{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T18:27:52Z","timestamp":1786991272309,"version":"build-2736575974"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82401895"],"award-info":[{"award-number":["82401895"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012245","name":"Science and Technology Planning Project of Guangdong Province","doi-asserted-by":"publisher","award":["GD24YGL19"],"award-info":[{"award-number":["GD24YGL19"]}],"id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Affective Disorders"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.jad.2025.120754","type":"journal-article","created":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T21:56:28Z","timestamp":1763762188000},"page":"120754","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"PA","title":["Impact of diabetes on cognitive function in middle-aged and older adults: A longitudinal study"],"prefix":"10.1016","volume":"395","author":[{"given":"Xiaoyu","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenze","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng-Hui","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"43","key":"10.1016\/j.jad.2025.120754_bb0005","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000035557","article-title":"The impact of diabetes in cognitive impairment: a review of current evidence and prospects for future investigations","volume":"102","author":"Aderinto","year":"2023","journal-title":"Medicine"},{"issue":"2","key":"10.1016\/j.jad.2025.120754_bb0010","first-page":"53","article-title":"The role of insulin resistance and glucose metabolism dysregulation in the development of Alzheimer\u2019s disease","volume":"68","author":"Arrieta-Cruz","year":"2016","journal-title":"Revista de Investigacion Clinica; organo del Hospital de Enfermedades de la Nutricion"},{"issue":"1","key":"10.1016\/j.jad.2025.120754_bb0015","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1186\/s12877-020-01776-5","article-title":"The type 2 diabetes-specific dementia risk score (DSDRS) is associated with frailty, cognitive and functional status amongst Mexican community-dwelling older adults","volume":"20","author":"Bello-Chavolla","year":"2020","journal-title":"BMC Geriatr."},{"issue":"2","key":"10.1016\/j.jad.2025.120754_bb0020","doi-asserted-by":"crossref","first-page":"421","DOI":"10.3233\/JAD-161192","article-title":"The link between type 2 diabetes and neurodegeneration: roles for amyloid-\u03b2, amylin, and tau proteins","volume":"59","author":"Bharadwaj","year":"2017","journal-title":"J. Alzheimer\u2019s Dis.: JAD"},{"issue":"1","key":"10.1016\/j.jad.2025.120754_bb0030","doi-asserted-by":"crossref","first-page":"2320","DOI":"10.1186\/s12889-021-12375-3","article-title":"From urban neighbourhood environments to cognitive health: a cross-sectional analysis of the role of physical activity and sedentary behaviours","volume":"21","author":"Cerin","year":"2021","journal-title":"BMC Public Health"},{"issue":"7","key":"10.1016\/j.jad.2025.120754_bb0035","doi-asserted-by":"crossref","DOI":"10.1212\/WNL.0000000000209165","article-title":"Trends in cognitive function before and after diabetes onset: the China health and retirement longitudinal study","volume":"102","author":"Chen","year":"2024","journal-title":"Neurology"},{"issue":"5","key":"10.1016\/j.jad.2025.120754_bb0040","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1111\/sms.13616","article-title":"Consequences of physical inactivity in older adults: a systematic review of reviews and meta-analyses","volume":"30","author":"Cunningham","year":"2020","journal-title":"Scand. J. Med. Sci. Sports"},{"key":"10.1016\/j.jad.2025.120754_bb0045","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.clnu.2025.03.016","article-title":"A comprehensive comparison of two commonly used BMI thresholds for non-communicable diseases and multimorbidity in the Chinese population","volume":"48","author":"Fan","year":"2025","journal-title":"Clin. Nutr."},{"issue":"7","key":"10.1016\/j.jad.2025.120754_bb0050","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2016-014920","article-title":"How are age-related differences in sleep quality associated with health outcomes? An epidemiological investigation in a UK cohort of 2406 adults","volume":"7","author":"Gadie","year":"2017","journal-title":"BMJ Open"},{"key":"10.1016\/j.jad.2025.120754_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2020.101232","article-title":"Combined physical and cognitive training for older adults with and without cognitive impairment: a systematic review and network meta-analysis of randomized controlled trials","volume":"66","author":"Gavelin","year":"2021","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.jad.2025.120754_bb0060","article-title":"Mediating role of Interleukin-6 in the predictive association of diabetes with Hippocampus atrophy, Amyloid, Tau, and Neurofilament pathology at pre-clinical stages of diabetes-related cognitive impairment","volume":"47","author":"Hallab","year":"2025","journal-title":"Brain Behav. Immun.-Health"},{"issue":"3","key":"10.1016\/j.jad.2025.120754_bb0065","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1159\/000517160","article-title":"Legacy of a 10-year multidomain lifestyle intervention on the cognitive trajectories of individuals with overweight\/obesity and type 2 diabetes mellitus","volume":"50","author":"Hayden","year":"2021","journal-title":"Dement. Geriatr. Cogn. Disord."},{"key":"10.1016\/j.jad.2025.120754_bb0070","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.jad.2024.02.014","article-title":"A longitudinal study of factors associated with cognitive frailty in middle-aged and elderly population based on the health ecology model","volume":"352","author":"Hou","year":"2024","journal-title":"J. Affect. Disord."},{"issue":"6","key":"10.1016\/j.jad.2025.120754_bb0075","doi-asserted-by":"crossref","DOI":"10.1111\/eci.70045","article-title":"Nutrition, cognition and chronic kidney disease: a comprehensive review of interactions and interventions","volume":"55","author":"Kanbay","year":"2025","journal-title":"Eur. J. Clin. Investig."},{"issue":"1","key":"10.1016\/j.jad.2025.120754_bb0080","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/s41576-022-00519-z","article-title":"Genetics of circadian rhythms and sleep in human health and disease","volume":"24","author":"Lane","year":"2023","journal-title":"Nat. Rev. Genet."},{"issue":"23","key":"10.1016\/j.jad.2025.120754_bb0085","doi-asserted-by":"crossref","first-page":"2551","DOI":"10.1001\/jama.2014.13806","article-title":"The diagnosis and management of mild cognitive impairment: a clinical review","volume":"312","author":"Langa","year":"2014","journal-title":"JAMA"},{"issue":"5","key":"10.1016\/j.jad.2025.120754_bb0090","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0318916","article-title":"Cognitive decline in older adults with type 2 diabetes: unraveling site-specific glycoproteomic alterations","volume":"20","author":"Levin","year":"2025","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.jad.2025.120754_bb0095","doi-asserted-by":"crossref","first-page":"485","DOI":"10.3233\/JAD-210612","article-title":"A tale of two diseases: exploring mechanisms linking diabetes mellitus with Alzheimer\u2019s disease","volume":"85","author":"Lynn","year":"2022","journal-title":"J. Alzheimer\u2019s Dis.: JAD"},{"issue":"2","key":"10.1016\/j.jad.2025.120754_bb0100","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/s41366-020-00698-x","article-title":"Trends in the prevalence of overweight, obesity, and abdominal obesity among Chinese adults between 1993 and 2015","volume":"45","author":"Ma","year":"2021","journal-title":"Int. J. Obes. (2005)"},{"key":"10.1016\/j.jad.2025.120754_bb0105","first-page":"1","article-title":"Prevalence of total, diagnosed, and undiagnosed diabetes among adults: United States, 2013-2016","volume":"319","author":"Mendola","year":"2018","journal-title":"NCHS Data Brief"},{"issue":"2","key":"10.1016\/j.jad.2025.120754_bb0110","doi-asserted-by":"crossref","first-page":"563","DOI":"10.3390\/jcm14020563","article-title":"Relationship between depression and decreased activity level and cognitive impairment in patients with diabetes mellitus type 2 and\/or atrial fibrillation","volume":"14","author":"Militaru","year":"2025","journal-title":"J. Clin. Med."},{"issue":"3","key":"10.1016\/j.jad.2025.120754_bb0115","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1017\/S1355617713001483","article-title":"Magnitude of cognitive dysfunction in adults with type 2 diabetes: a meta-analysis of six cognitive domains and the most frequently reported neuropsychological tests within domains","volume":"20","author":"Palta","year":"2014","journal-title":"J. Int. Neuropsychol. Soc.: JINS"},{"issue":"2","key":"10.1016\/j.jad.2025.120754_bb0120","first-page":"125","article-title":"Diabetes mellitus and blood-brain barrier dysfunction: an overview","volume":"2","author":"Prasad","year":"2014","journal-title":"J. Pharm."},{"key":"10.1016\/j.jad.2025.120754_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.buildenv.2024.111535","article-title":"Association of residential environment with depression and anxiety symptoms among older adults in China: a cross-sectional population-based study","volume":"257","author":"Qiao","year":"2024","journal-title":"Building Environ."},{"key":"10.1016\/j.jad.2025.120754_bb0130","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/1407896","article-title":"Effects of exercise on cognitive performance in older adults: a narrative review of the evidence, possible biological mechanisms, and recommendations for exercise prescription","volume":"2020","author":"Quigley","year":"2020","journal-title":"J. Aging Res."},{"issue":"10","key":"10.1016\/j.jad.2025.120754_bb0135","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.5665\/sleep.6166","article-title":"Sleep duration and neurocognitive function in the Hispanic community health study\/study of Latinos","volume":"39","author":"Ramos","year":"2016","journal-title":"Sleep"},{"issue":"2","key":"10.1016\/j.jad.2025.120754_bb0140","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.jalz.2019.08.191","article-title":"Sleep and neurocognitive decline in the Hispanic Community Health Study\/Study of Latinos","volume":"16","author":"Ramos","year":"2020","journal-title":"Alzheimers Dement."},{"issue":"11","key":"10.1016\/j.jad.2025.120754_bb0145","doi-asserted-by":"crossref","first-page":"785","DOI":"10.7326\/M14-0737","article-title":"Diabetes in midlife and cognitive change over 20 years: a cohort study","volume":"161","author":"Rawlings","year":"2014","journal-title":"Ann. Intern. Med."},{"issue":"3","key":"10.1016\/j.jad.2025.120754_bb0150","doi-asserted-by":"crossref","first-page":"e261","DOI":"10.1212\/WNL.0000000000007779","article-title":"Midlife adiposity predicts cognitive decline in the prospective multicenter AIDS Cohort Study","volume":"93","author":"Rubin","year":"2019","journal-title":"Neurology"},{"key":"10.1016\/j.jad.2025.120754_bb5000","doi-asserted-by":"crossref","DOI":"10.3389\/fpubh.2024.1474593","article-title":"Type II diabetes and cognitive function among older adults in India and China-results from Harmonized Cognitive Assessment Protocol studies","volume":"12","author":"Srikantha","year":"2024","journal-title":"Front. Public Health"},{"key":"10.1016\/j.jad.2025.120754_bb0155","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/4591938","article-title":"Risk factors for cognitive impairment in patients with type 2 diabetes","volume":"2020","author":"Sun","year":"2020","journal-title":"J. Diabetes Res."},{"key":"10.1016\/j.jad.2025.120754_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.diabres.2021.109119","article-title":"IDF Diabetes Atlas: global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045","volume":"183","author":"Sun","year":"2022","journal-title":"Diabetes Res. Clin. Pract."},{"key":"10.1016\/j.jad.2025.120754_bb0165","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/105828","article-title":"Inflammation and oxidative stress: the molecular connectivity between insulin resistance, obesity, and Alzheimer\u2019s disease","volume":"2015","author":"Verdile","year":"2015","journal-title":"Mediat. Inflamm."},{"issue":"10","key":"10.1016\/j.jad.2025.120754_bb0170","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.5665\/sleep.3052","article-title":"Midlife sleep characteristics associated with late life cognitive function","volume":"36","author":"Virta","year":"2013","journal-title":"Sleep"},{"issue":"6","key":"10.1016\/j.jad.2025.120754_bb0175","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1111\/ene.15281","article-title":"Risk factors, neuroimaging correlates and prognosis of the motoric cognitive risk syndrome: a population-based comparison with mild cognitive impairment","volume":"29","author":"Yaqub","year":"2022","journal-title":"Eur. J. Neurol."},{"issue":"6","key":"10.1016\/j.jad.2025.120754_bb0180","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1007\/s00592-020-01648-9","article-title":"The prevalence of mild cognitive impairment in type 2 diabetes mellitus patients: a systematic review and meta-analysis","volume":"58","author":"You","year":"2021","journal-title":"Acta Diabetol."},{"issue":"14","key":"10.1016\/j.jad.2025.120754_bb0185","doi-asserted-by":"crossref","first-page":"2414","DOI":"10.1017\/S0033291720001014","article-title":"Social isolation, rather than loneliness, is associated with cognitive decline in older adults: the China Health and Retirement Longitudinal Study","volume":"51","author":"Yu","year":"2021","journal-title":"Psychol. Med."},{"issue":"1","key":"10.1016\/j.jad.2025.120754_bb0190","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s12877-022-03220-2","article-title":"The transitions and predictors of cognitive frailty with multi-state Markov model: a cohort study","volume":"22","author":"Yuan","year":"2022","journal-title":"BMC Geriatr."},{"issue":"8","key":"10.1016\/j.jad.2025.120754_bb0195","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1136\/jech-2017-210116","article-title":"Cognitive function trajectories and their determinants in older people: 8 years of follow-up in the English Longitudinal Study of Ageing","volume":"72","author":"Zaninotto","year":"2018","journal-title":"J. Epidemiol. Community Health"},{"key":"10.1016\/j.jad.2025.120754_bb0200","doi-asserted-by":"crossref","first-page":"jrm18372","DOI":"10.2340\/jrm.v56.18372","article-title":"Association between cognitive dysfunction and diabetes in patients over 65 years old: a cross-sectional study using propensity score matching","volume":"56","author":"Zhai","year":"2024","journal-title":"J. Rehabil. Med."},{"key":"10.1016\/j.jad.2025.120754_bb0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.cities.2023.104312","article-title":"Creating livable cities for healthy ageing: cognitive health in older adults and their 15-minute walkable neighbourhoods","volume":"137","author":"Zhang","year":"2023","journal-title":"Cities"},{"issue":"9","key":"10.1016\/j.jad.2025.120754_bb0210","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s11892-016-0775-x","article-title":"Diabetes and cognitive impairment","volume":"16","author":"Zilliox","year":"2016","journal-title":"Curr. Diab. Rep."}],"container-title":["Journal of Affective Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032725021962?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032725021962?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T05:53:55Z","timestamp":1766123635000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165032725021962"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":42,"alternative-id":["S0165032725021962"],"URL":"https:\/\/doi.org\/10.1016\/j.jad.2025.120754","relation":{},"ISSN":["0165-0327"],"issn-type":[{"value":"0165-0327","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impact of diabetes on cognitive function in middle-aged and older adults: A longitudinal study","name":"articletitle","label":"Article Title"},{"value":"Journal of Affective Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jad.2025.120754","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"120754"}}