{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T18:31:59Z","timestamp":1793385119668,"version":"4.5.0"},"reference-count":206,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Affective Disorders"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.jad.2026.122261","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T06:28:47Z","timestamp":1783924127000},"page":"122261","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Individualized pharmacogenomics for depressive episodes: A narrative review"],"prefix":"10.1016","volume":"414","author":[{"given":"Michel","family":"Haddad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz Henrique Junqueira","family":"Dieckmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovana Regina Weber","family":"Hoss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jair","family":"de Jesus Mari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan H.","family":"Young","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario F.","family":"Juruena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jad.2026.122261_bb0005","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/nature15393","article-title":"A global reference for human genetic variation","volume":"526","author":"1000 Genomes Project Consortium","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.jad.2026.122261_bb0010","first-page":"765","article-title":"Smoking and the CYP1A2 genotype-mediated metabolism of clozapine","volume":"10","author":"Aitchison","year":"2000","journal-title":"Pharmacogenetics"},{"key":"10.1016\/j.jad.2026.122261_bb0015","doi-asserted-by":"crossref","first-page":"369","DOI":"10.2147\/PPA.S29716","article-title":"Treatment-resistant depression: therapeutic trends, challenges, and future directions","author":"Al-harbi","year":"2012","journal-title":"Patient Prefer. Adherence"},{"key":"10.1016\/j.jad.2026.122261_bb0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.jksus.2022.102076","article-title":"Association between the 5-methyl tetrahydrofolate reductase (5-MTHFR) and integrin \u03923 subunit (ITGB3) genes polymorphism and major depressive disorder","volume":"34","author":"Alhomrani","year":"2022","journal-title":"J. King Saud Univ. - Sci."},{"key":"10.1016\/j.jad.2026.122261_bb6000","series-title":"Diagnostic and Statistical Manual of Mental Disorders (DSM-5)","author":"American Psychiatric Association","year":"2013"},{"key":"10.1016\/j.jad.2026.122261_bb0025","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1038\/npp.2011.81","article-title":"Moderation of adult depression by a polymorphism in the FKBP5 gene and childhood physical abuse in the general population","volume":"36","author":"Appel","year":"2011","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.jad.2026.122261_bb0030","doi-asserted-by":"crossref","first-page":"535","DOI":"10.2165\/00023210-200721070-00002","article-title":"Treatment of cognitive deficits associated with schizophrenia: potential role of catechol-O-methyltransferase inhibitors","volume":"21","author":"Apud","year":"2007","journal-title":"CNS Drugs"},{"key":"10.1016\/j.jad.2026.122261_bb0035","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.jad.2005.11.008","article-title":"Analysis of COMT gene (Val 158 Met polymorphism) in the clinical response to SSRIs in depressive patients of European origin","volume":"90","author":"Arias","year":"2006","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2026.122261_bb0040","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1176\/appi.psy.44.6.515","article-title":"Pharmacokinetic drug interactions of morphine, codeine, and their derivatives: theory and clinical reality, Part II","volume":"44","author":"Armstrong","year":"2003","journal-title":"Psychosomatics"},{"key":"10.1016\/j.jad.2026.122261_bb0045","doi-asserted-by":"crossref","first-page":"228","DOI":"10.31083\/ph.2024.4601","article-title":"Methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms are associated with major depressive disorder in the Saudi patients attending Erada complex for mental health and Erada services - Jeddah, Saudi Arabia","volume":"79","author":"Bagher","year":"2024","journal-title":"Pharmazie"},{"issue":"4","key":"10.1016\/j.jad.2026.122261_bb2040","doi-asserted-by":"crossref","first-page":"3321","DOI":"10.3390\/ijerph20043321","article-title":"Associations between anxiety, depression, chronic pain and oral health-related quality of life, happiness, and polymorphisms in adolescents' genes","volume":"20","author":"Baldiotti","year":"2023","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.jad.2026.122261_bb0050","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1038\/sj.npp.1301462","article-title":"Association of the COMT val158met variant with antidepressant treatment response in major depression","volume":"33","author":"Baune","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.jad.2026.122261_bb0055","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.eurpsy.2009.12.007","article-title":"Effect of catechol-O-methyltransferase Val(108\/158)Met polymorphism on antidepressant efficacy of fluvoxamine","volume":"25","author":"Benedetti","year":"2010","journal-title":"Eur. Psychiatry"},{"key":"10.1016\/j.jad.2026.122261_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2020.e04015","article-title":"CYP2C19 polymorphisms and outcomes of Escitalopram treatment in Brazilians with major depression","volume":"6","author":"Bernini de Brito","year":"2020","journal-title":"Heliyon"},{"issue":"Suppl. 1","key":"10.1016\/j.jad.2026.122261_bb0065","doi-asserted-by":"crossref","first-page":"S186","DOI":"10.1016\/j.psyneuen.2009.05.021","article-title":"The role of FKBP5, a co-chaperone of the glucocorticoid receptor in the pathogenesis and therapy of affective and anxiety disorders","volume":"34","author":"Binder","year":"2009","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.jad.2026.122261_bb0070","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1038\/ng1479","article-title":"Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment","volume":"36","author":"Binder","year":"2004","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jad.2026.122261_bb0075","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1001\/jama.299.11.1291","article-title":"Association of FKBP5 polymorphisms and childhood abuse with risk of posttraumatic stress disorder symptoms in adults","volume":"299","author":"Binder","year":"2008","journal-title":"JAMA"},{"key":"10.1016\/j.jad.2026.122261_bb0080","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1002\/ajmg.b.32209","article-title":"Methylenetetrahydrofolate reductase (MTHFR) genetic variation and major depressive disorder prognosis: A five-year prospective cohort study of primary care attendees","volume":"165B","author":"Bousman","year":"2014","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet."},{"issue":"1","key":"10.1016\/j.jad.2026.122261_bb0085","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1002\/cpt.2903","article-title":"Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline for CYP2D6, CYP2C19, CYP2B6, SLC6A4, and HTR2A genotypes and serotonin reuptake inhibitor antidepressants","volume":"114","author":"Bousman","year":"2023","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.jad.2026.122261_bb0090","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1176\/appi.ajp.2009.09040576","article-title":"Association of FKBP5 polymorphisms with suicidal events in the Treatment of Resistant Depression in Adolescents (TORDIA) study","volume":"167","author":"Brent","year":"2010","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jad.2026.122261_bb0095","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s00228-007-0424-z","article-title":"Pharmacogenetics: data, concepts and tools to improve drug discovery and drug treatment","volume":"64","author":"Brockm\u00f6ller","year":"2008","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"10.1016\/j.jad.2026.122261_bb2030","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1038\/s41431-021-01004-7","article-title":"Dutch Pharmacogenetics Working Group (DPWG) guideline for the gene-drug interaction between CYP2C19 and CYP2D6 and SSRIs","volume":"30","author":"Brouwer","year":"2022","journal-title":"Eur. J. Hum. Genet."},{"key":"10.1016\/j.jad.2026.122261_bb0100","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1002\/cpt.2748","article-title":"Pharmacogenomic testing and depressive symptom remission: A systematic review and meta-analysis of prospective, controlled clinical trials","volume":"112","author":"Brown","year":"2022","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.jad.2026.122261_bb0105","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1590\/1516-4446-2019-0620","article-title":"Association of BDNF, HTR2A, TPH1, SLC6A4, and COMT polymorphisms with tDCS and escitalopram efficacy: ancillary analysis of a double-blind, placebo-controlled trial","volume":"42","author":"Brunoni","year":"2020","journal-title":"Rev. Bras. Psiquiatr."},{"key":"10.1016\/j.jad.2026.122261_bb0110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1590\/S0100-879X2009007500021","article-title":"Genetics of homocysteine metabolism and associated disorders","volume":"43","author":"Brustolin","year":"2010","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.1016\/j.jad.2026.122261_bb0115","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2020.491895","article-title":"How can drug metabolism and transporter genetics inform psychotropic prescribing?","volume":"11","author":"Carvalho Henriques","year":"2020","journal-title":"Front. Genet."},{"key":"10.1016\/j.jad.2026.122261_bb0120","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1111\/cts.12692","article-title":"Standardizing CYP2D6 genotype to phenotype translation: Consensus recommendations from the Clinical Pharmacogenetics Implementation Consortium and Dutch Pharmacogenetics Working Group","volume":"13","author":"Caudle","year":"2020","journal-title":"Clin. Transl. Sci."},{"key":"10.1016\/j.jad.2026.122261_bb0125","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1007\/s40262-014-0162-1","article-title":"Impact of cytochrome P450 2C19 polymorphisms on citalopram\/escitalopram exposure: a systematic review and meta-analysis","volume":"53","author":"Chang","year":"2014","journal-title":"Clin. Pharmacokinet."},{"key":"10.1016\/j.jad.2026.122261_bb0130","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.jad.2003.12.013","article-title":"Adverse childhood experiences and the risk of depressive disorders in adulthood","volume":"82","author":"Chapman","year":"2004","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2026.122261_bb0135","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.neulet.2008.10.077","article-title":"C677T methylenetetrahydrofolate reductase gene polymorphisms in bipolar disorder: an association study in the Chinese population and a meta-analysis of genetic association studies","volume":"449","author":"Chen","year":"2009","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.jad.2026.122261_bb0140","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.euroneuro.2017.12.015","article-title":"Serotonin transporter gene expression predicts the worsening of suicidal ideation and suicide attempts along a long-term follow-up of a major depressive episode","volume":"28","author":"Consoloni","year":"2018","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.jad.2026.122261_bb0145","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1007\/s13311-017-0549-4","article-title":"Evidence-based psychotherapy: advantages and challenges","volume":"14","author":"Cook","year":"2017","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.jad.2026.122261_bb0150","doi-asserted-by":"crossref","first-page":"645","DOI":"10.30773\/pi.2019.06.16","article-title":"Pharmacogenetics and Depression: A Critical Perspective","volume":"16","author":"Corponi","year":"2019","journal-title":"Psychiatry Investig."},{"key":"10.1016\/j.jad.2026.122261_bb0155","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2011.00006","article-title":"Pharmacogenetics of antidepressants","volume":"2","author":"Crisafulli","year":"2011","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jad.2026.122261_bb0160","doi-asserted-by":"crossref","DOI":"10.1177\/2326409817701471","article-title":"Homocysteine and psychiatric disorders","volume":"5","author":"da Silva","year":"2017","journal-title":"J. Inborn Errors Metab. Screen."},{"key":"10.1016\/j.jad.2026.122261_bb0165","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1017\/S0954579412000673","article-title":"The role of limbic system irritability in linking history of childhood maltreatment and psychiatric outcomes in low-income, high-risk women: moderation by FK506 binding protein 5 haplotype","volume":"24","author":"Dackis","year":"2012","journal-title":"Dev. Psychopathol."},{"key":"10.1016\/j.jad.2026.122261_bb0170","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1177\/0706743716656607","article-title":"Meta-analysis of the interval between the onset and management of bipolar disorder","volume":"62","author":"Dagani","year":"2017","journal-title":"Can. J. Psychiatr."},{"key":"10.1016\/j.jad.2026.122261_bb0175","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1159\/000351932","article-title":"Genetic factors in anxiety disorders","volume":"29","author":"Domschke","year":"2013","journal-title":"Mod. Trends Pharmacopsychiatry"},{"key":"10.1016\/j.jad.2026.122261_bb0180","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.pnpbp.2003.11.018","article-title":"Central monoamines and their role in major depression","volume":"28","author":"Elhwuegi","year":"2004","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.jad.2026.122261_bb0195","doi-asserted-by":"crossref","first-page":"415","DOI":"10.4149\/gpb_2012_049","article-title":"Analysis of genetic polymorphisms of brain-derived neurotrophic factor and methylenetetrahydrofolate reductase in depressed patients in a Slovak (Caucasian) population","volume":"31","author":"Evinova","year":"2012","journal-title":"Gen. Physiol. Biophys."},{"key":"10.1016\/j.jad.2026.122261_bb0200","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/j.euroneuro.2018.05.009","article-title":"Effect of cytochrome CYP2C19 metabolizing activity on antidepressant response and side effects: Meta-analysis of data from genome-wide association studies","volume":"28","author":"Fabbri","year":"2018","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.jad.2026.122261_bb0205","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1001\/2013.jamapsychiatry.210","article-title":"FKBP5 and attention bias for threat: associations with hippocampal function and shape: Associations with hippocampal function and shape","volume":"70","author":"Fani","year":"2013","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.jad.2026.122261_bb0210","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1017\/S1092852900003473","article-title":"The role of L-methylfolate in depressive disorders","volume":"14","author":"Farah","year":"2009","journal-title":"CNS Spectr."},{"key":"10.1016\/j.jad.2026.122261_bb0215","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.neuroscience.2013.04.060","article-title":"Inflammatory cytokines in depression: neurobiological mechanisms and therapeutic implications","volume":"246","author":"Felger","year":"2013","journal-title":"Neuroscience"},{"key":"10.1016\/j.jad.2026.122261_bb0220","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.jad.2015.05.003","article-title":"MTHFR: Genetic variants, expression analysis and COMT interaction in major depressive disorder","volume":"183","author":"Gabriela Nielsen","year":"2015","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2026.122261_bb0225","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/gim.2016.80","article-title":"Prediction of CYP2D6 phenotype from genotype across world populations","volume":"19","author":"Gaedigk","year":"2017","journal-title":"Genet. Med."},{"key":"10.1016\/j.jad.2026.122261_bb0230","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.pnpbp.2017.01.011","article-title":"Pharmacogenetics of antidepressant response: a polygenic approach","volume":"75","author":"Garcia-Gonzalez","year":"2017","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.jad.2026.122261_bb0235","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0378-1119(00)00392-9","article-title":"The human and mouse methylenetetrahydrofolate reductase (MTHFR) genes: genomic organization, mRNA structure and linkage to the CLCN6 gene","volume":"257","author":"Gaughan","year":"2000","journal-title":"Gene"},{"key":"10.1016\/j.jad.2026.122261_bb0245","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1177\/070674370204700202","article-title":"\u201cCade\u2019s disease\u201d and beyond: misdiagnosis, antidepressant use, and a proposed definition for bipolar spectrum disorder","volume":"47","author":"Ghaemi","year":"2002","journal-title":"Can. J. Psychiatr."},{"key":"10.1016\/j.jad.2026.122261_bb0250","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1038\/sj.clpt.6100367","article-title":"Tamoxifen pharmacogenomics: the role of CYP2D6 as a predictor of drug response","volume":"83","author":"Goetz","year":"2008","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.jad.2026.122261_bb0255","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.mce.2007.05.018","article-title":"The glucocorticoid responses are shaped by molecular chaperones","volume":"275","author":"Grad","year":"2007","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.jad.2026.122261_bb0260","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.jpsychires.2019.01.003","article-title":"Impact of pharmacogenomics on clinical outcomes in major depressive disorder in the GUIDED trial: A large, patient- and rater-blinded, randomized, controlled study","volume":"111","author":"Greden","year":"2019","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.jad.2026.122261_bb0265","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2015.00046","article-title":"Central serotonin-2A (5-HT2A) receptor dysfunction in depression and epilepsy: the missing link?","volume":"6","author":"Guiard","year":"2015","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jad.2026.122261_bb0270","doi-asserted-by":"crossref","first-page":"469","DOI":"10.9758\/cpn.2018.16.4.469","article-title":"A pharmacogenomic-based antidepressant treatment for patients with major depressive disorder: results from an 8-week, randomized, single-blinded clinical trial","volume":"16","author":"Han","year":"2018","journal-title":"Clin. Psychopharmacol. Neurosci."},{"key":"10.1016\/j.jad.2026.122261_bb0275","doi-asserted-by":"crossref","first-page":"57","DOI":"10.2174\/1570159X113119990043","article-title":"Ketamine as antidepressant? Current state and future perspectives","volume":"12","author":"Hasselmann","year":"2014","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.jad.2026.122261_bb0280","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.expneurol.2011.10.032","article-title":"Current research trends in early life stress and depression: review of human studies on sensitive periods, gene-environment interactions, and epigenetics","volume":"233","author":"Heim","year":"2012","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.jad.2026.122261_bb0285","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1093\/nar\/30.1.163","article-title":"PharmGKB: The Pharmacogenetics Knowledge Base","volume":"30","author":"Hewett","year":"2002","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jad.2026.122261_bb4000","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1002\/cpt.597","article-title":"Clinical pharmacogenetics implementation consortium guideline (CPIC) for CYP2D6 and CYP2C19 genotypes and dosing of tricyclic antidepressants: 2016 update","volume":"102","author":"Hicks","year":"2017","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.jad.2026.122261_bb0290","doi-asserted-by":"crossref","first-page":"218","DOI":"10.2174\/1389200215666140202215316","article-title":"Challenges in CYP2D6 phenotype assignment from genotype data: a critical assessment and call for standardization","volume":"15","author":"Hicks","year":"2014","journal-title":"Curr. Drug Metab."},{"key":"10.1016\/j.jad.2026.122261_bb0295","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1002\/cpt.147","article-title":"Clinical pharmacogenetics implementation consortium (CPIC) guideline for CYP2D6 and CYP2C19 genotypes and dosing of selective serotonin reuptake inhibitors","volume":"98","author":"Hicks","year":"2015","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.jad.2026.122261_bb0300","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0163-7258(99)00048-0","article-title":"Pharmacokinetics of selective serotonin reuptake inhibitors","volume":"85","author":"Hiemke","year":"2000","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.jad.2026.122261_bb0305","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1055\/s-0043-116492","article-title":"Consensus guidelines for therapeutic drug monitoring in neuropsychopharmacology: update 2017","volume":"51","author":"Hiemke","year":"2018","journal-title":"Pharmacopsychiatry"},{"key":"10.1016\/j.jad.2026.122261_bb0310","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1037\/a0038550","article-title":"A brief history of the development of antidepressant drugs: from monoamines to glutamate","volume":"23","author":"Hillhouse","year":"2015","journal-title":"Exp. Clin. Psychopharmacol."},{"key":"10.1016\/j.jad.2026.122261_bb2015","doi-asserted-by":"crossref","DOI":"10.1111\/cts.13822","article-title":"Rationale and design for a pragmatic randomized trial to assess gene-based prescribing for SSRIs in the treatment of depression","volume":"17","author":"Hines","year":"2024","journal-title":"Clin. Transl. Sci."},{"key":"10.1016\/j.jad.2026.122261_bb0315","doi-asserted-by":"crossref","first-page":"161","DOI":"10.4088\/JCP.v64n0209","article-title":"Perceptions and impact of bipolar disorder: how far have we really come? Results of the National Depressive and Manic-Depressive Association 2000 survey","volume":"64","author":"Hirschfeld","year":"2003","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.jad.2026.122261_bb0320","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.neuroscience.2012.04.003","article-title":"DNA memories of early social life","volume":"264","author":"Hoffmann","year":"2014","journal-title":"Neuroscience"},{"key":"10.1016\/j.jad.2026.122261_bb0325","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1038\/npp.2009.180","article-title":"Polymorphisms in GRIK4, HTR2A, and FKBP5 show interactive effects in predicting remission to antidepressant treatment","volume":"35","author":"Horstmann","year":"2010","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.jad.2026.122261_bb0330","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1001\/archpsyc.64.7.783","article-title":"Association between a functional serotonin transporter promoter polymorphism and citalopram treatment in adult outpatients with major depression","volume":"64","author":"Hu","year":"2007","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.jad.2026.122261_bb0335","first-page":"6","article-title":"Genetic polymorphisms of cytochrome P450 2D6 (CYP2D6): clinical consequences, evolutionary aspects and functional diversity","volume":"5","author":"Ingelman-Sundberg","year":"2005","journal-title":"Pharm. J."},{"key":"10.1016\/j.jad.2026.122261_bb0340","unstructured":"Institute for Health Metrics and Evaluation (IHME), 2018. Seattle, WA: IHME, University of Washington."},{"key":"10.1016\/j.jad.2026.122261_bb0345","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1038\/nature06258","article-title":"A second generation human haplotype map of over 3.1 million SNPs","volume":"449","author":"International HapMap Consortium","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.jad.2026.122261_bb0350","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1111\/j.1460-9568.2008.06332.x","article-title":"Polymorphisms in the FKBP5 gene region modulate recovery from psychosocial stress in healthy controls","volume":"28","author":"Ising","year":"2008","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.jad.2026.122261_bb0355","doi-asserted-by":"crossref","first-page":"5510","DOI":"10.1007\/s12035-015-9409-6","article-title":"Role of the 5-HTTLPR and SNP promoter polymorphisms on serotonin transporter gene expression: A closer look at genetic architecture and in vitro functional studies of common and uncommon Allelic variants","volume":"53","author":"Iurescia","year":"2016","journal-title":"Mol. Neurobiol."},{"issue":"1","key":"10.1016\/j.jad.2026.122261_bb2025","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1186\/s12888-024-06162-8","article-title":"Serotonin transporter 5-HTTLPR polymorphism and escitalopram treatment response in patients with major depressive disorder","volume":"24","author":"Jar\u010du\u0161kov\u00e1","year":"2024","journal-title":"BMC Psychiatry"},{"key":"10.1016\/j.jad.2026.122261_bb0360","first-page":"78","article-title":"Catechol O-methyltransferase pharmacogenomics and selective serotonin reuptake inhibitor response","volume":"12","author":"Ji","year":"2012","journal-title":"Pharm. J."},{"key":"10.1016\/j.jad.2026.122261_bb0365","doi-asserted-by":"crossref","first-page":"835","DOI":"10.2217\/pgs.13.52","article-title":"Pharmacogenetics in clinical practice: how far have we come and where are we going?","volume":"14","author":"Johnson","year":"2013","journal-title":"Pharmacogenomics"},{"key":"10.1016\/j.jad.2026.122261_bb0370","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1002\/cpt.668","article-title":"Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline for pharmacogenetics-guided warfarin dosing: 2017 update","volume":"102","author":"Johnson","year":"2017","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.jad.2026.122261_bb0375","doi-asserted-by":"crossref","DOI":"10.3390\/cells8080867","article-title":"Analysis of catecholamines and pterins in inborn errors of monoamine neurotransmitter metabolism-from past to future","volume":"8","author":"Jung-Klawitter","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.jad.2026.122261_bb0380","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1017\/S0033291716002774","article-title":"The efficacy of psychotherapy, pharmacotherapy and their combination on functioning and quality of life in depression: a meta-analysis","volume":"47","author":"Kamenov","year":"2017","journal-title":"Psychol. Med."},{"key":"10.1016\/j.jad.2026.122261_bb0385","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1159\/000123041","article-title":"FKBP family proteins: immunophilins with versatile biological functions","volume":"16","author":"Kang","year":"2008","journal-title":"Neurosignals"},{"key":"10.1016\/j.jad.2026.122261_bb0390","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/mp.2008.116","article-title":"Review and meta-analysis of antidepressant pharmacogenetic findings in major depressive disorder","volume":"15","author":"Kato","year":"2010","journal-title":"Mol. Psychiatry"},{"issue":"3","key":"10.1016\/j.jad.2026.122261_bb2065","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1017\/ipm.2014.18","article-title":"The impact of a change in prescribing policy on antipsychotic prescribing in a general adult psychiatric hospital","volume":"31","author":"Kelly","year":"2014","journal-title":"Ir. J. Psychol. Med."},{"key":"10.1016\/j.jad.2026.122261_bb0395","doi-asserted-by":"crossref","first-page":"3095","DOI":"10.1001\/jama.289.23.3095","article-title":"The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R)","volume":"289","author":"Kessler","year":"2003","journal-title":"JAMA"},{"key":"10.1016\/j.jad.2026.122261_bb0400","doi-asserted-by":"crossref","first-page":"841","DOI":"10.2217\/14622416.9.7.841","article-title":"Genetic variants in FKBP5 affecting response to antidepressant drug treatment","volume":"9","author":"Kirchheiner","year":"2008","journal-title":"Pharmacogenomics"},{"issue":"6","key":"10.1016\/j.jad.2026.122261_bb2055","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1016\/j.neuron.2015.05.036","article-title":"Epigenetics of stress-related psychiatric disorders and gene \u00d7 environment interactions","volume":"86","author":"Klengel","year":"2015","journal-title":"Neuron"},{"key":"10.1016\/j.jad.2026.122261_bb2050","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/nn.3275","article-title":"Allele-specific\u202fFKBP5\u202fDNA demethylation mediates gene\u2013childhood trauma interactions","volume":"16","author":"Klengel","year":"2013","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.jad.2026.122261_bb0405","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.pnpbp.2019.01.004","article-title":"Neuromodulatory treatments for post-traumatic stress disorder (PTSD)","volume":"92","author":"Koek","year":"2019","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.jad.2026.122261_bb0410","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1111\/j.1469-7610.2010.02249.x","volume":"51","author":"Kumsta","year":"2010","journal-title":"J. Child Psychol. Psychiatry"},{"key":"10.1016\/j.jad.2026.122261_bb0415","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1590\/S1415-475738120140179","article-title":"Association study of folate-related enzymes (MTHFR, MTR, MTRR) genetic variants with non-obstructive male infertility in a Polish population","volume":"38","author":"Kurzawski","year":"2015","journal-title":"Genet. Mol. Biol."},{"key":"10.1016\/j.jad.2026.122261_bb0420","first-page":"4","article-title":"The serotonin transporter gene (5-HTT) variant and psychiatric disorders: review of current literature","volume":"31","author":"Kuzelova","year":"2010","journal-title":"Neuro Endocrinol. Lett."},{"key":"10.1016\/j.jad.2026.122261_bb2060","first-page":"1","article-title":"Molecular biology of methylenetetrahydrofolate reductase (MTHFR) and overview of mutations\/polymorphisms","volume":"15","author":"Leclerc","year":"2005","journal-title":"MTHFR polymorphisms and disease"},{"key":"10.1016\/j.jad.2026.122261_bb0425","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/j.biopsych.2007.10.026","article-title":"The FKBP5-gene in depression and treatment response--an association study in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) cohort","volume":"63","author":"Lekman","year":"2008","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jad.2026.122261_bb0430","first-page":"1474","article-title":"Genome-wide association study meta-analysis of antidepressant response","volume":"25","author":"Li","year":"2020","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jad.2026.122261_bb0435","doi-asserted-by":"crossref","first-page":"63","DOI":"10.31887\/DCNS.2011.13.1\/jlicinio","article-title":"Pharmacogenomics of antidepressant treatment effects","volume":"13","author":"Licinio","year":"2011","journal-title":"Dialogues Clin. Neurosci."},{"key":"10.1016\/j.jad.2026.122261_bb0440","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1056\/NEJMoa051688","article-title":"Effectiveness of antipsychotic drugs in patients with chronic schizophrenia","volume":"353","author":"Lieberman","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jad.2026.122261_bb0445","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1590\/S0066-782X2007000200006","article-title":"Homocist\u00e9ina e metilenotetrahidrofolato redutase em indiv\u00edduos submetidos \u00e0 angiografia coronariana","volume":"88","author":"Lima","year":"2007","journal-title":"Arq. Bras. Cardiol."},{"key":"10.1016\/j.jad.2026.122261_bb0450","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/164_2018_172","article-title":"Selective serotonin reuptake inhibitors","volume":"250","author":"Lochmann","year":"2019","journal-title":"Handb. Exp. Pharmacol."},{"key":"10.1016\/j.jad.2026.122261_bb0455","first-page":"21","article-title":"Serotonin receptor 2A (HTR2A) gene polymorphism predicts treatment response to venlafaxine XR in generalized anxiety disorder","volume":"13","author":"Lohoff","year":"2013","journal-title":"Pharm. J."},{"key":"10.1016\/j.jad.2026.122261_bb0460","doi-asserted-by":"crossref","first-page":"2438","DOI":"10.1093\/hmg\/ddl166","article-title":"P2RX7, a gene coding for a purinergic ligand-gated ion channel, is associated with major depressive disorder","volume":"15","author":"Lucae","year":"2006","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.jad.2026.122261_bb0465","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.euroneuro.2009.08.006","article-title":"HTR2A gene variation is involved in antidepressant treatment response","volume":"20","author":"Lucae","year":"2010","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.jad.2026.122261_bb0470","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1016\/j.psyneuen.2010.04.012","article-title":"FKBP5 and resistant attachment predict cortisol reactivity in infants: gene-environment interaction","volume":"35","author":"Luijk","year":"2010","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.jad.2026.122261_bb0475","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0167-4838(95)00071-2","article-title":"Cloning, expression and structure of catechol-O-methyltransferase","volume":"1251","author":"Lundstr\u00f6m","year":"1995","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jad.2026.122261_bb0480","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.jpsychires.2017.12.009","article-title":"GWAS-based machine learning approach to predict duloxetine response in major depressive disorder","volume":"99","author":"Maciukiewicz","year":"2018","journal-title":"J. Psychiatr. Res."},{"issue":"Suppl. 1","key":"10.1016\/j.jad.2026.122261_bb0485","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1007\/s00406-007-1004-z","article-title":"Contribution of allelic variations to the phenotype of response to antidepressants and antipsychotics","volume":"258","author":"Maier","year":"2008","journal-title":"Eur. Arch. Psychiatry Clin. Neurosci."},{"key":"10.1016\/j.jad.2026.122261_bb0490","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1038\/mp.2012.21","article-title":"A mega-analysis of genome-wide association studies for major depressive disorder","volume":"18","author":"Major Depressive Disorder Working Group of the Psychiatric GWAS Consortium","year":"2013","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jad.2026.122261_bb0495","first-page":"127","article-title":"Challenges and future prospects of precision medicine in psychiatry","volume":"13","author":"Manchia","year":"2020","journal-title":"Pharmgenomics. Pers. Med."},{"key":"10.1016\/j.jad.2026.122261_bb0500","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/S0031-6997(24)01423-6","article-title":"Catechol-O-methyltransferase (COMT): biochemistry, molecular biology, pharmacology, and clinical efficacy of the new selective COMT inhibitors","volume":"51","author":"M\u00e4nnist\u00f6","year":"1999","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.jad.2026.122261_bb0510","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1146\/annurev-psych-010213-115100","article-title":"Gene-environment interaction","volume":"65","author":"Manuck","year":"2014","journal-title":"Annu. Rev. Psychol."},{"key":"10.1016\/j.jad.2026.122261_bb0515","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1097\/01.fpc.0000194423.20393.08","article-title":"Human methylenetetrahydrofolate reductase pharmacogenomics: gene resequencing and functional genomics","volume":"16","author":"Martin","year":"2006","journal-title":"Pharmacogenet. Genomics"},{"key":"10.1016\/j.jad.2026.122261_bb0520","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.2174\/0929867013372616","article-title":"A structural approach into human tryptophan hydroxylase and its implications for the regulation of serotonin biosynthesis","volume":"8","author":"Martinez","year":"2001","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.jad.2026.122261_bb0525","doi-asserted-by":"crossref","DOI":"10.1016\/j.pbb.2022.173371","article-title":"Early adversity as the prototype gene \u00d7 environment interaction in mental disorders?","volume":"215","author":"Martins","year":"2022","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.jad.2026.122261_bb0530","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.jad.2019.05.025","article-title":"Antidepressant pharmacogenetics in children and young adults: A systematic review","volume":"254","author":"Maruf","year":"2019","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2026.122261_bb0535","doi-asserted-by":"crossref","first-page":"6186","DOI":"10.1073\/pnas.0931309100","article-title":"Catechol O-methyltransferase val158-met genotype and individual variation in the brain response to amphetamine","volume":"100","author":"Mattay","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jad.2026.122261_bb0540","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1002\/ajmg.b.32763","article-title":"Genetics of resilience: Implications from genome-wide association studies and candidate genes of the stress response system in posttraumatic stress disorder and depression","volume":"183","author":"Maul","year":"2020","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet."},{"key":"10.1016\/j.jad.2026.122261_bb0545","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1086\/503820","article-title":"Variation in the gene encoding the serotonin 2A receptor is associated with outcome of antidepressant treatment","volume":"78","author":"McMahon","year":"2006","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.jad.2026.122261_bb0550","doi-asserted-by":"crossref","first-page":"668","DOI":"10.4088\/JCP.15m10166","volume":"77","author":"Mech","year":"2016","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.jad.2026.122261_bb0555","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1001\/archgenpsychiatry.2011.50","article-title":"Using polymorphisms in FKBP5 to define biologically distinct subtypes of posttraumatic stress disorder: evidence from endocrine and gene expression studies: Evidence from endocrine and gene expression studies","volume":"68","author":"Mehta","year":"2011","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.jad.2026.122261_bb0560","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1590\/S0004-27302012000700004","article-title":"Evaluation of plasma homocysteine level according to the C677T and A1298C polymorphism of the enzyme MTHRF in type 2 diabetic adults","volume":"56","author":"Mello","year":"2012","journal-title":"Arq. Bras. Endocrinol. Metabol."},{"key":"10.1016\/j.jad.2026.122261_bb0565","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/gbb.12026","article-title":"Genetic variation in FKBP5 associated with the extent of stress hormone dysregulation in major depression: HPA-axis dysregulation associated with FKBP5","volume":"12","author":"Menke","year":"2013","journal-title":"Genes Brain Behav."},{"key":"10.1016\/j.jad.2026.122261_bb0570","doi-asserted-by":"crossref","DOI":"10.1055\/s-0033-1353276","article-title":"GR-mediated FKBP5 RNA induction differentially influenced by weight in major depression and healthy controls","volume":"46","author":"Menke","year":"2013","journal-title":"Pharmacopsychiatry"},{"key":"10.1016\/j.jad.2026.122261_bb0575","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1038\/sj.mp.4001860","article-title":"Impact of complex genetic variation in COMT on human brain function","volume":"11","author":"Meyer-Lindenberg","year":"2006","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jad.2026.122261_bb0580","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1001\/jamapsychiatry.2020.3643","article-title":"Association of CYP2C19 and CYP2D6 poor and intermediate metabolizer status with antidepressant and antipsychotic exposure: A systematic review and meta-analysis","volume":"78","author":"Milosavljevic","year":"2021","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.jad.2026.122261_bb0585","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1017\/S1092852912000430","article-title":"Prevalence of MTHFR C677T and MS A2756G polymorphisms in major depressive disorder, and their impact on response to fluoxetine treatment","volume":"17","author":"Mischoulon","year":"2012","journal-title":"CNS Spectr."},{"key":"10.1016\/j.jad.2026.122261_bb0595","series-title":"Role of serotonin-2A receptors in pathophysiology and treatment of depression, in: 5-HT2A Receptors in the Central Nervous System","first-page":"205","author":"Morav\u010d\u00edkov\u00e1","year":"2018"},{"key":"10.1016\/j.jad.2026.122261_bb0600","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.biopsych.2005.12.018","article-title":"Polymorphisms in the regulatory region of the human serotonin 5-HT2A receptor gene (HTR2A) influence gene expression","volume":"61","author":"Myers","year":"2007","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jad.2026.122261_bb0605","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1248\/bpb.29.1655","article-title":"CYP2D6 genetic polymorphism in South Indian populations","volume":"29","author":"Naveen","year":"2006","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.jad.2026.122261_bb0610","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.jad.2016.09.053","article-title":"L-Methylfolate For Bipolar I depressive episodes: An open trial proof-of-concept registry","volume":"207","author":"Nierenberg","year":"2017","journal-title":"J. Affect. Disord."},{"issue":"12","key":"10.1016\/j.jad.2026.122261_bb3000","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1038\/s41431-022-01262-z","article-title":"Dutch pharmacogenetics working group (DPWG) guideline for the gene-drug interaction of CYP2D6 and COMT with atomoxetine and methylphenidate","volume":"31","author":"Nijenhuis","year":"2023","journal-title":"Eur. J. Hum. Genet."},{"key":"10.1016\/j.jad.2026.122261_bb0615","doi-asserted-by":"crossref","first-page":"D733","DOI":"10.1093\/nar\/gkv1189","article-title":"Reference sequence (RefSeq) database at NCBI: current status, taxonomic expansion, and functional annotation","volume":"44","author":"O\u2019Leary","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jad.2026.122261_bb0620","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1590\/S0004-27302008000800028","article-title":"Prevalence of the polymorphism MTHFR A1298C and not MTHFR C677T is related to chromosomal aneuploidy in Brazilian Turner syndrome patients","volume":"52","author":"Oliveira","year":"2008","journal-title":"Arq. Bras. Endocrinol. Metabol."},{"key":"10.1016\/j.jad.2026.122261_bb0625","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1001\/jama.2022.9805","article-title":"Effect of pharmacogenomic testing for drug\u2013gene interactions on medication selection and remission of symptoms in major depressive disorder: the PRIME Care randomized clinical trial","volume":"328","author":"Oslin","year":"2022","journal-title":"JAMA"},{"key":"10.1016\/j.jad.2026.122261_bb0630","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1176\/appi.ajp.2013.13020185","article-title":"The International Society for Bipolar Disorders (ISBD) task force report on antidepressant use in bipolar disorders","volume":"170","author":"Pacchiarotti","year":"2013","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jad.2026.122261_bb0635","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.bpsgos.2021.07.008","article-title":"Identifying the common genetic basis of antidepressant response","volume":"2","author":"Pain","year":"2022","journal-title":"Biol. Psychiatry Glob. Open Sci."},{"key":"10.1016\/j.jad.2026.122261_bb0640","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1177\/070674371205700703","article-title":"Folates and S-adenosylmethionine for major depressive disorder","volume":"57","author":"Papakostas","year":"2012","journal-title":"Can. J. Psychiatr."},{"key":"10.1016\/j.jad.2026.122261_bb0645","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1017\/neu.2017.39","article-title":"A brief history of antidepressant drug development: from tricyclics to beyond ketamine","volume":"30","author":"Pereira","year":"2018","journal-title":"Acta Neuropsychiatr."},{"key":"10.1016\/j.jad.2026.122261_bb0650","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/FPC.0b013e3283163ecd","article-title":"Resequencing of serotonin-related genes and association of tagging SNPs to citalopram response","volume":"19","author":"Peters","year":"2009","journal-title":"Pharmacogenet. Genomics"},{"key":"10.1016\/j.jad.2026.122261_bb0655","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1016\/S0140-6736(13)60989-7","article-title":"Bipolar disorder diagnosis: challenges and future directions","volume":"381","author":"Phillips","year":"2013","journal-title":"Lancet"},{"key":"10.1016\/j.jad.2026.122261_bb0660","doi-asserted-by":"crossref","DOI":"10.31744\/einstein_journal\/2020RC5522","article-title":"L-methylfolate, a new option in psychiatric treatment, would it be linked to psoriasis relapse?","volume":"18","author":"Pitliuk","year":"2020","journal-title":"Einstein (S\u00e3o Paulo)"},{"key":"10.1016\/j.jad.2026.122261_bb0665","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.euroneuro.2011.10.003","article-title":"Meta-analysis of serotonin transporter gene promoter polymorphism (5-HTTLPR) association with antidepressant efficacy","volume":"22","author":"Porcelli","year":"2012","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.jad.2026.122261_bb0670","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.jmoldx.2018.01.011","article-title":"Recommendations for clinical CYP2C19 genotyping allele selection: A report of the Association for molecular pathology","volume":"20","author":"Pratt","year":"2018","journal-title":"J. Mol. Diagn."},{"key":"10.1016\/j.jad.2026.122261_bb0675","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0082562","article-title":"Polymorphic cytochrome P450 enzymes (CYPs) and their role in personalized therapy","volume":"8","author":"Preissner","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jad.2026.122261_bb0680","doi-asserted-by":"crossref","first-page":"4739","DOI":"10.1523\/JNEUROSCI.2930-19.2020","article-title":"Trait anxiety mediated by amygdala serotonin transporter in the common marmoset","volume":"40","author":"Quah","year":"2020","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jad.2026.122261_bb0685","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1016\/j.pnpbp.2005.06.027","article-title":"Homocysteinemia as well as methylenetetrahydrofolate reductase polymorphism are associated with affective psychoses","volume":"29","author":"Reif","year":"2005","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.jad.2026.122261_bb0690","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1002\/cpt.1651","article-title":"The Clinical Pharmacogenetics Implementation Consortium: 10 years later","volume":"107","author":"Relling","year":"2020","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.jad.2026.122261_bb0695","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.jad.2020.04.058","article-title":"Pharmacogenetic association of bi- and triallelic polymorphisms of SLC6A4 with antidepressant response in major depressive disorder","volume":"273","author":"Ren","year":"2020","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2026.122261_bb0700","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1176\/ajp.2006.163.11.1905","article-title":"Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps: a STAR*D report","volume":"163","author":"Rush","year":"2006","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jad.2026.122261_bb0705","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1159\/000096416","article-title":"Data-mining methods as useful tools for predicting individual drug response: application to CYP2D6 data","volume":"62","author":"Sabbagh","year":"2006","journal-title":"Hum. Hered."},{"key":"10.1016\/j.jad.2026.122261_bb0710","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1046\/j.1365-2125.1999.00898.x","article-title":"Functional significance of a C\u2192A polymorphism in intron 1 of the cytochrome P450 CYP1A2 gene tested with caffeine","volume":"47","author":"Sachse","year":"1999","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.jad.2026.122261_bb0715","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1016\/j.pnpbp.2011.04.011","article-title":"Role of serotonergic-related systems in suicidal behavior: Data from a case\u2013control association study","volume":"35","author":"Saiz","year":"2011","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.jad.2026.122261_bb0720","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1007\/s00228-017-2323-2","article-title":"Effect of CYP3A4*22, CYP3A5*3, and CYP3A combined genotypes on tamoxifen metabolism","volume":"73","author":"Sanchez Spitman","year":"2017","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"10.1016\/j.jad.2026.122261_bb0725","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.2217\/pgs-2016-0105","article-title":"Pharmacogenetics to prevent maniac affective switching with treatment for bipolar disorder: CYP2D6","volume":"17","author":"S\u00e1nchez-Mart\u00edn","year":"2016","journal-title":"Pharmacogenomics"},{"key":"10.1016\/j.jad.2026.122261_bb0730","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/S0888-7543(03)00090-9","article-title":"Organization of the human FK506-binding immunophilin FKBP52 protein gene (FKBP4)","volume":"81","author":"Scammell","year":"2003","journal-title":"Genomics"},{"key":"10.1016\/j.jad.2026.122261_bb0735","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1038\/npp.2017.273","article-title":"Association of serotonin transporter gene AluJb methylation with major depression, amygdala responsiveness, 5-HTTLPR\/rs25531 polymorphism, and stress","volume":"43","author":"Schneider","year":"2018","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.jad.2026.122261_bb0740","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/sj.mp.4001926","article-title":"Meta-analysis of serotonin transporter gene promoter polymorphism (5-HTTLPR) association with selective serotonin reuptake inhibitor efficacy in depressed patients","volume":"12","author":"Serretti","year":"2007","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jad.2026.122261_bb0745","article-title":"Genetics factors in major depression disease","volume":"9","author":"Shadrina","year":"2018","journal-title":"Front. Psychol."},{"key":"10.1016\/j.jad.2026.122261_bb0750","article-title":"Assessing effects of l-methylfolate in depression management: Results of a real-world patient experience trial","volume":"15","author":"Shelton","year":"2013","journal-title":"Prim. Care Companion CNS Disord."},{"key":"10.1016\/j.jad.2026.122261_bb0755","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1111\/jcpp.13079","article-title":"Serotonin system genes and obsessive-compulsive trait dimensions in a population-based, pediatric sample: a genetic association study","volume":"60","author":"Sinopoli","year":"2019","journal-title":"J. Child Psychol. Psychiatry"},{"key":"10.1016\/j.jad.2026.122261_bb0760","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1590\/1516-4446-2019-0799","article-title":"Pharmacogenomic testing and antidepressant response: problems and promises","volume":"42","author":"Smith","year":"2020","journal-title":"Rev. Bras. Psiquiatr."},{"key":"10.1016\/j.jad.2026.122261_bb0765","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/sj.mp.4001488","article-title":"Influence of SERTPR and STin2 in the serotonin transporter gene on the effect of selective serotonin reuptake inhibitors in depression: a systematic review","volume":"9","author":"Smits","year":"2004","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jad.2026.122261_bb0770","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1590\/1516-4446-2020-0935","article-title":"How can we improve antidepressant adherence in themanagement of depression? A targeted review and 10 clinical recommendations","volume":"43","author":"Solmi","year":"2021","journal-title":"Rev. Bras. Psiquiatr."},{"key":"10.1016\/j.jad.2026.122261_bb0775","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2025.1690378","article-title":"The biological relationship among depression, vitamins B9, B12, and D, and genetic variants: a systematic review","volume":"12","author":"Soriano-Gonzalez","year":"2025","journal-title":"Front. Nutr."},{"key":"10.1016\/j.jad.2026.122261_bb0780","doi-asserted-by":"crossref","first-page":"7","DOI":"10.4088\/JCP.v61n0103","article-title":"Molecular neurobiology for practicing psychiatrists, Part 5: How a leucine zipper can turn on genes: immediate-early genes activate late-gene expression in the brain","volume":"61","author":"Stahl","year":"2000","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.jad.2026.122261_bb0785","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.4088\/JCP.v69n0901","article-title":"L-methylfolate: a vitamin for your monoamines","volume":"69","author":"Stahl","year":"2008","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.jad.2026.122261_bb0790","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/mp.2012.42","article-title":"Genetic variability of drug-metabolizing enzymes: the dual impact on psychiatric therapy and regulation of brain function","volume":"18","author":"Stingl","year":"2013","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jad.2026.122261_bb2005","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1038\/clpt.2011.34","article-title":"Pharmacogenetics: from bench to byte\u2014 an update of guidelines","volume":"89","author":"Swen","year":"2011","journal-title":"Clin. Pharmacol. Ther. (St. Louis, MO, U. S.)"},{"key":"10.1016\/j.jad.2026.122261_bb0795","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1517\/14656566.6.4.631","article-title":"Mirtazapine: a review of its clinical efficacy and tolerability","volume":"6","author":"Szegedi","year":"2005","journal-title":"Expert. Opin. Pharmacother."},{"key":"10.1016\/j.jad.2026.122261_bb0800","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.biopsych.2012.10.030","article-title":"Contribution of common genetic variants to antidepressant response","volume":"73","author":"Tansey","year":"2013","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jad.2026.122261_bb0805","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1111\/j.1432-1033.1994.tb19083.x","article-title":"Genomic organization of the human catechol O-methyltransferase gene and its expression from two distinct promoters","volume":"223","author":"Tenhunen","year":"1994","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.jad.2026.122261_bb0810","article-title":"Efficacy and safety of pharmacogenomic-guided antidepressant prescribing in patients with depression: an umbrella review and updated meta-analysis","volume":"15","author":"Tesfamicael","year":"2024","journal-title":"Front. Psychol."},{"key":"10.1016\/j.jad.2026.122261_bb0815","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1007\/s11920-007-0068-9","article-title":"STEP-BD and bipolar depression: what have we learned?","volume":"9","author":"Thase","year":"2007","journal-title":"Curr. Psychiatry Rep."},{"key":"10.1016\/j.jad.2026.122261_bb0820","first-page":"179","article-title":"PharmGKB: the pharmacogenetics and pharmacogenomics knowledge base","volume":"311","author":"Thorn","year":"2005","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.jad.2026.122261_bb0825","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/bs.apha.2018.04.007","article-title":"Cytochrome P450 in pharmacogenetics: An update","volume":"83","author":"Tornio","year":"2018","journal-title":"Adv. Pharmacol."},{"key":"10.1016\/j.jad.2026.122261_bb0830","doi-asserted-by":"crossref","DOI":"10.3390\/genes14020350","article-title":"COMT but not 5HTTLPR gene is associated with depression in first-episode psychosis: the role of stressful life events","volume":"14","author":"Tosato","year":"2023","journal-title":"Genes"},{"key":"10.1016\/j.jad.2026.122261_bb0835","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1016\/j.biopsych.2011.07.023","article-title":"FK506 binding protein 5 shapes stress responsiveness: modulation of neuroendocrine reactivity and coping behavior","volume":"70","author":"Touma","year":"2011","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jad.2026.122261_bb0840","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1007\/s00335-002-2167-6","article-title":"Multiple transcription start sites and alternative splicing in the methylenetetrahydrofolate reductase gene result in two enzyme isoforms","volume":"13","author":"Tran","year":"2002","journal-title":"Mamm. Genome"},{"key":"10.1016\/j.jad.2026.122261_bb0845","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.biopsych.2005.10.024","article-title":"Catechol-o-methyltransferase, cognition, and psychosis: Val158Met and beyond","volume":"60","author":"Tunbridge","year":"2006","journal-title":"Biol. Psychiatry"},{"issue":"4","key":"10.1016\/j.jad.2026.122261_bb2020","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0165-6147(00)01675-8","article-title":"Biological and clinical implications of the MTHFR C677T polymorphism","volume":"22","author":"Ueland","year":"2001","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.jad.2026.122261_bb0850","first-page":"17","article-title":"The influence of cytochrome P450 pharmacogenetics on disposition of common antidepressant and antipsychotic medications","volume":"27","author":"van der Weide","year":"2006","journal-title":"Clin. Biochem. Rev."},{"key":"10.1016\/j.jad.2026.122261_bb0855","first-page":"94","article-title":"Pharmacogenomics of antidepressant and antipsychotic treatment: how far have we got and where are we going?","volume":"11","author":"van Westrhenen","year":"2020","journal-title":"Front. Psychol."},{"key":"10.1016\/j.jad.2026.122261_bb0860","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/j.psyneuen.2011.01.003","article-title":"Genetics of cortisol secretion and depressive symptoms: a candidate gene and genome wide association approach","volume":"36","author":"Velders","year":"2011","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.jad.2026.122261_bb0865","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2019.00083","article-title":"Cytochrome P450 2C19 poor metabolizer phenotype in treatment resistant depression: treatment and diagnostic implications","volume":"10","author":"Veldic","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jad.2026.122261_bb0870","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.amjmed.2005.09.027","article-title":"Posttraumatic stress disorder: clinical features, pathophysiology, and treatment","volume":"119","author":"Vieweg","year":"2006","journal-title":"Am. J. Med."},{"key":"10.1016\/j.jad.2026.122261_bb0875","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.psychres.2018.02.055","article-title":"Genetic testing for CYP2D6 and CYP2C19 suggests improved outcome for antidepressant and antipsychotic medication","volume":"279","author":"Walden","year":"2019","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.jad.2026.122261_bb0880","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1038\/s41398-018-0276-6","article-title":"Methylenetetrahydrofolate reductase and psychiatric diseases","volume":"8","author":"Wan","year":"2018","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.jad.2026.122261_bb0885","first-page":"274","article-title":"Intronic polymorphism in CYP3A4 affects hepatic expression and response to statin drugs","volume":"11","author":"Wang","year":"2011","journal-title":"Pharm. J."},{"key":"10.1016\/j.jad.2026.122261_bb0890","doi-asserted-by":"crossref","first-page":"3922","DOI":"10.1021\/jm400087k","article-title":"Increasing the efficiency of ligands for FK506-binding protein 51 by conformational control","volume":"56","author":"Wang","year":"2013","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.jad.2026.122261_bb0895","first-page":"40","article-title":"Pharmacogenomic testing in child and adolescent psychiatry: An evidence-based review","volume":"48","author":"Wehry","year":"2018","journal-title":"Curr. Probl. Pediatr. Adolesc. Health Care"},{"key":"10.1016\/j.jad.2026.122261_bb0900","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1192\/bjp.bp.106.032219","article-title":"Treatment of depression in primary care. Socio-economic status, clinical need and receipt of treatment","volume":"191","author":"Weich","year":"2007","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.jad.2026.122261_bb0905","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1038\/clpt.2014.129","article-title":"Functional gene variants of CYP3A4","volume":"96","author":"Werk","year":"2014","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.jad.2026.122261_bb0910","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1038\/clpt.2012.96","article-title":"Pharmacogenomics knowledge for personalized medicine","volume":"92","author":"Whirl-Carrillo","year":"2012","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.jad.2026.122261_bb0915","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/j.neuroimage.2010.04.030","article-title":"Imaging the effects of genetic polymorphisms on radioligand binding in the living human brain: A review on genetic neuroreceptor imaging of monoaminergic systems in psychiatry","volume":"53","author":"Willeit","year":"2010","journal-title":"Neuroimage"},{"key":"10.1016\/j.jad.2026.122261_bb0920","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1185\/03007995.2015.1063483","article-title":"Combinatorial pharmacogenomic guidance for psychiatric medications reduces overall pharmacy costs in a 1 year prospective evaluation","volume":"31","author":"Winner","year":"2015","journal-title":"Curr. Med. Res. Opin."},{"key":"10.1016\/j.jad.2026.122261_bb0925","doi-asserted-by":"crossref","first-page":"391","DOI":"10.9758\/cpn.2017.15.4.391","article-title":"Paroxetine versus venlafaxine and escitalopram in Korean patients with major depressive disorder: A randomized, rater-blinded, six-week study","volume":"15","author":"Woo","year":"2017","journal-title":"Clin. Psychopharmacol. Neurosci."},{"key":"10.1016\/j.jad.2026.122261_bb0930","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1038\/npp.2010.37","article-title":"Interaction of FKBP5 with childhood adversity on risk for post-traumatic stress disorder","volume":"35","author":"Xie","year":"2010","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.jad.2026.122261_bb0935","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0033222","article-title":"Polymorphisms in MTHFR, MS and CBS genes and homocysteine levels in a Pakistani population","volume":"7","author":"Yakub","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jad.2026.122261_bb0940","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.euroneuro.2005.12.004","article-title":"Association study of two serotonin 1A receptor gene polymorphisms and fluoxetine treatment response in Chinese major depressive disorders","volume":"16","author":"Yu","year":"2006","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.jad.2026.122261_bb0945","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.pharmthera.2012.12.007","article-title":"Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation","volume":"138","author":"Zanger","year":"2013","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.jad.2026.122261_bb2045","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/gbb.12104","article-title":"Gene\u2013environment interactions at the\u202fFKBP5\u202flocus: sensitive periods, mechanisms and pleiotropism","volume":"13","author":"Zannas","year":"2014","journal-title":"Genes Brain Behav."},{"key":"10.1016\/j.jad.2026.122261_bb0950","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1038\/mp.2017.35","article-title":"Epigenetic programming by stress and glucocorticoids along the human lifespan","volume":"22","author":"Zannas","year":"2017","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jad.2026.122261_bb0955","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1176\/appi.ajp.2018.17111282","article-title":"Clinical implementation of pharmacogenetic decision support tools for antidepressant drug prescribing","volume":"175","author":"Zeier","year":"2018","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jad.2026.122261_bb0960","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2015.00225","article-title":"The role of serotonin 5-HT2A receptors in memory and cognition","volume":"6","author":"Zhang","year":"2015","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jad.2026.122261_bb0965","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1097\/FPC.0b013e32832c15c6","article-title":"Catechol O-methyltransferase pharmacogenomics: human liver genotype-phenotype correlation and proximal promoter studies","volume":"19","author":"Zhang","year":"2009","journal-title":"Pharmacogenet. Genomics"},{"key":"10.1016\/j.jad.2026.122261_bb0970","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1080\/03602530902843483","article-title":"Polymorphism of human cytochrome P450 enzymes and its clinical impact","volume":"41","author":"Zhou","year":"2009","journal-title":"Drug Metab. Rev."},{"key":"10.1016\/j.jad.2026.122261_bb0975","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1002\/cpt.690","article-title":"Worldwide distribution of cytochrome P450 alleles: A meta-analysis of population-scale sequencing projects","volume":"102","author":"Zhou","year":"2017","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.jad.2026.122261_bb0980","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.neulet.2010.08.019","article-title":"Meta-analysis of FKBP5 gene polymorphisms association with treatment response in patients with mood disorders","volume":"484","author":"Zou","year":"2010","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.jad.2026.122261_bb2010","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1111\/1460-6984.12901","article-title":"A randomized study of parent- versus child-directed intervention for Dutch toddlers with DLD","volume":"58","author":"Zwitserlood-Nijenhuis","year":"2023","journal-title":"Int. J. Lang. Commun. Disord."}],"container-title":["Journal of Affective Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032726011146?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032726011146?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T17:52:00Z","timestamp":1793382720000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165032726011146"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":206,"alternative-id":["S0165032726011146"],"URL":"https:\/\/doi.org\/10.1016\/j.jad.2026.122261","relation":{},"ISSN":["0165-0327"],"issn-type":[{"value":"0165-0327","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Individualized pharmacogenomics for depressive episodes: A narrative review","name":"articletitle","label":"Article Title"},{"value":"Journal of Affective Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jad.2026.122261","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"122261"}}