{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T15:38:58Z","timestamp":1789141138377,"version":"build-2803163510"},"reference-count":57,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82471567"],"award-info":[{"award-number":["82471567"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81801757"],"award-info":[{"award-number":["81801757"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023A1515010256"],"award-info":[{"award-number":["2023A1515010256"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2024A1515010279"],"award-info":[{"award-number":["2024A1515010279"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Affective Disorders"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.jad.2026.122035","type":"journal-article","created":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T06:54:00Z","timestamp":1779864840000},"page":"122035","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Neuroclearance dysfunction in autism with sleep disorder: MRI evidence and mediation by systemic iron deficiency"],"prefix":"10.1016","volume":"411","author":[{"given":"Bo-Ya","family":"Yin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Yin","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Yuan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Xuan","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang-Shuang","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng-Yun","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Shan","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Wen","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Lu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Ying","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Zhu","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruo-Mi","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jad.2026.122035_bb0005","doi-asserted-by":"crossref","DOI":"10.31083\/FBL46455","article-title":"Autism pathoetiology and pathophysiology: roles of STAT3 and NF-\u03baB dimer interactions in regulating the mitochondrial melatonergic pathway in placental, CNS, and systemic cells","volume":"31","author":"Anderson","year":"2026","journal-title":"Front. Biosci. Landmark"},{"key":"10.1016\/j.jad.2026.122035_bb0010","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1212\/WNL.0000000000003884","article-title":"Monophasic demyelination reduces brain growth in children","volume":"88","author":"Aubert-Broche","year":"2017","journal-title":"Neurology"},{"key":"10.1016\/j.jad.2026.122035_bb0015","doi-asserted-by":"crossref","DOI":"10.3390\/biom15020164","article-title":"Intracerebral hemorrhage-associated iron release leads to pericyte-dependent cerebral capillary function disruption","volume":"15","author":"Balk","year":"2025","journal-title":"Biomolecules"},{"key":"10.1016\/j.jad.2026.122035_bb0020","doi-asserted-by":"crossref","first-page":"1468S","DOI":"10.1093\/jn\/133.5.1468S","article-title":"Iron deficiency alters brain development and functioning","volume":"133","author":"Beard","year":"2003","journal-title":"J. Nutr."},{"key":"10.1016\/j.jad.2026.122035_bb0025","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1002\/mrm.23186","article-title":"Motion correction and registration of high b-value diffusion weighted images","volume":"67","author":"Ben-Amitay","year":"2012","journal-title":"Magn. Reson. Med."},{"key":"10.1016\/j.jad.2026.122035_bb0030","doi-asserted-by":"crossref","DOI":"10.5665\/sleep.4726","article-title":"Virchow-robin spaces: correlations with polysomnography-derived sleep parameters","author":"Berezuk","year":"2015","journal-title":"Sleep"},{"key":"10.1016\/j.jad.2026.122035_bb0035","doi-asserted-by":"crossref","first-page":"9710","DOI":"10.1007\/s12035-025-04809-5","article-title":"Melatonin interventions in autism spectrum disorder: sleep regulation, behavioral outcomes, and challenges across the lifespan","volume":"62","author":"Bj\u00f8rklund","year":"2025","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.jad.2026.122035_bb0040","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1001\/jamapediatrics.2014.210","article-title":"Costs of autism spectrum disorders in the United Kingdom and the United States","volume":"168","author":"Buescher","year":"2014","journal-title":"JAMA Pediatr."},{"key":"10.1016\/j.jad.2026.122035_bb0045","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/s10194-024-01825-z","article-title":"Abnormally glymphatic system functional in patients with migraine: a diffusion kurtosis imaging study","volume":"25","author":"Cao","year":"2024","journal-title":"J. Headache Pain"},{"key":"10.1016\/j.jad.2026.122035_bb0050","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.bbi.2025.04.005","article-title":"Association between peripheral inflammation and body mass index on white matter integrity and free water in bipolar II depression","volume":"128","author":"Cao","year":"2025","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.jad.2026.122035_bb0055","doi-asserted-by":"crossref","first-page":"2902","DOI":"10.1161\/STROKEAHA.115.009713","article-title":"Intracerebral hematoma contributes to hydrocephalus after intraventricular hemorrhage via aggravating iron accumulation","volume":"46","author":"Chen","year":"2015","journal-title":"Stroke"},{"key":"10.1016\/j.jad.2026.122035_bb0060","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1212\/WNL.0000000000206872","article-title":"Author response: prospective natural history study in 24 adult patients with LGMDR12 over 2 years of follow-up: quantitative MRI and clinical outcome measures","volume":"100","author":"De Wel","year":"2023","journal-title":"Neurology"},{"key":"10.1016\/j.jad.2026.122035_bb0065","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.pediatrneurol.2006.11.004","article-title":"Children with autism: effect of iron supplementation on sleep and ferritin","volume":"36","author":"Dosman","year":"2007","journal-title":"Pediatr. Neurol."},{"key":"10.1016\/j.jad.2026.122035_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.scib.2025.05.015","article-title":"The glymphatic system in psychiatric disorders: a new perspective","author":"Gao","year":"2025","journal-title":"Sci. Bull."},{"key":"10.1016\/j.jad.2026.122035_bb0075","doi-asserted-by":"crossref","DOI":"10.1093\/gigascience\/giae049","article-title":"CAT: a computational anatomy toolbox for the analysis of structural MRI data","volume":"13","author":"Gaser","year":"2024","journal-title":"GigaScience"},{"key":"10.1016\/j.jad.2026.122035_bb0080","doi-asserted-by":"crossref","first-page":"S43","DOI":"10.1111\/j.1753-4887.2011.00432.x","article-title":"Long-term brain and behavioral consequences of early iron deficiency","volume":"69","author":"Georgieff","year":"2011","journal-title":"Nutr. Rev."},{"key":"10.1016\/j.jad.2026.122035_bb0085","doi-asserted-by":"crossref","first-page":"321","DOI":"10.2174\/1871527319666200628015039","article-title":"Inflammation and mitochondrial dysfunction in autism spectrum disorder","volume":"19","author":"Gevezova","year":"2020","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"10.1016\/j.jad.2026.122035_bb0090","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.3390\/ijms22041637","article-title":"The effect of lead exposure on autism development","volume":"22","author":"Goel","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jad.2026.122035_bb0095","doi-asserted-by":"crossref","first-page":"2576","DOI":"10.1093\/brain\/awaa179","article-title":"Impaired glymphatic function and clearance of tau in an Alzheimer\u2019s disease model","volume":"143","author":"Harrison","year":"2020","journal-title":"Brain"},{"key":"10.1016\/j.jad.2026.122035_bb0100","unstructured":"Hauglund NL. Norepinephrine-mediated slow vasomotion drives glymphatic clearance during sleep n.d."},{"key":"10.1016\/j.jad.2026.122035_bb0105","series-title":"[Re]optimization of a Free Water Elimination Two-compartment Model for Diffusion Tensor Imaging","author":"Henriques","year":"2017"},{"key":"10.1016\/j.jad.2026.122035_bb0110","doi-asserted-by":"crossref","DOI":"10.3390\/jcm12051793","article-title":"The putative role of neuroinflammation in the interaction between traumatic brain injuries, sleep, pain and other neuropsychiatric outcomes: a state-of-the-art review","volume":"12","author":"Herrero Babiloni","year":"2023","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.jad.2026.122035_bb0115","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1016\/j.immuni.2025.02.026","article-title":"The transcription factor MEF2C restrains microglial overactivation by inhibiting kinase CDK2","volume":"58","author":"Hu","year":"2025","journal-title":"Immunity"},{"key":"10.1016\/j.jad.2026.122035_bb0120","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1002\/nbm.1518","article-title":"MRI quantification of non-Gaussian water diffusion by kurtosis analysis","volume":"23","author":"Jensen","year":"2010","journal-title":"NMR Biomed."},{"key":"10.1016\/j.jad.2026.122035_bb0125","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1002\/mrm.20508","article-title":"Diffusional kurtosis imaging: the quantification of non-gaussian water diffusion by means of magnetic resonance imaging","volume":"53","author":"Jensen","year":"2005","journal-title":"Magn. Reson. Med."},{"key":"10.1016\/j.jad.2026.122035_bb0130","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1016\/j.jnutbio.2014.07.003","article-title":"Iron and mechanisms of emotional behavior","volume":"25","author":"Kim","year":"2014","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.jad.2026.122035_bb0135","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.nic.2024.11.001","article-title":"Diffusion tensor imaging in neurofluids","volume":"35","author":"Levendovszky","year":"2025","journal-title":"Neuroimaging Clin. N. Am."},{"key":"10.1016\/j.jad.2026.122035_bb0140","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.jneumeth.2016.03.001","article-title":"The first step for neuroimaging data analysis: DICOM to NIfTI conversion","volume":"264","author":"Li","year":"2016","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.jad.2026.122035_bb0145","doi-asserted-by":"crossref","DOI":"10.1148\/radiol.250753","article-title":"Microstructural bias in the assessment of periventricular flow as revealed in postmortem brains","volume":"316","author":"Li","year":"2025","journal-title":"Radiology"},{"key":"10.1016\/j.jad.2026.122035_bb0150","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.70063","article-title":"Melatonin enhances aquaporin 4 and alpha-syntrophin interaction by inhibiting cyclin-dependent kinase 5 activity to preserve glymphatic function in neonatal hypoxic-ischemic encephalopathy","volume":"77","author":"Li","year":"2025","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.jad.2026.122035_bb0155","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s12987-025-00651-y","article-title":"Reactive astrocyte-derived exosomes enhance intracranial lymphatic drainage in mice after intracranial hemorrhage","volume":"22","author":"Li","year":"2025","journal-title":"Fluids Barriers CNS"},{"key":"10.1016\/j.jad.2026.122035_bb0160","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.5665\/sleep.5230","article-title":"Early blood lead levels and sleep disturbance in preadolescence","volume":"38","author":"Liu","year":"2015","journal-title":"Sleep"},{"key":"10.1016\/j.jad.2026.122035_bb0165","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/S0140-6736(18)31129-2","article-title":"Autism spectrum disorder","volume":"392","author":"Lord","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.jad.2026.122035_bb0170","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15585\/mmwr.ss7202a1","article-title":"Prevalence and characteristics of autism spectrum disorder among children aged 8 years \u2014 autism and developmental disabilities monitoring network, 11 sites, United States, 2020","volume":"72","author":"Maenner","year":"2023","journal-title":"MMWR Surveill. Summ."},{"key":"10.1016\/j.jad.2026.122035_bb0175","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyt.2014.00188","article-title":"Validating the Children\u2019s Sleep Habits Questionnaire against polysomnography and actigraphy in school-aged children","volume":"5","author":"Markovich","year":"2015","journal-title":"Front. Psychiatry"},{"key":"10.1016\/j.jad.2026.122035_bb0180","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1126\/science.abb8739","article-title":"Glymphatic failure as a final common pathway to dementia","volume":"370","author":"Nedergaard","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.jad.2026.122035_bb0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2022.120607","article-title":"Interactions between heavy metals and sleep duration among pre-and postmenopausal women: a current approach to molecular mechanisms involved","volume":"316","author":"Nguyen","year":"2023","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.jad.2026.122035_bb0190","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/sleep\/23.8.1d","article-title":"The Children\u2019s Sleep Habits Questionnaire (CSHQ): psychometric properties of a survey instrument for school-aged children","volume":"23","author":"Owens","year":"2000","journal-title":"Sleep"},{"key":"10.1016\/j.jad.2026.122035_bb0195","doi-asserted-by":"crossref","first-page":"2096","DOI":"10.1038\/s41598-017-02152-x","article-title":"Disruption of melatonin synthesis is associated with impaired 14-3-3 and miR-451 levels in patients with autism spectrum disorders","volume":"7","author":"Pagan","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jad.2026.122035_bb0200","article-title":"Melatonin regulates iron homeostasis by inducing hepcidin expression in hepatocytes","volume":"23","author":"Park","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jad.2026.122035_bb0205","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2018-0492","article-title":"Sleep problems in 2- to 5-year-olds with autism spectrum disorder and other developmental delays","volume":"143","author":"Reynolds","year":"2019","journal-title":"Pediatrics"},{"key":"10.1016\/j.jad.2026.122035_bb0210","doi-asserted-by":"crossref","first-page":"674","DOI":"10.3390\/antiox12030674","article-title":"Mitochondria need their sleep: redox, bioenergetics, and temperature regulation of circadian rhythms and the role of cysteine-mediated redox signaling, uncoupling proteins, and substrate cycles","volume":"12","author":"Richardson","year":"2023","journal-title":"Antioxidants"},{"key":"10.1016\/j.jad.2026.122035_bb0215","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.smrv.2009.02.003","article-title":"Sleep problems in autism spectrum disorders: prevalence, nature, & possible biopsychosocial aetiologies","volume":"13","author":"Richdale","year":"2009","journal-title":"Sleep Med. Rev."},{"key":"10.1016\/j.jad.2026.122035_bb0220","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1176\/appi.ajp.2020.20071119","article-title":"Variable emergence of autism spectrum disorder symptoms from childhood to early adulthood","volume":"178","author":"Riglin","year":"2021","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jad.2026.122035_bb0225","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s00234-023-03270-2","article-title":"Glymphatic imaging: a critical look at the DTI-ALPS index","volume":"66","author":"Ringstad","year":"2024","journal-title":"Neuroradiology"},{"key":"10.1016\/j.jad.2026.122035_bb0230","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s00415-025-13539-6","article-title":"Diagnostic utility of biomarkers in progressive supranuclear palsy: toward a biotyping framework","volume":"273","author":"Ryan","year":"2026","journal-title":"J. Neurol."},{"key":"10.1016\/j.jad.2026.122035_bb0235","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1515\/revneuro-2017-0015","article-title":"Status of essential elements in autism spectrum disorder: systematic review and meta-analysis","volume":"28","author":"Saghazadeh","year":"2017","journal-title":"Rev. Neurosci."},{"key":"10.1016\/j.jad.2026.122035_bb0240","doi-asserted-by":"crossref","first-page":"80","DOI":"10.3945\/ajcn.110.004416","article-title":"Maternal periconceptional folic acid intake and risk of autism spectrum disorders and developmental delay in the CHARGE (CHildhood autism risks from genetics and environment) case-control study","volume":"96","author":"Schmidt","year":"2012","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.jad.2026.122035_bb0245","doi-asserted-by":"crossref","DOI":"10.5414\/TEX01188","article-title":"Copper, zinc, calcium and magnesium profiles in subjects with autistic disorder according to their functioning level","author":"Sempr\u00fan-Hern\u00e1ndez","year":"2011","journal-title":"Trace Elem. Electrolytes"},{"key":"10.1016\/j.jad.2026.122035_bb0250","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1007\/s11604-017-0617-z","article-title":"Evaluation of glymphatic system activity with the diffusion MR technique: diffusion tensor image analysis along the perivascular space (DTI-ALPS) in Alzheimer\u2019s disease cases","volume":"35","author":"Taoka","year":"2017","journal-title":"Jpn. J. Radiol."},{"key":"10.1016\/j.jad.2026.122035_bb0255","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/s00431-025-06246-x","article-title":"Abnormal glymphatic system function in children with autism spectrum disorder: a diffusion kurtosis imaging study","volume":"184","author":"Tian","year":"2025","journal-title":"Eur. J. Pediatr."},{"key":"10.1016\/j.jad.2026.122035_bb0260","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2023.1238950","article-title":"Editorial: endocrine consequences of sleep disorders","volume":"14","author":"Uchima Koecklin","year":"2023","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.jad.2026.122035_bb0265","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-80372-8","article-title":"Tensor-valued diffusion MRI detects brain microstructural abnormalities in HIV infected individuals with cognitive impairment","volume":"14","author":"Uddin","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jad.2026.122035_bb0270","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1126\/science.1241224","article-title":"Sleep drives metabolite clearance from the adult brain","volume":"342","author":"Xie","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.jad.2026.122035_bb0275","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1038\/s41398-023-02614-z","article-title":"Melatonin alleviates depression-like behaviors and cognitive dysfunction in mice by regulating the circadian rhythm of AQP4 polarization","volume":"13","author":"Yao","year":"2023","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.jad.2026.122035_bb0280","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s12987-021-00264-1","article-title":"Increased extracellular fluid is associated with white matter fiber degeneration in CADASIL: in vivo evidence from diffusion magnetic resonance imaging","volume":"18","author":"Yu","year":"2021","journal-title":"Fluids Barriers CNS"},{"key":"10.1016\/j.jad.2026.122035_bb0285","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1002\/aur.2696","article-title":"Global prevalence of autism: a systematic review update","volume":"15","author":"Zeidan","year":"2022","journal-title":"Autism Res."}],"container-title":["Journal of Affective Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032726008876?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032726008876?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T02:18:15Z","timestamp":1783131495000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165032726008876"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":57,"alternative-id":["S0165032726008876"],"URL":"https:\/\/doi.org\/10.1016\/j.jad.2026.122035","relation":{},"ISSN":["0165-0327"],"issn-type":[{"value":"0165-0327","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neuroclearance dysfunction in autism with sleep disorder: MRI evidence and mediation by systemic iron deficiency","name":"articletitle","label":"Article Title"},{"value":"Journal of Affective Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jad.2026.122035","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"122035"}}