{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T04:48:37Z","timestamp":1782190117284,"version":"3.54.5"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100009156","name":"Nantong Municipal Science and Technology Bureau","doi-asserted-by":"publisher","award":["MS2024039"],"award-info":[{"award-number":["MS2024039"]}],"id":[{"id":"10.13039\/501100009156","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2023YFC2506800"],"award-info":[{"award-number":["2023YFC2506800"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371505"],"award-info":[{"award-number":["82371505"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017950","name":"Shanghai Municipal Health Commission","doi-asserted-by":"publisher","award":["202440203"],"award-info":[{"award-number":["202440203"]}],"id":[{"id":"10.13039\/100017950","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Affective Disorders"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.jad.2026.121300","type":"journal-article","created":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T17:47:28Z","timestamp":1769708848000},"page":"121300","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Right orbitofrontal cortex rTMS targets anxiety, not depressive, symptoms in first-episode schizophrenia"],"prefix":"10.1016","volume":"401","author":[{"given":"YiYi","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiong","family":"Jiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YanYan","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HuiRu","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"XiaoChen","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LiHua","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YingYing","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HaiChun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LingYun","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ChunBo","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JiJun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"TianHong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jad.2026.121300_bb0005","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.schres.2024.05.020","article-title":"The effect of second-generation antipsychotics on anxiety\/depression in patients with schizophrenia: A systematic review and meta-analysis","volume":"270","author":"Abdolizadeh","year":"2024","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.jad.2026.121300_bb0010","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/s41398-020-0751-8","article-title":"Low-frequency parietal repetitive transcranial magnetic stimulation reduces fear and anxiety","volume":"10","author":"Balderston","year":"2020","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.jad.2026.121300_bb0015","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.jad.2019.03.085","article-title":"Efficacy of repetitive transcranial magnetic stimulation in the treatment of depression with comorbid anxiety disorders","volume":"252","author":"Clarke","year":"2019","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2026.121300_bb0020","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/j.cub.2019.02.015","article-title":"Orbitofrontal cortex: a \u2018non-rewarding\u2019 new treatment target in depression?","volume":"29","author":"Downar","year":"2019","journal-title":"Curr. Biol."},{"key":"10.1016\/j.jad.2026.121300_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.psychres.2021.113784","article-title":"Efficacy of intensive orbitofrontal continuous Theta Burst Stimulation (iOFcTBS) in obsessive compulsive disorder: a randomized placebo controlled study","volume":"298","author":"Dutta","year":"2021","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.jad.2026.121300_bb0030","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.euroneuro.2017.11.011","article-title":"1Hz rTMS of the right orbitofrontal cortex for major depression: Safety, tolerability and clinical outcomes","volume":"28","author":"Feffer","year":"2018","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.jad.2026.121300_bb0035","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.biopsych.2014.03.030","article-title":"Amygdala-prefrontal cortex functional connectivity during threat-induced anxiety and goal distraction","volume":"77","author":"Gold","year":"2015","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jad.2026.121300_bb0040","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/s41398-022-02297-y","article-title":"Neuroinflammation mechanisms of neuromodulation therapies for anxiety and depression","volume":"13","author":"Guo","year":"2023","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.jad.2026.121300_bb0045","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/j.2044-8341.1959.tb00467.x","article-title":"The assessment of anxiety states by rating","volume":"32","author":"Hamilton","year":"1959","journal-title":"Br. J. Med. Psychol."},{"key":"10.1016\/j.jad.2026.121300_bb0050","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1136\/jnnp.23.1.56","article-title":"A rating scale for depression","volume":"23","author":"Hamilton","year":"1960","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.jad.2026.121300_bb0055","article-title":"Orbitofrontal cortex-hippocampus potentiation mediates relief for depression: A randomized double-blind trial and TMS-EEG study","volume":"4","author":"Han","year":"2023","journal-title":"Cell Rep. Med."},{"key":"10.1016\/j.jad.2026.121300_bb0060","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.jpsychires.2025.05.045","article-title":"Early improvement of psychopathological symptoms with add-on repetitive transcranial magnetic stimulation treatment as the key contributor to improving remission in schizophrenia","volume":"188","author":"Hu","year":"2025","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.jad.2026.121300_bb0065","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.biopsych.2024.05.024","article-title":"Abnormal global cortical responses in drug-naive patients with schizophrenia following orbitofrontal cortex stimulation: a concurrent transcranial magnetic stimulation-electroencephalography study","volume":"96","author":"Jiao","year":"2024","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jad.2026.121300_bb0070","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1093\/schbul\/13.2.261","article-title":"The positive and negative syndrome scale (PANSS) for schizophrenia","volume":"13","author":"Kay","year":"1987","journal-title":"Schizophr. Bull."},{"key":"10.1016\/j.jad.2026.121300_bb0075","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.jad.2025.01.148","article-title":"Comorbid anxiety in depression and rTMS treatment response: A retrospective study","volume":"376","author":"Kazemi","year":"2025","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2026.121300_bb0080","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.jpsychires.2022.10.025","article-title":"A double blind randomized clinical trial of the effectiveness of low frequency rTMS over right DLPFC or OFC for treatment of obsessive-compulsive disorder","volume":"156","author":"Khedr","year":"2022","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.jad.2026.121300_bb0085","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1001\/archpsyc.56.4.315","article-title":"Therapeutic efficacy of right prefrontal slow repetitive transcranial magnetic stimulation in major depression: a double-blind controlled study","volume":"56","author":"Klein","year":"1999","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.jad.2026.121300_bb0090","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1177\/0706743720923064","volume":"65","author":"Leong","year":"2020","journal-title":"Can. J. Psychiatr."},{"key":"10.1016\/j.jad.2026.121300_bb0095","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s00406-020-01163-6","article-title":"Frontal-striatal connectivity and positive symptoms of schizophrenia: implications for the mechanistic basis of prefrontal rTMS","volume":"271","author":"Limongi","year":"2021","journal-title":"Eur. Arch. Psychiatry Clin. Neurosci."},{"key":"10.1016\/j.jad.2026.121300_bb0100","doi-asserted-by":"crossref","first-page":"3109","DOI":"10.2147\/IJGM.S318069","article-title":"Continuous theta-burst stimulation over the right orbitofrontal cortex in treatment-resistant obsessive-compulsive disorder treatment: a randomized sham-controlled trial","volume":"14","author":"Liu","year":"2021","journal-title":"Int. J. Gen. Med."},{"key":"10.1016\/j.jad.2026.121300_bb0105","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.jad.2006.11.027","article-title":"Repetitive Transcranial Magnetic Stimulation (rTMS) in the treatment of panic disorder (PD) with comorbid major depression","volume":"102","author":"Mantovani","year":"2007","journal-title":"J. Affect. Disord."},{"issue":"2","key":"10.1016\/j.jad.2026.121300_bb0110","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.biopsych.2025.03.016","article-title":"Brain network resilience and cognitive function in patients with first-episode schizophrenia spectrum disorders","volume":"99","author":"Odkhuu","year":"2026","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jad.2026.121300_bb0115","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/S0140-6736(15)01121-6","article-title":"Schizophrenia","volume":"388","author":"Owen","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.jad.2026.121300_bb0120","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.brs.2025.03.002","article-title":"Sequential bilateral dorsolateral prefrontal versus right lateral orbitofrontal\/left dorsolateral prefrontal TMS for major depression: A large naturalistic case series","volume":"18","author":"Prentice","year":"2025","journal-title":"Brain Stimul."},{"key":"10.1016\/j.jad.2026.121300_bb0125","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1176\/appi.ajp.2020.20060821","article-title":"Effect of experimental manipulation of the orbitofrontal cortex on short-term markers of compulsive behavior: a theta burst stimulation study","volume":"178","author":"Price","year":"2021","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jad.2026.121300_bb0130","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1016\/j.brs.2025.05.010","article-title":"Improving cerebellar TMS targeting: MRI-neuronavigation and landmark-based approaches assessed by E-field modeling","volume":"18","author":"Rohira","year":"2025","journal-title":"Brain Stimul."},{"key":"10.1016\/j.jad.2026.121300_bb0135","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1002\/ar.a.20126","article-title":"Convergence of sensory systems in the orbitofrontal cortex in primates and brain design for emotion","volume":"281","author":"Rolls","year":"2004","journal-title":"Anat Rec A Discov Mol Cell Evol Biol"},{"key":"10.1016\/j.jad.2026.121300_bb0140","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.tins.2005.12.006","article-title":"Orbitofrontal cortex, decision-making and drug addiction","volume":"29","author":"Schoenbaum","year":"2006","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.jad.2026.121300_bb0145","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.psychres.2013.09.023","article-title":"An ecologically valid performance-based social functioning assessment battery for schizophrenia","volume":"210","author":"Shi","year":"2013","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.jad.2026.121300_bb0150","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.biopsych.2023.11.011","article-title":"Targeting symptom-specific networks with transcranial magnetic stimulation","volume":"95","author":"Siddiqi","year":"2024","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jad.2026.121300_bb0155","doi-asserted-by":"crossref","DOI":"10.3390\/brainsci14050483","article-title":"Neuronavigated right orbitofrontal 20 hz theta burst transcranial magnetic stimulation augmentation for obsessive-compulsive disorder with comorbid depression and anxiety disorders: an open-label study","volume":"14","author":"Stubbeman","year":"2024","journal-title":"Brain Sci."},{"key":"10.1016\/j.jad.2026.121300_bb0160","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.comppsych.2015.12.007","article-title":"Comparing how co-morbid depression affects individual domains of functioning and life satisfaction in schizophrenia","volume":"66","author":"Tan","year":"2016","journal-title":"Compr. Psychiatry"},{"key":"10.1016\/j.jad.2026.121300_bb0165","first-page":"240","article-title":"Depression and schizophrenia: cause, consequence, or trans-diagnostic issue?","volume":"43","author":"Upthegrove","year":"2017","journal-title":"Schizophr. Bull."},{"key":"10.1016\/j.jad.2026.121300_bb0170","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1007\/s00406-021-01337-w","article-title":"Limbic links to paranoia: increased resting-state functional connectivity between amygdala, hippocampus and orbitofrontal cortex in schizophrenia patients with paranoia","volume":"272","author":"Walther","year":"2022","journal-title":"Eur. Arch. Psychiatry Clin. Neurosci."},{"key":"10.1016\/j.jad.2026.121300_bb0175","doi-asserted-by":"crossref","first-page":"E153","DOI":"10.1503\/jpn.210201","article-title":"Frontoparietal paired associative stimulation versus single-site stimulation for generalized anxiety disorder: a pilot rTMS study","volume":"47","author":"Wang","year":"2022","journal-title":"J. Psychiatry Neurosci."},{"key":"10.1016\/j.jad.2026.121300_bb0180","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1002\/jclp.23141","article-title":"Depressive symptoms, anxiety symptoms, and their co-occurrence among people living with schizophrenia in China: Prevalence and correlates","volume":"77","author":"Xi","year":"2021","journal-title":"J. Clin. Psychol."},{"key":"10.1016\/j.jad.2026.121300_bb0185","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1186\/s12888-025-07197-1","article-title":"The prevalence and clinical correlates of severe anxiety symptoms in first-episode drug-naive schizophrenia: a Chinese population study","volume":"25","author":"Xu","year":"2025","journal-title":"BMC Psychiatry"},{"key":"10.1016\/j.jad.2026.121300_bb0190","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.jad.2024.10.071","article-title":"Efficacy and acceptability of brain stimulation for anxiety disorders, OCD, and PTSD: A systematic review and network meta-analysis of randomized controlled trials","volume":"370","author":"Yang","year":"2025","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2026.121300_bb0195","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.jad.2020.05.151","article-title":"Comparative efficacy of add-on rTMS in treating the somatic and psychic anxiety symptoms of depression comorbid with anxiety in adolescents, adults, and elderly patients-A real-world clinical application","volume":"276","author":"Zhang","year":"2020","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2026.121300_bb0200","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2024.15110","article-title":"Cognitive impairments in drug-naive patients with first-episode negative symptom-dominant psychosis","volume":"7","author":"Zhang","year":"2024","journal-title":"JAMA Netw. Open"},{"key":"10.1016\/j.jad.2026.121300_bb0205","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1186\/s12916-025-04059-1","article-title":"Neurocognitive resilience as a predictor of psychosis onset and functional outcomes in individuals at high risk","volume":"23","author":"Zhang","year":"2025","journal-title":"BMC Med."},{"key":"10.1016\/j.jad.2026.121300_bb0210","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.biopsych.2025.01.021","article-title":"Two-month cognitive changes enhance prediction of nonremission in clinical high-risk individuals","volume":"98","author":"Zhang","year":"2025","journal-title":"Biol. Psychiatry"}],"container-title":["Journal of Affective Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032726001515?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032726001515?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T04:18:03Z","timestamp":1782188283000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165032726001515"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":42,"alternative-id":["S0165032726001515"],"URL":"https:\/\/doi.org\/10.1016\/j.jad.2026.121300","relation":{},"ISSN":["0165-0327"],"issn-type":[{"value":"0165-0327","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Right orbitofrontal cortex rTMS targets anxiety, not depressive, symptoms in first-episode schizophrenia","name":"articletitle","label":"Article Title"},{"value":"Journal of Affective Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jad.2026.121300","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"121300"}}