{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T18:17:00Z","timestamp":1783189020161,"version":"3.54.6"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["111-2314-B-075-013"],"award-info":[{"award-number":["111-2314-B-075-013"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["NSTC113-2314-B-075-042"],"award-info":[{"award-number":["NSTC113-2314-B-075-042"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST111-2314-B-075-014-MY2"],"award-info":[{"award-number":["MOST111-2314-B-075-014-MY2"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["114-2628-B-A49-008-MY3"],"award-info":[{"award-number":["114-2628-B-A49-008-MY3"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC114-2314-B-075-022"],"award-info":[{"award-number":["NSTC114-2314-B-075-022"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC114-2314-B-075-023"],"award-info":[{"award-number":["NSTC114-2314-B-075-023"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011913","name":"Kaohsiung Veterans General Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011913","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010425","name":"Tri-Service General Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010425","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000779","name":"University of London","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000779","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006477","name":"National Taiwan University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006477","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100024990","name":"National Yang Ming Chiao Tung University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100024990","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005937","name":"Cheng Hsin General Hospital Foundation","doi-asserted-by":"publisher","award":["CY11402-1"],"award-info":[{"award-number":["CY11402-1"]}],"id":[{"id":"10.13039\/501100005937","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005937","name":"Cheng Hsin General Hospital Foundation","doi-asserted-by":"publisher","award":["CY11402-2"],"award-info":[{"award-number":["CY11402-2"]}],"id":[{"id":"10.13039\/501100005937","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007354","name":"Yen Tjing Ling Medical Foundation","doi-asserted-by":"publisher","award":["CI-113-32"],"award-info":[{"award-number":["CI-113-32"]}],"id":[{"id":"10.13039\/501100007354","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007354","name":"Yen Tjing Ling Medical Foundation","doi-asserted-by":"publisher","award":["CI-114-35"],"award-info":[{"award-number":["CI-114-35"]}],"id":[{"id":"10.13039\/501100007354","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007354","name":"Yen Tjing Ling Medical Foundation","doi-asserted-by":"publisher","award":["CI-113-30"],"award-info":[{"award-number":["CI-113-30"]}],"id":[{"id":"10.13039\/501100007354","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001869","name":"Academia Sinica","doi-asserted-by":"publisher","award":["VTA114-V1-4-1"],"award-info":[{"award-number":["VTA114-V1-4-1"]}],"id":[{"id":"10.13039\/501100001869","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001869","name":"Academia Sinica","doi-asserted-by":"publisher","award":["VTA112-V1-6-1"],"award-info":[{"award-number":["VTA112-V1-6-1"]}],"id":[{"id":"10.13039\/501100001869","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011912","name":"Taipei Veterans General Hospital","doi-asserted-by":"publisher","award":["V114C-217"],"award-info":[{"award-number":["V114C-217"]}],"id":[{"id":"10.13039\/501100011912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011912","name":"Taipei Veterans General Hospital","doi-asserted-by":"publisher","award":["V113C-010"],"award-info":[{"award-number":["V113C-010"]}],"id":[{"id":"10.13039\/501100011912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011912","name":"Taipei Veterans General Hospital","doi-asserted-by":"publisher","award":["V113C-039"],"award-info":[{"award-number":["V113C-039"]}],"id":[{"id":"10.13039\/501100011912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011912","name":"Taipei Veterans General Hospital","doi-asserted-by":"publisher","award":["V114C-064"],"award-info":[{"award-number":["V114C-064"]}],"id":[{"id":"10.13039\/501100011912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011912","name":"Taipei Veterans General Hospital","doi-asserted-by":"publisher","award":["V113C-011"],"award-info":[{"award-number":["V113C-011"]}],"id":[{"id":"10.13039\/501100011912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011912","name":"Taipei Veterans General Hospital","doi-asserted-by":"publisher","award":["V114C-089"],"award-info":[{"award-number":["V114C-089"]}],"id":[{"id":"10.13039\/501100011912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005792","name":"University System of Taiwan","doi-asserted-by":"publisher","award":["VGHUST112-G1-8-1"],"award-info":[{"award-number":["VGHUST112-G1-8-1"]}],"id":[{"id":"10.13039\/501100005792","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005792","name":"University System of Taiwan","doi-asserted-by":"publisher","award":["VGHUST114-G1-9-1"],"award-info":[{"award-number":["VGHUST114-G1-9-1"]}],"id":[{"id":"10.13039\/501100005792","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Affective Disorders"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.jad.2026.121906","type":"journal-article","created":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T06:22:13Z","timestamp":1777875733000},"page":"121906","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Treatment-resistant depression is associated with reduced brain entropy"],"prefix":"10.1016","volume":"409","author":[{"given":"Wei-Chen","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Kai","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tung-Ping","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Fen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei-Chi","family":"Tu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Ta","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Mei","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih-Jen","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mu-Hong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jad.2026.121906_bb0005","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.neuroimage.2007.07.007","article-title":"A fast diffeomorphic image registration algorithm","volume":"38","author":"Ashburner","year":"2007","journal-title":"NeuroImage"},{"key":"10.1016\/j.jad.2026.121906_bb0010","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.neuroimage.2005.02.018","article-title":"Unified segmentation","volume":"26","author":"Ashburner","year":"2005","journal-title":"NeuroImage"},{"key":"10.1016\/j.jad.2026.121906_bb0015","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.conb.2012.12.012","article-title":"Large-scale brain networks in affective and social neuroscience: towards an integrative functional architecture of the brain","volume":"23","author":"Barrett","year":"2013","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.jad.2026.121906_bb0020","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.tics.2010.04.004","article-title":"Large-scale brain networks in cognition: emerging methods and principles","volume":"14","author":"Bressler","year":"2010","journal-title":"Trends Cogn. Sci."},{"key":"10.1016\/j.jad.2026.121906_bb0025","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1038\/s44220-024-00325-y","article-title":"The neural connectome of suicidality in adults with mood and anxiety disorders","volume":"2","author":"Bryant","year":"2024","journal-title":"Nat. Ment. Health"},{"key":"10.1016\/j.jad.2026.121906_bb0030","doi-asserted-by":"crossref","first-page":"5331","DOI":"10.1002\/hbm.23737","article-title":"The impact of T1 versus EPI spatial normalization templates for fMRI data analyses","volume":"38","author":"Calhoun","year":"2017","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.jad.2026.121906_bb0035","doi-asserted-by":"crossref","DOI":"10.1002\/jnr.25310","article-title":"Task-induced changes in brain entropy","volume":"102","author":"Camargo","year":"2024","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.jad.2026.121906_bb0040","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1007\/s12311-021-01246-7","article-title":"Functional convergence of motor and social processes in lobule IV\/V of the mouse cerebellum","volume":"20","author":"Chao","year":"2021","journal-title":"Cerebellum"},{"key":"10.1016\/j.jad.2026.121906_bb0045","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1093\/ijnp\/pyaa056","article-title":"Functional dysconnectivity of frontal cortex to striatum predicts ketamine infusion response in treatment-resistant depression","volume":"23","author":"Chen","year":"2020","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.jad.2026.121906_bb0050","doi-asserted-by":"crossref","first-page":"177","DOI":"10.4088\/JCP.08m04309","article-title":"A multidimensional tool to quantify treatment resistance in depression: the Maudsley staging method","volume":"70","author":"Fekadu","year":"2009","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.jad.2026.121906_bb0055","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0259448","article-title":"EntropyHub: an open-source toolkit for entropic time series analysis","volume":"16","author":"Flood","year":"2021","journal-title":"PloS One"},{"key":"10.1016\/j.jad.2026.121906_bb0060","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1002\/mrm.1910350312","article-title":"Movement-related effects in fMRI time-series","volume":"35","author":"Friston","year":"1996","journal-title":"Magn. Reson. Med."},{"key":"10.1016\/j.jad.2026.121906_bb0065","doi-asserted-by":"crossref","DOI":"10.1093\/scan\/nsad044","article-title":"Relation of resting brain signal variability to cognitive and socioemotional measures in an adult lifespan sample","volume":"18","author":"Grady","year":"2023","journal-title":"Soc. Cogn. Affect. Neurosci."},{"key":"10.1016\/j.jad.2026.121906_bb0070","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.pnpbp.2013.01.010","article-title":"Abnormal resting-state cerebellar-cerebral functional connectivity in treatment-resistant depression and treatment sensitive depression","volume":"44","author":"Guo","year":"2013","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.jad.2026.121906_bb0075","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1016\/j.jpsychires.2012.07.003","article-title":"Abnormal neural activity of brain regions in treatment-resistant and treatment-sensitive major depressive disorder: a resting-state fMRI study","volume":"46","author":"Guo","year":"2012","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.jad.2026.121906_bb0080","doi-asserted-by":"crossref","DOI":"10.1093\/scan\/nsaf019","article-title":"Crus control: effective cerebello-cerebral connectivity during social action prediction using dynamic causal modelling","volume":"20","author":"Haihambo","year":"2025","journal-title":"Soc. Cogn. Affect. Neurosci."},{"key":"10.1016\/j.jad.2026.121906_bb0085","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1136\/jnnp.23.1.56","article-title":"A rating scale for depression","volume":"23","author":"Hamilton","year":"1960","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.jad.2026.121906_bb0090","first-page":"21","article-title":"Sequenced Treatment Alternatives to Relieve Depression (STAR*D). Part 2: study outcomes","volume":"46","author":"Howland","year":"2008","journal-title":"J. Psychosoc. Nurs. Ment. Health Serv."},{"key":"10.1016\/j.jad.2026.121906_bb0095","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.peptides.2013.10.002","article-title":"The median raphe nucleus participates in the depressive-like behavior induced by MCH: differences with the dorsal raphe nucleus","volume":"50","author":"Lopez Hill","year":"2013","journal-title":"Peptides"},{"key":"10.1016\/j.jad.2026.121906_bb0100","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.jad.2014.06.030","article-title":"Possible involvement of rumination in gray matter abnormalities in persistent symptoms of major depression: an exploratory magnetic resonance imaging voxel-based morphometry study","volume":"168","author":"Machino","year":"2014","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2026.121906_bb0105","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.0030442","article-title":"Projections of global mortality and burden of disease from 2002 to 2030","volume":"3","author":"Mathers","year":"2006","journal-title":"PLoS Med."},{"key":"10.1016\/j.jad.2026.121906_bb0110","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1002\/wps.21120","article-title":"Treatment-resistant depression: definition, prevalence, detection, management, and investigational interventions","volume":"22","author":"McIntyre","year":"2023","journal-title":"World Psychiatry"},{"key":"10.1016\/j.jad.2026.121906_bb0115","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.jad.2016.06.059","article-title":"Default mode network coherence in treatment-resistant major depressive disorder during electroconvulsive therapy","volume":"205","author":"Mulders","year":"2016","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2026.121906_bb0120","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/s41398-025-03406-3","article-title":"In vivo serotonin 1A receptor distribution in treatment-resistant depression","volume":"15","author":"Murgas","year":"2025","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.jad.2026.121906_bb0125","doi-asserted-by":"crossref","first-page":"700","DOI":"10.3389\/fnins.2020.00700","article-title":"Functional MRI signal complexity analysis using sample entropy","volume":"14","author":"Nezafati","year":"2020","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.jad.2026.121906_bb0130","series-title":"Handbook of Functional Connectivity Magnetic Resonance Imaging Methods in CONN2020","author":"Nieto-Castanon","year":"2020"},{"key":"10.1016\/j.jad.2026.121906_bb0135","doi-asserted-by":"crossref","DOI":"10.1002\/npr2.70015","article-title":"Functional diversity of serotonin neurons in the dorsal and median raphe nuclei in emotional responses","volume":"45","author":"Ohmura","year":"2025","journal-title":"Neuropsychopharmacol. Rep."},{"key":"10.1016\/j.jad.2026.121906_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.peptides.2019.170249","article-title":"Melanin-concentrating hormone (MCH) in the median raphe nucleus: fibers, receptors and cellular effects","volume":"126","author":"Pascovich","year":"2020","journal-title":"Peptides"},{"key":"10.1016\/j.jad.2026.121906_bb0145","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.neuroimage.2013.08.048","article-title":"Methods to detect, characterize, and remove motion artifact in resting state fMRI","volume":"84","author":"Power","year":"2014","journal-title":"NeuroImage"},{"key":"10.1016\/j.jad.2026.121906_bb0150","doi-asserted-by":"crossref","first-page":"H2039","DOI":"10.1152\/ajpheart.2000.278.6.H2039","article-title":"Physiological time-series analysis using approximate entropy and sample entropy","volume":"278","author":"Richman","year":"2000","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.jad.2026.121906_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroimage.2019.116189","article-title":"Automated anatomical labelling atlas 3","volume":"206","author":"Rolls","year":"2020","journal-title":"NeuroImage"},{"key":"10.1016\/j.jad.2026.121906_bb0160","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1177\/0269881120928203","article-title":"Brain entropy and neurotrophic molecular markers accompanying clinical improvement after ketamine: preliminary evidence in adolescents with treatment-resistant depression","volume":"35","author":"Roy","year":"2021","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.jad.2026.121906_bb0165","article-title":"Functional connectivity of the cerebellar vermis in bipolar disorder and associations with mood","volume":"14","author":"Saleem","year":"2023","journal-title":"Front. Psych."},{"key":"10.1016\/j.jad.2026.121906_bb0170","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0191582","article-title":"Brain entropy and human intelligence: a resting-state fMRI study","volume":"13","author":"Saxe","year":"2018","journal-title":"PloS One"},{"key":"10.1016\/j.jad.2026.121906_bb0175","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1177\/1073858412440596","article-title":"The angular gyrus: multiple functions and multiple subdivisions","volume":"19","author":"Seghier","year":"2013","journal-title":"Neuroscientist"},{"key":"10.1016\/j.jad.2026.121906_bb0180","doi-asserted-by":"crossref","first-page":"2482","DOI":"10.1038\/npp.2017.94","article-title":"Dose-related effects of adjunctive ketamine in Taiwanese patients with treatment-resistant depression","volume":"42","author":"Su","year":"2017","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.jad.2026.121906_bb0185","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/s41380-024-02640-3","article-title":"Thalamocortical functional connectivity and rapid antidepressant and antisuicidal effects of low-dose ketamine infusion among patients with treatment-resistant depression","volume":"30","author":"Tu","year":"2025","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jad.2026.121906_bb0190","article-title":"Brain entropy mapping using fMRI","volume":"9","author":"Wang","year":"2014","journal-title":"PloS One"},{"key":"10.1016\/j.jad.2026.121906_bb0195","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1089\/brain.2012.0073","article-title":"Conn: a functional connectivity toolbox for correlated and anticorrelated brain networks","volume":"2","author":"Whitfield-Gabrieli","year":"2012","journal-title":"Brain Connect."},{"key":"10.1016\/j.jad.2026.121906_bb0200","series-title":"Artifact Detection Tools (ART)","first-page":"11","volume":"7","author":"Whitfield-Gabrieli","year":"2011"},{"key":"10.1016\/j.jad.2026.121906_bb0205","doi-asserted-by":"crossref","first-page":"2629","DOI":"10.2147\/NDT.S220743","article-title":"Disrupted brain entropy and functional connectivity patterns of thalamic subregions in major depressive disorder","volume":"15","author":"Xue","year":"2019","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"10.1016\/j.jad.2026.121906_bb0210","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2018.00398","article-title":"A strategy to reduce bias of entropy estimates in resting-state fMRI signals","volume":"12","author":"Yang","year":"2018","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.jad.2026.121906_bb0215","doi-asserted-by":"crossref","DOI":"10.1111\/cns.14690","article-title":"Molecular basis underlying changes of brain entropy and functional connectivity in major depressive disorders after electroconvulsive therapy","volume":"30","author":"Yu","year":"2024","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.jad.2026.121906_bb0220","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/s41398-025-03518-w","article-title":"Subjective cognitive decline in major depressive patients is associated with altered entropy and connectivity changes of temporal and insular region","volume":"15","author":"Yulug","year":"2025","journal-title":"Transl. Psychiatry"}],"container-title":["Journal of Affective Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032726007585?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032726007585?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T17:32:50Z","timestamp":1783186370000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165032726007585"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":44,"alternative-id":["S0165032726007585"],"URL":"https:\/\/doi.org\/10.1016\/j.jad.2026.121906","relation":{},"ISSN":["0165-0327"],"issn-type":[{"value":"0165-0327","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Treatment-resistant depression is associated with reduced brain entropy","name":"articletitle","label":"Article Title"},{"value":"Journal of Affective Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jad.2026.121906","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"121906"}}