{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T02:57:21Z","timestamp":1792465041999,"version":"4.5.0"},"reference-count":64,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01MH122490"],"award-info":[{"award-number":["R01MH122490"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100021528","name":"Advancing a Healthier Wisconsin Endowment","doi-asserted-by":"publisher","award":["00003864"],"award-info":[{"award-number":["00003864"]}],"id":[{"id":"10.13039\/100021528","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Affective Disorders"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.jad.2026.121387","type":"journal-article","created":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T07:54:33Z","timestamp":1770882873000},"page":"121387","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Accelerated brain aging in prolonged grief disorder of later life: Influence of comorbid depression"],"prefix":"10.1016","volume":"402","author":[{"given":"Gyujoon","family":"Hwang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nutta-on","family":"Blair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacy A.","family":"Claesges","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles F.","family":"Reynolds","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christos","family":"Davatzikos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph S.","family":"Goveas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jad.2026.121387_bb0005","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.jagp.2021.11.011","article-title":"Structural MRI-based measures of accelerated brain aging do not moderate the acute antidepressant response in late-life depression","volume":"30","author":"Ahmed","year":"2022","journal-title":"Am. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.jad.2026.121387_bb0010","article-title":"Accelerated brain aging in major depressive disorder and antidepressant treatment response: a CAN-BIND report","volume":"32","author":"Ballester","year":"2021","journal-title":"NeuroImage: Clinical"},{"key":"10.1016\/j.jad.2026.121387_bb0015","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J. R. Stat. Soc. Ser. B"},{"key":"10.1016\/j.jad.2026.121387_bb0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pscychresns.2019.06.001","article-title":"Machine-learning based brain age estimation in major depression showing no evidence of accelerated aging","volume":"290","author":"Besteher","year":"2019","journal-title":"Psychiatry Res. Neuroimaging"},{"key":"10.1016\/j.jad.2026.121387_bb0025","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2020.0121","article-title":"Associations of widowhood and beta-amyloid with cognitive decline in cognitively unimpaired older adults","volume":"3","author":"Biddle","year":"2020","journal-title":"JAMA Netw. Open"},{"key":"10.1016\/j.jad.2026.121387_bb0030","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1002\/jts.22059","article-title":"The posttraumatic stress disorder checklist for DSM-5 (PCL-5): development and initial psychometric evaluation","volume":"28","author":"Blevins","year":"2015","journal-title":"J. Trauma. Stress"},{"key":"10.1016\/j.jad.2026.121387_bb0035","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1002\/da.22385","article-title":"The structured clinical interview for complicated grief: reliability, validity, and exploratory factor analysis","volume":"32","author":"Bui","year":"2015","journal-title":"Depress. Anxiety"},{"key":"10.1016\/j.jad.2026.121387_bb0040","doi-asserted-by":"crossref","first-page":"345","DOI":"10.31887\/DCNS.2008.10.3\/mabutters","article-title":"Pathways linking late-life depression to persistent cognitive impairment and dementia","volume":"10","author":"Butters","year":"2008","journal-title":"Dialogues Clin. Neurosci."},{"key":"10.1016\/j.jad.2026.121387_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.jad.2025.119536","article-title":"Depression is associated with treatment response trajectories in adults with prolonged grief disorder: a machine learning analysis","volume":"388","author":"Calderon","year":"2025","journal-title":"J. Affect Disorders"},{"key":"10.1016\/j.jad.2026.121387_bb0050","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1017\/S0033291798008137","article-title":"Gender differences in the effects of bereavement-related psychological distress in health outcomes","volume":"29","author":"Chen","year":"1999","journal-title":"Psychol. Med."},{"key":"10.1016\/j.jad.2026.121387_bb0055","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/s41398-020-01004-z","article-title":"Accelerated brain aging predicts impaired cognitive performance and greater disability in geriatric but not midlife adult depression","volume":"10","author":"Christman","year":"2020","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.jad.2026.121387_bb0060","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1038\/mp.2017.62","article-title":"Brain age predicts mortality","volume":"23","author":"Cole","year":"2018","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jad.2026.121387_bb0065","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41380-018-0098-1","article-title":"Brain age and other bodily \u2018ages\u2019: implications for neuropsychiatry","volume":"24","author":"Cole","year":"2019","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jad.2026.121387_bb0070","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/nrn2555","article-title":"How do you feel\u2014now? The anterior insula and human awareness","volume":"10","author":"Craig","year":"2009","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.jad.2026.121387_bb0075","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1016\/j.brat.2003.07.010","article-title":"Psychometric properties of the Impact of Event Scale - Revised","volume":"41","author":"Creamer","year":"2003","journal-title":"Behav. Res. Ther."},{"key":"10.1016\/j.jad.2026.121387_bb0080","doi-asserted-by":"crossref","first-page":"2026","DOI":"10.1093\/brain\/awp091","article-title":"Longitudinal progression of Alzheimer\u2019s-like patterns of atrophy in normal older adults: the SPARE-AD index","volume":"132","author":"Davatzikos","year":"2009","journal-title":"Brain"},{"key":"10.1016\/j.jad.2026.121387_bb0085","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1038\/s41583-024-00895-x","article-title":"The brain\u2019s action-mode network","volume":"26","author":"Dosenbach","year":"2025","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.jad.2026.121387_bb0090","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.neuroimage.2015.11.073","article-title":"MUSE: multi-atlas region segmentation utilizing ensembles of registration algorithms and parameters, and locally optimal atlas selection","volume":"127","author":"Doshi","year":"2016","journal-title":"Neuroimage"},{"key":"10.1016\/j.jad.2026.121387_bb0095","doi-asserted-by":"crossref","first-page":"3829","DOI":"10.1038\/s41380-019-0626-7","article-title":"Brain-age in midlife is associated with accelerated biological aging and cognitive decline in a longitudinal birth cohort","volume":"26","author":"Elliott","year":"2021","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jad.2026.121387_bb0100","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0067346","article-title":"BrainAGE in mild cognitive impaired patients: predicting the conversion to Alzheimer\u2019s disease","volume":"8","author":"Gaser","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jad.2026.121387_bb0105","doi-asserted-by":"crossref","first-page":"44604","DOI":"10.1038\/s41598-025-28397-5","article-title":"Iyengar yoga and health education interventions for prolonged grief disorder in later life: feasibility of a randomized controlled pilot trial","volume":"15","author":"Goveas","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jad.2026.121387_bb0110","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1093\/brain\/aww008","article-title":"White matter hyperintensities and imaging patterns of brain ageing in the general population","volume":"139","author":"Habes","year":"2016","journal-title":"Brain"},{"key":"10.1016\/j.jad.2026.121387_bb0115","doi-asserted-by":"crossref","DOI":"10.1038\/tp.2016.39","article-title":"Advanced brain aging: relationship with epidemiologic and genetic risk factors, and overlap with Alzheimer disease atrophy patterns","volume":"6","author":"Habes","year":"2016","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.jad.2026.121387_bb0120","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1002\/alz.12178","article-title":"The brain chart of aging: machine-learning analytics reveals links between brain aging, white matter disease, amyloid burden, and cognition in the iSTAGING consortium of 10,216 harmonized MR scans","volume":"17","author":"Habes","year":"2021","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.jad.2026.121387_bb0125","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2023.16182","article-title":"Patterns of regional brain atrophy and brain aging in middle- and older-aged adults with type 1 diabetes","volume":"6","author":"Habes","year":"2023","journal-title":"JAMA Netw. Open."},{"key":"10.1016\/j.jad.2026.121387_bb0130","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.jpsychires.2014.07.002","article-title":"Cognitive functioning in complicated grief","volume":"58","author":"Hall","year":"2014","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.jad.2026.121387_bb0135","first-page":"21","article-title":"Rating depressive patients","volume":"41","author":"Hamilton","year":"1980","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.jad.2026.121387_bb0140","doi-asserted-by":"crossref","first-page":"5124","DOI":"10.1038\/s41380-020-0754-0","article-title":"Brain aging in major depressive disorder: results from the ENIGMA major depressive disorder working group","volume":"26","author":"Han","year":"2021","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jad.2026.121387_bb0145","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1177\/0004867414557161","article-title":"Amyloid-beta and depression in healthy older adults: a systematic review","volume":"49","author":"Harrington","year":"2015","journal-title":"Aust. N. Z. J. Psychiatry"},{"key":"10.1016\/j.jad.2026.121387_bb0150","first-page":"1284","article-title":"Amygdala-centered emotional processing in prolonged grief disorder: relationship with clinical symptomatology","volume":"10","author":"Hwang","year":"2025","journal-title":"Biol. Psychiatry Cogn. Neurosci. Neuroimag."},{"key":"10.1016\/j.jad.2026.121387_bb0155","article-title":"Loneliness, circulating endocannabinoid concentrations, and grief trajectories in bereaved older adults: a longitudinal study","volume":"12","author":"Kang","year":"2021","journal-title":"Front. Psych."},{"key":"10.1016\/j.jad.2026.121387_bb0160","doi-asserted-by":"crossref","first-page":"283","DOI":"10.2105\/AJPH.77.3.283","article-title":"Mortality after bereavement: a prospective study of 95,647 widowed persons","volume":"77","author":"Kaprio","year":"1987","journal-title":"Am. J. Public Health"},{"key":"10.1016\/j.jad.2026.121387_bb0165","first-page":"103","article-title":"Brain age is not a significant predictor of relapse risk in late-life depression","volume":"10","author":"Karim","year":"2025","journal-title":"Biol. Psychiatry Cogn. Neurosci. Neuroimag."},{"key":"10.1016\/j.jad.2026.121387_bb0170","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1097\/PSY.0000000000000693","article-title":"A systematic review of the association between bereavement and biomarkers of immune function","volume":"81","author":"Knowles","year":"2019","journal-title":"Psychosom. Med."},{"key":"10.1016\/j.jad.2026.121387_bb0175","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1521\/suli.34.4.350.53737","article-title":"Suicidality and bereavement: complicated grief as psychiatric disorder presenting greatest risk for suicidality","volume":"34","author":"Latham","year":"2004","journal-title":"Suicide Life Threat. Behav."},{"key":"10.1016\/j.jad.2026.121387_bb0180","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.jpsychires.2020.06.030","article-title":"Are there gender differences in prolonged grief trajectories? A registry-sampled cohort study","volume":"129","author":"Lundorff","year":"2020","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.jad.2026.121387_bb0185","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/j.jagp.2023.06.001","article-title":"Neuroinflammation: a modifiable pathway linking obesity, Alzheimer\u2019s disease, and depression","volume":"31","author":"Ly","year":"2023","journal-title":"Am. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.jad.2026.121387_bb0190","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1017\/S0033291721003391","article-title":"An exploration of gender and prolonged grief symptoms using network analysis","volume":"53","author":"Maccallum","year":"2023","journal-title":"Psychol. Med."},{"key":"10.1016\/j.jad.2026.121387_bb0195","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/0165-0327(88)90072-9","article-title":"The Hamilton Anxiety Scale: reliability, validity and sensitivity to change in anxiety and depressive disorders","volume":"14","author":"Maier","year":"1988","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2026.121387_bb0200","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/0165-1781(92)90005-N","article-title":"Rating chronic medical illness burden in geropsychiatric practice and research: application of the Cumulative Illness Rating Scale","volume":"41","author":"Miller","year":"1992","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.jad.2026.121387_bb0205","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1111\/j.1532-5415.2005.53221.x","article-title":"The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment","volume":"53","author":"Nasreddine","year":"2005","journal-title":"J. Am. Geriatr. Soc."},{"key":"10.1016\/j.jad.2026.121387_bb0210","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1080\/07481187.2013.782928","article-title":"Developing the yearning in situations of loss scale: convergent and discriminant validity for bereavement, romantic breakup, and homesickness","volume":"38","author":"O'Connor","year":"2014","journal-title":"Death Stud."},{"key":"10.1016\/j.jad.2026.121387_bb0215","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.psyneuen.2011.08.009","article-title":"Diurnal cortisol in Complicated and Non-Complicated Grief: slope differences across the day","volume":"37","author":"O\u2019Connor","year":"2012","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.jad.2026.121387_bb0220","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.jagp.2017.12.003","article-title":"Prolonged grief and cognitive decline: a prospective population-based study in middle-aged and older persons","volume":"26","author":"Perez","year":"2018","journal-title":"Am. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.jad.2026.121387_bb0225","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1176\/ajp.154.5.616","article-title":"Traumatic grief as a risk factor for mental and physical morbidity","volume":"154","author":"Prigerson","year":"1997","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jad.2026.121387_bb0230","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1002\/wps.20823","article-title":"Validation of the new DSM-5-TR criteria for prolonged grief disorder and the PG-13-Revised (PG-13-R) scale","volume":"20","author":"Prigerson","year":"2021","journal-title":"World Psychiatry"},{"key":"10.1016\/j.jad.2026.121387_bb0235","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1001\/jamapsychiatry.2021.4201","article-title":"Prolonged grief disorder diagnostic criteria-helping those with maladaptive grief responses","volume":"79","author":"Prigerson","year":"2022","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.jad.2026.121387_bb0240","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1207\/s15327752jpa6601_2","article-title":"UCLA Loneliness Scale (Version 3): reliability, validity, and factor structure","volume":"66","author":"Russell","year":"1996","journal-title":"J. Pers. Assess."},{"key":"10.1016\/j.jad.2026.121387_bb0245","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1017\/S0033291714002499","article-title":"Cognition, structural brain changes and complicated grief. A population-based study","volume":"45","author":"Saavedra Perez","year":"2015","journal-title":"Psychol. Med."},{"key":"10.1016\/j.jad.2026.121387_bb0250","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1097\/PSY.0000000000000422","article-title":"The impact of complicated grief on diurnal cortisol levels two years after loss: a population-based study","volume":"79","author":"Saavedra Perez","year":"2017","journal-title":"Psychosom. Med."},{"key":"10.1016\/j.jad.2026.121387_bb0255","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.jagp.2012.10.019","article-title":"A systematic review and meta-analysis of magnetic resonance imaging studies in late-life depression","volume":"21","author":"Sexton","year":"2013","journal-title":"Am. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.jad.2026.121387_bb0260","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/s00406-007-0745-z","article-title":"An attachment-based model of complicated grief including the role of avoidance","volume":"257","author":"Shear","year":"2007","journal-title":"Eur. Arch. Psychiatry Clin. Neurosci."},{"key":"10.1016\/j.jad.2026.121387_bb0265","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1001\/jamapsychiatry.2016.0892","article-title":"Optimizing treatment of complicated grief: a randomized clinical trial","volume":"73","author":"Shear","year":"2016","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.jad.2026.121387_bb0270","doi-asserted-by":"crossref","DOI":"10.1080\/20008066.2024.2403250","article-title":"Atrophy in the supramarginal gyrus associated with impaired cognitive inhibition in grieving Chinese Shidu parents","volume":"15","author":"Shi","year":"2024","journal-title":"Eur. J. Psychotraumatol."},{"key":"10.1016\/j.jad.2026.121387_bb0275","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/j.jagp.2018.03.013","article-title":"Widowhood status as a risk factor for cognitive decline among older adults","volume":"26","author":"Shin","year":"2018","journal-title":"Am. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.jad.2026.121387_bb0280","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1056\/NEJMcp2308707","article-title":"Prolonged grief disorder","volume":"391","author":"Simon","year":"2024","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jad.2026.121387_bb0285","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.comppsych.2007.05.002","article-title":"The prevalence and correlates of psychiatric comorbidity in individuals with complicated grief","volume":"48","author":"Simon","year":"2007","journal-title":"Compr. Psychiatry"},{"key":"10.1016\/j.jad.2026.121387_bb0290","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1136\/jnnp-2017-316274","article-title":"Marriage and risk of dementia: systematic review and meta-analysis of observational studies","volume":"89","author":"Sommerlad","year":"2018","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.jad.2026.121387_bb0295","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1097\/JGP.0b013e3181d6c245","article-title":"Change in hippocampal volume on magnetic resonance imaging and cognitive decline among older depressed and nondepressed subjects in the neurocognitive outcomes of depression in the elderly study","volume":"19","author":"Steffens","year":"2011","journal-title":"Am. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.jad.2026.121387_bb0300","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1111\/j.1943-278X.1997.tb00291.x","article-title":"Suicidal ideation in elderly bereaved: the role of complicated grief","volume":"27","author":"Szanto","year":"1997","journal-title":"Suicide Life Threat. Behav."},{"key":"10.1016\/j.jad.2026.121387_bb0305","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1038\/mp.2013.20","article-title":"The vascular depression hypothesis: mechanisms linking vascular disease with depression","volume":"18","author":"Taylor","year":"2013","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jad.2026.121387_bb0310","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jad.2023.02.047","article-title":"BrainAge of patients with severe late-life depression referred for electroconvulsive therapy","volume":"330","author":"Wagenmakers","year":"2023","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2026.121387_bb0315","series-title":"International Conference on Learning Representations (ICLR)","article-title":"Surreal-GAN: semi-supervised representation learning via GAN for uncovering heterogeneous disease-related imaging patterns","author":"Yang","year":"2022"},{"key":"10.1016\/j.jad.2026.121387_bb0320","doi-asserted-by":"crossref","first-page":"3015","DOI":"10.1038\/s41591-024-03144-x","article-title":"Brain aging patterns in a large and diverse cohort of 49,482 individuals","volume":"30","author":"Yang","year":"2024","journal-title":"Nat. Med."}],"container-title":["Journal of Affective Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032726002387?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032726002387?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T04:09:59Z","timestamp":1782274199000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165032726002387"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":64,"alternative-id":["S0165032726002387"],"URL":"https:\/\/doi.org\/10.1016\/j.jad.2026.121387","relation":{},"ISSN":["0165-0327"],"issn-type":[{"value":"0165-0327","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Accelerated brain aging in prolonged grief disorder of later life: Influence of comorbid depression","name":"articletitle","label":"Article Title"},{"value":"Journal of Affective Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jad.2026.121387","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"121387"}}