{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T21:02:04Z","timestamp":1784581324706,"version":"3.55.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100009898","name":"Beckett-Fonden","doi-asserted-by":"publisher","award":["48282"],"award-info":[{"award-number":["48282"]}],"id":[{"id":"10.13039\/501100009898","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006197","name":"Fonden til L\u00e6gevidenskabens Fremme","doi-asserted-by":"publisher","award":["15-55"],"award-info":[{"award-number":["15-55"]}],"id":[{"id":"10.13039\/501100006197","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003554","name":"Lundbeck Foundation","doi-asserted-by":"publisher","award":["R464-2024-122"],"award-info":[{"award-number":["R464-2024-122"]}],"id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003554","name":"Lundbeck Foundation","doi-asserted-by":"publisher","award":["R403-2022-1519"],"award-info":[{"award-number":["R403-2022-1519"]}],"id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020584","name":"Region Hovedstadens Psykiatri","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020584","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008392","name":"Sundhed og Sygdom, Det Frie Forskningsr\u00e5d","doi-asserted-by":"publisher","award":["DFF-4183-00570"],"award-info":[{"award-number":["DFF-4183-00570"]}],"id":[{"id":"10.13039\/100008392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005275","name":"Region Hovedstaden","doi-asserted-by":"publisher","award":["164019"],"award-info":[{"award-number":["164019"]}],"id":[{"id":"10.13039\/501100005275","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Affective Disorders"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.jad.2026.122142","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T15:45:10Z","timestamp":1781883910000},"page":"122142","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Lifetime comorbid substance misuse in patients newly diagnosed with bipolar disorder"],"prefix":"10.1016","volume":"412","author":[{"given":"S.","family":"Stanislaus","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.F.","family":"Thirstrup","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.L.","family":"Kj\u00e6rstad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.S.O.","family":"Sletved","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Faurholt-Jepsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Munkholm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.W.","family":"Miskowiak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Vinberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Coello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.V.","family":"Kessing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.jad.2026.122142_bb0005","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/S2215-0366(15)00544-1","article-title":"Childhood maltreatment and unfavourable clinical outcomes in bipolar disorder: a systematic review and meta-analysis","volume":"3","author":"Agnew-Blais","year":"2016","journal-title":"Lancet Psychiatry"},{"issue":"6","key":"10.1016\/j.jad.2026.122142_bb0010","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1111\/j.1399-5618.2007.00575.x","article-title":"Sequencing of substance use and affective morbidity in 166 first-episode bipolar I disorder patients","volume":"10","author":"Baethge","year":"2008","journal-title":"Bipolar Disord."},{"issue":"4","key":"10.1016\/j.jad.2026.122142_bb0015","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1111\/j.1399-5618.2007.00385.x","article-title":"Effects of treatment latency on response to maintenance treatment in manic-depressive disorders","volume":"9","author":"Baldessarini","year":"2007","journal-title":"Bipolar Disord."},{"issue":"4","key":"10.1016\/j.jad.2026.122142_bb0020","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.jsat.2006.10.001","article-title":"The self-report drug use disorders identification test: extended (DUDIT-E): reliability, validity, and motivational index","volume":"32","author":"Berman","year":"2007","journal-title":"J. Subst. Abuse Treat."},{"issue":"8","key":"10.1016\/j.jad.2026.122142_bb0025","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1176\/ajp.151.8.1132","article-title":"Initial reliability and validity of a new retrospective measure of child abuse and neglect","volume":"151","author":"Bernstein","year":"1994","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jad.2026.122142_bb0030","author":"Besk\u00e6ftigelsesministeriet"},{"issue":"3","key":"10.1016\/j.jad.2026.122142_bb0035","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.jad.2008.10.003","article-title":"Self-medication of mood disorders with alcohol and drugs in the National Epidemiologic Survey on Alcohol and Related Conditions","volume":"115","author":"Bolton","year":"2009","journal-title":"J. Affect. Disord."},{"issue":"6","key":"10.1016\/j.jad.2026.122142_bb0040","article-title":"Comprehensive review on association of bipolar disorder and substance abuse: dual diagnosis and treatment approaches","volume":"17","author":"Bonner-Reid","year":"2025","journal-title":"Cureus"},{"issue":"7","key":"10.1016\/j.jad.2026.122142_bb0045","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2018.4493","article-title":"Association of childhood trauma exposure with adult psychiatric disorders and functional outcomes","volume":"1","author":"Copeland","year":"2018","journal-title":"JAMA Netw. Open"},{"issue":"4","key":"10.1016\/j.jad.2026.122142_bb0050","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1177\/0706743716656607","article-title":"Meta-analysis of the interval between the onset and management of bipolar disorder","volume":"62","author":"Dagani","year":"2017","journal-title":"Can. J. Psychiatry"},{"issue":"2","key":"10.1016\/j.jad.2026.122142_bb0055","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1080\/10550490500528423","article-title":"Validity of the distinction between primary and secondary substance use disorder in patients with bipolar disorder: data from the first 1000 STEP-BD participants","volume":"15","author":"Fossey","year":"2006","journal-title":"Am. J. Addict."},{"issue":"Pt A","key":"10.1016\/j.jad.2026.122142_bb0060","article-title":"Risk of cardiovascular diseases in relation to substance use disorders","volume":"229","author":"Gan","year":"2021","journal-title":"Drug Alcohol Depend."},{"issue":"1","key":"10.1016\/j.jad.2026.122142_bb0065","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1001\/jamapsychiatry.2015.2132","article-title":"Epidemiology of DSM-5 drug use disorder: results from the National Epidemiologic Survey on Alcohol and Related Conditions-III","volume":"73","author":"Grant","year":"2016","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.jad.2026.122142_bb0070","article-title":"Comorbid bipolar and alcohol use disorder-a therapeutic challenge","volume":"12","author":"Grunze","year":"2021","journal-title":"Front. Psych."},{"issue":"1","key":"10.1016\/j.jad.2026.122142_bb0075","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1136\/jnnp.23.1.56","article-title":"A rating scale for depression","volume":"23","author":"Hamilton","year":"1960","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.jad.2026.122142_bb0080","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.jpsychires.2020.03.015","article-title":"Trends in the incidence and DALYs of bipolar disorder at global, regional, and national levels: results from the global burden of Disease Study 2017","volume":"125","author":"He","year":"2020","journal-title":"J. Psychiatr. Res."},{"issue":"9","key":"10.1016\/j.jad.2026.122142_bb0085","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/S2215-0366(15)00207-2","article-title":"Association between alcohol and substance use disorders and all-cause and cause-specific mortality in schizophrenia, bipolar disorder, and unipolar depression: a nationwide, prospective, register-based study","volume":"2","author":"Hjorth\u00f8j","year":"2015","journal-title":"Lancet Psychiatry"},{"issue":"9","key":"10.1016\/j.jad.2026.122142_bb0090","article-title":"Medical and psychiatric comorbidities in bipolar disorder: insights from National Inpatient Population-based Study","volume":"11","author":"Hossain","year":"2019","journal-title":"Cureus"},{"key":"10.1016\/j.jad.2026.122142_bb0095","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.jad.2016.08.048","article-title":"Trajectories of body mass index change in first episode of mania: 3-year data from the Systematic Treatment Optimization Program for Early Mania (STOP-EM)","volume":"208","author":"Hu","year":"2017","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2026.122142_bb0100","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.jad.2016.07.011","article-title":"Prevalence of comorbid bipolar and substance use disorders in clinical settings, 1990-2015: systematic review and meta-analysis","volume":"206","author":"Hunt","year":"2016","journal-title":"J. Affect. Disord."},{"issue":"15","key":"10.1016\/j.jad.2026.122142_bb0105","doi-asserted-by":"crossref","first-page":"2592","DOI":"10.1017\/S0033291718000223","article-title":"Association between alcohol and substance use disorders and psychiatric service use in patients with severe mental illness: a nationwide Danish register-based cohort study","volume":"48","author":"J\u00f8rgensen","year":"2018","journal-title":"Psychol. Med."},{"issue":"5","key":"10.1016\/j.jad.2026.122142_bb0110","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1111\/bdi.12296","article-title":"Life expectancy in bipolar disorder","volume":"17","author":"Kessing","year":"2015","journal-title":"Bipolar Disord."},{"issue":"6","key":"10.1016\/j.jad.2026.122142_bb0115","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2016-015462","article-title":"The bipolar illness onset study: research protocol for the BIO cohort study","volume":"7","author":"Kessing","year":"2017","journal-title":"BMJ Open"},{"key":"10.1016\/j.jad.2026.122142_bb0120","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.jad.2021.07.065","article-title":"A nation-wide population-based longitudinal study on life expectancy and cause specific mortality in patients with bipolar disorder and their siblings","volume":"294","author":"Kessing","year":"2021","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2026.122142_bb0125","article-title":"Substance misuse trajectories and risk of relapse in the early course of bipolar disorder","volume":"12","author":"Lagerberg","year":"2021","journal-title":"Front. Psych."},{"key":"10.1016\/j.jad.2026.122142_bb0130","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.psychres.2017.02.067","article-title":"Substance abuse in patients with bipolar disorder: a systematic review and meta-analysis","volume":"253","author":"Messer","year":"2017","journal-title":"Psychiatry Res."},{"issue":"14","key":"10.1016\/j.jad.2026.122142_bb0135","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1001\/jama.2023.18588","article-title":"Diagnosis and treatment of bipolar disorder: a review","volume":"330","author":"Nierenberg","year":"2023","journal-title":"JAMA"},{"key":"10.1016\/j.jad.2026.122142_bb0140","article-title":"Bipolar disorders: an update on critical aspects","volume":"48","author":"Oliva","year":"2025","journal-title":"Lancet Reg. Health Eur."},{"issue":"3","key":"10.1016\/j.jad.2026.122142_bb0145","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1176\/appi.ajp.2009.09020299","article-title":"Impact of substance use disorders on recovery from episodes of depression in bipolar disorder patients: prospective data from the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD)","volume":"167","author":"Ostacher","year":"2010","journal-title":"Am. J. Psychiatry"},{"issue":"7","key":"10.1016\/j.jad.2026.122142_bb0150","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1111\/add.13788","volume":"112","author":"\u00d8stergaard","year":"2017","journal-title":"Addiction"},{"key":"10.1016\/j.jad.2026.122142_bb0155","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.jad.2018.08.054","article-title":"Association between completed suicide and bipolar disorder: a systematic review of the literature","volume":"242","author":"Plans","year":"2019","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2026.122142_bb0160","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1745-0179-3-5","article-title":"Validity and reliability of the Functioning Assessment Short Test (FAST) in bipolar disorder","volume":"3","author":"Rosa","year":"2007","journal-title":"Clin. Pract. Epidemiol. Ment. Health"},{"issue":"2","key":"10.1016\/j.jad.2026.122142_bb0165","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1080\/08039488.2017.1400098","article-title":"Substance use among Danish psychiatric patients: a cross-sectional study","volume":"72","author":"S\u00f8rensen","year":"2018","journal-title":"Nord. J. Psychiatry"},{"issue":"1","key":"10.1016\/j.jad.2026.122142_bb0170","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1176\/ajp.2007.164.1.100","article-title":"A randomized trial of integrated group therapy versus group drug counseling for patients with bipolar disorder and substance dependence","volume":"164","author":"Weiss","year":"2007","journal-title":"Am. J. Psychiatry"},{"issue":"3","key":"10.1016\/j.jad.2026.122142_bb0175","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.drugalcdep.2009.04.018","article-title":"A \u201ccommunity-friendly\u201d version of integrated group therapy for patients with bipolar disorder and substance dependence: a randomized controlled trial","volume":"104","author":"Weiss","year":"2009","journal-title":"Drug Alcohol Depend."},{"issue":"6","key":"10.1016\/j.jad.2026.122142_bb0180","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1001\/archpsyc.1990.01810180089012","article-title":"SCAN. Schedules for clinical assessment in neuropsychiatry","volume":"47","author":"Wing","year":"1990","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.jad.2026.122142_bb0185","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1192\/bjp.133.5.429","article-title":"A rating scale for mania: reliability, validity and sensitivity","volume":"133","author":"Young","year":"1978","journal-title":"Br. J. Psychiatry"},{"issue":"1","key":"10.1016\/j.jad.2026.122142_bb0190","article-title":"Integrating treatment for co-occurring mental health conditions","volume":"40","author":"Yule","year":"2019","journal-title":"Alcohol Res."}],"container-title":["Journal of Affective Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032726009948?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032726009948?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T20:07:14Z","timestamp":1784578034000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165032726009948"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":38,"alternative-id":["S0165032726009948"],"URL":"https:\/\/doi.org\/10.1016\/j.jad.2026.122142","relation":{},"ISSN":["0165-0327"],"issn-type":[{"value":"0165-0327","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lifetime comorbid substance misuse in patients newly diagnosed with bipolar disorder","name":"articletitle","label":"Article Title"},{"value":"Journal of Affective Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jad.2026.122142","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"122142"}}