{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T21:26:59Z","timestamp":1783027619349,"version":"3.54.6"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Affective Disorders"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.jad.2025.120770","type":"journal-article","created":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T07:45:25Z","timestamp":1764143125000},"page":"120770","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"PB","title":["Identification of endoplasmic reticulum stress-related genes associated with Alzheimer's disease risk: A multi-omics Mendelian randomization analysis"],"prefix":"10.1016","volume":"395","author":[{"given":"Bingyu","family":"Liang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jad.2025.120770_bb0005","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2022.742408","article-title":"Alzheimer\u2019s disease: an update and insights into pathophysiology","volume":"14","author":"Abubakar","year":"2022","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.jad.2025.120770_bb0010","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.ijbiomac.2020.11.192","article-title":"Review on Alzheimer\u2019s disease: inhibition of amyloid beta and tau tangle formation","volume":"167","author":"Ashrafian","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jad.2025.120770_bb0015","doi-asserted-by":"crossref","first-page":"2048","DOI":"10.1038\/s41380-020-0670-3","article-title":"GWAS significance thresholds for deep phenotyping studies can depend upon minor allele frequencies and sample size","volume":"26","author":"Asif","year":"2021","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jad.2025.120770_bb0020","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1016\/j.neuron.2016.09.006","article-title":"Basal forebrain cholinergic circuits and signaling in cognition and cognitive decline","volume":"91","author":"Ballinger","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/j.jad.2025.120770_bb0025","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/s41588-022-01024-z","article-title":"New insights into the genetic etiology of Alzheimer\u2019s disease and related dementias","volume":"54","author":"Bellenguez","year":"2022","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jad.2025.120770_bb0030","doi-asserted-by":"crossref","first-page":"e17","DOI":"10.1093\/brain\/awad363","article-title":"Impact of multiple sclerosis risk alleles on the plasma proteome","volume":"147","author":"Bernard Healey","year":"2024","journal-title":"Brain"},{"key":"10.1016\/j.jad.2025.120770_bb0035","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1186\/s12967-023-04246-9","article-title":"SIRT3 ameliorates diabetes-associated cognitive dysfunction via regulating mitochondria-associated ER membranes","volume":"21","author":"Chang","year":"2023","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.jad.2025.120770_bb0040","doi-asserted-by":"crossref","first-page":"11445","DOI":"10.1074\/jbc.RA119.007813","article-title":"Deficiency in the membrane protein Tmbim3a\/Grinaa initiates cold-induced ER stress and cell death by activating an intrinsic apoptotic pathway in zebrafish","volume":"294","author":"Chen","year":"2019","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jad.2025.120770_bb0045","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.3390\/molecules27061816","article-title":"Role of cholinergic signaling in Alzheimer\u2019s disease","volume":"27","author":"Chen","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.jad.2025.120770_bb0050","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/s41392-023-01570-w","article-title":"Endoplasmic reticulum stress: molecular mechanism and therapeutic targets","volume":"8","author":"Chen","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.jad.2025.120770_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2023.104934","article-title":"Multi-omic insight into the molecular networks of mitochondrial dysfunction in the pathogenesis of inflammatory bowel disease","volume":"99","author":"Chen","year":"2024","journal-title":"EBioMedicine"},{"key":"10.1016\/j.jad.2025.120770_bb0060","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1126\/science.aaz1776","article-title":"The GTEx Consortium atlas of genetic regulatory effects across human tissues","volume":"369","author":"Consortium","year":"2020","journal-title":"Science"},{"issue":"973\u2013986","key":"10.1016\/j.jad.2025.120770_bb0065","article-title":"The ESCRT-III protein CHMP1A mediates secretion of sonic hedgehog on a distinctive subtype of extracellular vesicles","volume":"24","author":"Coulter","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.jad.2025.120770_bb0070","doi-asserted-by":"crossref","first-page":"3417","DOI":"10.1038\/s41467-021-22491-8","article-title":"Common variants in Alzheimer\u2019s disease and risk stratification by polygenic risk scores","volume":"12","author":"De Rojas","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jad.2025.120770_bb0075","first-page":"1","article-title":"Oxidative stress, endoplasmic reticulum stress and apoptosis in the pathology of Alzheimer\u2019s disease","author":"Ekundayo","year":"2024","journal-title":"Cell Biochem. Biophys."},{"key":"10.1016\/j.jad.2025.120770_bb0080","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1080\/15548627.2019.1633862","article-title":"MAPT\/Tau accumulation represses autophagy flux by disrupting IST1-regulated ESCRT-III complex formation: a vicious cycle in Alzheimer neurodegeneration","volume":"16","author":"Feng","year":"2020","journal-title":"Autophagy"},{"key":"10.1016\/j.jad.2025.120770_bb0085","doi-asserted-by":"crossref","first-page":"406","DOI":"10.3389\/fnmol.2018.00406","article-title":"The impact of ESCRT on A\u03b21-42 induced membrane lesions in a yeast model for Alzheimer\u2019s disease","volume":"11","author":"Fruhmann","year":"2018","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.jad.2025.120770_bb0090","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1004383","article-title":"Bayesian test for colocalisation between pairs of genetic association studies using summary statistics","volume":"10","author":"Giambartolomei","year":"2014","journal-title":"PLoS Genet."},{"key":"10.1016\/j.jad.2025.120770_bb0095","doi-asserted-by":"crossref","first-page":"4005","DOI":"10.3390\/ijms20164005","article-title":"Deciphering GRINA\/Lifeguard1: nuclear location, ca2+ homeostasis and vesicle transport","volume":"20","author":"Jim\u00e9nez-Gonz\u00e1lez","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jad.2025.120770_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2023.101914","article-title":"The endoplasmic reticulum stress and unfolded protein response in Alzheimer\u2019s disease: a calcium dyshomeostasis perspective","volume":"87","author":"Lim","year":"2023","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.jad.2025.120770_bb0105","doi-asserted-by":"crossref","first-page":"5058","DOI":"10.1038\/s41467-019-12991-z","article-title":"ESCRT-III-driven piecemeal micro-ER-phagy remodels the ER during recovery from ER stress","volume":"10","author":"Loi","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jad.2025.120770_bb0110","doi-asserted-by":"crossref","first-page":"25763","DOI":"10.1038\/s41598-024-77401-x","article-title":"Druggable targets for Parkinson\u2019s disease: transcriptomics based Mendelian randomization study","volume":"14","author":"Lyu","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jad.2025.120770_bb0115","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/1755-8794-7-31","article-title":"Overlap of expression quantitative trait loci (eQTL) in human brain and blood","volume":"7","author":"McKenzie","year":"2014","journal-title":"BMC Med. Genomics"},{"key":"10.1016\/j.jad.2025.120770_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2022.101580","article-title":"Global and regional projections of the economic burden of Alzheimer\u2019s disease and related dementias from 2019 to 2050: a value of statistical life approach","volume":"51","author":"Nandi","year":"2022","journal-title":"EClinicalMedicine"},{"key":"10.1016\/j.jad.2025.120770_bb0125","doi-asserted-by":"crossref","first-page":"e105","DOI":"10.1016\/S2468-2667(21)00249-8","article-title":"Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: an analysis for the Global Burden of Disease Study 2019","volume":"7","author":"Nichols","year":"2022","journal-title":"Lancet Public Health"},{"key":"10.1016\/j.jad.2025.120770_bb0130","doi-asserted-by":"crossref","DOI":"10.1002\/cpz1.426","article-title":"Molecular quantitative trait locus mapping in human complex diseases","volume":"2","author":"Olayinka","year":"2022","journal-title":"Curr. Protoc."},{"key":"10.1016\/j.jad.2025.120770_bb0135","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1038\/s41586-023-06034-3","article-title":"GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19","volume":"617","author":"Pairo-Castineira","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.jad.2025.120770_bb0140","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1080\/19768354.2024.2380294","article-title":"ESCRT-III: a versatile membrane remodeling machinery and its implications in cellular processes and diseases","volume":"28","author":"Park","year":"2024","journal-title":"Anim. Cells Syst."},{"key":"10.1016\/j.jad.2025.120770_bb0145","doi-asserted-by":"crossref","first-page":"647","DOI":"10.3390\/antiox9080647","article-title":"Mitochondrial dysfunction, oxidative stress, and neuroinflammation: intertwined roads to neurodegeneration","volume":"9","author":"Picca","year":"2020","journal-title":"Antioxidants"},{"key":"10.1016\/j.jad.2025.120770_bb0150","doi-asserted-by":"crossref","first-page":"3300","DOI":"10.1038\/s41467-019-10936-0","article-title":"Mendelian randomization integrating GWAS and eQTL data reveals genetic determinants of complex and clinical traits","volume":"10","author":"Porcu","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jad.2025.120770_bb0155","doi-asserted-by":"crossref","DOI":"10.1002\/cpz1.627","article-title":"Bayesian genetic colocalization test of two traits using coloc","volume":"2","author":"Rasooly","year":"2022","journal-title":"Curr. Protoc."},{"key":"10.1016\/j.jad.2025.120770_bb0160","article-title":"HHV-6A infection dysregulates autophagy\/UPR interplay increasing beta amyloid production and tau phosphorylation in astrocytoma cells as well as in primary neurons, possible molecular mechanisms linking viral infection to Alzheimer\u2019s disease","volume":"1866","author":"Romeo","year":"2020","journal-title":"Biochim. Biophys. Acta (BBA)-Mol. Basis Dis."},{"key":"10.1016\/j.jad.2025.120770_bb0165","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/s41586-023-06592-6","article-title":"Plasma proteomic associations with genetics and health in the UK Biobank","volume":"622","author":"Sun","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.jad.2025.120770_bb0170","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/s13073-023-01229-9","article-title":"Identification of novel protein biomarkers and drug targets for colorectal cancer by integrating human plasma proteome with genome","volume":"15","author":"Sun","year":"2023","journal-title":"Genome Med."},{"key":"10.1016\/j.jad.2025.120770_bb0175","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/s41398-022-02024-7","article-title":"Neuronal hyperexcitability in Alzheimer\u2019s disease: what are the drivers behind this aberrant phenotype?","volume":"12","author":"Targa Dias Anastacio","year":"2022","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.jad.2025.120770_bb0180","doi-asserted-by":"crossref","first-page":"2902","DOI":"10.1007\/s12035-020-01929-y","article-title":"Molecular mechanisms of ER stress and UPR in the pathogenesis of Alzheimer\u2019s disease","volume":"57","author":"Uddin","year":"2020","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.jad.2025.120770_bb0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmb.2025.169200","article-title":"Allosteric modulation of SERCA pumps in health and disease: structural dynamics, posttranslational modifications, and therapeutic potential","volume":"437","author":"Viskupicova","year":"2025","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.jad.2025.120770_bb0190","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1038\/s41588-021-00913-z","article-title":"Large-scale cis-and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression","volume":"53","author":"V\u00f5sa","year":"2021","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jad.2025.120770_bb0195","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1008720","article-title":"Eliciting priors and relaxing the single causal variant assumption in colocalisation analyses","volume":"16","author":"Wallace","year":"2020","journal-title":"PLoS Genet."},{"key":"10.1016\/j.jad.2025.120770_bb0200","doi-asserted-by":"crossref","first-page":"3701","DOI":"10.1002\/alz.13065","article-title":"Cytosolic calcium: judge, jury and executioner of neurodegeneration in Alzheimer\u2019s disease and beyond","volume":"19","author":"Webber","year":"2023","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.jad.2025.120770_bb0205","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1038\/s41467-018-03371-0","article-title":"Integrative analysis of omics summary data reveals putative mechanisms underlying complex traits","volume":"9","author":"Wu","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jad.2025.120770_bb0210","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1186\/s12916-023-02878-8","article-title":"Oxidative stress gene expression, DNA methylation, and gut microbiota interaction trigger Crohn\u2019s disease: a multi-omics Mendelian randomization study","volume":"21","author":"Xu","year":"2023","journal-title":"BMC Med."},{"key":"10.1016\/j.jad.2025.120770_bb0215","doi-asserted-by":"crossref","first-page":"6817","DOI":"10.1038\/s41598-023-34021-1","article-title":"Identification of oxidative stress-related genes differentially expressed in Alzheimer\u2019s disease and construction of a hub gene-based diagnostic model","volume":"13","author":"Zhang","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jad.2025.120770_bb0220","doi-asserted-by":"crossref","first-page":"313","DOI":"10.14283\/jpad.2021.15","article-title":"The epidemiology of Alzheimer\u2019s disease modifiable risk factors and prevention","volume":"8","author":"Zhang","year":"2021","journal-title":"J. Prev Alzheimers Dis."},{"key":"10.1016\/j.jad.2025.120770_bb0225","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/ng.3538","article-title":"Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets","volume":"48","author":"Zhu","year":"2016","journal-title":"Nat. Genet."}],"container-title":["Journal of Affective Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032725022128?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032725022128?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T21:07:58Z","timestamp":1783026478000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165032725022128"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":45,"alternative-id":["S0165032725022128"],"URL":"https:\/\/doi.org\/10.1016\/j.jad.2025.120770","relation":{},"ISSN":["0165-0327"],"issn-type":[{"value":"0165-0327","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification of endoplasmic reticulum stress-related genes associated with Alzheimer's disease risk: A multi-omics Mendelian randomization analysis","name":"articletitle","label":"Article Title"},{"value":"Journal of Affective Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jad.2025.120770","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"120770"}}