{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T19:18:12Z","timestamp":1783192692456,"version":"3.54.6"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2503902"],"award-info":[{"award-number":["2022YFC2503902"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Affective Disorders"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.jad.2026.121884","type":"journal-article","created":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T23:33:41Z","timestamp":1777332821000},"page":"121884","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Increased presynaptic dopamine activity in adolescent with major depressive disorder: an 18F-FDOPA PET study"],"prefix":"10.1016","volume":"410","author":[{"given":"Xi-zhe","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-xian","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi-jun","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-ying","family":"Ling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gui-mei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-jing","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-xi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tu-zhi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-jin","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-xuan","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-yang","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jad.2026.121884_bb0005","article-title":"The affective reactivity index: a concise irritability scale for clinical and research settings","volume":"53","author":"A","year":"2012","journal-title":"J. Child Psychol. Psychiatry."},{"key":"10.1016\/j.jad.2026.121884_bb0010","series-title":"Childhood Trauma in Mental Disorders: A Comprehensive Approach","first-page":"385","article-title":"Neurobiological basis of childhood trauma and the risk for neurological deficits later in life","author":"Assogna","year":"2020"},{"key":"10.1016\/j.jad.2026.121884_bb0015","article-title":"Depression in childhood and adolescence","volume":"22","author":"B","year":"2013","journal-title":"J. Can. Acad. Child Adolesc. Psychiatry J. Acad. Can. Psychiatr. Enfant Adolesc."},{"key":"10.1016\/j.jad.2026.121884_bb0020","doi-asserted-by":"crossref","first-page":"8161","DOI":"10.1523\/JNEUROSCI.1554-07.2007","article-title":"The role of the dorsal striatum in reward and decision-making","volume":"27","author":"Balleine","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jad.2026.121884_bb0025","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.pscychresns.2006.07.002","article-title":"Dopaminergic function in depressed patients with affective flattening or with impulsivity: [18F]fluoro-L-dopa positron emission tomography study with voxel-based analysis","volume":"154","author":"Bragulat","year":"2007","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.jad.2026.121884_bb0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2022.147803","article-title":"Mapping frontostriatal white matter tracts and their association with reward-related ventral striatum activation in adolescence","volume":"1780","author":"Calabrese","year":"2022","journal-title":"Brain Res."},{"key":"10.1016\/j.jad.2026.121884_bb0035","article-title":"Transcranial direct current stimulation as an add-on treatment to cognitive-behavior therapy in first episode drug-na\u00efve major depression patients: the ESAP study protocol","volume":"11","author":"Carvalho","year":"2020","journal-title":"Front. Psych."},{"key":"10.1016\/j.jad.2026.121884_bb0040","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1196\/annals.1440.010","article-title":"The adolescent brain","volume":"1124","author":"Casey","year":"2008","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.jad.2026.121884_bb0045","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1177\/070674370505000612","article-title":"Ropinirole in treatment-resistant depression: a 16-week pilot study","volume":"50","author":"Cassano","year":"2005","journal-title":"Can. J. Psychiatry Rev. Can. Psychiatr."},{"key":"10.1016\/j.jad.2026.121884_bb0050","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.jad.2020.12.156","article-title":"The relationship between search for meaning in life and symptoms of depression and anxiety: key roles of the presence of meaning in life and life events among Chinese adolescents","volume":"282","author":"Chen","year":"2021","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2026.121884_bb0055","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.pscychresns.2014.01.003","article-title":"Antidepressant response to aripiprazole augmentation associated with enhanced FDOPA utilization in striatum: a preliminary PET study","volume":"221","author":"Conway","year":"2014","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.jad.2026.121884_bb0060","doi-asserted-by":"crossref","first-page":"634","DOI":"10.3389\/fpsyt.2018.00634","article-title":"Cerebellar contributions to major depression","volume":"9","author":"Depping","year":"2018","journal-title":"Front. Psych."},{"key":"10.1016\/j.jad.2026.121884_bb0065","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1192\/bjp.188.3.216","article-title":"Longitudinal investigation into childhood- and adolescence-onset depression: psychiatric outcome in early adulthood","volume":"188","author":"Dunn","year":"2006","journal-title":"Br. J. Psychiatry J. Ment. Sci."},{"key":"10.1016\/j.jad.2026.121884_bb0070","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1176\/ajp.156.8.1209","article-title":"High midbrain [18F]DOPA accumulation in children with attention deficit hyperactivity disorder","volume":"156","author":"Ernst","year":"1999","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jad.2026.121884_bb0075","doi-asserted-by":"crossref","first-page":"15200","DOI":"10.1073\/pnas.1911778117","article-title":"The ventral striatum dissociates information expectation, reward anticipation, and reward receipt","volume":"117","author":"Filimon","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jad.2026.121884_bb0080","doi-asserted-by":"crossref","first-page":"F8","DOI":"10.1111\/j.1467-7687.2006.00579.x","article-title":"Risk-taking and the adolescent brain: who is at risk?","volume":"10","author":"Galvan","year":"2007","journal-title":"Dev. Sci."},{"key":"10.1016\/j.jad.2026.121884_bb0085","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.nbd.2019.01.003","article-title":"Integrative analysis of blood metabolomics and PET brain neuroimaging data for Parkinson\u2019s disease","volume":"124","author":"Glaab","year":"2019","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.jad.2026.121884_bb0090","first-page":"23","article-title":"Elaboraci\u00f3n de una plantilla de SPM para la normalizaci\u00f3n de im\u00e1genes de PET con 18F-DOPA","volume":"9","author":"G\u00f3mez","year":"2018","journal-title":"Imagen Diagn\u00f3stica"},{"key":"10.1016\/j.jad.2026.121884_bb0095","series-title":"Neurobiology of Sensation and Reward","article-title":"Neuroanatomy of reward: A view from the ventral striatum","author":"Haber","year":"2011"},{"key":"10.1016\/j.jad.2026.121884_bb0100","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1037\/abn0000089","article-title":"Depression from childhood into late adolescence: influence of gender, development, genetic susceptibility, and peer stress","volume":"124","author":"Hankin","year":"2015","journal-title":"J. Abnorm. Psychol."},{"key":"10.1016\/j.jad.2026.121884_bb0105","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.jad.2022.12.057","article-title":"Anhedonia and dysregulation of an angular gyrus-centred and dynamic functional network in adolescent-onset depression","volume":"324","author":"Kang","year":"2023","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2026.121884_bb0110","doi-asserted-by":"crossref","first-page":"104","DOI":"10.3390\/brainsci9050104","article-title":"What role does the prefrontal cortex play in the processing of negative and positive stimuli in adolescent depression?","volume":"9","author":"Kaya","year":"2019","journal-title":"Brain Sci."},{"key":"10.1016\/j.jad.2026.121884_bb0115","doi-asserted-by":"crossref","first-page":"315","DOI":"10.31887\/DCNS.2013.15.3\/ekim","article-title":"Molecular imaging as a guide for the treatment of central nervous system disorders","volume":"15","author":"Kim","year":"2013","journal-title":"Dialogues Clin. Neurosci."},{"key":"10.1016\/j.jad.2026.121884_bb0120","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1186\/s40814-023-01423-x","article-title":"Transcranial direct current stimulation as treatment for major depression in a home treatment setting (HomeDC trial): study protocol and methodology of a double-blind, placebo-controlled pilot study","volume":"9","author":"Kumpf","year":"2023","journal-title":"Pilot Feasibility Stud."},{"key":"10.1016\/j.jad.2026.121884_bb0125","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1093\/scan\/nsp052","article-title":"Type I and type II error concerns in fMRI research: re-balancing the scale","volume":"4","author":"Lieberman","year":"2009","journal-title":"Soc. Cogn. Affect. Neurosci."},{"key":"10.1016\/j.jad.2026.121884_bb0130","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1176\/appi.ajp.158.2.314","article-title":"Decreased presynaptic dopamine function in the left caudate of depressed patients with affective flattening and psychomotor retardation","volume":"158","author":"Martinot","year":"2001","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jad.2026.121884_bb0135","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1016\/j.jaac.2010.05.017","article-title":"Lifetime prevalence of mental disorders in U.S. adolescents: results from the National Comorbidity Survey Replication--Adolescent Supplement (NCS-A)","volume":"49","author":"Merikangas","year":"2010","journal-title":"J. Am. Acad. Child Adolesc. Psychiatry"},{"key":"10.1016\/j.jad.2026.121884_bb0140","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1001\/jamapsychiatry.2016.0700","article-title":"Structural and functional brain abnormalities in attention-deficit\/hyperactivity disorder and obsessive-compulsive disorder: a comparative meta-analysis","volume":"73","author":"Norman","year":"2016","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.jad.2026.121884_bb0145","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1002\/cne.903580306","article-title":"Postnatal maturation of the dopaminergic innervation of monkey prefrontal and motor cortices: a tyrosine hydroxylase immunohistochemical analysis","volume":"358","author":"Rosenberg","year":"1995","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.jad.2026.121884_bb0150","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1471-2202-13-18","article-title":"Developmental changes in human dopamine neurotransmission: cortical receptors and terminators","volume":"13","author":"Rothmond","year":"2012","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.jad.2026.121884_bb0155","doi-asserted-by":"crossref","first-page":"7554","DOI":"10.1523\/JNEUROSCI.1451-23.2023","article-title":"Cognitive-affective functions of the cerebellum","volume":"43","author":"Rudolph","year":"2023","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jad.2026.121884_bb0160","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1192\/bjp.167.1.99","article-title":"A scale for the assessment of hedonic tone the Snaith-Hamilton Pleasure Scale","volume":"167","author":"Snaith","year":"1995","journal-title":"Br. J. Psychiatry J. Ment. Sci."},{"key":"10.1016\/j.jad.2026.121884_bb0165","first-page":"159","article-title":"A review of the neuropharmacology of bupropion, a dual norepinephrine and dopamine reuptake inhibitor","volume":"6","author":"Stahl","year":"2004","journal-title":"Prim. Care Companion J. Clin. Psychiatry"},{"key":"10.1016\/j.jad.2026.121884_bb0170","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.neuroimage.2008.08.039","article-title":"Functional topography in the human cerebellum: a meta-analysis of neuroimaging studies","volume":"44","author":"Stoodley","year":"2009","journal-title":"NeuroImage"},{"key":"10.1016\/j.jad.2026.121884_bb0175","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1016\/S0140-6736(11)60871-4","article-title":"Depression in adolescence","volume":"379","author":"Thapar","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.jad.2026.121884_bb0180","doi-asserted-by":"crossref","DOI":"10.1111\/psyp.14257","article-title":"Neural deficits in anticipatory and consummatory reward processing are uniquely associated with current depressive symptoms during adolescence","volume":"60","author":"Thompson","year":"2023","journal-title":"Psychophysiology"},{"key":"10.1016\/j.jad.2026.121884_bb0185","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s11307-018-1256-1","article-title":"Physiological whole-brain distribution of [18F]FDOPA uptake index in relation to age and gender: results from a voxel-based semi-quantitative analysis","volume":"21","author":"Toch","year":"2019","journal-title":"Mol. Imaging Biol."},{"key":"10.1016\/j.jad.2026.121884_bb0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.pnpbp.2021.110425","article-title":"Efficacy and safety of 24-week pramipexole augmentation in patients with treatment resistant depression. A retrospective cohort study","volume":"112","author":"Tundo","year":"2022","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.jad.2026.121884_bb0195","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1016\/j.clinph.2017.03.049","article-title":"Neural mechanisms of reward processing associated with depression-related personality traits","volume":"128","author":"Umemoto","year":"2017","journal-title":"Clin. Neurophysiol. Off. J. Int. Fed. Clin. Neurophysiol."},{"key":"10.1016\/j.jad.2026.121884_bb0200","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1016\/S0140-6736(12)61729-2","article-title":"Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010","volume":"380","author":"Vos","year":"2012","journal-title":"Lancet Lond. Engl."},{"key":"10.1016\/j.jad.2026.121884_bb0205","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1212\/WNL.0000000000001215","article-title":"Reduced striatal dopamine transmission in REM sleep behavior disorder comorbid with depression","volume":"84","author":"Wing","year":"2015","journal-title":"Neurology"},{"key":"10.1016\/j.jad.2026.121884_bb0210","doi-asserted-by":"crossref","first-page":"107","DOI":"10.3389\/fnins.2017.00107","article-title":"Activation and functional connectivity of the left inferior temporal gyrus during visual speech priming in healthy listeners and listeners with schizophrenia","volume":"11","author":"Wu","year":"2017","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.jad.2026.121884_bb0215","article-title":"Volumetric deficit within the fronto-limbic-striatal circuit in first-episode drug na\u00efve patients with major depression disorder","volume":"11","author":"Zhang","year":"2020","journal-title":"Front. Psych."}],"container-title":["Journal of Affective Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032726007366?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032726007366?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T19:04:41Z","timestamp":1783191881000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165032726007366"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":43,"alternative-id":["S0165032726007366"],"URL":"https:\/\/doi.org\/10.1016\/j.jad.2026.121884","relation":{},"ISSN":["0165-0327"],"issn-type":[{"value":"0165-0327","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Increased presynaptic dopamine activity in adolescent with major depressive disorder: an 18F-FDOPA PET study","name":"articletitle","label":"Article Title"},{"value":"Journal of Affective Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jad.2026.121884","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"121884"}}