{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:08:40Z","timestamp":1786118920044,"version":"build-2736575974"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100018754","name":"Science and Technology Plan Projects of Tibet Autonomous Region","doi-asserted-by":"publisher","award":["ZZKY2024084"],"award-info":[{"award-number":["ZZKY2024084"]}],"id":[{"id":"10.13039\/501100018754","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Affective Disorders"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.jad.2026.121435","type":"journal-article","created":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T16:12:35Z","timestamp":1771258355000},"page":"121435","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["The aggregate index of systemic inflammation as peripheral inflammatory markers for first-episode drug-na\u00efve patients with major depressive disorder"],"prefix":"10.1016","volume":"403","author":[{"given":"Qi","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binjie","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiyang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodong","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanmei","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yitong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shihui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongqi","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianchao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jad.2026.121435_bb0005","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1038\/mp.2015.67","article-title":"Childhood trauma and adulthood inflammation: a meta-analysis of peripheral C-reactive protein, interleukin-6 and tumour necrosis factor-\u03b1","volume":"21","author":"Baumeister","year":"2016","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jad.2026.121435_bb0010","doi-asserted-by":"crossref","first-page":"4113","DOI":"10.1038\/s41380-022-01715-3","article-title":"Functional connectivity in reward circuitry and symptoms of anhedonia as therapeutic targets in depression with high inflammation: evidence from a dopamine challenge study","volume":"27","author":"Bekhbat","year":"2022","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jad.2026.121435_bb0015","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0145-2134(02)00541-0","article-title":"Development and validation of a brief screening version of the childhood trauma questionnaire","volume":"27","author":"Bernstein","year":"2003","journal-title":"Child Abuse Negl."},{"key":"10.1016\/j.jad.2026.121435_bb0020","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1016\/j.ajcnut.2024.08.032","article-title":"Flavonoid intakes, chronic obstructive pulmonary disease, adult asthma, and lung function: a cohort study in the UK biobank","volume":"120","author":"Bondonno","year":"2024","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.jad.2026.121435_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.neubiorev.2023.105307","article-title":"Stress to inflammation and anhedonia: mechanistic insights from preclinical and clinical models","volume":"152","author":"Boyle","year":"2023","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.jad.2026.121435_bb0030","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/S0140-6736(20)30925-9","article-title":"Global burden of 369 diseases and injuries in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease study 2019","volume":"396","year":"2020","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.jad.2026.121435_bb0035","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1146\/annurev-psych-010416-044208","article-title":"Hidden wounds? Inflammatory links between childhood trauma and psychopathology","volume":"68","author":"Danese","year":"2017","journal-title":"Annu. Rev. Psychol."},{"key":"10.1016\/j.jad.2026.121435_bb0040","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.bbi.2022.07.158","article-title":"Childhood trauma and LPS-stimulated inflammation in adulthood: results from the Netherlands study of depression and anxiety","volume":"106","author":"de Koning","year":"2022","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.jad.2026.121435_bb0045","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.jad.2025.03.139","article-title":"The U-shape relationship between the aggregate index of systemic inflammation and depression in American adults: a cross-sectional study","volume":"380","author":"Duan","year":"2025","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2026.121435_bb0050","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1002\/hbm.25222","article-title":"Childhood trauma is associated with elevated anhedonia and altered core reward circuitry in major depression patients and controls","volume":"42","author":"Fan","year":"2021","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.jad.2026.121435_bb0055","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1038\/s41380-018-0096-3","article-title":"What does plasma CRP tell us about peripheral and central inflammation in depression?","volume":"25","author":"Felger","year":"2020","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jad.2026.121435_bb0060","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0259861","article-title":"Usefulness of Hamilton rating scale for depression subset scales and full versions for electroconvulsive therapy","volume":"16","author":"Fenton","year":"2021","journal-title":"PLoS One"},{"key":"10.1016\/j.jad.2026.121435_bb0065","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.jad.2006.08.020","article-title":"The assessment of anhedonia in clinical and non-clinical populations: further validation of the Snaith-Hamilton pleasure scale (SHAPS)","volume":"99","author":"Franken","year":"2007","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2026.121435_bb0070","doi-asserted-by":"crossref","first-page":"4955","DOI":"10.2147\/JIR.S312925","article-title":"Circulating inflammation markers partly explain the link between the dietary inflammatory index and depressive symptoms","volume":"14","author":"Gialluisi","year":"2021","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.jad.2026.121435_bb0075","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.jad.2025.01.150","article-title":"Peripheral protein inflammatory biomarkers in bipolar disorder and major depressive disorder: a systematic review and meta-analysis","volume":"376","author":"Gopalakrishnan","year":"2025","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2026.121435_bb0080","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1186\/s12877-024-05012-2","article-title":"Associations of CBC-derived inflammatory indicators with sarcopenia and mortality in adults: evidence from Nhanes 1999\u223c2006","volume":"24","author":"Guo","year":"2024","journal-title":"BMC Geriatr."},{"key":"10.1016\/j.jad.2026.121435_bb0085","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1111\/jcpp.13955","article-title":"Annual research review: puberty and the development of anhedonia - considering childhood adversity and inflammation","volume":"65","author":"Gupta","year":"2024","journal-title":"J. Child Psychol. Psychiatry"},{"key":"10.1016\/j.jad.2026.121435_bb0090","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.jad.2023.10.107","article-title":"Anhedonia mediates the relationships between childhood trauma and symptom severity of PTSD and depression, but not of social anxiety","volume":"344","author":"Haim-Nachum","year":"2024","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2026.121435_bb0095","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2022-071521","article-title":"Adolescent\u2019s anhedonia and association with childhood trauma among Chinese adolescents: a cross-sectional study","volume":"13","author":"Han","year":"2023","journal-title":"BMJ Open"},{"key":"10.1016\/j.jad.2026.121435_bb0100","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.2147\/CIA.S314131","article-title":"The association between systemic inflammatory markers and post-stroke depression: a prospective stroke cohort","volume":"16","author":"Hu","year":"2021","journal-title":"Clin. Interv. Aging"},{"key":"10.1016\/j.jad.2026.121435_bb0105","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.jad.2024.11.071","article-title":"Blood cytokines in major depressive disorder in drug-na\u00efve adolescents: a systematic review and meta-analysis","volume":"372","author":"Jadhav","year":"2025","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2026.121435_bb0110","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.bbi.2024.07.037","article-title":"Sex differences in the inflammation-depression link: a systematic review and meta-analysis","volume":"121","author":"Jarkas","year":"2024","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.jad.2026.121435_bb0115","doi-asserted-by":"crossref","DOI":"10.3390\/cells13050423","article-title":"Role of inflammatory mechanisms in major depressive disorder: from etiology to potential pharmacological targets","volume":"13","author":"Kouba","year":"2024","journal-title":"Cells"},{"key":"10.1016\/j.jad.2026.121435_bb0120","first-page":"1097196","article-title":"Association of systemic inflammatory biomarkers with depression risk: Results from National Health and nutrition examination survey 2005-2018 analyses","volume":"14","author":"Li","year":"2023","journal-title":"Front. Psychol."},{"key":"10.1016\/j.jad.2026.121435_bb0125","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.jad.2023.06.064","article-title":"Association between body mass index and suicide attempts in Chinese patients of a hospital in Shanxi district with first-episode drug-na\u00efve major depressive disorder","volume":"339","author":"Liu","year":"2023","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2026.121435_bb0130","doi-asserted-by":"crossref","first-page":"16033","DOI":"10.1038\/s41598-023-43166-y","article-title":"Gender differences in the association between body mass index and recent suicide attempts in Chinese patients with first-episode drug-na\u00efve major depressive disorder","volume":"13","author":"Liu","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jad.2026.121435_bb0135","first-page":"1342933","article-title":"Association between triglyceride glucose index (TyG) and psychotic symptoms in patients with first-episode drug-na\u00efve major depressive disorder","volume":"15","author":"Liu","year":"2024","journal-title":"Front. Psychol."},{"key":"10.1016\/j.jad.2026.121435_bb0140","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1007\/s00406-024-01847-3","article-title":"Exploring the correlation between childhood trauma experiences, inflammation, and brain activity in first-episode, drug-naive major depressive disorder","volume":"275","author":"Liu","year":"2025","journal-title":"Eur. Arch. Psychiatry Clin. Neurosci."},{"key":"10.1016\/j.jad.2026.121435_bb0145","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.biopsych.2015.05.017","article-title":"Early-life adversity and physical and emotional health across the lifespan: a Neuroimmune network hypothesis","volume":"80","author":"Nusslock","year":"2016","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jad.2026.121435_bb0150","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1192\/bjp.2022.185","article-title":"Childhood trauma, perceived stress and anhedonia in individuals at clinical high risk for psychosis: multigroup mediation analysis","volume":"223","author":"O\u2019Brien","year":"2023","journal-title":"Br. J. Psychiatry J. Ment. Sci."},{"key":"10.1016\/j.jad.2026.121435_bb0155","article-title":"Sex differences in childhood maltreatment, inflammation, and adulthood depression: a network analysis","volume":"29","author":"O\u2019Shields","year":"2023","journal-title":"Brain, behavior, & immunity - health"},{"key":"10.1016\/j.jad.2026.121435_bb0160","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1017\/S0033291719001454","article-title":"Prevalence of low-grade inflammation in depression: a systematic review and meta-analysis of CRP levels","volume":"49","author":"Osimo","year":"2019","journal-title":"Psychol. Med."},{"key":"10.1016\/j.jad.2026.121435_bb0165","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1186\/s12905-025-04033-2","article-title":"Inflammatory status and clinical phenotypes of PCOS: the role of NLR, SII, SIRI, and AISI","volume":"25","author":"Ozkan","year":"2025","journal-title":"BMC Womens Health"},{"key":"10.1016\/j.jad.2026.121435_bb0170","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/s41398-024-02921-z","article-title":"Inflammatory mediators in major depression and bipolar disorder","volume":"14","author":"Poletti","year":"2024","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.jad.2026.121435_bb0175","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s12991-024-00511-3","article-title":"Brain-derived neurotrophic factor and C-reactive protein (CRP) biomarkers in suicide attempter and non-attempter major depression disorder (MDD) patients","volume":"23","author":"Saadat","year":"2024","journal-title":"Ann. General Psychiatry"},{"key":"10.1016\/j.jad.2026.121435_bb0180","series-title":"Theory of Ridge Regression Estimation with Applications","author":"Saleh","year":"2019"},{"key":"10.1016\/j.jad.2026.121435_bb0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2023.e20127","article-title":"Association between platelet to lymphocyte ratio and depression and symptom severity among adults in the United States: a cross-sectional study","volume":"9","author":"Shan","year":"2023","journal-title":"Heliyon"},{"key":"10.1016\/j.jad.2026.121435_bb0190","article-title":"A comparative study of the aggregate index of systemic inflammation (AISI) and C-reactive protein (CRP) in predicting odontogenic abscesses severity: a novel approach to assessing immunoinflammatory response","volume":"14","author":"Tarle","year":"2024","journal-title":"Diagnostics (Basel, Switzerland)"},{"key":"10.1016\/j.jad.2026.121435_bb0195","doi-asserted-by":"crossref","first-page":"97","DOI":"10.2147\/CIA.S285000","article-title":"Association between systemic immune-inflammation index and diabetic depression","volume":"16","author":"Wang","year":"2021","journal-title":"Clin. Interv. Aging"},{"key":"10.1016\/j.jad.2026.121435_bb0200","doi-asserted-by":"crossref","first-page":"1330338","DOI":"10.3389\/fneur.2024.1330338","article-title":"Association between systemic immune-inflammation index and post-stroke depression: a cross-sectional study of the national health and nutrition examination survey 2005-2020","volume":"15","author":"Wang","year":"2024","journal-title":"Front. Neurol."},{"key":"10.1016\/j.jad.2026.121435_bb0205","doi-asserted-by":"crossref","first-page":"1163900","DOI":"10.3389\/fcvm.2023.1163900","article-title":"The aggregate index of systemic inflammation (AISI): a novel predictor for hypertension","volume":"10","author":"Xiu","year":"2023","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.jad.2026.121435_bb0210","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1186\/s12888-024-05860-7","article-title":"Non-linear relationship between TSH and psychotic symptoms on first episode and drug na\u00efve major depressive disorder patients: a large sample sized cross-sectional study in China","volume":"24","author":"Yang","year":"2024","journal-title":"BMC Psychiatry"},{"key":"10.1016\/j.jad.2026.121435_bb0215","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.jad.2021.10.003","article-title":"Relationship between CRP and depression: a genetically sensitive study in Sri Lanka","volume":"297","author":"Zavos","year":"2022","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2026.121435_bb0220","doi-asserted-by":"crossref","first-page":"32014","DOI":"10.1038\/s41598-024-83733-5","article-title":"The relationship between complete blood cell count-derived inflammatory biomarkers and erectile dysfunction in the United States","volume":"14","author":"Zhang","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jad.2026.121435_bb0225","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.jad.2025.03.101","article-title":"Systemic inflammation mediates the association between dietary inflammation index and incident anxiety and depression in UK biobank","volume":"381","author":"Zhou","year":"2025","journal-title":"J. Affect. Disord."}],"container-title":["Journal of Affective Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032726002867?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032726002867?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T17:03:29Z","timestamp":1786035809000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165032726002867"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":45,"alternative-id":["S0165032726002867"],"URL":"https:\/\/doi.org\/10.1016\/j.jad.2026.121435","relation":{},"ISSN":["0165-0327"],"issn-type":[{"value":"0165-0327","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The aggregate index of systemic inflammation as peripheral inflammatory markers for first-episode drug-na\u00efve patients with major depressive disorder","name":"articletitle","label":"Article Title"},{"value":"Journal of Affective Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jad.2026.121435","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"121435"}}