{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T03:22:53Z","timestamp":1791256973237,"version":"4.1.0"},"reference-count":76,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T00:00:00Z","timestamp":1775779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Affective Disorders"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.jad.2026.121741","type":"journal-article","created":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T17:07:11Z","timestamp":1775840831000},"page":"121741","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Depression and anxiety in adults with epilepsy. Systematic literature review and meta-analysis"],"prefix":"10.1016","volume":"407","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-2349-4283","authenticated-orcid":false,"given":"Juan Camilo","family":"Rojas-L\u00f3pez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1236-194X","authenticated-orcid":false,"given":"Suhamny","family":"Navas-Pe\u00f1aranda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0140-8860","authenticated-orcid":false,"given":"Mateo","family":"Avil\u00e9s-G\u00f3mez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9503-139X","authenticated-orcid":false,"given":"Ximena","family":"Palacios-Espinosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6792-5855","authenticated-orcid":false,"given":"Leonardo","family":"Palacios-S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4646-4324","authenticated-orcid":false,"given":"Ana Mar\u00eda","family":"Barrag\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jad.2026.121741_bb0005","doi-asserted-by":"crossref","first-page":"106649","DOI":"10.1016\/j.yebeh.2019.106649","article-title":"Comparison of psychiatric comorbidities and impact on quality of life in patients with epilepsy or psychogenic nonepileptic spells","volume":"102","author":"Abe","year":"2020","journal-title":"Epilepsy Behav."},{"issue":"2","key":"10.1016\/j.jad.2026.121741_bb0010","doi-asserted-by":"crossref","first-page":"128","DOI":"10.4314\/gmj.v55i2.5","article-title":"Psychological comorbidities in epilepsy: a cross-sectional survey among Ghanaian epilepsy patients","volume":"55","author":"Adjei","year":"2021","journal-title":"Ghana Med. J."},{"key":"10.1016\/j.jad.2026.121741_bb0015","doi-asserted-by":"crossref","first-page":"106973","DOI":"10.1016\/j.yebeh.2020.106973","article-title":"Trends in prevalence and treatment of depressive symptoms in adult patients with epilepsy in the United States","volume":"105","author":"Ajinkya","year":"2020","journal-title":"Epilepsy Behav."},{"issue":"16_supplement","key":"10.1016\/j.jad.2026.121741_bb0020","doi-asserted-by":"crossref","DOI":"10.1212\/WNL.86.16_supplement.P4.209","article-title":"Depression in epileptic patients is influenced by the duration of epilepsy: a cross sectional study in patients with epilepsy (P4.209)","volume":"86","author":"Al Qahtani","year":"2016","journal-title":"Neurology"},{"issue":"6","key":"10.1016\/j.jad.2026.121741_bb0025","first-page":"422","article-title":"Depression in patients with epilepsy is influenced by the duration of epilepsy","volume":"10","author":"Babtain","year":"2020","journal-title":"Am. J. Med. Med. Sci."},{"issue":"2","key":"10.1016\/j.jad.2026.121741_bb0030","first-page":"136","article-title":"Frequency of anxiety and depression in epileptic patients","volume":"25","author":"Balibey","year":"2015","journal-title":"Klin Psikofarmakol B\u00fcl-Bull. Clin. Psychopharmacol."},{"issue":"7","key":"10.1016\/j.jad.2026.121741_bb0035","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1111\/epi.13766","article-title":"Psychiatric and behavioral comorbidities in epilepsy: a critical reappraisal","volume":"58","author":"Berg","year":"2017","journal-title":"Epilepsia"},{"issue":"1","key":"10.1016\/j.jad.2026.121741_bb0040","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s44192-025-00161-1","article-title":"Depression and associated factors among people with epilepsy at Wolaita Sodo University hospital, South Ethiopia","volume":"5","author":"Berhanu","year":"2025","journal-title":"Discov. Ment. Health"},{"issue":"5","key":"10.1016\/j.jad.2026.121741_bb0045","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1016\/j.pharep.2016.06.011","article-title":"Epilepsy coexisting with depression","volume":"68","author":"B\u0142aszczyk","year":"2016","journal-title":"Pharmacol. Rep."},{"issue":"2","key":"10.1016\/j.jad.2026.121741_bb0050","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.pjnns.2015.01.008","article-title":"Subtypes of interictal depressive disorders according to ICD-10 in patients with epilepsy","volume":"49","author":"Bosak","year":"2015","journal-title":"Neurol. Neurochir. Pol."},{"issue":"2","key":"10.1016\/j.jad.2026.121741_bb0055","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.yebeh.2009.12.009","article-title":"Prevalence of anxiety disorders in patients with refractory focal epilepsy\u2014a prospective clinic based survey","volume":"17","author":"Brandt","year":"2010","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.jad.2026.121741_bb0060","doi-asserted-by":"crossref","first-page":"107511","DOI":"10.1016\/j.yebeh.2020.107511","article-title":"The mediating role of epileptic seizures, irritability, and depression on quality of life in people with epilepsy","volume":"113","author":"Campos-Fern\u00e1ndez","year":"2020","journal-title":"Epilepsy Behav."},{"issue":"S 01","key":"10.1016\/j.jad.2026.121741_bb0065","doi-asserted-by":"crossref","first-page":"S013","DOI":"10.4103\/jnrp.jnrp_21_17","article-title":"High frequency of depressive symptoms among adults with epilepsy: results from a hospital-based study","volume":"08","author":"Chandrasekharan","year":"2017","journal-title":"J. Neurosci. Rural Pract."},{"issue":"12","key":"10.1016\/j.jad.2026.121741_bb0070","doi-asserted-by":"crossref","first-page":"4834","DOI":"10.1111\/epi.18579","article-title":"Association of epilepsy with trajectory of depressive symptoms in late life: the cardiovascular health study","volume":"66","author":"Choi","year":"2025","journal-title":"Epilepsia"},{"issue":"3","key":"10.1016\/j.jad.2026.121741_bb0075","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1002\/epi4.12766","article-title":"Anxiety and depressive symptoms in adults with new-onset seizures: a scoping review","volume":"8","author":"Cronin","year":"2023","journal-title":"Epilepsia Open."},{"issue":"01","key":"10.1016\/j.jad.2026.121741_bb0080","doi-asserted-by":"crossref","first-page":"29","DOI":"10.4236\/ojd.2019.81004","article-title":"Symptoms of depression and associated risk factors in patients with epilepsy in Burkina Faso","volume":"08","author":"Dabilgou","year":"2019","journal-title":"Open J. Depress."},{"issue":"1","key":"10.1016\/j.jad.2026.121741_bb0085","first-page":"7","article-title":"Depression, anxiety and suicidal ideation\/behaviour among persons with epilepsy: common but underestimated comorbidities in Haryana, North India","volume":"25","author":"Dabla","year":"2020","journal-title":"Neurol. Asia"},{"issue":"3","key":"10.1016\/j.jad.2026.121741_bb0090","doi-asserted-by":"crossref","first-page":"138","DOI":"10.4038\/cmj.v66i3.9492","article-title":"Prevalence and correlates of depression in patients with epilepsy in Sri Lanka","volume":"66","author":"De Silva","year":"2021","journal-title":"Ceylon Med. J."},{"issue":"6","key":"10.1016\/j.jad.2026.121741_bb0095","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1111\/j.1528-1167.2011.02983.x","article-title":"William Gowers\u2019 interpretation of epileptogenic mechanisms: 1880-1906: Gowers and epileptogenic mechanisms","volume":"52","author":"Eadie","year":"2011","journal-title":"Epilepsia"},{"key":"10.1016\/j.jad.2026.121741_bb0100","doi-asserted-by":"crossref","first-page":"109515","DOI":"10.1016\/j.yebeh.2023.109515","article-title":"Shorter duration of slow wave sleep is related to symptoms of depression in patients with epilepsy","volume":"149","author":"Eyj\u00f3lfsd\u00f3ttir","year":"2023","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.jad.2026.121741_bb0105","doi-asserted-by":"crossref","first-page":"109922","DOI":"10.1016\/j.yebeh.2024.109922","article-title":"Brivaracetam effectiveness and tolerability in older and younger adults with epilepsy: EXPERIENCE, a pooled analysis of international data from retrospective studies","volume":"158","author":"Faught","year":"2024","journal-title":"Epilepsy Behav."},{"issue":"6","key":"10.1016\/j.jad.2026.121741_bb0110","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1212\/WNL.0b013e31827b1ae0","article-title":"Depression in epilepsy: a systematic review and meta-analysis","volume":"80","author":"Fiest","year":"2013","journal-title":"Neurology"},{"issue":"4","key":"10.1016\/j.jad.2026.121741_bb0115","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1111\/epi.12550","article-title":"ILAE official report: a practical clinical definition of epilepsy","volume":"55","author":"Fisher","year":"2014","journal-title":"Epilepsia"},{"issue":"6","key":"10.1016\/j.jad.2026.121741_bb0120","doi-asserted-by":"crossref","first-page":"881","DOI":"10.4103\/mjdrdypu.mjdrdypu_654_20","article-title":"Prevalence and correlates of psychiatric comorbidity in patients with epilepsy: a Cross-sectional hospital-based study","volume":"15","author":"Gandhi","year":"2022","journal-title":"Med. J. Dr. Patil. Vidyapeeth."},{"issue":"4","key":"10.1016\/j.jad.2026.121741_bb0125","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1111\/epi.18252","article-title":"Integrated care for mental health in epilepsy: a systematic review and meta-synthesis by the international league against epilepsy integrated mental health care pathways task force","volume":"66","author":"Gandy","year":"2025","journal-title":"Epilepsia"},{"issue":"9","key":"10.1016\/j.jad.2026.121741_bb0130","doi-asserted-by":"crossref","first-page":"858","DOI":"10.3390\/brainsci14090858","article-title":"Influence of epilepsy characteristics on the anxiety occurrence","volume":"14","author":"Gavrilovic","year":"2024","journal-title":"Brain Sci."},{"key":"10.1016\/j.jad.2026.121741_bb0135","doi-asserted-by":"crossref","first-page":"108965","DOI":"10.1016\/j.yebeh.2022.108965","article-title":"Psychiatric comorbidities among people with epilepsy: a population-based assessment in disadvantaged communities","volume":"137","author":"Goel","year":"2022","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.jad.2026.121741_bb0140","doi-asserted-by":"crossref","first-page":"1283983","DOI":"10.3389\/fpsyt.2023.1283983","article-title":"Risk analysis of depression among adult patients with epilepsy of different sex: a retrospective single-center study from China","volume":"14","author":"Guo","year":"2023","journal-title":"Front. Psych."},{"issue":"1","key":"10.1016\/j.jad.2026.121741_bb0145","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s13760-024-02632-8","article-title":"Clinical and sociodemographic predictors of depressive symptoms in epilepsy patients in a single tertiary epilepsy center","volume":"125","author":"Hajder","year":"2025","journal-title":"Acta Neurol. Belg."},{"issue":"4","key":"10.1016\/j.jad.2026.121741_bb0150","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1002\/epi4.12958","article-title":"Prevalence and associated factors of psychiatric comorbidities in epilepsy in the Casablanca\u2013Settat region of Morocco: a cross-sectional study","volume":"9","author":"Hajji","year":"2024","journal-title":"Epilepsia Open."},{"issue":"1","key":"10.1016\/j.jad.2026.121741_bb0155","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1186\/s12883-025-04331-0","article-title":"Global, regional and national burdens of epilepsy in the adolescents and young adults from 1990 to 2021 and its predictions","volume":"25","author":"Han","year":"2025","journal-title":"BMC Neurol."},{"key":"10.1016\/j.jad.2026.121741_bb0160","doi-asserted-by":"crossref","DOI":"10.12809\/hkmj198310","article-title":"Factors associated with depression in people with epilepsy: a retrospective case-control analysis","author":"Ho","year":"2020","journal-title":"Hong Kong Med. J."},{"key":"10.1016\/j.jad.2026.121741_bb0165","doi-asserted-by":"crossref","first-page":"110570","DOI":"10.1016\/j.yebeh.2025.110570","article-title":"Occurrence and treatment of depression symptoms and anxiety in patients with epilepsy: findings from a German multicentre cross-sectional study","volume":"173","author":"Hock","year":"2025","journal-title":"Epilepsy Behav."},{"issue":"10","key":"10.1016\/j.jad.2026.121741_bb0170","doi-asserted-by":"crossref","DOI":"10.53350\/pjmhs20231710150","article-title":"Frequency of anxiety and depression in patients of epilepsy","volume":"17","author":"Jalal","year":"2023","journal-title":"Pak. J. Med. Health Sci."},{"key":"10.1016\/j.jad.2026.121741_bb0175","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.yebeh.2018.06.046","article-title":"Interictal psychiatric comorbidities of drug-resistant focal epilepsy: prevalence and influence of the localization of the epilepsy","volume":"94","author":"Jansen","year":"2019","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.jad.2026.121741_bb0180","doi-asserted-by":"crossref","DOI":"10.7759\/cureus.32971","article-title":"The impact of palliative radiation therapy on patients with advanced gastric Cancer: results of a retrospective cohort study","author":"Katano","year":"2022","journal-title":"Cureus"},{"key":"10.1016\/j.jad.2026.121741_bb0185","doi-asserted-by":"crossref","first-page":"108342","DOI":"10.1016\/j.yebeh.2021.108342","article-title":"Prevalence of depression and suicidal ideation in persons with epilepsy during the COVID-19 pandemic: a longitudinal study from India","volume":"124","author":"Katyal","year":"2021","journal-title":"Epilepsy Behav."},{"issue":"1","key":"10.1016\/j.jad.2026.121741_bb0190","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1186\/s12883-024-03670-8","article-title":"Psychiatric implications of anti-seizure medications in epileptic population","volume":"24","author":"Khalid","year":"2024","journal-title":"BMC Neurol."},{"issue":"1","key":"10.1016\/j.jad.2026.121741_bb0195","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/1744-859X-6-28","article-title":"Depression and anxiety in epilepsy: the association with demographic and seizure-related variables","volume":"6","author":"Kimiskidis","year":"2007","journal-title":"Ann. General Psychiatry"},{"key":"10.1016\/j.jad.2026.121741_bb0200","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.yebeh.2018.11.004","article-title":"Prevalence of psychiatric disorders in Thai patients with epilepsy","volume":"90","author":"Kuladee","year":"2019","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.jad.2026.121741_bb0205","doi-asserted-by":"crossref","first-page":"108318","DOI":"10.1016\/j.yebeh.2021.108318","article-title":"Sex differences in seizure effects on social anxiety in persons with epilepsy","volume":"124","author":"Lee","year":"2021","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.jad.2026.121741_bb0210","doi-asserted-by":"crossref","first-page":"108376","DOI":"10.1016\/j.yebeh.2021.108376","article-title":"The impact of social factors, especially psychological worries on anxiety and depression in patients with epilepsy","volume":"125","author":"Li","year":"2021","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.jad.2026.121741_bb0215","doi-asserted-by":"crossref","first-page":"670","DOI":"10.3389\/fpsyt.2020.00670","article-title":"Gender differences in associated and predictive factors of anxiety and depression in people with epilepsy","volume":"11","author":"Liu","year":"2020","journal-title":"Front. Psych."},{"key":"10.1016\/j.jad.2026.121741_bb0220","series-title":"Comprehensive Management of Epilepsy in Infancy, Childhood and Adolescence","author":"Livingston","year":"1972"},{"issue":"4","key":"10.1016\/j.jad.2026.121741_bb0225","doi-asserted-by":"crossref","first-page":"623","DOI":"10.3390\/jpm13040623","article-title":"State of the art and challenges in epilepsy\u2014a narrative review","volume":"13","author":"Manole","year":"2023","journal-title":"J. Pers. Med."},{"key":"10.1016\/j.jad.2026.121741_bb0230","doi-asserted-by":"crossref","first-page":"110326","DOI":"10.1016\/j.yebeh.2025.110326","article-title":"Prevalence of depression in people with epilepsy: a hospital-based study in Cameroon","volume":"165","author":"Massi","year":"2025","journal-title":"Epilepsy Behav."},{"issue":"1","key":"10.1016\/j.jad.2026.121741_bb0235","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.yebeh.2007.04.012","article-title":"A community study of the presence of anxiety disorder in people with epilepsy","volume":"11","author":"Mensah","year":"2007","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.jad.2026.121741_bb0240","doi-asserted-by":"crossref","first-page":"109253","DOI":"10.1016\/j.yebeh.2023.109253","article-title":"Clinical relevance of interictal dysphoric disorder and its impact on quality of life in drug-resistant epilepsy","volume":"144","author":"Monteagudo-Gimeno","year":"2023","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.jad.2026.121741_bb0245","series-title":"JBI Manual for Evidence Synthesis [Internet]","first-page":"1","article-title":"Checklist for case control studies","author":"Moola","year":"2017"},{"key":"10.1016\/j.jad.2026.121741_bb0250","series-title":"JBI Manual for Evidence Synthesis [Internet]","article-title":"Checklist For Analytical Cross Sectional Studies Critical Appraisal tools for use in JBI Systematic Reviews","author":"Moola","year":"2020"},{"key":"10.1016\/j.jad.2026.121741_bb0255","series-title":"JBI Manual for Evidence Synthesis [Internet]","first-page":"1","article-title":"Checklist for cohort studies","author":"Moola","year":"2020"},{"issue":"2","key":"10.1016\/j.jad.2026.121741_bb0260","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1097\/WCO.0000000000000431","article-title":"Depression in epilepsy","volume":"30","author":"Mula","year":"2017","journal-title":"Curr. Opin. Neurol."},{"key":"10.1016\/j.jad.2026.121741_bb0265","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.yebeh.2018.05.024","article-title":"Anxiety is common and independently associated with clinical features of epilepsy","volume":"85","author":"Munger Clary","year":"2018","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.jad.2026.121741_bb0270","doi-asserted-by":"crossref","first-page":"107092","DOI":"10.1016\/j.eplepsyres.2023.107092","article-title":"Afraid to go out: poor quality of life with phobic anxiety in a large cross-sectional adult epilepsy center sample","volume":"190","author":"Munger Clary","year":"2023","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.jad.2026.121741_bb0275","doi-asserted-by":"crossref","first-page":"109665","DOI":"10.1016\/j.yebeh.2024.109665","article-title":"Risk factors for anxiety in patients with epilepsy: a meta-analysis","volume":"153","author":"Niu","year":"2024","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.jad.2026.121741_bb0280","doi-asserted-by":"crossref","first-page":"106344","DOI":"10.1016\/j.eplepsyres.2020.106344","article-title":"Correlates of depression and quality of life among patients with epilepsy in Nigeria","volume":"164","author":"Ogundare","year":"2020","journal-title":"Epilepsy Res."},{"issue":"16_supplement","key":"10.1016\/j.jad.2026.121741_bb0285","doi-asserted-by":"crossref","DOI":"10.1212\/WNL.86.16_supplement.P4.207","article-title":"Depression in clinically diagnosed patients with epilepsy in northwestern Nigeria (P4.207)","volume":"86","author":"Owolabi","year":"2016","journal-title":"Neurology"},{"issue":"03","key":"10.1016\/j.jad.2026.121741_bb0290","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.14482\/sun.40.03.654.456","article-title":"Reflexiones sobre la estigmatizaci\u00f3n de la epilepsia a trav\u00e9s de la historia","volume":"40","author":"Palacios Espinosa","year":"2024","journal-title":"Salud Uninorte"},{"issue":"12","key":"10.1016\/j.jad.2026.121741_bb0295","doi-asserted-by":"crossref","first-page":"e0278907","DOI":"10.1371\/journal.pone.0278907","article-title":"Exploring the association between epilepsy and depression: a systematic review and meta-analysis. Farrukh MJ, editor","volume":"17","author":"Qin","year":"2022","journal-title":"PLoS One"},{"key":"10.1016\/j.jad.2026.121741_bb0300","doi-asserted-by":"crossref","first-page":"108620","DOI":"10.1016\/j.yebeh.2022.108620","article-title":"Factors associated with initiation of the modified Atkins diet in adults with drug-resistant epilepsy","volume":"129","author":"Quiroga-Padilla","year":"2022","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.jad.2026.121741_bb0305","doi-asserted-by":"crossref","first-page":"110692","DOI":"10.1016\/j.yebeh.2025.110692","article-title":"Depression in older adults with epilepsy: pathophysiology and management considerations","volume":"172","author":"Sadek","year":"2025","journal-title":"Epilepsy Behav."},{"issue":"3","key":"10.1016\/j.jad.2026.121741_bb0310","doi-asserted-by":"crossref","first-page":"225","DOI":"10.32598\/CJNS.10.38.389.4","article-title":"Mental health and seizure patterns in epileptic patients during COVID-19 pandemic: a case study in Northeast Iran","volume":"10","author":"Saeedi","year":"2024","journal-title":"Casp. J. Neurol. Sci."},{"key":"10.1016\/j.jad.2026.121741_bb0315","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.seizure.2018.08.002","article-title":"Pathophysiology of convulsive status epilepticus","volume":"68","author":"S\u00e1nchez Fern\u00e1ndez","year":"2019","journal-title":"Seizure"},{"issue":"6","key":"10.1016\/j.jad.2026.121741_bb0320","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1111\/epi.13769","article-title":"Anxiety and depressive disorders in people with epilepsy: a meta-analysis","volume":"58","author":"Scott","year":"2017","journal-title":"Epilepsia"},{"key":"10.1016\/j.jad.2026.121741_bb0325","doi-asserted-by":"crossref","first-page":"107703","DOI":"10.1016\/j.yebeh.2020.107703","article-title":"How frequently is anxiety and depression identified and treated in hospital and community samples of adults with epilepsy?","volume":"115","author":"Scott","year":"2021","journal-title":"Epilepsy Behav."},{"issue":"1","key":"10.1016\/j.jad.2026.121741_bb0330","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s43045-022-00190-4","article-title":"Prevalence and determinants of depression in patients with epilepsy during the COVID-19 pandemic","volume":"29","author":"Sehlo","year":"2022","journal-title":"Middle East Curr. Psychiatry"},{"key":"10.1016\/j.jad.2026.121741_bb0335","doi-asserted-by":"crossref","DOI":"10.1177\/17562864231187194","article-title":"Prevalence and risk factors of anxiety and depression in adult patients with epilepsy: a multicenter survey-based study","volume":"16","author":"Shi","year":"2023","journal-title":"Ther. Adv. Neurol. Disord."},{"issue":"T7","key":"10.1016\/j.jad.2026.121741_bb0340","doi-asserted-by":"crossref","first-page":"108","DOI":"10.3889\/oamjms.2022.9255","article-title":"Factors associated with anxiety scores in people with epilepsy in neurological installations of haji Adam Medan center general hospital","volume":"10","author":"Soraya","year":"2022","journal-title":"Open Access Maced. J. Med. Sci."},{"issue":"4","key":"10.1016\/j.jad.2026.121741_bb0345","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/S1474-4422(24)00038-3","article-title":"Global, regional, and national burden of disorders affecting the nervous system, 1990\u20132021: a systematic analysis for the global burden of disease study 2021","volume":"23","author":"Steinmetz","year":"2024","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.jad.2026.121741_bb0350","doi-asserted-by":"crossref","first-page":"107475","DOI":"10.1016\/j.yebeh.2020.107475","article-title":"Prevalence, severity, and associations of depression in people with epilepsy in Guinea: a single-center study","volume":"113","author":"Sylla","year":"2020","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.jad.2026.121741_bb0355","doi-asserted-by":"crossref","first-page":"109838","DOI":"10.1016\/j.yebeh.2024.109838","article-title":"The relationship of psychiatric comorbidities and symptoms, quality of life, and stigmatization in patients with epilepsy","volume":"156","author":"Tal\u0131bov","year":"2024","journal-title":"Epilepsy Behav."},{"issue":"4","key":"10.1016\/j.jad.2026.121741_bb0360","doi-asserted-by":"crossref","first-page":"935","DOI":"10.54029\/2023xmy","article-title":"Depression as comorbidity in Sundanese epilepsy patients","volume":"28","author":"Tandiawan","year":"2023","journal-title":"Neurol. Asia"},{"issue":"3","key":"10.1016\/j.jad.2026.121741_bb0365","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1007\/s10072-021-05589-1","article-title":"Depressive symptoms in patients with epilepsy and clinically associated features in a single tertiary center","volume":"43","author":"Vacca","year":"2022","journal-title":"Neurol. Sci."},{"key":"10.1016\/j.jad.2026.121741_bb0370","article-title":"Depressive Disorder (Depression) [Internet]. World Health","author":"World Health Organization [WHO]","year":"2025","journal-title":"Organization"},{"key":"10.1016\/j.jad.2026.121741_bb0375","doi-asserted-by":"crossref","first-page":"107030","DOI":"10.1016\/j.yebeh.2020.107030","article-title":"Risk factors for depression in patients with epilepsy: a meta-analysis","volume":"106","author":"Yang","year":"2020","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.jad.2026.121741_bb0380","doi-asserted-by":"crossref","first-page":"107801","DOI":"10.1016\/j.yebeh.2021.107801","article-title":"Sex differences in anxiety in patients with epilepsy: status and risk factors analysis","volume":"116","author":"Zhong","year":"2021","journal-title":"Epilepsy Behav."}],"container-title":["Journal of Affective Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032726005926?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032726005926?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T13:44:00Z","timestamp":1777470240000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165032726005926"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":76,"alternative-id":["S0165032726005926"],"URL":"https:\/\/doi.org\/10.1016\/j.jad.2026.121741","relation":{},"ISSN":["0165-0327"],"issn-type":[{"value":"0165-0327","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Depression and anxiety in adults with epilepsy. Systematic literature review and meta-analysis","name":"articletitle","label":"Article Title"},{"value":"Journal of Affective Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jad.2026.121741","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"121741"}}