{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:49:35Z","timestamp":1786927775133,"version":"build-2736575974"},"reference-count":87,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004000","name":"Guangzhou Municipal Science and Technology Program key projects","doi-asserted-by":"publisher","award":["2024B03J1299"],"award-info":[{"award-number":["2024B03J1299"]}],"id":[{"id":"10.13039\/501100004000","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971597"],"award-info":[{"award-number":["81971597"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82472057"],"award-info":[{"award-number":["82472057"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Affective Disorders"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.jad.2025.121141","type":"journal-article","created":{"date-parts":[[2026,1,4]],"date-time":"2026-01-04T15:07:12Z","timestamp":1767539232000},"page":"121141","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Associations of glymphatic system dysfunction and personality traits alterations in bipolar depression with suicidal attempt"],"prefix":"10.1016","volume":"399","author":[{"given":"Chao","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guixian","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanmao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruoyi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuming","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunkai","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanbin","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jad.2025.121141_bb0005","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1186\/s40478-024-01870-4","article-title":"Crucial role of Aquaporin-4 extended isoform in brain water homeostasis and amyloid-\u03b2 clearance: implications for edema and neurodegenerative diseases","volume":"12","author":"Abbrescia","year":"2024","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.jad.2025.121141_bb0010","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1093\/schbul\/sbae060","article-title":"Evaluation of the glymphatic system in schizophrenia spectrum disorder using proton magnetic resonance spectroscopy measurement of brain macromolecule and diffusion tensor image analysis along the perivascular space index","volume":"50","author":"Abdolizadeh","year":"2024","journal-title":"Schizophr. Bull."},{"key":"10.1016\/j.jad.2025.121141_bb0015","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.psychres.2018.02.003","article-title":"Psychopathic personality traits as a form of dispositional capability for suicide","volume":"262","author":"Anestis","year":"2018","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.jad.2025.121141_bb0020","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.neuroimage.2005.02.018","article-title":"Unified segmentation","volume":"26","author":"Ashburner","year":"2005","journal-title":"Neuroimage"},{"key":"10.1016\/j.jad.2025.121141_bb0025","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1007\/s12021-011-9109-y","article-title":"An open source multivariate framework for n-tissue segmentation with evaluation on public data","volume":"9","author":"Avants","year":"2011","journal-title":"Neuroinformatics"},{"key":"10.1016\/j.jad.2025.121141_bb0030","doi-asserted-by":"crossref","DOI":"10.1148\/radiol.221848","article-title":"Altered brain glymphatic flow at diffusion-tensor MRI in rapid eye movement sleep behavior disorder","volume":"307","author":"Bae","year":"2023","journal-title":"Radiology"},{"key":"10.1016\/j.jad.2025.121141_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2024.115323","article-title":"Lower DTI-ALPS index in patients with major depressive disorder: correlation with fatigue","volume":"478","author":"Bao","year":"2025","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.jad.2025.121141_bb0040","article-title":"Robust, fully-automated assessment of cerebral perivascular spaces and white matter lesions: a multicentre MRI longitudinal study of their evolution and association with risk of dementia and accelerated brain atrophy","volume":"111","author":"Barisano","year":"2024","journal-title":"EBioMedicine"},{"key":"10.1016\/j.jad.2025.121141_bb0045","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.jad.2010.07.023","article-title":"Impulsivity and suicidality: the mediating role of painful and provocative experiences","volume":"129","author":"Bender","year":"2011","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2025.121141_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2022.104987","article-title":"The glymphatic system: current understanding and modeling","volume":"25","author":"Bohr","year":"2022","journal-title":"Iscience"},{"key":"10.1016\/j.jad.2025.121141_bb0055","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1111\/j.1600-0447.2005.00702.x","article-title":"Personality traits as correlates of suicidal ideation, suicide attempts, and suicide completions: a systematic review","volume":"113","author":"Brezo","year":"2006","journal-title":"Acta Psychiatr. Scand."},{"key":"10.1016\/j.jad.2025.121141_bb0060","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1037\/0022-006X.68.3.371","article-title":"Risk factors for suicide in psychiatric outpatients: a 20-year prospective study","volume":"68","author":"Brown","year":"2000","journal-title":"J. Consult. Clin. Psychol."},{"key":"10.1016\/j.jad.2025.121141_bb0065","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1002\/jclp.20445","article-title":"Hypomanic symptoms among first-time suicide attempters predict future multiple attempt status","volume":"64","author":"Bryan","year":"2008","journal-title":"J. Clin. Psychol."},{"key":"10.1016\/j.jad.2025.121141_bb0070","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1093\/brain\/awab454","article-title":"Glymphatic system impairment in multiple sclerosis: relation with brain damage and disability","volume":"145","author":"Carotenuto","year":"2022","journal-title":"Brain"},{"key":"10.1016\/j.jad.2025.121141_bb0075","doi-asserted-by":"crossref","first-page":"e890","DOI":"10.1212\/WNL.0000000000011121","article-title":"Association of dilated perivascular spaces and disease severity in patients with huntington disease","volume":"96","author":"Chan","year":"2021","journal-title":"Neurology"},{"key":"10.1016\/j.jad.2025.121141_bb0080","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.jad.2024.08.229","article-title":"Impairments of neurovascular coupling after stroke lower glymphatic system function and lead to depressive symptom: a longitudinal cohort study","volume":"367","author":"Chao","year":"2024","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2025.121141_bb0085","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/s41398-025-03486-1","article-title":"Glymphatic dysfunction associated with cortisol dysregulation in major depressive disorder","volume":"15","author":"Chen","year":"2025","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.jad.2025.121141_bb0090","doi-asserted-by":"crossref","DOI":"10.1038\/s41398-025-03753-1","article-title":"Decreased diffusivity along the perivascular spaces in bipolar disorder: an MRI-based cross-sectional and Mendelian randomization study","author":"Chen","year":"2025","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.jad.2025.121141_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.smrv.2021.101572","article-title":"Sleep, cerebrospinal fluid, and the glymphatic system: a systematic review","volume":"61","author":"Chong","year":"2022","journal-title":"Sleep Med. Rev."},{"key":"10.1016\/j.jad.2025.121141_bb0100","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1038\/sj.npp.1300982","article-title":"Astroglial plasticity in the hippocampus is affected by chronic psychosocial stress and concomitant fluoxetine treatment","volume":"31","author":"Cz\u00e9h","year":"2006","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.jad.2025.121141_bb0105","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1111\/sltb.12632","article-title":"Suicide ideation among male prisoners: preliminary evidence that psychopathic traits are indirectly linked to suicide ideation through thwarted interpersonal needs","volume":"50","author":"Dhingra","year":"2020","journal-title":"Suicide Life Threat. Behav."},{"key":"10.1016\/j.jad.2025.121141_bb0110","article-title":"Prevalence of suicide attempts in bipolar disorder: a systematic review and meta-analysis of observational studies","volume":"29","author":"Dong","year":"2019","journal-title":"Epidemiol. Psychiatr. Sci."},{"key":"10.1016\/j.jad.2025.121141_bb0115","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1007\/s10979-007-9122-8","article-title":"Relation of antisocial and psychopathic traits to suicide-related behavior among offenders","volume":"32","author":"Douglas","year":"2008","journal-title":"Law Hum. Behav."},{"key":"10.1016\/j.jad.2025.121141_bb0120","series-title":"Medical Image Computing and Computer-Assisted Intervention\u2014MICCAI\u201998: First International Conference Cambridge, MA, USA, October 11\u201313, 1998 Proceedings 1","first-page":"130","article-title":"Multiscale vessel enhancement filtering","author":"Frangi","year":"1998"},{"key":"10.1016\/j.jad.2025.121141_bb0125","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.82232","article-title":"Loss of aquaporin-4 results in glymphatic system dysfunction via brain-wide interstitial fluid stagnation","volume":"12","author":"Gomolka","year":"2023","journal-title":"eLife"},{"key":"10.1016\/j.jad.2025.121141_bb0130","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1111\/j.1755-5949.2012.00324.x","article-title":"Female early adult depression results in detrimental impacts on the behavioral performance and brain development in offspring","volume":"18","author":"Gong","year":"2012","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.jad.2025.121141_bb0135","doi-asserted-by":"crossref","first-page":"3284","DOI":"10.1038\/s41467-023-39030-2","article-title":"The monoaminergic system is a bilaterian innovation","volume":"14","author":"Goulty","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jad.2025.121141_bb0140","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1177\/070674370905401202","article-title":"Psychopathy: assessment and forensic implications","volume":"54","author":"Hare","year":"2009","journal-title":"Can. J. Psychiatry"},{"key":"10.1016\/j.jad.2025.121141_bb0145","doi-asserted-by":"crossref","first-page":"2576","DOI":"10.1093\/brain\/awaa179","article-title":"Impaired glymphatic function and clearance of tau in an Alzheimer\u2019s disease model","volume":"143","author":"Harrison","year":"2020","journal-title":"Brain J. Neurol."},{"key":"10.1016\/j.jad.2025.121141_bb0150","article-title":"Understanding MMPI-2 response structure between schizophrenia and healthy individuals","volume":"13","author":"Hsu","year":"2022","journal-title":"Front. Psych."},{"key":"10.1016\/j.jad.2025.121141_bb0155","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3003748","article-title":"A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid \u03b2","volume":"4","author":"Iliff","year":"2012","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.jad.2025.121141_bb0160","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/j.neuroimage.2011.09.015","volume":"62","author":"Jenkinson","year":"2012","journal-title":"FSL. Neuroimage"},{"key":"10.1016\/j.jad.2025.121141_bb0165","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1002\/ana.26710","article-title":"Regional glymphatic abnormality in behavioral variant frontotemporal dementia","volume":"94","author":"Jiang","year":"2023","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.jad.2025.121141_bb0170","doi-asserted-by":"crossref","first-page":"e2648","DOI":"10.1212\/WNL.0000000000201300","article-title":"Association of MRI indices of glymphatic system with amyloid deposition and cognition in mild cognitive impairment and Alzheimer disease","volume":"99","author":"Kamagata","year":"2022","journal-title":"Neurology"},{"key":"10.1016\/j.jad.2025.121141_bb0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.jad.2025.119686","article-title":"Association between frontal pole atrophy and glymphatic dysfunction in patients with bipolar disorder","volume":"389","author":"Kikuta","year":"2025","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2025.121141_bb0180","doi-asserted-by":"crossref","first-page":"15310","DOI":"10.1038\/s41598-021-94839-5","article-title":"Detecting suicidal risk using MMPI-2 based on machine learning algorithm","volume":"11","author":"Kim","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jad.2025.121141_bb0185","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1111\/sltb.12684","article-title":"Maladaptive personality traits and the course of suicidal ideation in young adults with bipolar disorder: cross-sectional and prospective approaches","volume":"51","author":"Kudinova","year":"2021","journal-title":"Suicide Life Threat. Behav."},{"key":"10.1016\/j.jad.2025.121141_bb2185","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1038\/s41398-024-03163-9","article-title":"An exploratory study of metabolomics in endogenous and cannabis-use-associated psychotic-ike experiences in adolescence","volume":"14","author":"Kurkinen","year":"2024","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.jad.2025.121141_bb0190","first-page":"1","article-title":"White matter and glymphatic system alterations in patients with focal epilepsy: insights from PSMD and DTI-ALPS index","author":"Lee","year":"2025","journal-title":"Neuroradiology"},{"key":"10.1016\/j.jad.2025.121141_bb0195","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1002\/ana.26648","article-title":"Choroid plexus enlargement exacerbates white matter hyperintensity growth through glymphatic impairment","volume":"94","author":"Li","year":"2023","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.jad.2025.121141_bb0200","doi-asserted-by":"crossref","DOI":"10.1212\/WNL.0000000000209306","article-title":"Perivascular spaces, diffusivity along perivascular spaces, and free water in cerebral small vessel disease","volume":"102","author":"Li","year":"2024","journal-title":"Neurology"},{"key":"10.1016\/j.jad.2025.121141_bb0205","doi-asserted-by":"crossref","first-page":"3726","DOI":"10.1007\/s00330-023-09473-8","article-title":"Glymphatic system dysfunction in pediatric acute lymphoblastic leukemia without clinically diagnosed central nervous system infiltration: a novel DTI-ALPS method","volume":"33","author":"Lin","year":"2023","journal-title":"Eur. Radiol."},{"key":"10.1016\/j.jad.2025.121141_bb0210","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.bbi.2020.07.022","article-title":"Polyunsaturated fatty acid supplement alleviates depression-incident cognitive dysfunction by protecting the cerebrovascular and glymphatic systems","volume":"89","author":"Liu","year":"2020","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.jad.2025.121141_bb0215","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.40070","article-title":"Aquaporin-4-dependent glymphatic solute transport in the rodent brain","volume":"7","author":"Mestre","year":"2018","journal-title":"eLife"},{"key":"10.1016\/j.jad.2025.121141_bb0220","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1007\/s11920-020-1130-0","article-title":"Bipolar disorder and suicide: a review","volume":"22","author":"Miller","year":"2020","journal-title":"Curr. Psychiatry Rep."},{"key":"10.1016\/j.jad.2025.121141_bb0225","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.jad.2022.11.039","article-title":"Comparison of bipolar disorder type II and major depressive disorder","volume":"323","author":"Miola","year":"2023","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2025.121141_bb0230","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0140-6736(02)07450-0","article-title":"Bipolar disorder","volume":"359","author":"M\u00fcller-Oerlinghausen","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.jad.2025.121141_bb0235","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/hbm.1058","article-title":"Nonparametric permutation tests for functional neuroimaging: a primer with examples","volume":"15","author":"Nichols","year":"2002","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.jad.2025.121141_bb0240","doi-asserted-by":"crossref","first-page":"8124","DOI":"10.1007\/s12035-019-01661-2","article-title":"Aquaporin 4 suppresses neural hyperactivity and synaptic fatigue and fine-tunes neurotransmission to regulate visual function in the mouse retina","volume":"56","author":"Ozawa","year":"2019","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.jad.2025.121141_bb0245","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.jpsychires.2020.12.069","article-title":"Association among early life stress, mood features, hopelessness and suicidal risk in bipolar disorder: the potential contribution of insomnia symptoms","volume":"135","author":"Palagini","year":"2021","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.jad.2025.121141_bb0250","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1586\/14737175.2016.1171144","article-title":"Targeting astrocytes in bipolar disorder","volume":"16","author":"Peng","year":"2016","journal-title":"Expert Rev. Neurother."},{"key":"10.1016\/j.jad.2025.121141_bb0255","doi-asserted-by":"crossref","DOI":"10.1212\/WNL.0000000000214215","article-title":"Mapping the association of cerebral small vessel disease, gray matter integrity, and cognitive function","volume":"105","author":"Petersen","year":"2025","journal-title":"Neurology"},{"key":"10.1016\/j.jad.2025.121141_bb0260","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.euroneuro.2021.12.003","article-title":"A review and meta-analysis of gene expression profiles in suicide","volume":"56","author":"Piras","year":"2022","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.jad.2025.121141_bb0265","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1159\/000146069","article-title":"Temperament and personality dimensions in suicidal and nonsuicidal psychiatric inpatients","volume":"41","author":"Pompili","year":"2008","journal-title":"Psychopathology"},{"key":"10.1016\/j.jad.2025.121141_bb0270","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.neubiorev.2020.12.031","article-title":"Bipolar disorder: an evolutionary psychoneuroimmunological approach","volume":"122","author":"Rantala","year":"2021","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.jad.2025.121141_bb0275","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.cpr.2015.09.001","article-title":"The role of sleep dysfunction in the occurrence of delusions and hallucinations: a systematic review","volume":"42","author":"Reeve","year":"2015","journal-title":"Clin. Psychol. Rev."},{"key":"10.1016\/j.jad.2025.121141_bb0280","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1111\/acps.12894","article-title":"Factors associated with poor functional outcome in bipolar disorder: sociodemographic, clinical, and neurocognitive variables","volume":"138","author":"Sanchez-Moreno","year":"2018","journal-title":"Acta Psychiatr. Scand."},{"key":"10.1016\/j.jad.2025.121141_bb0285","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1152\/physrev.00060.2021","article-title":"The choroid plexus: a missing link in our understanding of brain development and function","volume":"103","author":"Saunders","year":"2023","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.jad.2025.121141_bb0290","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-48910-x","article-title":"Image processing approaches to enhance perivascular space visibility and quantification using MRI","volume":"9","author":"Sepehrband","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jad.2025.121141_bb0295","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1038\/s41531-022-00437-1","article-title":"Diffusion along perivascular spaces as marker for impairment of glymphatic system in Parkinson's disease","volume":"8","author":"Shen","year":"2022","journal-title":"NPJ Parkinsons Dis."},{"key":"10.1016\/j.jad.2025.121141_bb0300","doi-asserted-by":"crossref","first-page":"3837","DOI":"10.1017\/S0033291722000484","article-title":"Alterations of insular dynamic functional connectivity and psychological characteristics in unmedicated bipolar depression patients with a recent suicide attempt","volume":"53","author":"Shunkai","year":"2023","journal-title":"Psychol. Med."},{"key":"10.1016\/j.jad.2025.121141_bb0305","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2024.1480405","article-title":"Neuroinflammation modifies the relationship between stress and perivascular spaces in an elderly population with different levels of cognitive impairment","volume":"18","author":"Sibilia","year":"2024","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.jad.2025.121141_bb0310","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1111\/j.1399-5618.2007.00408.x","article-title":"Risk of suicide attempt and suicide death in patients treated for bipolar disorder","volume":"9","author":"Simon","year":"2007","journal-title":"Bipolar Disord."},{"key":"10.1016\/j.jad.2025.121141_bb0315","doi-asserted-by":"crossref","first-page":"e829","DOI":"10.1212\/WNL.0000000000013215","article-title":"Association of sleep, neuropsychological performance, and gray matter volume with glymphatic function in community-dwelling older adults","volume":"98","author":"Siow","year":"2022","journal-title":"Neurology"},{"key":"10.1016\/j.jad.2025.121141_bb0320","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/acps.12834","article-title":"Risk profiles of personality traits for suicidality among mood disorder patients and community controls","volume":"137","author":"Su","year":"2018","journal-title":"Acta Psychiatr. Scand."},{"key":"10.1016\/j.jad.2025.121141_bb0325","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.jpsychires.2022.10.034","article-title":"The association of personality polygenic risk score, psychosocial protective factors and suicide attempt in mood disorder","volume":"156","author":"Su","year":"2022","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.jad.2025.121141_bb0330","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1007\/s00415-025-13201-1","article-title":"Regional free-water diffusion is more strongly related to neuroinflammation than neurodegeneration","volume":"272","author":"Sumra","year":"2025","journal-title":"J. Neurol."},{"key":"10.1016\/j.jad.2025.121141_bb2330","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.neubiorev.2019.05.016","article-title":"Establishing a framework for neuropathological correlates and glymphatic system functioning in Parkinson\u2019s disease","volume":"103","author":"Sundaram","year":"2019","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.jad.2025.121141_bb0335","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/bdi.12962","article-title":"Regulatory effect of lithium on hippocampal blood-brain barrier integrity in a rat model of depressive-like behavior","volume":"23","author":"Taler","year":"2021","journal-title":"Bipolar Disord."},{"key":"10.1016\/j.jad.2025.121141_bb0340","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1176\/appi.ajp.2019.18091044","article-title":"Altered cellular white matter but not extracellular free water on diffusion MRI in individuals at clinical high risk for psychosis","volume":"176","author":"Tang","year":"2019","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jad.2025.121141_bb0345","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1002\/jmri.26892","article-title":"Glymphatic imaging using MRI","volume":"51","author":"Taoka","year":"2020","journal-title":"J. Magn. Reson. Imaging"},{"key":"10.1016\/j.jad.2025.121141_bb0350","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1007\/s11604-017-0617-z","article-title":"Evaluation of glymphatic system activity with the diffusion MR technique: diffusion tensor image analysis along the perivascular space (DTI-ALPS) in Alzheimer\u2019s disease cases","volume":"35","author":"Taoka","year":"2017","journal-title":"Jpn. J. Radiol."},{"key":"10.1016\/j.jad.2025.121141_bb0355","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s11604-021-01187-5","article-title":"Reproducibility of diffusion tensor image analysis along the perivascular space (DTI-ALPS) for evaluating interstitial fluid diffusivity and glymphatic function: CHanges in Alps index on multiple conditiON acquIsition eXperiment (CHAMONIX) study","volume":"40","author":"Taoka","year":"2022","journal-title":"Jpn. J. Radiol."},{"key":"10.1016\/j.jad.2025.121141_bb0360","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1093\/schbul\/sbae039","article-title":"Glymphatic system dysfunction underlying schizophrenia is associated with cognitive impairment","volume":"50","author":"Tu","year":"2024","journal-title":"Schizophr. Bull."},{"key":"10.1016\/j.jad.2025.121141_bb0365","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.neuroscience.2024.07.026","article-title":"Glymphatic system dysfunction in mood disorders: evaluation by diffusion magnetic resonance imaging","volume":"555","author":"Ueda","year":"2024","journal-title":"Neuroscience"},{"key":"10.1016\/j.jad.2025.121141_bb0370","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1007\/s00213-018-5147-6","article-title":"Chronic stress impairs the aquaporin-4-mediated glymphatic transport through glucocorticoid signaling","volume":"236","author":"Wei","year":"2019","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.jad.2025.121141_bb0375","doi-asserted-by":"crossref","DOI":"10.48101\/ujms.v130.12006","article-title":"Elevated levels of aquaporin-4-containing extracellular vesicles in cerebrospinal fluid of patients with bipolar disorder","volume":"130","author":"Wetterberg","year":"2025","journal-title":"Ups. J. Med. Sci."},{"key":"10.1016\/j.jad.2025.121141_bb0380","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s00213-016-4473-9","article-title":"Mechanism of depression as a risk factor in the development of Alzheimer's disease: the function of AQP4 and the glymphatic system","volume":"234","author":"Xia","year":"2017","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.jad.2025.121141_bb0385","doi-asserted-by":"crossref","DOI":"10.1111\/cns.14803","article-title":"Advances in the study of the glymphatic system and aging","volume":"30","author":"Xiong","year":"2024","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.jad.2025.121141_bb0390","doi-asserted-by":"crossref","first-page":"6397","DOI":"10.21037\/qims-24-510","article-title":"Glymphatic function assessment with diffusion tensor imaging along the perivascular space in patients with major depressive disorder and its relation to cerebral white-matter alteration","volume":"14","author":"Yang","year":"2024","journal-title":"Quant. Imaging Med. Surg."},{"key":"10.1016\/j.jad.2025.121141_bb0395","doi-asserted-by":"crossref","DOI":"10.1016\/j.jstrokecerebrovasdis.2024.108187","article-title":"Association of glymphatic clearance function with imaging markers and risk factors of cerebral small vessel disease","volume":"34","author":"Yang","year":"2025","journal-title":"J. Stroke Cerebrovasc. Dis."},{"key":"10.1016\/j.jad.2025.121141_bb0400","doi-asserted-by":"crossref","DOI":"10.1080\/0886022X.2024.2425160","article-title":"Glymphatic system dysfunction in nondialysis-dependent ESRD patients with diabetic kidney disease: associations with clinical characteristics and cognitive function","volume":"46","author":"Yu","year":"2024","journal-title":"Ren. Fail."},{"key":"10.1016\/j.jad.2025.121141_bb0405","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/BF00296784","article-title":"Directional and compartmentalised drainage of interstitial fluid and cerebrospinal fluid from the rat brain","volume":"83","author":"Zhang","year":"1992","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.jad.2025.121141_bb0410","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroimage.2021.118257","article-title":"Glymphatic clearance function in patients with cerebral small vessel disease","volume":"238","author":"Zhang","year":"2021","journal-title":"Neuroimage"},{"key":"10.1016\/j.jad.2025.121141_bb0415","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.neurad.2023.05.009","article-title":"The asymmetry of glymphatic system dysfunction in patients with temporal lobe epilepsy: a DTI-ALPS study","volume":"50","author":"Zhao","year":"2023","journal-title":"J. Neuroradiol."},{"issue":"2","key":"10.1016\/j.jad.2025.121141_bb0420","doi-asserted-by":"crossref","DOI":"10.1002\/alz.14484","article-title":"Choroid plexus cysts on 7T MRI: Relationship to aging and neurodegenerative diseases","volume":"21","author":"Zhen","year":"2025","journal-title":"Alzheimer Dement."},{"key":"10.1016\/j.jad.2025.121141_bb0425","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1159\/000534033","article-title":"Hippocampal dynamic functional connectivity, HPA Axis activity, and personality trait in bipolar disorder with suicidal attempt","volume":"114","author":"Zhong","year":"2024","journal-title":"Neuroendocrinology"}],"container-title":["Journal of Affective Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032725025832?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032725025832?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T04:10:56Z","timestamp":1776571856000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165032725025832"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":87,"alternative-id":["S0165032725025832"],"URL":"https:\/\/doi.org\/10.1016\/j.jad.2025.121141","relation":{},"ISSN":["0165-0327"],"issn-type":[{"value":"0165-0327","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Associations of glymphatic system dysfunction and personality traits alterations in bipolar depression with suicidal attempt","name":"articletitle","label":"Article Title"},{"value":"Journal of Affective Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jad.2025.121141","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"121141"}}