{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T13:57:27Z","timestamp":1792159047029,"version":"4.4.0"},"reference-count":86,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100005230","name":"Chongqing Natural Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004374","name":"Chongqing Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004374","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Affective Disorders"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.jad.2026.121695","type":"journal-article","created":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T08:07:00Z","timestamp":1774598820000},"page":"121695","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Medial prefrontal cortical CB1Rs and astrocytes are involved in depression and the antidepressant effects of running exercise in male rats"],"prefix":"10.1016","volume":"406","author":[{"given":"Du-juan","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-yu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-min","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-xia","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-hui","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei-lin","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng-Lei","family":"Chao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-ni","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jad.2026.121695_bb0005","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1523\/JNEUROSCI.3101-05.2006","article-title":"The endocannabinoid system promotes astroglial differentiation by acting on neural progenitor cells","volume":"26","author":"Aguado","year":"2006","journal-title":"Neurosci"},{"key":"10.1016\/j.jad.2026.121695_bb0010","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1007\/s11064-022-03771-1","article-title":"Glial Glutamine Homeostasis in Health and Disease","volume":"48","author":"Andersen","year":"2023","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.jad.2026.121695_bb0015","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s40279-019-01187-6","article-title":"Exercise as Medicine for Mental and Substance Use Disorders: A Meta-review of the Benefits for Neuropsychiatric and Cognitive Outcomes","volume":"50","author":"Ashdown-Franks","year":"2020","journal-title":"Sports Med."},{"key":"10.1016\/j.jad.2026.121695_bb0020","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/j.biopsych.2008.06.008","article-title":"Glial loss in the prefrontal cortex is sufficient to induce depressive-like behaviors","volume":"64","author":"Banasr","year":"2008","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jad.2026.121695_bb0025","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1186\/s12974-020-01935-w","article-title":"Astrocyte remodeling in the beneficial effects of long-term voluntary exercise in Alzheimer\u2019s disease","volume":"17","author":"Belaya","year":"2020","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.jad.2026.121695_bb0030","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2024.51208","article-title":"Daily Step Count and Depression in Adults: A Systematic Review and Meta-Analysis","volume":"7","author":"Bizzozero-Peroni","year":"2024","journal-title":"JAMA Netw. Open"},{"key":"10.1016\/j.jad.2026.121695_bb0035","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/s13643-022-01980-x","article-title":"The effects of exercise on circulating endocannabinoid levels-a protocol for a systematic review and meta-analysis","volume":"11","author":"Bristot","year":"2022","journal-title":"Syst. Rev."},{"key":"10.1016\/j.jad.2026.121695_bb0040","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1111\/jnc.12716","article-title":"Relationships between serotonergic and cannabinoid system in depressive-like behavior: a PET study with [11C]-DASB","volume":"130","author":"Burokas","year":"2014","journal-title":"Neurochem"},{"key":"10.1016\/j.jad.2026.121695_bb0045","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1002\/bies.201500046","article-title":"Dissecting the cannabinergic control of behavior: The where matters","volume":"37","author":"Busquets-Garcia","year":"2015","journal-title":"BioEssays : news and reviews in molecular, cellular and developmental biology"},{"key":"10.1016\/j.jad.2026.121695_bb0050","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1126\/science.aan8868","article-title":"What constitutes the prefrontal cortex?","volume":"358","author":"Carlen","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.jad.2026.121695_bb0055","doi-asserted-by":"crossref","first-page":"7792","DOI":"10.1523\/JNEUROSCI.1598-05.2005","article-title":"Morphological correlates of corticosteroid-induced changes in prefrontal cortex-dependent behaviors","volume":"25","author":"Cerqueira","year":"2005","journal-title":"Neurosci"},{"key":"10.1016\/j.jad.2026.121695_bb0060","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2409773121","article-title":"CB1R activates the epilepsy-associated protein Go to regulate neurotransmitter release and synaptic plasticity in the cerebellum","volume":"121","author":"Choi","year":"2024","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jad.2026.121695_bb0065","doi-asserted-by":"crossref","first-page":"9605","DOI":"10.1038\/s41598-022-13724-x","article-title":"Cell type specific cannabinoid CB1 receptor distribution across the human and non-human primate cortex","volume":"12","author":"Chou","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jad.2026.121695_bb0070","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S2215-0366(21)00395-3","article-title":"Global, regional, and national burden of 12 mental disorders in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019","volume":"9","author":"Collaborators","year":"2022","journal-title":"Lancet Psychiatry"},{"key":"10.1016\/j.jad.2026.121695_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2021.108678","article-title":"CB1R-dependent regulation of astrocyte physiology and astrocyte-neuron interactions","volume":"195","author":"Covelo","year":"2021","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.jad.2026.121695_bb0080","doi-asserted-by":"crossref","first-page":"4999","DOI":"10.3390\/ijms23094999","article-title":"Stress-Induced Depression and Alzheimer\u2019s Disease: Focus on Astrocytes","volume":"23","author":"Dolotov","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jad.2026.121695_bb0085","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.bbi.2020.07.015","article-title":"Chronic stress followed by social isolation promotes depressive-like behaviour, alters microglial and astrocyte biology and reduces hippocampal neurogenesis in male mice","volume":"91","author":"Du Preez","year":"2021","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.jad.2026.121695_bb0090","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1038\/s41593-025-01891-9","article-title":"Astrocytic cannabinoid receptor 1 promotes resilience by dampening stress-induced blood-brain barrier alterations","volume":"28","author":"Dudek","year":"2025","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.jad.2026.121695_bb0095","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/s41419-020-2615-9","article-title":"Astrocytic BDNF and TrkB regulate severity and neuronal activity in mouse models of temporal lobe epilepsy","volume":"11","author":"Fern\u00e1ndez-Garc\u00eda","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.jad.2026.121695_bb0100","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1017\/S1461145713000163","volume":"16","author":"Freitas","year":"2013","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.jad.2026.121695_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2019.107914","article-title":"Astrocyte control of glutamatergic activity: Downstream effects on serotonergic function and emotional behavior","volume":"166","author":"Fullana","year":"2020","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.jad.2026.121695_bb0110","doi-asserted-by":"crossref","first-page":"13105","DOI":"10.1073\/pnas.1514996112","article-title":"A runner's high depends on cannabinoid receptors in mice","volume":"112","author":"Fuss","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jad.2026.121695_bb0115","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.neuropharm.2013.09.022","article-title":"The endocannabinoid system mediates aerobic exercise-induced antinociception in rats","volume":"77","author":"Galdino","year":"2014","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.jad.2026.121695_bb0120","doi-asserted-by":"crossref","DOI":"10.1111\/jnc.16226","article-title":"The GFAP proteoform puzzle: How to advance GFAP as a fluid biomarker in neurological diseases","volume":"169","author":"Gogishvili","year":"2025","journal-title":"J. Neurochem."},{"key":"10.1016\/j.jad.2026.121695_bb0125","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1017\/S0033291722001179","article-title":"Major depression is a serious and potentially fatal brain syndrome requiring pharmacotherapy or neuromodulation, and psychotherapy","volume":"52","author":"Goldberg","year":"2022","journal-title":"Psychol. Med."},{"key":"10.1016\/j.jad.2026.121695_bb0130","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1002\/glia.24518","article-title":"Adenosine receptors are the on-and-off switch of astrocytic cannabinoid type 1 (CB1) receptor effect upon synaptic plasticity in the medial prefrontal cortex","volume":"72","author":"Goncalves-Ribeiro","year":"2024","journal-title":"Glia"},{"key":"10.1016\/j.jad.2026.121695_bb0135","doi-asserted-by":"crossref","first-page":"3856","DOI":"10.1038\/s41380-023-02269-8","article-title":"Dysfunctional serotonergic neuron-astrocyte signaling in depressive-like states","volume":"28","author":"Gonz\u00e1lez-Arias","year":"2023","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jad.2026.121695_bb0140","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/s41583-020-0263-9","article-title":"Immune cell regulation of glia during CNS injury and disease","volume":"21","author":"Greenhalgh","year":"2020","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.jad.2026.121695_bb0145","doi-asserted-by":"crossref","first-page":"4347","DOI":"10.1038\/s41467-024-48730-2","article-title":"Astrocytic ALKBH5 in stress response contributes to depressive-like behaviors in mice","volume":"15","author":"Guo","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jad.2026.121695_bb0150","article-title":"Aerobic Exercise and Endocannabinoids: A Narrative Review of Stress Regulation and Brain Reward Systems","volume":"16","author":"Gupta","year":"2024","journal-title":"Cureus"},{"key":"10.1016\/j.jad.2026.121695_bb0155","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1007\/s10616-015-9902-9","article-title":"Astrocyte\/neuron ratio and its importance on glutamate toxicity: an in vitro voltammetric study","volume":"68","author":"Hacimuftuoglu","year":"2016","journal-title":"Cytotechnology"},{"key":"10.1016\/j.jad.2026.121695_bb0160","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1002\/hipo.20647","article-title":"Endogenous cannabinoid signaling is required for voluntary exercise-induced enhancement of progenitor cell proliferation in the hippocampus","volume":"20","author":"Hill","year":"2010","journal-title":"Hippocampus"},{"key":"10.1016\/j.jad.2026.121695_bb0165","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.smim.2014.04.001","article-title":"Stress regulates endocannabinoid-CB1 receptor signaling","volume":"26","author":"Hillard","year":"2014","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.jad.2026.121695_bb0170","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1007\/s00213-014-3812-y","article-title":"Medial prefrontal cannabinoid CB1 receptors modulate consolidation and extinction of cocaine-associated memory in mice","volume":"232","author":"Hu","year":"2015","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.jad.2026.121695_bb0175","doi-asserted-by":"crossref","first-page":"3056","DOI":"10.1002\/cne.25397","article-title":"Positive effects of running exercise on astrocytes in the medial prefrontal cortex in an animal model of depression","volume":"530","author":"Huang","year":"2022","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.jad.2026.121695_bb0180","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/sj.mp.4001376","article-title":"Upregulation of CB1 receptors and agonist-stimulated [35S]GTPgammaS binding in the prefrontal cortex of depressed suicide victims","volume":"9","author":"Hungund","year":"2004","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jad.2026.121695_bb0185","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1111\/jnc.13267","article-title":"Genetic deletion of monoacylglycerol lipase leads to impaired cannabinoid receptor CB\u2081R signaling and anxiety-like behavior","volume":"135","author":"Imperatore","year":"2015","journal-title":"Neurochem"},{"key":"10.1016\/j.jad.2026.121695_bb0190","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1152\/physrev.00019.2008","article-title":"Endocannabinoid-mediated control of synaptic transmission","volume":"89","author":"Kano","year":"2009","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.jad.2026.121695_bb0195","doi-asserted-by":"crossref","first-page":"314","DOI":"10.3390\/brainsci13020314","article-title":"Dual Cannabinoid and Orexin Regulation of Anhedonic Behaviour Caused by Prolonged Restraint Stress","volume":"13","author":"Kim","year":"2023","journal-title":"Brain Sci."},{"key":"10.1016\/j.jad.2026.121695_bb0200","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/s41573-022-00390-x","article-title":"Function and therapeutic value of astrocytes in neurological diseases","volume":"21","author":"Lee","year":"2022","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.jad.2026.121695_bb0205","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1007\/s12264-024-01178-2","article-title":"Functional Changes in Astrocytes Lead to Cognitive Deficits After Social Deprivation","volume":"40","author":"Li","year":"2024","journal-title":"Neurosci. Bull."},{"key":"10.1016\/j.jad.2026.121695_bb0210","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/s41398-021-01216-x","article-title":"The positive effects of running exercise on hippocampal astrocytes in a rat model of depression","volume":"11","author":"Li","year":"2021","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.jad.2026.121695_bb0215","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2019.112115","article-title":"Exercise improves depressive symptoms by increasing the number of excitatory synapses in the hippocampus of CUS-Induced depression model rats","volume":"374","author":"Liang","year":"2019","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.jad.2026.121695_bb0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2022.114103","article-title":"Exercise more efficiently regulates the maturation of newborn neurons and synaptic plasticity than fluoxetine in a CUS-induced depression mouse model","volume":"354","author":"Liang","year":"2022","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.jad.2026.121695_bb0225","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.pnpbp.2015.01.005","article-title":"Cannabinoid CB1 receptors in the dorsal hippocampus and prelimbic medial prefrontal cortex modulate anxiety-like behavior in rats: additional evidence","volume":"59","author":"Lisboa","year":"2015","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.jad.2026.121695_bb0230","doi-asserted-by":"crossref","DOI":"10.1038\/s41380-024-02464-1","article-title":"Running exercise alleviates hippocampal neuroinflammation and shifts the balance of microglial M1\/M2 polarization through adiponectin\/AdipoR1 pathway activation in mice exposed to chronic unpredictable stress","author":"Liu","year":"2024","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jad.2026.121695_bb0235","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.biopsych.2021.11.022","article-title":"Glucocorticoid Receptor-Dependent Astrocytes Mediate Stress Vulnerability","volume":"92","author":"Lu","year":"2022","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jad.2026.121695_bb0240","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1038\/s41398-019-0662-8","article-title":"Running exercise protects oligodendrocytes in the medial prefrontal cortex in chronic unpredictable stress rat model","volume":"9","author":"Luo","year":"2019","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.jad.2026.121695_bb0245","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1038\/s42003-023-05003-w","article-title":"Treadmill exercise modulates the medial prefrontal-amygdala neural circuit to improve the resilience against chronic restraint stress","volume":"6","author":"Luo","year":"2023","journal-title":"Communications biology"},{"key":"10.1016\/j.jad.2026.121695_bb0250","first-page":"75","article-title":"Depression and the Glutamate\/GABA-Glutamine Cycle","volume":"23","author":"M., M.","year":"2024","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.jad.2026.121695_bb0255","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.brainresbull.2021.06.017","article-title":"Cannabidiol in the prelimbic cortex modulates the comorbid condition between the chronic neuropathic pain and depression-like behaviour in rats: The role of medial prefrontal cortex 5-HT(1A) and CB(1) receptors","volume":"174","author":"Malvestio","year":"2021","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.jad.2026.121695_bb0260","doi-asserted-by":"crossref","first-page":"14371","DOI":"10.1038\/s41598-021-93813-5","article-title":"A single session of moderate intensity exercise influences memory, endocannabinoids and brain derived neurotrophic factor levels in men","volume":"11","author":"Marin Bosch","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jad.2026.121695_bb0265","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.3390\/ijms24031989","article-title":"The Endocannabinoid System and Physical Exercise","volume":"24","author":"Matei","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jad.2026.121695_bb0270","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.bcp.2018.08.012","article-title":"Selective up-regulation of cannabinoid CB(1) receptor coupling to Go-proteins in suicide victims with mood disorders","volume":"157","author":"Mato","year":"2018","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.jad.2026.121695_bb0275","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.molmet.2019.08.005","article-title":"mTORC1 and CB1 receptor signaling regulate excitatory glutamatergic inputs onto the hypothalamic paraventricular nucleus in response to energy availability","volume":"28","author":"Mazier","year":"2019","journal-title":"Molecular metabolism"},{"key":"10.1016\/j.jad.2026.121695_bb0280","doi-asserted-by":"crossref","first-page":"12655","DOI":"10.3390\/ijms232012655","article-title":"Treadmill Exercise Reduces Neuroinflammation, Glial Cell Activation and Improves Synaptic Transmission in the Prefrontal Cortex in 3 \u00d7 Tg-AD Mice","volume":"23","author":"Mu","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jad.2026.121695_bb0285","doi-asserted-by":"crossref","DOI":"10.1136\/bmj-2023-075847","article-title":"Effect of exercise for depression: systematic review and network meta-analysis of randomised controlled trials","volume":"384","author":"Noetel","year":"2024","journal-title":"BMJ"},{"key":"10.1016\/j.jad.2026.121695_bb0290","doi-asserted-by":"crossref","first-page":"5500","DOI":"10.1038\/s41467-023-40968-6","article-title":"Astrocyte reactivity and inflammation-induced depression-like behaviors are regulated by Orai1 calcium channels","volume":"14","author":"Novakovic","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jad.2026.121695_bb0295","doi-asserted-by":"crossref","first-page":"16065","DOI":"10.1038\/nrdp.2016.65","article-title":"Major depressive disorder","volume":"2","author":"Otte","year":"2016","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.jad.2026.121695_bb0300","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2019.03.002","article-title":"The role of astrocytic glutamate transporters GLT-1 and GLAST in neurological disorders: Potential targets for neurotherapeutics","volume":"161","author":"Pajarillo","year":"2019","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.jad.2026.121695_bb0305","first-page":"273","volume":"30","author":"Pandarakalam","year":"2018","journal-title":"Challenges of treatment-resistant depression. Psychiat Danub"},{"key":"10.1016\/j.jad.2026.121695_bb0310","series-title":"The rat brain in stereotaxic coordinates","author":"Paxinos","year":"2018"},{"key":"10.1016\/j.jad.2026.121695_bb0315","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1001\/jamapsychiatry.2022.0609","article-title":"Association Between Physical Activity and Risk of Depression: A Systematic Review and Meta-analysis","volume":"79","author":"Pearce","year":"2022","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.jad.2026.121695_bb0320","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.jad.2023.03.066","article-title":"High-frequency repetitive transcranial magnetic stimulation regulates neural oscillations of the hippocampus and prefrontal cortex in mice by modulating endocannabinoid signalling","volume":"331","author":"Peng","year":"2023","journal-title":"Affect Disord"},{"key":"10.1016\/j.jad.2026.121695_bb0325","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1038\/nrn1247","article-title":"The molecular logic of endocannabinoid signalling","volume":"4","author":"Piomelli","year":"2003","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.jad.2026.121695_bb0330","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/0014-2999(78)90118-8","article-title":"Behavioural despair in rats: a new model sensitive to antidepressant treatments","volume":"47","author":"Porsolt","year":"1978","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jad.2026.121695_bb0335","doi-asserted-by":"crossref","first-page":"2529","DOI":"10.1016\/j.neubiorev.2013.07.018","article-title":"Neural correlates of dysfunctional emotion regulation in major depressive disorder. A systematic review of neuroimaging studies","volume":"37","author":"Rive","year":"2013","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.jad.2026.121695_bb0340","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/s41380-022-01819-w","article-title":"The role of exercise in the treatment of depression: biological underpinnings and clinical outcomes","volume":"28","author":"Ross","year":"2023","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jad.2026.121695_bb0345","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1038\/mp.2016.118","article-title":"Cellular and molecular basis for stress-induced depression","volume":"22","author":"Seo","year":"2017","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jad.2026.121695_bb0350","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1038\/s41386-023-01533-3","article-title":"Neuronal and astrocytic CB1R signaling differentially modulates goal-directed behavior and working memory by distinct temporal mechanisms","volume":"48","author":"Shang","year":"2023","journal-title":"Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology"},{"key":"10.1016\/j.jad.2026.121695_bb0355","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2020.113007","article-title":"Further evidence of anxiety- and depression-like behavior for total genetic ablation of cannabinoid receptor type 1","volume":"400","author":"Soriano","year":"2021","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.jad.2026.121695_bb0360","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainresbull.2019.04.001","article-title":"The effects of running exercise on oligodendrocytes in the hippocampus of rats with depression induced by chronic unpredictable stress","volume":"149","author":"Tang","year":"2019","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.jad.2026.121695_bb0365","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1038\/s41398-020-0832-8","article-title":"Cannabinoid receptor CNR1 expression and DNA methylation in human prefrontal cortex, hippocampus and caudate in brain development and schizophrenia","volume":"10","author":"Tao","year":"2020","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.jad.2026.121695_bb0370","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.tins.2020.03.007","article-title":"Where is Cingulate Cortex?","volume":"43","author":"van Heukelum","year":"2020","journal-title":"A Cross-Species View. Trends Neurosci"},{"key":"10.1016\/j.jad.2026.121695_bb0375","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.jad.2023.02.064","article-title":"Antidepressants or running therapy: Comparing effects on mental and physical health in patients with depression and anxiety disorders","volume":"329","author":"Verhoeven","year":"2023","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2026.121695_bb0380","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.jad.2023.02.064","article-title":"Antidepressants or running therapy: Comparing effects on mental and physical health in patients with depression and anxiety disorders","volume":"329","author":"Verhoeven","year":"2023","journal-title":"Affect Disord"},{"key":"10.1016\/j.jad.2026.121695_bb0385","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1038\/s41392-021-00577-5","article-title":"The anti-inflammatory astrocyte revealed: the role of the microbiome in shaping brain defences","volume":"6","author":"Verkhratsky","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.jad.2026.121695_bb0390","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.pbb.2005.01.029","article-title":"Endocannabinoid system and stress and anxiety responses","volume":"81","author":"Viveros","year":"2005","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.jad.2026.121695_bb0395","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.mam.2018.10.001","article-title":"Endocannabinoids, exercise, pain, and a path to health with aging","volume":"64","author":"Watkins","year":"2018","journal-title":"Mol. Asp. Med."},{"key":"10.1016\/j.jad.2026.121695_bb0400","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1007\/BF00187257","article-title":"Reduction of sucrose preference by chronic unpredictable mild stress, and its restoration by a tricyclic antidepressant","volume":"93","author":"Willner","year":"1987","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.jad.2026.121695_bb0405","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1478-811X-8-12","article-title":"Cannabinoid receptor CB1 mediates baseline and activity-induced survival of new neurons in adult hippocampal neurogenesis","volume":"8","author":"Wolf","year":"2010","journal-title":"Cell Commun. Signal"},{"key":"10.1016\/j.jad.2026.121695_bb0410","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1146\/annurev-neuro-112723-035356","article-title":"Astrocytes as Key Regulators of Neural Signaling in Health and Disease","volume":"48","author":"Won","year":"2025","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.jad.2026.121695_bb0415","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1038\/s41398-023-02311-x","article-title":"Physical exercise mediates a cortical FMRP-mTOR pathway to improve resilience against chronic stress in adolescent mice","volume":"13","author":"Yan","year":"2023","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.jad.2026.121695_bb0420","doi-asserted-by":"crossref","first-page":"239","DOI":"10.2174\/1874467212666190215112036","article-title":"New Insights in Cannabinoid Receptor Structure and Signaling","volume":"12","author":"Ye","year":"2019","journal-title":"Curr. Mol. Pharmacol."},{"key":"10.1016\/j.jad.2026.121695_bb0425","series-title":"Astrocytic PCBP1 Suppresses Ferroptosis to Restore Glutamatergic Homeostasis and Mitigate Stress-Induced Depression in Male Mice. Advanced science","first-page":"e13438","author":"Zhang","year":"2025"},{"key":"10.1016\/j.jad.2026.121695_bb0430","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1111\/cns.13385","article-title":"Exercise, brain plasticity, and depression","volume":"26","author":"Zhao","year":"2020","journal-title":"CNS Neurosci. Ther."}],"updated-by":[{"DOI":"10.1016\/j.jad.2026.122526","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000}},{"DOI":"10.1016\/j.jad.2026.122526","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000}}],"container-title":["Journal of Affective Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016503272600546X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016503272600546X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T21:54:30Z","timestamp":1780955670000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S016503272600546X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":86,"alternative-id":["S016503272600546X"],"URL":"https:\/\/doi.org\/10.1016\/j.jad.2026.121695","relation":{},"ISSN":["0165-0327"],"issn-type":[{"value":"0165-0327","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Medial prefrontal cortical CB1Rs and astrocytes are involved in depression and the antidepressant effects of running exercise in male rats","name":"articletitle","label":"Article Title"},{"value":"Journal of Affective Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jad.2026.121695","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"121695"}}