampal neurogenesis via modulating the JNK\/GluR1 signaling pathway"],"prefix":"10.1016","volume":"394","author":[{"given":"Bi-Yue","family":"Liang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhuo","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen-Yue","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian-Qian","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin-Yu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shan-Shan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue-Ming","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.jad.2025.120630_bb0005","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1002\/jnr.22275","article-title":"Alterations in GluR2 AMPA receptor phosphorylation at serine 880 following group I metabotropic glutamate receptor stimulation in the rat dorsal striatum","volume":"88","author":"Ahn","year":"2010","journal-title":"J. Neurosci. Res."},{"issue":"11","key":"10.1016\/j.jad.2025.120630_bb0010","doi-asserted-by":"crossref","first-page":"2350","DOI":"10.3390\/cells9112350","article-title":"Alarmins and c-Jun N-Terminal Kinase (JNK) signaling in neuroinflammation","volume":"9","author":"Anfinogenova","year":"2020","journal-title":"Cells"},{"issue":"3","key":"10.1016\/j.jad.2025.120630_bb0015","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.conb.2011.12.006","article-title":"Regulation of AMPA receptor trafficking and synaptic plasticity","volume":"22","author":"Anggono","year":"2012","journal-title":"Curr. Opin. Neurobiol."},{"issue":"6","key":"10.1016\/j.jad.2025.120630_bb0020","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.2741\/e528","article-title":"The JNK signalling transduction pathway in the brain","volume":"4","author":"Antoniou","year":"2012","journal-title":"Front. Biosci.-Elite"},{"issue":"1","key":"10.1016\/j.jad.2025.120630_bb0025","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0306-4522(96)00435-6","article-title":"Temporal dynamics of glutamate efflux in the prefrontal cortex and in the hippocampus following repeated stress: effects of pretreatment with saline or diazepam","volume":"77","author":"Bagley","year":"1997","journal-title":"Neuroscience"},{"issue":"23","key":"10.1016\/j.jad.2025.120630_bb0030","doi-asserted-by":"crossref","first-page":"10037","DOI":"10.1523\/JNEUROSCI.18-23-10037.1998","article-title":"Specific and differential activation of mitogen-activated protein kinase cascades by unfamiliar taste in the insular cortex of the behaving rat","volume":"18","author":"Berman","year":"1998","journal-title":"J. Neurosci."},{"issue":"9","key":"10.1016\/j.jad.2025.120630_bb0035","doi-asserted-by":"crossref","first-page":"3129","DOI":"10.1096\/fj.08-106450","article-title":"AMPA receptor subunit 1 (GluR-A) knockout mice model the glutamate hypothesis of depression","volume":"22","author":"Chourbaji","year":"2008","journal-title":"FASEB J."},{"issue":"2","key":"10.1016\/j.jad.2025.120630_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2022.103808","article-title":"Bidirectional protein\u2013protein interactions control liquid\u2013liquid phase separation of PSD-95 and its interaction partners","volume":"25","author":"Christensen","year":"2022","journal-title":"IScience"},{"issue":"9","key":"10.1016\/j.jad.2025.120630_bb0045","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1016\/S0006-3223(99)00177-8","article-title":"Neural plasticity to stress and antidepressant treatment","volume":"46","author":"Duman","year":"1999","journal-title":"Biol. Psychiatry"},{"issue":"3","key":"10.1016\/j.jad.2025.120630_bb0050","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1037\/h0071444","article-title":"Emotional behavior in the rat. I. Defecation and urination as measures of individual differences in emotionality","volume":"18","author":"Hall","year":"1934","journal-title":"J. Comp. Psychol."},{"key":"10.1016\/j.jad.2025.120630_bb0055","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.pnpbp.2013.04.009","article-title":"Monoamine neurocircuitry in depression and strategies for new treatments","volume":"45","author":"Hamon","year":"2013","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.jad.2025.120630_bb0060","first-page":"1130989","article-title":"Chronic stress, neuroinflammation, and depression: an overview of pathophysiological mechanisms and emerging anti-inflammatories","volume":"14","author":"Hassamal","year":"2023","journal-title":"Front. Psychol."},{"issue":"1","key":"10.1016\/j.jad.2025.120630_bb0065","doi-asserted-by":"crossref","first-page":"11","DOI":"10.31887\/DCNS.2013.15.1\/jhenley","article-title":"AMPA receptor trafficking and the mechanisms underlying synaptic plasticity and cognitive aging","volume":"15","author":"Henley","year":"2013","journal-title":"Dialogues Clin. Neurosci."},{"issue":"6","key":"10.1016\/j.jad.2025.120630_bb0070","first-page":"4","article-title":"History and evolution of the monoamine hypothesis of depression","volume":"61","author":"Hirschfeld","year":"2000","journal-title":"J. Clin. Psychiatry"},{"issue":"2","key":"10.1016\/j.jad.2025.120630_bb0075","doi-asserted-by":"crossref","first-page":"145","DOI":"10.3233\/BPL-170062","article-title":"JNK regulation of depression and anxiety","volume":"3","author":"Hollos","year":"2018","journal-title":"Brain Plasticity"},{"issue":"24","key":"10.1016\/j.jad.2025.120630_bb0085","doi-asserted-by":"crossref","first-page":"12035","DOI":"10.1073\/pnas.1821775116","article-title":"PSD-95 binding dynamically regulates NLGN1 trafficking and function","volume":"116","author":"Jeong","year":"2019","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"1","key":"10.1016\/j.jad.2025.120630_bb0090","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0254-6272(12)60023-5","article-title":"Integrated traditional and Western medicine for treatment of depression based on syndrome differentiation: a meta-analysis of randomized controlled trials based on the Hamilton depression scale","volume":"32","author":"Kou","year":"2012","journal-title":"J. Tradit. Chin. Med."},{"issue":"1\u20133","key":"10.1016\/j.jad.2025.120630_bb0095","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.jad.2008.06.026","article-title":"The PHQ-8 as a measure of current depression in the general population","volume":"114","author":"Kroenke","year":"2009","journal-title":"J. Affect. Disord."},{"issue":"15","key":"10.1016\/j.jad.2025.120630_bb0100","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.4155\/fmc.15.132","article-title":"JNK pathway signaling: a novel and smarter therapeutic target for various biological diseases","volume":"7","author":"Kumar","year":"2015","journal-title":"Future Med. Chem."},{"key":"10.1016\/j.jad.2025.120630_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.dcn.2019.100666","article-title":"Altered development of hippocampus-dependent associative learning following early-life adversity","volume":"38","author":"Lambert","year":"2019","journal-title":"Dev. Cogn. Neurosci."},{"issue":"1","key":"10.1016\/j.jad.2025.120630_bb0110","article-title":"Effects of the Chinese Traditional Prescription Xiaoyaosan Decoction on Chronic Immobilization Stress-Induced Changes in Behavior and Ultrastructure in Rat Hippocampus","volume":"2013","author":"Liang","year":"2013","journal-title":"Evid. Based Complement. Alternat. Med."},{"issue":"43","key":"10.1016\/j.jad.2025.120630_bb0115","doi-asserted-by":"crossref","first-page":"10493","DOI":"10.1021\/jf503132c","article-title":"Down-regulation of slit\u2013Robo pathway mediating neuronal cytoskeletal remodeling processes facilitates the antidepressive-like activity of Gastrodia elata Blume","volume":"62","author":"Lin","year":"2014","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jad.2025.120630_bb0120","doi-asserted-by":"crossref","first-page":"7646","DOI":"10.12659\/MSM.908422","article-title":"Anti-depressant-like effect of sinomenine on chronic unpredictable mild stress-induced depression in a mouse model","volume":"24","author":"Liu","year":"2018","journal-title":"Medical science monitor: international medical journal of experimental and clinical research"},{"key":"10.1016\/j.jad.2025.120630_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2019.112219","article-title":"Plasma metabolomics of depressed patients and treatment with Xiaoyaosan based on mass spectrometry technique","volume":"246","author":"Liu","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jad.2025.120630_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.113549","article-title":"Integrating hippocampal metabolomics and network pharmacology deciphers the antidepressant mechanisms of **aoyaosan","volume":"268","author":"Liu","year":"2021","journal-title":"J. Ethnopharmacol."},{"issue":"3","key":"10.1016\/j.jad.2025.120630_bb0135","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/mrc.2865","article-title":"Urinary metabonomic study using a CUMS rat model of depression","volume":"50","author":"Liu","year":"2012","journal-title":"Magn. Reson. Chem."},{"issue":"2","key":"10.1016\/j.jad.2025.120630_bb0140","article-title":"Fluoxetine modulates the TLR4\/NF-\u03baB\/NLRP3 inflammatory signaling pathway to improve depression-like behavior in CUMS rats","volume":"51","author":"Lv","year":"2023","journal-title":"Tian** Medical Journal"},{"key":"10.1016\/j.jad.2025.120630_bb0145","first-page":"910","article-title":"**aoyaosan ameliorates chronic immobilization stress-induced depression-like behaviors and anorexia in rats: The role of the nesfatin-1\u2013oxytocin\u2013proopiomelanocortin neural pathway in the hypothalamus","volume":"10","author":"Ma","year":"2019","journal-title":"Front. Psychol."},{"issue":"9","key":"10.1016\/j.jad.2025.120630_bb0150","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.2174\/092986712799462711","article-title":"The glutamatergic neurotransmission in the central nervous system","volume":"19","author":"Marmiroli","year":"2012","journal-title":"Curr. Med. Chem."},{"issue":"3","key":"10.1016\/j.jad.2025.120630_bb0155","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1007\/s12031-010-9454-6","article-title":"JNK: a stress-activated protein kinase therapeutic strategies and involvement in Alzheimer\u2019s and various neurodegenerative abnormalities","volume":"43","author":"Mehan","year":"2011","journal-title":"J. Mol. Neurosci."},{"issue":"4","key":"10.1016\/j.jad.2025.120630_bb0160","doi-asserted-by":"crossref","first-page":"419","DOI":"10.3109\/10253890.2015.1040986","article-title":"The influence of chronic stress on anxiety-like behavior and cognitive function in different human GFAP-ApoE transgenic adult male mice","volume":"18","author":"Meng","year":"2015","journal-title":"Stress"},{"key":"10.1016\/j.jad.2025.120630_bb0165","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.jad.2019.04.054","article-title":"Effects of early life adversity and FKBP5 genotype on hippocampal subfields volume in major depression","volume":"252","author":"Mikolas","year":"2019","journal-title":"J. Affect. Disord."},{"issue":"15","key":"10.1016\/j.jad.2025.120630_bb0170","doi-asserted-by":"crossref","first-page":"3708","DOI":"10.1523\/JNEUROSCI.1913-17.2018","article-title":"JIP1-mediated JNK activation negatively regulates synaptic plasticity and spatial memory","volume":"38","author":"Morel","year":"2018","journal-title":"J. Neurosci."},{"issue":"7","key":"10.1016\/j.jad.2025.120630_bb0175","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1038\/s41380-018-0252-9","article-title":"Glutamatergic neurometabolite levels in major depressive disorder: a systematic review and meta-analysis of proton magnetic resonance spectroscopy studies","volume":"24","author":"Moriguchi","year":"2019","journal-title":"Mol. Psychiatry"},{"issue":"1","key":"10.1016\/j.jad.2025.120630_bb0180","first-page":"4","article-title":"The global burden of disease","volume":"106","author":"Murphy","year":"2013","journal-title":"Ir. Med. J."},{"key":"10.1016\/j.jad.2025.120630_bb0185","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.bbr.2014.12.051","article-title":"Sex-specific impairment and recovery of spatial learning following the end of chronic unpredictable restraint stress: potential relevance of limbic GAD","volume":"282","author":"Ortiz","year":"2015","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.jad.2025.120630_bb0190","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.neubiorev.2019.04.010","article-title":"Stress, epigenetics and depression: a systematic review","volume":"102","author":"Park","year":"2019","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.jad.2025.120630_bb0195","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1007\/s00702-019-02084-y","article-title":"Animal models of major depression: drawbacks and challenges","volume":"126","author":"Planchez","year":"2019","journal-title":"J. Neural Transm."},{"issue":"3","key":"10.1016\/j.jad.2025.120630_bb0200","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1038\/s41380-019-0615-x","article-title":"Neuroplasticity in cognitive and psychological mechanisms of depression: an integrative model","volume":"25","author":"Price","year":"2020","journal-title":"Mol. Psychiatry"},{"issue":"2","key":"10.1016\/j.jad.2025.120630_bb0205","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1002\/dneu.20590","article-title":"Differential regulation of dendrite complexity by AMPA receptor subunits GluR1 and GluR2 in motor neurons","volume":"68","author":"Prithviraj","year":"2008","journal-title":"Dev. Neurobiol."},{"issue":"1","key":"10.1016\/j.jad.2025.120630_bb0210","first-page":"8056370","article-title":"Dendritic spines in depression: what we learned from animal models","volume":"2016","author":"Qiao","year":"2016","journal-title":"Neural Plast."},{"issue":"1","key":"10.1016\/j.jad.2025.120630_bb0215","doi-asserted-by":"crossref","first-page":"71","DOI":"10.2174\/1570159X14666160202121111","article-title":"Synaptic plasticity, metaplasticity and depression","volume":"15","author":"R Vose","year":"2017","journal-title":"Curr. Neuropharmacol."},{"issue":"1","key":"10.1016\/j.jad.2025.120630_bb0220","doi-asserted-by":"crossref","first-page":"71","DOI":"10.2174\/1570159X14666160202121111","article-title":"Synaptic plasticity, metaplasticity and depression","volume":"15","author":"R Vose","year":"2017","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.jad.2025.120630_bb0225","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1023\/A:1026021307833","article-title":"Stress and plasticity in the limbic system","volume":"28","author":"Sapolsky","year":"2003","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.jad.2025.120630_bb0230","article-title":"Glutamate and GABA homeostasis and neurometabolism in major depressive disorder","volume":"12","author":"Sarawagi","year":"2021","journal-title":"Front. Psychol."},{"key":"10.1016\/j.jad.2025.120630_bb0235","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.jpsychires.2024.04.029","article-title":"Anxiety-, and depression-like behavior following short-term finasteride administration is associated with impaired synaptic plasticity and cognitive behavior in male rats","volume":"174","author":"Sasibhushana","year":"2024","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.jad.2025.120630_bb0240","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13029-015-0041-7","article-title":"Symmetrical treatment of \u201cdiagnostic and statistical manual of mental disorders, \u201d, for major depressive disorders","volume":"11","author":"Sawamura","year":"2016","journal-title":"Source Code Biol. Med."},{"issue":"4","key":"10.1016\/j.jad.2025.120630_bb0245","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1515\/rns.2011.032","article-title":"c\u2010Jun N\u2010terminal kinases in memory and synaptic plasticity","volume":"22","author":"Sherrin","year":"2011","journal-title":"Rev. Neurosci."},{"issue":"4","key":"10.1016\/j.jad.2025.120630_bb0250","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1176\/appi.ajp.2015.15020162","article-title":"Depression-related increases and decreases in appetite: dissociable patterns of aberrant activity in reward and interoceptive neurocircuitry","volume":"173","author":"Simmons","year":"2016","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jad.2025.120630_bb0255","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.bbr.2015.02.047","article-title":"The impact of social stress during adolescence or adulthood and co** strategy on cognitive function of female rats","volume":"286","author":"Snyder","year":"2015","journal-title":"Behav. Brain Res."},{"issue":"1","key":"10.1016\/j.jad.2025.120630_bb0260","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.neuroscience.2004.10.031","article-title":"Stress suppresses and learning induces plasticity in CA3 of rat hippocampus: a three-dimensional ultrastructural study of thorny excrescences and their postsynaptic densities","volume":"131","author":"Stewart","year":"2005","journal-title":"Neuroscience"},{"issue":"16","key":"10.1016\/j.jad.2025.120630_bb0265","first-page":"1225","article-title":"Effects of naringin on desperate behavior in climacteric depression model mice and its neuroprotective mechanism","volume":"29","author":"Su","year":"2019","journal-title":"J. Hainan Med. Coll."},{"issue":"6","key":"10.1016\/j.jad.2025.120630_bb0270","doi-asserted-by":"crossref","first-page":"2689","DOI":"10.1038\/s41380-022-01520-y","article-title":"Dysregulation of adult hippocampal neuroplasticity in major depression: pathogenesis and therapeutic implications","volume":"27","author":"Tartt","year":"2022","journal-title":"Mol. Psychiatry"},{"issue":"6","key":"10.1016\/j.jad.2025.120630_bb0275","doi-asserted-by":"crossref","first-page":"2689","DOI":"10.1038\/s41380-022-01520-y","article-title":"Dysregulation of adult hippocampal neuroplasticity in major depression: pathogenesis and therapeutic implications","volume":"27","author":"Tartt","year":"2022","journal-title":"Mol. Psychiatry"},{"issue":"2","key":"10.1016\/j.jad.2025.120630_bb0280","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/sj.emboj.7601969","article-title":"Rapid and bi-directional regulation of AMPA receptor phosphorylation and trafficking by JNK","volume":"27","author":"Thomas","year":"2008","journal-title":"EMBO J."},{"issue":"18","key":"10.1016\/j.jad.2025.120630_bb0285","doi-asserted-by":"crossref","first-page":"6811","DOI":"10.1523\/JNEUROSCI.20-18-06811.2000","article-title":"The inhibitory effect of interleukin-1\u03b2 on long-term potentiation is coupled with increased activity of stress-activated protein kinases","volume":"20","author":"Vereker","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jad.2025.120630_bb0290","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbr.2014.05.031","article-title":"Histone modifications of the Crhr1 gene in a rat model of depression following chronic stress","volume":"271","author":"Wan","year":"2014","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.jad.2025.120630_bb0295","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.pnpbp.2017.04.008","article-title":"The recent progress in animal models of depression","volume":"77","author":"Wang","year":"2017","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"issue":"4","key":"10.1016\/j.jad.2025.120630_bb0300","doi-asserted-by":"crossref","DOI":"10.1007\/s002130050472","article-title":"Does decreased sucrose intake indicate loss of preference in CMS model?","volume":"134","author":"Weiss","year":"1997","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.jad.2025.120630_bb0305","first-page":"1214","article-title":"Effect of Zhuyang Kaiyu Fang on behavior and hippocampal neuroplasticity in depressed rats","volume":"5","author":"Xiaojuan","year":"2018","journal-title":"Chinese Materia Medica"},{"issue":"1","key":"10.1016\/j.jad.2025.120630_bb0310","article-title":"Diverse Roles of JNK and MKK Pathways in the Brain","volume":"2012","author":"Yamasaki","year":"2012","journal-title":"J. Signal Transduction"},{"issue":"9","key":"10.1016\/j.jad.2025.120630_bb0315","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1111\/j.1460-9568.2011.07661.x","article-title":"Hippocampal long-term depression is enhanced, depotentiation is inhibited and long-term potentiation is unaffected by the application of a selective c-Jun N-terminal kinase inhibitor to freely behaving rats","volume":"33","author":"Yang","year":"2011","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.jad.2025.120630_bb0320","article-title":"Clinical effect of acupuncture combined with fluoxetine on mild to moderate depression and regulation of related brain areas [D]","author":"Yeqing","year":"2021","journal-title":"Shanghai university of traditional Chinese medicine"},{"issue":"4","key":"10.1016\/j.jad.2025.120630_bb0325","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.neuron.2018.03.049","article-title":"Ras and Rap signal bidirectional synaptic plasticity via distinct subcellular microdomains","volume":"98","author":"Zhang","year":"2018","journal-title":"Neuron"},{"key":"10.1016\/j.jad.2025.120630_bb0330","article-title":"**Aoyaosan alleviates hippocampal glutamate-induced toxicity in the CUMS rats via NR2B and PI3K\/Akt signaling pathway","volume":"12","author":"Zhou","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jad.2025.120630_bb0335","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.108621","article-title":"**aoyaosan improves depressive-like behavior in rats with chronic immobilization stress through modulation of the gut microbiota","volume":"112","author":"Zhu","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jad.2025.120630_bb0340","article-title":"Xiaoyaosan improves depressive-like behavior in rats with chronic immobilization stress through modulation of the gut microbiota","volume":"112","author":"Zhu","year":"2019","journal-title":"Biomedicine & pharmacotherapy =: Biomedecine & pharmacotherapie"},{"issue":"6","key":"10.1016\/j.jad.2025.120630_bb0345","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/j.neuron.2005.04.037","article-title":"Rap2-JNK removes synaptic AMPA receptors during depotentiation","volume":"46","author":"Zhu","year":"2005","journal-title":"Neuron"}],"container-title":["Journal of Affective Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032725020725?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032725020725?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:26:06Z","timestamp":1777494366000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165032725020725"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":68,"alternative-id":["S0165032725020725"],"URL":"https:\/\/doi.org\/10.1016\/j.jad.2025.120630","relation":{},"ISSN":["0165-0327"],"issn-type":[{"value":"0165-0327","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Xiaoyaosan alleviates CUMS rat by promoting hippocampal neurogenesis via modulating the JNK\/GluR1 signaling pathway","name":"articletitle","label":"Article Title"},{"value":"Journal of Affective Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jad.2025.120630","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"120630"}}