{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T22:56:11Z","timestamp":1791845771428,"version":"4.3.4"},"reference-count":78,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFF0306503"],"award-info":[{"award-number":["2021YFF0306503"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82201689"],"award-info":[{"award-number":["82201689"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005047","name":"Natural Science Foundation of Liaoning Province","doi-asserted-by":"publisher","award":["2024\\u201384"],"award-info":[{"award-number":["2024\\u201384"]}],"id":[{"id":"10.13039\/501100005047","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005047","name":"Natural Science Foundation of Liaoning Province","doi-asserted-by":"publisher","award":["2022-YGJC-40"],"award-info":[{"award-number":["2022-YGJC-40"]}],"id":[{"id":"10.13039\/501100005047","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Affective Disorders"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.jad.2025.120988","type":"journal-article","created":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T23:17:11Z","timestamp":1766272631000},"page":"120988","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["The elevated plasma levels of Claudin-5 are associated with peripheral inflammatory activity in patients with major depressive disorder"],"prefix":"10.1016","volume":"398","author":[{"given":"Longhai","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengxue","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siqi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyan","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowei","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingtao","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jad.2025.120988_bb0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103266","article-title":"Metformin ameliorates neuroinflammatory environment for neurons and astrocytes during in vitro and in vivo stroke and tobacco smoke chemical exposure: role of Nrf2 activation","volume":"75","author":"Akter","year":"2024","journal-title":"Redox Biol."},{"key":"10.1016\/j.jad.2025.120988_bb0010","first-page":"812","article-title":"Abnormal distribution and function of circulating monocytes and enhanced bacterial translocation in major depressive disorder","volume":"10","author":"Alvarez-Mon","year":"2019","journal-title":"Front. Psychol."},{"key":"10.1016\/j.jad.2025.120988_bb0015","article-title":"Blunted expansion of regulatory T lymphocytes is associated with increased bacterial translocation in patients with major depressive disorder","volume":"11","author":"Alvarez-Mon","year":"2020","journal-title":"Front. Psychol."},{"key":"10.1016\/j.jad.2025.120988_bb0020","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.cyto.2011.10.016","article-title":"TNF-alpha induced NF\u03baB signaling and p65 (RelA) overexpression repress Cldn5 promoter in mouse brain endothelial cells","volume":"57","author":"Aslam","year":"2012","journal-title":"Cytokine"},{"key":"10.1016\/j.jad.2025.120988_bb0025","article-title":"Regulation of stress-induced immunosuppression in the context of neuroendocrine, cytokine, and cellular processes","volume":"14","author":"Balakin","year":"2025","journal-title":"Biol.-Basel"},{"key":"10.1016\/j.jad.2025.120988_bb0030","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1007\/s00018-019-03030-7","article-title":"Tight junction proteins at the blood-brain barrier: far more than claudin-5","volume":"76","author":"Berndt","year":"2019","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.jad.2025.120988_bb0035","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1073\/pnas.0438019100","article-title":"A mechanism converting psychosocial stress into mononuclear cell activation","volume":"100","author":"Bierhaus","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jad.2025.120988_bb0040","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jneuroim.2015.05.008","article-title":"Transitory loss of glia and the subsequent modulation in inflammatory cytokines\/chemokines regulate paracellular claudin-5 expression in endothelial cells","volume":"284","author":"Camire","year":"2015","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.jad.2025.120988_bb0045","doi-asserted-by":"crossref","first-page":"E7622","DOI":"10.1073\/pnas.1710848114","article-title":"CD146 coordinates brain endothelial cell-pericyte communication for blood-brain barrier development","volume":"114","author":"Chen","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jad.2025.120988_bb0050","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.bbi.2018.02.003","article-title":"TNF\u03b1 disrupts blood brain barrier integrity to maintain prolonged depressive-like behavior in mice","volume":"69","author":"Cheng","year":"2018","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.jad.2025.120988_bb0055","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.immuni.2009.02.007","article-title":"Critical regulation of early Th17 cell differentiation by interleukin-1 signaling","volume":"30","author":"Chung","year":"2009","journal-title":"Immunity"},{"key":"10.1016\/j.jad.2025.120988_bb0060","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.cyto.2010.02.011","article-title":"CRP-induced levels of oxidative stress are higher in brain than aortic endothelial cells","volume":"50","author":"Closhen","year":"2010","journal-title":"Cytokine"},{"key":"10.1016\/j.jad.2025.120988_bb0065","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.jad.2020.09.025","article-title":"Depression and inflammation among children and adolescents: a meta-analysis","volume":"277","author":"Colasanto","year":"2020","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2025.120988_bb0070","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1177\/1099800408323220","article-title":"Symptoms of postpartum depression associated with elevated levels of interleukin-1 beta during the first month postpartum","volume":"10","author":"Corwin","year":"2008","journal-title":"Biol. Res. Nurs."},{"key":"10.1016\/j.jad.2025.120988_bb0075","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/s41392-024-01738-y","article-title":"Major depressive disorder: hypothesis, mechanism, prevention and treatment","volume":"9","author":"Cui","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.jad.2025.120988_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.psychres.2020.113568","article-title":"Higher levels of serum IL-1\u03b2 and TNF-\u03b1 are associated with an increased probability of major depressive disorder","volume":"295","author":"Das","year":"2021","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.jad.2025.120988_bb0085","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1038\/s41467-021-27604-x","article-title":"Vascular and blood-brain barrier-related changes underlie stress responses and resilience in female mice and depression in human tissue","volume":"13","author":"Dion-Albert","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jad.2025.120988_bb0090","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25115601","article-title":"The basic requirement of tight junction proteins in blood-brain barrier function and their role in pathologies","volume":"25","author":"Dithmer","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jad.2025.120988_bb0095","doi-asserted-by":"crossref","first-page":"3326","DOI":"10.1073\/pnas.1914655117","article-title":"Molecular adaptations of the blood-brain barrier promote stress resilience vs. depression","volume":"117","author":"Dudek","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jad.2025.120988_bb0100","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/acps.12656","article-title":"Interleukin-1 \u03b2-targeted treatment strategies in inflammatory depression: toward personalized care","volume":"134","author":"Ellul","year":"2016","journal-title":"Acta Psychiatr. Scand."},{"key":"10.1016\/j.jad.2025.120988_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2024.109651","article-title":"IL-1\u03b2 disrupts the initiation of blood-brain barrier development by inhibiting endothelial Wnt\/\u03b2-catenin signaling","volume":"27","author":"Fetsko","year":"2024","journal-title":"iScience"},{"key":"10.1016\/j.jad.2025.120988_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.pnpbp.2019.109800","article-title":"Abnormal C-reactive protein blood levels as a specific biomarker of major depression and non-remission under antidepressants in schizophrenia","volume":"97","author":"Fond","year":"2020","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.jad.2025.120988_bb0115","doi-asserted-by":"crossref","DOI":"10.3390\/brainsci11010077","article-title":"Astrocyte-derived TGF\u03b21 facilitates blood-brain barrier function via non-canonical hedgehog signaling in brain microvascular endothelial cells","volume":"11","author":"Fu","year":"2021","journal-title":"Brain Sci."},{"key":"10.1016\/j.jad.2025.120988_bb0120","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1152\/physrev.00019.2012","article-title":"Claudins and the modulation of tight junction permeability","volume":"93","author":"G\u00fcnzel","year":"2013","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.jad.2025.120988_bb0125","doi-asserted-by":"crossref","first-page":"5816","DOI":"10.1038\/s41467-019-13812-z","article-title":"Dual microglia effects on blood brain barrier permeability induced by systemic inflammation","volume":"10","author":"Haruwaka","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jad.2025.120988_bb0130","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.bbi.2023.01.015","article-title":"Serum claudin-5 levels among patients with unipolar and bipolar depression in relation to the pro-inflammatory cytokine tumor necrosis factor-alpha levels","volume":"109","author":"Hochman","year":"2023","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.jad.2025.120988_bb0135","doi-asserted-by":"crossref","first-page":"18010","DOI":"10.1073\/pnas.1009399107","article-title":"Claudin-4 forms paracellular chloride channel in the kidney and requires claudin-8 for tight junction localization","volume":"107","author":"Hou","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jad.2025.120988_bb0140","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1159\/000343302","article-title":"C-reactive protein increases BBB permeability: implications for obesity and neuroinflammation","volume":"30","author":"Hsuchou","year":"2012","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.jad.2025.120988_bb0145","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1083\/jcb.147.6.1351","article-title":"Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins","volume":"147","author":"Itoh","year":"1999","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.jad.2025.120988_bb0150","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.psyneuen.2017.01.023","article-title":"Can C-reactive protein inform antidepressant medication selection in depressed outpatients? Findings from the CO-MED trial","volume":"78","author":"Jha","year":"2017","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.jad.2025.120988_bb0155","doi-asserted-by":"crossref","DOI":"10.1177\/17590914231181037","article-title":"How oxidative stress induces depression?","volume":"15","author":"Ji","year":"2023","journal-title":"ASN Neuro"},{"key":"10.1016\/j.jad.2025.120988_bb0160","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1016\/j.neuroscience.2005.06.090","article-title":"Catecholamines mediate stress-induced increases in peripheral and central inflammatory cytokines","volume":"135","author":"Johnson","year":"2005","journal-title":"Neuroscience"},{"key":"10.1016\/j.jad.2025.120988_bb0165","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.jneumeth.2014.03.002","article-title":"Interleukin-1\u03b2 induces an inflammatory response and the breakdown of the endothelial cell layer in an improved human THBMEC-based in vitro blood-brain barrier model","volume":"228","author":"Labus","year":"2014","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.jad.2025.120988_bb0170","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.yexcr.2018.10.002","article-title":"IL-1\u03b2 promotes transendothelial migration of PBMCs by upregulation of the FN\/\u03b1(5)\u03b2(1) signalling pathway in immortalised human brain microvascular endothelial cells","volume":"373","author":"Labus","year":"2018","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.jad.2025.120988_bb0175","doi-asserted-by":"crossref","first-page":"13064","DOI":"10.1038\/s41598-018-30875-y","article-title":"Real-time in vivo two-photon imaging study reveals decreased cerebro-vascular volume and increased blood-brain barrier permeability in chronically stressed mice","volume":"8","author":"Lee","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jad.2025.120988_bb0180","doi-asserted-by":"crossref","DOI":"10.3390\/brainsci13081223","article-title":"Elevated plasma levels of mature brain-derived neurotrophic factor in major depressive disorder patients with higher suicidal ideation","volume":"13","author":"Li","year":"2023","journal-title":"Brain Sci."},{"key":"10.1016\/j.jad.2025.120988_bb0185","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.2174\/1570159X16666180222164809","article-title":"The role of VE-cadherin in blood-brain barrier integrity under central nervous system pathological conditions","volume":"16","author":"Li","year":"2018","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.jad.2025.120988_bb0190","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1186\/s12974-024-03097-5","article-title":"Bone-derived PDGF-BB enhances hippocampal non-specific transcytosis through microglia-endothelial crosstalk in HFD-induced metabolic syndrome","volume":"21","author":"Liu","year":"2024","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.jad.2025.120988_bb0195","doi-asserted-by":"crossref","first-page":"3698","DOI":"10.1038\/s41380-023-02255-0","article-title":"Brain microvascular endothelial cells and blood-brain barrier dysfunction in psychotic disorders","volume":"28","author":"Lizano","year":"2023","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jad.2025.120988_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2024.115286","article-title":"Exercise alleviates CUS-induced depressive-like behaviors by modulating paracellular and transcellular permeability of the blood-brain barrier in the prefrontal cortex","volume":"476","author":"Luo","year":"2025","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.jad.2025.120988_bb0205","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.biopsych.2019.11.017","article-title":"Peripheral blood cell-stratified subgroups of inflamed depression","volume":"88","author":"Lynall","year":"2020","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jad.2025.120988_bb0210","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1038\/s41593-017-0010-3","article-title":"Social stress induces neurovascular pathology promoting depression","volume":"20","author":"Menard","year":"2017","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.jad.2025.120988_bb0215","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.biopsych.2020.01.014","article-title":"Depression heterogeneity and its biological underpinnings: toward Immunometabolic depression","volume":"88","author":"Milaneschi","year":"2020","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jad.2025.120988_bb0220","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1089\/ars.2012.5149","article-title":"Reactive oxygen species in inflammation and tissue injury","volume":"20","author":"Mittal","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.jad.2025.120988_bb0225","doi-asserted-by":"crossref","first-page":"8011","DOI":"10.1073\/pnas.0912901107","article-title":"Claudin-2-deficient mice are defective in the leaky and cation-selective paracellular permeability properties of renal proximal tubules","volume":"107","author":"Muto","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jad.2025.120988_bb0230","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1083\/jcb.200302070","article-title":"Size-selective loosening of the blood-brain barrier in claudin-5-deficient mice","volume":"161","author":"Nitta","year":"2003","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.jad.2025.120988_bb0235","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23031616","article-title":"C-reactive protein as a biomarker for major depressive disorder?","volume":"23","author":"Orsolini","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jad.2025.120988_bb0240","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/j.bbi.2020.02.010","article-title":"Inflammatory markers in depression: a meta-analysis of mean differences and variability in 5,166 patients and 5,083 controls","volume":"87","author":"Osimo","year":"2020","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.jad.2025.120988_bb0245","doi-asserted-by":"crossref","DOI":"10.1002\/hbm.70053","article-title":"Predicting antidepressant treatment response from cortical structure on MRI: a mega-analysis from the ENIGMA-MDD working group","volume":"46","author":"Poirot","year":"2025","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.jad.2025.120988_bb0250","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.biopsych.2012.09.024","article-title":"Coverage of blood vessels by astrocytic endfeet is reduced in major depressive disorder","volume":"73","author":"Rajkowska","year":"2013","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jad.2025.120988_bb0255","doi-asserted-by":"crossref","DOI":"10.1002\/brb3.2598","article-title":"Perivascular spaces as a marker of psychological trauma in depression: a 7-tesla MRI study","volume":"12","author":"Ranti","year":"2022","journal-title":"Brain Behav."},{"key":"10.1016\/j.jad.2025.120988_bb0260","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1272\/jnms.84.148","article-title":"Dynamic regulation of vascular permeability by vascular endothelial cadherin-mediated endothelial cell-cell junctions","volume":"84","author":"Rho","year":"2017","journal-title":"J. Nippon Med. Sch."},{"key":"10.1016\/j.jad.2025.120988_bb0265","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.63253","article-title":"Nano-scale architecture of blood-brain barrier tight-junctions","volume":"10","author":"Sasson","year":"2021","journal-title":"Elife"},{"key":"10.1016\/j.jad.2025.120988_bb0270","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.tins.2020.12.002","article-title":"Blood-brain barrier dynamics to maintain brain homeostasis","volume":"44","author":"Segarra","year":"2021","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.jad.2025.120988_bb0275","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1038\/s41380-024-02736-w","article-title":"Transcriptomic profiles in major depressive disorder: the role of immunometabolic and cell-cycle-related pathways in depression with different levels of inflammation","volume":"30","author":"Sforzini","year":"2025","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jad.2025.120988_bb0280","doi-asserted-by":"crossref","DOI":"10.1016\/j.pscychresns.2023.111761","article-title":"Higher blood-brain barrier permeability in patients with major depressive disorder identified by DCE-MRI imaging","volume":"337","author":"Shang","year":"2024","journal-title":"Psychiatry Res. Neuroimaging"},{"key":"10.1016\/j.jad.2025.120988_bb0285","article-title":"Th17 cells and inflammation in neurological disorders: possible mechanisms of action","volume":"13","author":"Shi","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jad.2025.120988_bb0290","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.jagp.2019.05.011","article-title":"Chronic systemic inflammation is associated with symptoms of late-life depression: the ARIC study","volume":"28","author":"Sonsin-Diaz","year":"2020","journal-title":"Am. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.jad.2025.120988_bb0295","doi-asserted-by":"crossref","first-page":"120","DOI":"10.3389\/fnmol.2020.00120","article-title":"Reciprocal interplay between astrocytes and CD4+ cells affects blood-brain barrier and neuronal function in response to \u03b2 amyloid","volume":"13","author":"Spampinato","year":"2020","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.jad.2025.120988_bb0300","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.bbi.2023.10.010","article-title":"Blood-brain barrier dysfunction mediated by the EZH2-Claudin-5 axis drives stress-induced TNF-\u03b1 infiltration and depression-like behaviors","volume":"115","author":"Sun","year":"2024","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.jad.2025.120988_bb0305","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1053\/j.gastro.2007.11.040","article-title":"Megaintestine in claudin-15-deficient mice","volume":"134","author":"Tamura","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jad.2025.120988_bb0310","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1038\/s41398-025-03286-7","article-title":"Dissecting biological heterogeneity in major depressive disorder based on neuroimaging subtypes with multi-omics data","volume":"15","author":"Tang","year":"2025","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.jad.2025.120988_bb0315","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1176\/appi.ajp.162.1.175","article-title":"Increase in interleukin-1beta in late-life depression","volume":"162","author":"Thomas","year":"2005","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jad.2025.120988_bb0320","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/j.jad.2024.08.152","article-title":"Network analysis of depressive symptoms and C-reactive protein levels in major depressive disorder","volume":"367","author":"Wang","year":"2024","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2025.120988_bb0325","doi-asserted-by":"crossref","DOI":"10.1016\/j.physbeh.2025.114881","article-title":"The relationship between \u201cmicrobiota-gut-brain\u201d axis and depression: chronic stress-induced inflammation","volume":"294","author":"Wang","year":"2025","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.jad.2025.120988_bb0330","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.104769","article-title":"Stress-induced blood brain barrier disruption: molecular mechanisms and signaling pathways","volume":"157","author":"Welcome","year":"2020","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.jad.2025.120988_bb0335","doi-asserted-by":"crossref","first-page":"711","DOI":"10.3389\/fimmu.2019.00711","article-title":"PECAM-1 stabilizes blood-brain barrier integrity and favors Paracellular T-cell diapedesis across the blood-brain barrier during Neuroinflammation","volume":"10","author":"Wimmer","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jad.2025.120988_bb0340","doi-asserted-by":"crossref","first-page":"13820","DOI":"10.1523\/JNEUROSCI.1671-13.2013","article-title":"Stress-induced recruitment of bone marrow-derived monocytes to the brain promotes anxiety-like behavior","volume":"33","author":"Wohleb","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jad.2025.120988_bb0345","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.jad.2022.11.058","article-title":"Biomarkers of intestinal permeability and blood-brain barrier permeability in adolescents with major depressive disorder","volume":"323","author":"Wu","year":"2023","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2025.120988_bb0350","doi-asserted-by":"crossref","first-page":"2571","DOI":"10.1007\/s10571-021-01153-9","article-title":"Blood-brain barrier dysfunction in the pathogenesis of major depressive disorder","volume":"42","author":"Wu","year":"2022","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.jad.2025.120988_bb0355","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.578879","article-title":"Burns impair blood-brain barrier and mesenchymal stem cells can reverse the process in mice","volume":"11","author":"Yang","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jad.2025.120988_bb0360","doi-asserted-by":"crossref","first-page":"1013933","DOI":"10.3389\/fnmol.2022.1013933","article-title":"New insight into neurological degeneration: inflammatory cytokines and blood-brain barrier","volume":"15","author":"Yang","year":"2022","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.jad.2025.120988_bb0365","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2019.112165","article-title":"Xiao-Yao-san reduces blood-brain barrier injury induced by chronic stress in vitro and vivo via glucocorticoid receptor-mediated upregulation of Occludin","volume":"246","author":"Yu","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jad.2025.120988_bb0370","doi-asserted-by":"crossref","first-page":"349","DOI":"10.59249\/YZLQ4631","article-title":"Omega-3 polyunsaturated fatty acids and blood-brain barrier integrity in major depressive disorder: restoring balance for Neuroinflammation and neuroprotection","volume":"97","author":"Zailani","year":"2024","journal-title":"Yale J. Biol. Med."},{"key":"10.1016\/j.jad.2025.120988_bb0375","first-page":"1395235","article-title":"Evaluation of serum zonulin and occludin levels in obsessive-compulsive disorder and the effect of major depressive disorder comorbidity","volume":"15","author":"Zengil","year":"2024","journal-title":"Front. Psychol."},{"key":"10.1016\/j.jad.2025.120988_bb0380","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.bbi.2024.02.004","article-title":"Midbrain FA initiates neuroinflammation and depression onset in both acute and chronic LPS-induced depressive model mice","volume":"117","author":"Zhao","year":"2024","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.jad.2025.120988_bb0385","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2022.147937","article-title":"Factors influencing the blood-brain barrier permeability","volume":"1788","author":"Zhao","year":"2022","journal-title":"Brain Res."},{"key":"10.1016\/j.jad.2025.120988_bb0390","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115272","article-title":"Tight junction proteins related to blood-brain barrier and their regulatory signaling pathways in ischemic stroke","volume":"165","author":"Zheng","year":"2023","journal-title":"Biomed. Pharmacother."}],"container-title":["Journal of Affective Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032725024309?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032725024309?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T13:19:46Z","timestamp":1781702386000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165032725024309"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":78,"alternative-id":["S0165032725024309"],"URL":"https:\/\/doi.org\/10.1016\/j.jad.2025.120988","relation":{},"ISSN":["0165-0327"],"issn-type":[{"value":"0165-0327","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The elevated plasma levels of Claudin-5 are associated with peripheral inflammatory activity in patients with major depressive disorder","name":"articletitle","label":"Article Title"},{"value":"Journal of Affective Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jad.2025.120988","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"120988"}}