{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T10:09:50Z","timestamp":1789034990617,"version":"build-2803163510"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007514","name":"University of Pisa","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007514","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Affective Disorders"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.jad.2026.121527","type":"journal-article","created":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T19:59:30Z","timestamp":1772308770000},"page":"121527","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Clinical characterization of bipolar disorder in adults with autism without intellectual disability: a cross-sectional study"],"prefix":"10.1016","volume":"405","author":[{"given":"Margherita","family":"Barbuti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Amadori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ugo","family":"De Rosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulio","family":"Perugi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jad.2026.121527_bb0005","series-title":"Diagnostic and Statistical Manual of Mental Disorders","article-title":"Diagnostic and statistical manual of mental disorders","author":"American Psychiatric Association","year":"2013"},{"key":"10.1016\/j.jad.2026.121527_bb0010","doi-asserted-by":"crossref","DOI":"10.1023\/B:JADD.0000022607.19833.00","article-title":"The empathy quotient: an investigation of adults with Asperger syndrome or high functioning autism, and normal sex differences","volume":"34","author":"Baron-Cohen","year":"2004","journal-title":"J. Autism Dev. Disord."},{"key":"10.1016\/j.jad.2026.121527_bb0015","doi-asserted-by":"crossref","DOI":"10.1023\/A:1005653411471","article-title":"The autism-spectrum quotient (AQ): evidence from Asperger syndrome\/high-functioning autism, males and females, scientists and mathematicians","volume":"31","author":"Baron-Cohen","year":"2001","journal-title":"J. Autism Dev. Disord."},{"key":"10.1016\/j.jad.2026.121527_bb0020","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1016\/j.jaac.2016.08.011","article-title":"Longitudinal course of bipolar disorder in youth with high-functioning autism spectrum disorder","volume":"55","author":"Borue","year":"2016","journal-title":"J. Am. Acad. Child Adolesc. Psychiatry"},{"key":"10.1016\/j.jad.2026.121527_bb0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.rasd.2014.10.014","article-title":"Autistic spectrum disorder, attention deficit hyperactivity disorder, and psychiatric comorbidities: a nationwide study","volume":"10","author":"Chen","year":"2015","journal-title":"Res. Autism Spectr. Disord."},{"key":"10.1016\/j.jad.2026.121527_bb0030","article-title":"Differentiation and comorbidity of bipolar disorder and attention deficit and hyperactivity disorder in children, adolescents, and adults: a clinical and nosological perspective","volume":"13","author":"Comparelli","year":"2022","journal-title":"Front. Psych."},{"key":"10.1016\/j.jad.2026.121527_bb0035","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1097\/00004583-199803000-00006","article-title":"Medication-induced hypomania in Asperger\u2019s disorder","volume":"37","author":"Damore","year":"1998","journal-title":"J. Am. Acad. Child Adolesc. Psychiatry"},{"key":"10.1016\/j.jad.2026.121527_bb0040","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1007\/s10803-018-3689-4","article-title":"Subtyping the autism spectrum disorder: comparison of children with high functioning autism and Asperger syndrome","volume":"49","author":"De Giambattista","year":"2019","journal-title":"J. Autism Dev. Disord."},{"key":"10.1016\/j.jad.2026.121527_bb0045","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.12740\/PP\/OnlineFirst\/122350","article-title":"Comorbidity of bipolar disorder and autism spectrum disorder - review paper","volume":"55","author":"Dunalska","year":"2021","journal-title":"Psychiatr. Pol."},{"key":"10.1016\/j.jad.2026.121527_bb0050","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1001\/archpsyc.1976.01770060086012","article-title":"The global assessment scale. A procedure for measuring overall severity of psychiatric disturbance","volume":"33","author":"Endicott","year":"1976","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.jad.2026.121527_bb0055","first-page":"79","article-title":"Comorbidity of autism spectrum disorder and bipolar disorder","volume":"45","author":"Espluga-Frigola","year":"2017","journal-title":"Actas Esp. Psiquiatr."},{"key":"10.1016\/j.jad.2026.121527_bb0060","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.jad.2019.09.034","article-title":"Validation of the brief TEMPS-M temperament questionnaire in a clinical Italian sample of bipolar and cyclothymic patients","volume":"260","author":"Fico","year":"2020","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2026.121527_bb0065","series-title":"Structured Clinical Interview for DSM-5 Disorders, Clinician Version (SCID-5-CV)","author":"First","year":"2016"},{"key":"10.1016\/j.jad.2026.121527_bb0070","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.chc.2020.02.004","article-title":"Bipolar Disorder and Psychosis in Autism","volume":"29","author":"Ghaziuddin","year":"2020","journal-title":"Child Adolesc. Psychiatr. Clin. N. Am."},{"key":"10.1016\/j.jad.2026.121527_bb0075","doi-asserted-by":"crossref","first-page":"S114","DOI":"10.1542\/peds.2015-2851I","article-title":"medical and behavioral correlates of depression history in children and adolescents with autism spectrum disorder","volume":"137","author":"Greenlee","year":"2016","journal-title":"Pediatrics"},{"key":"10.1016\/j.jad.2026.121527_bb0080","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1089\/cap.2011.2131","article-title":"Treatment of bipolar disorder in an adolescent with autistic disorder: a diagnostic and treatment dilemma","volume":"21","author":"Howell","year":"2011","journal-title":"J. Child Adolesc. Psychopharmacol."},{"key":"10.1016\/j.jad.2026.121527_bb0085","doi-asserted-by":"crossref","first-page":"578","DOI":"10.4088\/JCP.12m07392","article-title":"Examining the comorbidity of bipolar disorder and autism spectrum disorders: a large controlled analysis of phenotypic and familial correlates in a referred population of youth with bipolar I disorder with and without autism spectrum disorders","volume":"74","author":"Joshi","year":"2013","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.jad.2026.121527_bb0090","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1007\/s10803-012-1679-5","article-title":"Psychiatric comorbidity and functioning in a clinically referred population of adults with autism spectrum disorders: a comparative study","volume":"43","author":"Joshi","year":"2013","journal-title":"J. Autism Dev. Disord."},{"key":"10.1016\/j.jad.2026.121527_bb2090","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2024.102863","article-title":"Association of self-harm and suicidality with psychiatric co-occurring conditions in autistic individuals: a systematic review and pooled analysis","volume":"77","author":"Kim","year":"2024","journal-title":"EClinicalMedicine"},{"key":"10.1016\/j.jad.2026.121527_bb0095","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1001\/jamapediatrics.2019.4368","article-title":"Association of comorbid mood and anxiety disorders with autism spectrum disorder","volume":"174","author":"Kirsch","year":"2020","journal-title":"JAMA Pediatr."},{"key":"10.1016\/j.jad.2026.121527_bb0100","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/S2215-0366(15)00277-1","article-title":"Identifying the lost generation of adults with autism spectrum conditions","volume":"2","author":"Lai","year":"2015","journal-title":"Lancet Psychiatry"},{"key":"10.1016\/j.jad.2026.121527_bb0105","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/S0140-6736(13)61539-1","article-title":"Autism","volume":"383","author":"Lai","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.jad.2026.121527_bb0110","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/S2215-0366(19)30289-5","article-title":"Prevalence of co-occurring mental health diagnoses in the autism population: a systematic review and meta-analysis","volume":"6","author":"Lai","year":"2019","journal-title":"Lancet Psychiatry"},{"key":"10.1016\/j.jad.2026.121527_bb0115","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1111\/j.1399-5618.2006.00342.x","article-title":"Attention-deficit hyperactivity disorder -- bipolar comorbidity in children and adolescents","volume":"8","author":"Masi","year":"2006","journal-title":"Bipolar Disord."},{"key":"10.1016\/j.jad.2026.121527_bb0120","doi-asserted-by":"crossref","first-page":"750","DOI":"10.3390\/brainsci10100750","article-title":"Suicidal ideation and suicidal attempts in referred adolescents with high functioning autism spectrum disorder and comorbid bipolar disorder: a pilot study","volume":"10","author":"Masi","year":"2020","journal-title":"Brain Sci."},{"key":"10.1016\/j.jad.2026.121527_bb0125","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.jad.2008.02.015","article-title":"High prevalence of bipolar disorder comorbidity in adolescents and young adults with high-functioning autism spectrum disorder: a preliminary study of 44 outpatients","volume":"111","author":"Munesue","year":"2008","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2026.121527_bb0130","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1080\/09540261.2021.1872506","article-title":"Autism and mood disorders","volume":"33","author":"Oakley","year":"2021","journal-title":"Int. Rev. Psychiatry"},{"key":"10.1016\/j.jad.2026.121527_bb0135","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0165-0327(01)00443-8","article-title":"Clinical characterization of depressive mixed state in bipolar-I patients: Pisa-San Diego collaboration","volume":"67","author":"Perugi","year":"2001","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2026.121527_bb0140","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.jad.2014.08.052","article-title":"General medical conditions in 347 bipolar disorder patients: clinical correlates of metabolic and autoimmune-allergic diseases","volume":"170","author":"Perugi","year":"2015","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2026.121527_bb0145","doi-asserted-by":"crossref","DOI":"10.2174\/1570159X14666160616120157","article-title":"Diagnosis and treatment of cyclothymia: the \u201cprimacy\u201d of temperament","volume":"15","author":"Perugi","year":"2017","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.jad.2026.121527_bb0150","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/1745-0179-4-26","article-title":"Comorbidity of Asperger\u2019s syndrome and bipolar disorder","volume":"4","author":"Raja","year":"2008","journal-title":"Clin. Pract. Epidemiol. Ment. Health"},{"key":"10.1016\/j.jad.2026.121527_bb0155","first-page":"1089","article-title":"The Ritvo Autism Asperger Diagnostic Scale-Revised (RAADS-R): a scale to assist the diagnosis of autism spectrum disorder in adults: an international validation study","volume":"41","author":"Ritvo","year":"2010","journal-title":"J. Autism Dev. Disord."},{"key":"10.1016\/j.jad.2026.121527_bb0160","article-title":"Parent report of community psychiatric comorbid diagnoses in autism spectrum disorders","volume":"2011","author":"Rosenberg","year":"2011","journal-title":"Autism Res. Treat."},{"key":"10.1016\/j.jad.2026.121527_bb0165","doi-asserted-by":"crossref","first-page":"2800","DOI":"10.1007\/s10803-018-3541-x","article-title":"The clinical features of comorbid pediatric bipolar disorder in children with autism spectrum disorder","volume":"48","author":"Sapmaz","year":"2018","journal-title":"J. Autism Dev. Disord."},{"key":"10.1016\/j.jad.2026.121527_bb0170","doi-asserted-by":"crossref","first-page":"2543","DOI":"10.1017\/S0033291718003483","article-title":"Risk of non-affective psychotic disorder or bipolar disorder in autism spectrum disorder: a longitudinal register-based study in the Netherlands","volume":"49","author":"Schalbroeck","year":"2019","journal-title":"Psychol. Med."},{"key":"10.1016\/j.jad.2026.121527_bb0175","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1001\/jamapsychiatry.2014.3059","article-title":"Risks for nonaffective psychotic disorder and bipolar disorder in young people with autism spectrum disorder: a population-based study","volume":"72","author":"Selten","year":"2015","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.jad.2026.121527_bb0180","doi-asserted-by":"crossref","first-page":"934","DOI":"10.2174\/1570159X20666220706104117","article-title":"Comorbidities in youth with bipolar disorder: clinical features and pharmacological management","volume":"21","author":"Sesso","year":"2023","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.jad.2026.121527_bb0185","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1097\/CHI.0b013e318179964f","article-title":"Psychiatric disorders in children with autism spectrum disorders: prevalence, comorbidity, and associated factors in a population-derived sample","volume":"47","author":"Simonoff","year":"2008","journal-title":"J. Am. Acad. Child Adolesc. Psychiatry"},{"key":"10.1016\/j.jad.2026.121527_bb0190","first-page":"123","article-title":"Neurodevelopmental disorders with comorbid affective disorders sometimes produce psychiatric conditions traditionally diagnosed as schizophrenia","volume":"10","author":"Skeppar","year":"2013","journal-title":"Clin. Neuropsychiatry"},{"key":"10.1016\/j.jad.2026.121527_bb0195","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1007\/s10567-011-0097-0","article-title":"Anxiety disorders in children and adolescents with autistic spectrum disorders: a meta-analysis","volume":"14","author":"van Steensel","year":"2011","journal-title":"Clin. Child. Fam. Psychol. Rev."},{"key":"10.1016\/j.jad.2026.121527_bb0200","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.jad.2014.06.042","article-title":"Bipolar disorder in adults with Asperger\u2019s Syndrome: a systematic review","volume":"168","author":"Vannucchi","year":"2014","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2026.121527_bb0205","series-title":"Psychopathology in Adolescents and Adults With Autism Spectrum Disorders","first-page":"89","article-title":"Bipolar disorder and ASD","author":"Vannucchi","year":"2019"}],"container-title":["Journal of Affective Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032726003782?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032726003782?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T13:24:17Z","timestamp":1787059457000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165032726003782"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":42,"alternative-id":["S0165032726003782"],"URL":"https:\/\/doi.org\/10.1016\/j.jad.2026.121527","relation":{},"ISSN":["0165-0327"],"issn-type":[{"value":"0165-0327","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinical characterization of bipolar disorder in adults with autism without intellectual disability: a cross-sectional study","name":"articletitle","label":"Article Title"},{"value":"Journal of Affective Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jad.2026.121527","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"121527"}}