{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T21:02:31Z","timestamp":1784581351411,"version":"3.55.0"},"reference-count":85,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:00:00Z","timestamp":1781136000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013816","name":"Generalitat de Catalunya Departament d'Innovacio Universitats I Empresa","doi-asserted-by":"publisher","award":["2021SGR00706"],"award-info":[{"award-number":["2021SGR00706"]}],"id":[{"id":"10.13039\/501100013816","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008062","name":"Fundaci\u00f3n Alicia Koplowitz","doi-asserted-by":"publisher","award":["A.KOPLOWITZ21_07"],"award-info":[{"award-number":["A.KOPLOWITZ21_07"]}],"id":[{"id":"10.13039\/100008062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Carlos III Health Institute","doi-asserted-by":"publisher","award":["FI23\/00144"],"award-info":[{"award-number":["FI23\/00144"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Carlos III Health Institute","doi-asserted-by":"publisher","award":["PI22\/01245"],"award-info":[{"award-number":["PI22\/01245"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Carlos III Health Institute","doi-asserted-by":"publisher","award":["PI15\/00793"],"award-info":[{"award-number":["PI15\/00793"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Carlos III Health Institute","doi-asserted-by":"publisher","award":["PI15\/00723"],"award-info":[{"award-number":["PI15\/00723"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005774","name":"Universitat de Barcelona","doi-asserted-by":"publisher","award":["PI15\/00097"],"award-info":[{"award-number":["PI15\/00097"]}],"id":[{"id":"10.13039\/501100005774","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002809","name":"Generalitat de Catalunya","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100023561","name":"Government of Spain Ministry of Universities","doi-asserted-by":"publisher","award":["FPU21\/03927"],"award-info":[{"award-number":["FPU21\/03927"]}],"id":[{"id":"10.13039\/501100023561","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Affective Disorders"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.jad.2026.122108","type":"journal-article","created":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T15:47:30Z","timestamp":1780933650000},"page":"122108","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Allostatic load as a moderating factor between child maltreatment exposure and mental health challenges in children and adolescents: a study based on the EPI_Young_Stress Project"],"prefix":"10.1016","volume":"412","author":[{"given":"Laia","family":"Marques-Feixa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nerea","family":"Moreno-Gamazo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soledad","family":"Romero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaume","family":"March-Llanes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariadna","family":"Mas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Rapado-Castro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilario","family":"Blasco-Fontecilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I\u00f1aki","family":"Zorrilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Lu\u00eds","family":"Monteser\u00edn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Jos\u00e9","family":"Mu\u00f1oz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nerea","family":"San Mart\u00edn-Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lourdes","family":"Fa\u00f1an\u00e1s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Mart\u00edn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maite","family":"Ram\u00edrez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Mar\u00edn-Vila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Gadea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Jos\u00e9","family":"Lobato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eulalia","family":"Anglada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Santamarina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandra","family":"Aznar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"F\u00e0bregas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mireia","family":"Forner-Puntonet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena","family":"Palma-Gudiel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1gueda","family":"Castro-Quintas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.jad.2026.122108_bb0005","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1002\/wps.21078","article-title":"Candidate biomarkers in psychiatric disorders: state of the field","volume":"22","author":"Abi-Dargham","year":"2023","journal-title":"World Psychiatry"},{"issue":"3","key":"10.1016\/j.jad.2026.122108_bb0010","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1007\/s00406-005-0624-4","article-title":"The enduring effects of abuse and related adverse experiences in childhood. A convergence of evidence from neurobiology and epidemiology","volume":"256","author":"Anda","year":"2006","journal-title":"Eur. Arch. Psychiatry Clin. Neurosci."},{"key":"10.1016\/j.jad.2026.122108_bb0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.neubiorev.2022.104590","article-title":"Stress and its sequelae: an active inference account of the etiological pathway from allostatic overload to depression","volume":"135","author":"Arnaldo","year":"2022","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"4","key":"10.1016\/j.jad.2026.122108_bb0020","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1007\/s00127-021-02189-4","article-title":"Structure and trends of externalizing and internalizing psychiatric symptoms and gender differences among adolescents in the US from 1991 to 2018","volume":"57","author":"Askari","year":"2022","journal-title":"Soc. Psychiatry Psychiatr. Epidemiol."},{"issue":"1","key":"10.1016\/j.jad.2026.122108_bb0025","doi-asserted-by":"crossref","DOI":"10.1186\/s12887-015-0366-z","article-title":"Waist circumference, waist-to-hip ratio and waist-to-height ratio reference percentiles for abdominal obesity among Greek adolescents","volume":"15","author":"Bacopoulou","year":"2015","journal-title":"BMC Pediatr."},{"issue":"2","key":"10.1016\/j.jad.2026.122108_bb0030","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1176\/appi.ajp.20220174","article-title":"Childhood maltreatment and mental health problems: a systematic review and meta-analysis of quasi-experimental studies","volume":"180","author":"Baldwin","year":"2023","journal-title":"Am. J. Psychiatry"},{"issue":"8","key":"10.1016\/j.jad.2026.122108_bb0035","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1001\/jamapsychiatry.2024.0818","article-title":"Prospective and retrospective measures of child maltreatment and their association with psychopathology","volume":"81","author":"Baldwin","year":"2024","journal-title":"JAMA Psychiatry"},{"issue":"24","key":"10.1016\/j.jad.2026.122108_bb0040","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph192417006","article-title":"Allostatic load measurement: a systematic review of reviews, database inventory, and considerations for neighborhood research","volume":"19","author":"Beese","year":"2022","journal-title":"Int. J. Environ. Res. Public Health"},{"issue":"2","key":"10.1016\/j.jad.2026.122108_bb0045","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0145-2134(02)00541-0","article-title":"Development and validation of a brief screening version of the Childhood Trauma Questionnaire","volume":"27","author":"Bernstein","year":"2003","journal-title":"Child Abuse Negl."},{"issue":"4","key":"10.1016\/j.jad.2026.122108_bb0050","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1097\/00006842-199707000-00012","article-title":"Attenuated free cortisol response to psychosocial stress in children with atopic dermatitis","volume":"59","author":"Buske-Kirschbaum","year":"1997","journal-title":"Psychosom. Med."},{"key":"10.1016\/j.jad.2026.122108_bb0055","series-title":"Instrumento para la valoraci\u00f3n de la gravedad de las situaciones de desprotecci\u00f3n infantil (Tool for assessing the severity of situations in which children are vulnerable- TASSCV)","author":"CARM","year":"2012"},{"key":"10.1016\/j.jad.2026.122108_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.yfrne.2023.101083","article-title":"Salivary secretory immunoglobulin A as a potential biomarker of psychosocial stress response during the first stages of life: a systematic review","volume":"71","author":"Castro-Quintas","year":"2023","journal-title":"Front. Neuroendocrinol."},{"issue":"4","key":"10.1016\/j.jad.2026.122108_bb0065","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1017\/S0954579401004035","article-title":"The impact of child maltreatment and psychopathology on neuroendocrine functioning","volume":"13","author":"Cicchetti","year":"2001","journal-title":"Dev. Psychopathol."},{"issue":"2","key":"10.1016\/j.jad.2026.122108_bb0070","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1017\/S0954579415000152","article-title":"Child maltreatment, inflammation, and internalizing symptoms: investigating the roles of C-reactive protein, gene variation, and neuroendocrine regulation","volume":"27","author":"Cicchetti","year":"2015","journal-title":"Dev. Psychopathol."},{"issue":"1","key":"10.1016\/j.jad.2026.122108_bb0075","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/npp.2016.198","article-title":"Psychoneuroimmunology of early-life stress: the hidden wounds of childhood trauma?","volume":"42","author":"Danese","year":"2016","journal-title":"Neuropsychopharmacology"},{"issue":"1","key":"10.1016\/j.jad.2026.122108_bb0080","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.physbeh.2011.08.019","article-title":"Adverse childhood experiences, allostatic load, and age-related disease","volume":"106","author":"Danese","year":"2012","journal-title":"Physiol. Behav."},{"issue":"5","key":"10.1016\/j.jad.2026.122108_bb0085","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1038\/mp.2013.54","article-title":"Childhood maltreatment and obesity: systematic review and meta-analysis","volume":"19","author":"Danese","year":"2014","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jad.2026.122108_bb0090","first-page":"28","article-title":"Construct validity and parent-child agreement of the six new or modified disorders included in the Spanish version of the Kiddie Schedule for Affective Disorders and Schizophrenia present and Lifetime Version DSM-5 (K-SADS-PL-5)","volume":"101","author":"de la Pe\u00f1a","year":"2018"},{"issue":"8","key":"10.1016\/j.jad.2026.122108_bb0095","doi-asserted-by":"crossref","first-page":"4549","DOI":"10.1210\/jc.2005-0069","article-title":"Defining the proinflammatory phenotype using high sensitive C-reactive protein levels as the biomarker","volume":"90","author":"Devaraj","year":"2005","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"3","key":"10.1016\/j.jad.2026.122108_bb0100","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1111\/cdev.12346","article-title":"Children\u2019s emotionality moderates the association between maternal responsiveness and allostatic load: investigation into differential susceptibility","volume":"86","author":"Dich","year":"2015","journal-title":"Child Dev."},{"issue":"11","key":"10.1016\/j.jad.2026.122108_bb0105","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1037\/a0034790","article-title":"Childhood cumulative risk and later allostatic load: mediating role of substance use","volume":"33","author":"Doan","year":"2014","journal-title":"Health Psychol."},{"issue":"1","key":"10.1016\/j.jad.2026.122108_bb0110","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-49461-x","article-title":"Externalizing behaviors buffer the effects of early life adversity on physiologic dysregulation","volume":"9","author":"Doan","year":"2019","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.jad.2026.122108_bb0115","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1097\/HRP.0000000000000014","article-title":"Childhood maltreatment, emotional dysregulation, and psychiatric comorbidities","volume":"22","author":"Dvir","year":"2014","journal-title":"Harv. Rev. Psychiatry"},{"issue":"5","key":"10.1016\/j.jad.2026.122108_bb0120","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1037\/0012-1649.39.5.924","article-title":"A multimethodological analysis of cumulative risk and allostatic load among rural children","volume":"39","author":"Evans","year":"2003","journal-title":"Dev. Psychol."},{"issue":"9","key":"10.1016\/j.jad.2026.122108_bb0125","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1177\/0956797612441218","article-title":"Childhood poverty and young adults\u2019 allostatic load: the mediating role of childhood cumulative risk exposure","volume":"23","author":"Evans","year":"2012","journal-title":"Psychol. Sci."},{"issue":"3","key":"10.1016\/j.jad.2026.122108_bb0130","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1007\/s40746-021-00226-7","article-title":"Metabolic syndrome in children and adolescents: looking to new markers","volume":"7","author":"Fazeli","year":"2021","journal-title":"Curr. Treat. Options Pediatr."},{"key":"10.1016\/j.jad.2026.122108_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.neubiorev.2022.104605","article-title":"Adverse childhood experiences and allostatic load: a systematic review","volume":"136","author":"Finlay","year":"2022","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"2","key":"10.1016\/j.jad.2026.122108_bb0140","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1097\/PSY.0000000000000147","article-title":"Early life adversity and adult biological risk profiles","volume":"77","author":"Friedman","year":"2015","journal-title":"Psychosom. Med."},{"issue":"2","key":"10.1016\/j.jad.2026.122108_bb0145","first-page":"153","article-title":"An update on promising biomarkers in schizophrenia","volume":"16","author":"Goldsmith","year":"2018","journal-title":"Focus Am. Psychiatr. Publ."},{"issue":"9","key":"10.1016\/j.jad.2026.122108_bb0150","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1037\/amp0000893","article-title":"Forty years of research on stress and development: what have we learned and future directions","volume":"76","author":"Gunnar","year":"2021","journal-title":"Am. Psychol."},{"issue":"7","key":"10.1016\/j.jad.2026.122108_bb0155","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1017\/S0033291716003585","article-title":"Altered fear processing in adolescents with a history of severe childhood maltreatment: an fMRI study","volume":"48","author":"Hart","year":"2018","journal-title":"Psychol. Med."},{"issue":"47","key":"10.1016\/j.jad.2026.122108_bb0160","doi-asserted-by":"crossref","first-page":"19119","DOI":"10.1073\/pnas.1310766110","article-title":"Childhood maltreatment is associated with altered fear circuitry and increased internalizing symptoms by late adolescence","volume":"110","author":"Herringa","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jad.2026.122108_bb0165","series-title":"Four Factor Index of Social Status","author":"Hollingshead","year":"1975"},{"issue":"4","key":"10.1016\/j.jad.2026.122108_bb0170","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1177\/1077559515597063","article-title":"From childhood maltreatment to allostatic load in adulthood: the role of social support","volume":"20","author":"Horan","year":"2015","journal-title":"Child Maltreat."},{"issue":"1","key":"10.1016\/j.jad.2026.122108_bb0190","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/npp.2014.165","article-title":"Deviations from the expectable environment in early childhood and emerging psychopathology","volume":"40","author":"Humphreys","year":"2015","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.jad.2026.122108_bb0195","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1146\/annurev-clinpsy-032816-045005","article-title":"Child maltreatment and risk for psychopathology in childhood and adulthood","volume":"13","author":"Jaffee","year":"2017","journal-title":"Annu. Rev. Clin. Psychol."},{"issue":"1","key":"10.1016\/j.jad.2026.122108_bb0200","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.neubiorev.2009.10.002","article-title":"Allostatic load biomarkers of chronic stress and impact on health and cognition","volume":"35","author":"Juster","year":"2010","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"4","key":"10.1016\/j.jad.2026.122108_bb0205","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1024\/1422-4917\/a000115","article-title":"Childhood Experiences of Care and Abuse (CECA) - Validierung der deutschen version von fragebogen und korrespondierendem interview sowie ergebnisse einer untersuchung von zusammenh\u00e4ngen belastender kindheitserlebnissemit suizidalen verhaltensweisen","volume":"39","author":"Kaess","year":"2011","journal-title":"Z. Kinder Jugendpsychiatr. Psychother."},{"issue":"1","key":"10.1016\/j.jad.2026.122108_bb0210","first-page":"79","article-title":"Somatization in children and adolescents: practical implications","volume":"12","author":"Karkhanis","year":"2016","journal-title":"J. Indian Assoc. Child Adolesc. Ment. Health"},{"issue":"1","key":"10.1016\/j.jad.2026.122108_bb0215","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13034-021-00434-x","article-title":"The mediating role of internalizing and externalizing symptoms in the relationship between childhood trauma and suicidality among adolescents: a structural equation model","volume":"15","author":"Kim","year":"2021","journal-title":"Child Adolesc. Psychiatry Ment. Health"},{"issue":"4","key":"10.1016\/j.jad.2026.122108_bb0220","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1111\/jcpp.12784","article-title":"Annual research review: early adversity, the hypothalamic-pituitary-adrenocortical axis, and child psychopathology","volume":"59","author":"Koss","year":"2018","journal-title":"J. Child Psychol. Psychiatry"},{"issue":"4","key":"10.1016\/j.jad.2026.122108_bb0225","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1037\/abn0000258","article-title":"The Hierarchical Taxonomy of Psychopathology (HiTOP): a dimensional alternative to traditional nosologies","volume":"126","author":"Kotov","year":"2017","journal-title":"J. Abnorm. Psychol."},{"key":"10.1016\/j.jad.2026.122108_bb0230","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1146\/annurev.clinpsy.2.022305.095213","article-title":"Reinterpreting comorbidity: a model-based approach to understanding and classifying psychopathology","volume":"2","author":"Krueger","year":"2006","journal-title":"Annu. Rev. Clin. Psychol."},{"issue":"3","key":"10.1016\/j.jad.2026.122108_bb0235","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2018-024079","article-title":"Childhood maltreatment and biomarkers for cardiometabolic disease in mid-adulthood in a prospective British birth cohort: associations and potential explanations","volume":"9","author":"Li","year":"2019","journal-title":"BMJ Open"},{"issue":"5","key":"10.1016\/j.jad.2026.122108_bb0240","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1159\/000533424","article-title":"Allostatic load in children and adolescents: a systematic review","volume":"92","author":"Lucente","year":"2023","journal-title":"Psychother. Psychosom."},{"issue":"3","key":"10.1016\/j.jad.2026.122108_bb0245","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1002\/wps.21122","article-title":"Adverse childhood experiences: a meta-analysis of prevalence and moderators among half a million adults in 206 studies","volume":"22","author":"Madigan","year":"2023","journal-title":"World Psychiatry"},{"key":"10.1016\/j.jad.2026.122108_bb0250","doi-asserted-by":"crossref","first-page":"5293","DOI":"10.3390\/jcm10225293","article-title":"Risk of suicidal behavior in children and adolescents exposed to maltreatment: the mediating role of borderline personality traits and recent stressful life events","volume":"10","author":"Marques-Feixa","year":"2021","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.jad.2026.122108_bb0255","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.bbi.2022.04.010","article-title":"Secretory immunoglobulin A (s-IgA) reactivity to acute psychosocial stress in children and adolescents: the influence of pubertal development and history of maltreatment","volume":"103","author":"Marques-Feixa","year":"2022","journal-title":"Brain Behav. Immun."},{"issue":"3","key":"10.1016\/j.jad.2026.122108_bb0260","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1017\/S003329172100249X","article-title":"Childhood maltreatment disrupts HPA-axis activity under basal and stress conditions in a dose\u2013response relationship in children and adolescents","volume":"53","author":"Marques-Feixa","year":"2023","journal-title":"Psychol. Med."},{"key":"10.1016\/j.jad.2026.122108_bb0265","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.jad.2023.03.088","article-title":"Complex post-traumatic stress disorder (CPTSD) of ICD-11 in youths with childhood maltreatment: associations with age of exposure and clinical outcomes","volume":"332","author":"Marques-Feixa","year":"2023","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2026.122108_bb0270","series-title":"Medical Devices and Systems","first-page":"66-1","article-title":"Blood glucose monitoring","author":"Mathew","year":"2023"},{"issue":"10","key":"10.1016\/j.jad.2026.122108_bb0275","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1111\/j.1469-7610.2010.02271.x","article-title":"Research review: the neurobiology and genetics of maltreatment and adversity","volume":"51","author":"McCrory","year":"2010","journal-title":"J. Child Psychol. Psychiatry Allied Discip."},{"issue":"18","key":"10.1016\/j.jad.2026.122108_bb0280","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1001\/archinte.1993.00410180039004","article-title":"Stress and the individual: mechanisms leading to disease","volume":"153","author":"McEwen","year":"1993","journal-title":"Arch. Intern. Med."},{"key":"10.1016\/j.jad.2026.122108_bb0285","author":"Medline"},{"key":"10.1016\/j.jad.2026.122108_bb0290","author":"Medline"},{"key":"10.1016\/j.jad.2026.122108_bb0295","series-title":"StatPearls","first-page":"237","article-title":"C reactive protein","volume":"vol. 65(5)","author":"Nehring","year":"2023"},{"issue":"8","key":"10.1016\/j.jad.2026.122108_bb0300","doi-asserted-by":"crossref","DOI":"10.3390\/children8080709","article-title":"Biomarkers of allostatic load as correlates of impairment in youth with chronic pain: an initial investigation","volume":"8","author":"Nelson","year":"2021","journal-title":"Children"},{"issue":"1","key":"10.1016\/j.jad.2026.122108_bb0305","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1146\/annurev-clinpsy-081219-112621","article-title":"Child sexual abuse as a unique risk factor for the development of psychopathology: the compounded convergence of mechanisms","volume":"17","author":"Noll","year":"2021","journal-title":"Annu. Rev. Clin. Psychol."},{"issue":"16","key":"10.1016\/j.jad.2026.122108_bb0310","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2304704121","article-title":"Childhood maltreatment influences adult brain structure through its effects on immune, metabolic, and psychosocial factors","volume":"121","author":"Orellana","year":"2024","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jad.2026.122108_bb0315","doi-asserted-by":"crossref","DOI":"10.1016\/j.psyneuen.2021.105130","article-title":"Depressive symptoms, childhood maltreatment, and allostatic load: the importance of sex differences","volume":"126","author":"O\u2019Shields","year":"2021","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.jad.2026.122108_bb0320","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.pneurobio.2017.05.004","article-title":"Uncertainty and stress: why it causes diseases and how it is mastered by the brain","volume":"156","author":"Peters","year":"2017","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.jad.2026.122108_bb0325","doi-asserted-by":"crossref","DOI":"10.1016\/j.psyneuen.2020.104645","article-title":"A history of childhood trauma and allostatic load in patients with psychotic disorders with respect to stress coping strategies","volume":"115","author":"Piotrowski","year":"2020","journal-title":"Psychoneuroendocrinology"},{"issue":"9","key":"10.1016\/j.jad.2026.122108_bb0330","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph18094865","article-title":"Coping and post-traumatic stress in children and adolescents after an acute onset disaster: a systematic review","volume":"18","author":"Powell","year":"2021","journal-title":"Int. J. Environ. Res. Public Health"},{"issue":"7","key":"10.1016\/j.jad.2026.122108_bb0335","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1016\/S0306-4530(02)00108-7","article-title":"Two formulas for computation of the area under the curve represent measures of total hormone concentration versus time-dependent change","volume":"28","author":"Pruessner","year":"2003","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.jad.2026.122108_bb0340","doi-asserted-by":"crossref","DOI":"10.1016\/j.brat.2019.103501","article-title":"Adolescent development and risk for the onset of social-emotional disorders: a review and conceptual model","volume":"123","author":"Rapee","year":"2019","journal-title":"Behav. Res. Ther."},{"key":"10.1016\/j.jad.2026.122108_bb0345","doi-asserted-by":"crossref","DOI":"10.1016\/j.chiabu.2023.106131","article-title":"The stronger and the weaker sex - gender differences in the perception of individuals who experienced physical and sexual violence in childhood. A scoping review","volume":"140","author":"Rechenberg","year":"2023","journal-title":"Child Abuse Negl."},{"issue":"1","key":"10.1016\/j.jad.2026.122108_bb0350","doi-asserted-by":"crossref","DOI":"10.1186\/s12889-018-5177-3","article-title":"Is waist-to-height ratio the best predictive indicator of hypertension incidence? A cohort study","volume":"18","author":"Rezende","year":"2018","journal-title":"BMC Public Health"},{"issue":"Suppl. 1","key":"10.1016\/j.jad.2026.122108_bb0355","first-page":"3","article-title":"Allostatic load: importance, markers, and score determination in minority and disparity populations","volume":"96","author":"Rodriquez","year":"2019","journal-title":"J. Urban Health. Bull. New York Acad. Med."},{"issue":"4","key":"10.1016\/j.jad.2026.122108_bb0360","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1017\/S0954579411000587","article-title":"Child maltreatment and allostatic load: consequences for physical and mental health in children from low-income families","volume":"23","author":"Rogosch","year":"2011","journal-title":"Dev. Psychopathol."},{"key":"10.1016\/j.jad.2026.122108_bb0365","doi-asserted-by":"crossref","DOI":"10.1016\/j.chiabu.2021.105215","article-title":"Child maltreatment and the development of psychopathology: the role of developmental timing and chronicity","volume":"120","author":"Russotti","year":"2021","journal-title":"Child Abuse Negl."},{"key":"10.1016\/j.jad.2026.122108_bb0370","doi-asserted-by":"crossref","DOI":"10.3389\/fpubh.2024.1261133","article-title":"Associations between social network addiction, anxiety symptoms, and risk of metabolic syndrome in Peruvian adolescents\u2014a cross-sectional study","volume":"12","author":"Saintila","year":"2024","journal-title":"Front. Public Health"},{"issue":"3","key":"10.1016\/j.jad.2026.122108_bb0375","first-page":"447","article-title":"El cuestionario CBCL de Achenbach: Adaptaci\u00f3n espa\u00f1ola y aplicaciones cl\u00ednico-epidemiol\u00f3gicas","volume":"8","author":"Sardinero Garc\u00eda","year":"1997"},{"key":"10.1016\/j.jad.2026.122108_bb0380","doi-asserted-by":"crossref","DOI":"10.1016\/j.yfrne.2022.100987","article-title":"Child maltreatment and hypothalamic-pituitary-adrenal axis functioning: a systematic review and meta-analysis","volume":"66","author":"Sch\u00e4r","year":"2022","journal-title":"Front. Neuroendocrinol."},{"key":"10.1016\/j.jad.2026.122108_bb0385","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.psyneuen.2018.04.020","article-title":"Childhood abuse and depression in adulthood: the mediating role of allostatic load","volume":"94","author":"Scheuer","year":"2018","journal-title":"Psychoneuroendocrinology"},{"issue":"19","key":"10.1016\/j.jad.2026.122108_bb0390","doi-asserted-by":"crossref","first-page":"2259","DOI":"10.1001\/archinte.1997.00440400111013","article-title":"Price of adaptation\u2014allostatic load and its health consequences: MacArthur studies of successful aging","volume":"157","author":"Seeman","year":"1997","journal-title":"Arch. Intern. Med."},{"issue":"8","key":"10.1016\/j.jad.2026.122108_bb0395","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1007\/s10802-019-00515-8","article-title":"Protective factors buffer life stress and behavioral health outcomes among high-risk youth","volume":"47","author":"Sharma","year":"2019","journal-title":"J. Abnorm. Child Psychol."},{"issue":"2","key":"10.1016\/j.jad.2026.122108_bb0400","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.genhosppsych.2013.10.004","article-title":"The association between childhood trauma and lipid levels in an adult low income, minority population","volume":"36","author":"Spann","year":"2014","journal-title":"Gen. Hosp. Psychiatry"},{"key":"10.1016\/j.jad.2026.122108_bb0405","doi-asserted-by":"crossref","DOI":"10.1016\/j.psychres.2020.113398","article-title":"Childhood maltreatment and adult mental disorders \u2013 the prevalence of different types of maltreatment and associations with age of onset and severity of symptoms","volume":"293","author":"Struck","year":"2020","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.jad.2026.122108_bb0410","article-title":"The relationship between emotion dysregulation and suicide ideation and behaviour: a systematic review","volume":"5","author":"Turton","year":"2021","journal-title":"J. Affect. Disord. Rep."},{"key":"10.1016\/j.jad.2026.122108_bb0415","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.socscimed.2014.07.019","article-title":"Is self-rated health a stable and predictive factor for allostatic load in early adulthood? Findings from the Nord Tr\u00f8ndelag Health Study (HUNT)","volume":"117","author":"Vie","year":"2014","journal-title":"Soc. Sci. Med."},{"issue":"1","key":"10.1016\/j.jad.2026.122108_bb0420","doi-asserted-by":"crossref","DOI":"10.1080\/20008198.2019.1710400","article-title":"Complex post-traumatic stress symptoms in female adolescents: the role of emotion dysregulation in impairment and trauma exposure after an acute sexual assault","volume":"11","author":"Villalta","year":"2020","journal-title":"Eur. J. Psychotraumatol."},{"key":"10.1016\/j.jad.2026.122108_bb0425","doi-asserted-by":"crossref","DOI":"10.1016\/j.childyouth.2020.105305","article-title":"Childhood abuse and internalizing symptoms: exploring mediating & moderating role of attachment, competency, and self-regulation","volume":"117","author":"Watters","year":"2020","journal-title":"Child Youth Serv. Rev."},{"key":"10.1016\/j.jad.2026.122108_bb0430","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1186\/s12888-015-0512-z","article-title":"Analyzing pathways from childhood maltreatment to internalizing symptoms and disorders in children and adolescents (AMIS): a study protocol","volume":"15","author":"White","year":"2015","journal-title":"BMC Psychiatry"},{"issue":"1","key":"10.1016\/j.jad.2026.122108_bb0435","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.jaac.2019.04.006","article-title":"Internalizing and externalizing symptoms are associated with different trajectories of cortical development during late childhood","volume":"59","author":"Whittle","year":"2020","journal-title":"J. Am. Acad. Child Adolesc. Psychiatry"},{"key":"10.1016\/j.jad.2026.122108_bb0440","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.chiabu.2015.01.016","article-title":"Childhood maltreatment predicts allostatic load in adulthood","volume":"47","author":"Widom","year":"2015","journal-title":"Child Abuse Negl."}],"container-title":["Journal of Affective Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032726009602?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032726009602?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T20:12:58Z","timestamp":1784578378000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165032726009602"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":85,"alternative-id":["S0165032726009602"],"URL":"https:\/\/doi.org\/10.1016\/j.jad.2026.122108","relation":{},"ISSN":["0165-0327"],"issn-type":[{"value":"0165-0327","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Allostatic load as a moderating factor between child maltreatment exposure and mental health challenges in children and adolescents: a study based on the EPI_Young_Stress Project","name":"articletitle","label":"Article Title"},{"value":"Journal of Affective Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jad.2026.122108","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"122108"}}