{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T18:33:21Z","timestamp":1793385201532,"version":"4.5.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007620","name":"Department of Education of Liaoning Province","doi-asserted-by":"publisher","award":["LJ222510161002"],"award-info":[{"award-number":["LJ222510161002"]}],"id":[{"id":"10.13039\/501100007620","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010086","name":"Liaoning Provincial Education Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010086","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012465","name":"Dalian Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012465","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82471464"],"award-info":[{"award-number":["82471464"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82501624"],"award-info":[{"award-number":["82501624"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Affective Disorders"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.jad.2026.122376","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T15:01:56Z","timestamp":1786633316000},"page":"122376","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Depolymerization of aquaporin-4 orthogonal array particles via the A25Q mutation does not cause behavioral deficits but confers resilience to chronic unpredictable mild stress"],"prefix":"10.1016","volume":"414","author":[{"given":"Supratik","family":"Kundu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Ai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue-lin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-cheng","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan-yue","family":"Shan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-fan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ao-ran","family":"Sui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan-dan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong-hui","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.jad.2026.122376_bb0005","article-title":"The impact of chronic unpredictable mild stress-induced depression on spatial, recognition and reference memory tasks in mice: behavioral and histological study","volume":"12","author":"Alqurashi","year":"2022","journal-title":"Behav Sci (Basel)."},{"key":"10.1016\/j.jad.2026.122376_bb0010","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.1007\/s11064-015-1519-z","article-title":"Regulation and function of AQP4 in the central nervous system","volume":"40","author":"Assentoft","year":"2015","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.jad.2026.122376_bb0015","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.jad.2019.07.008","article-title":"Electroconvulsive shock restores the decreased coverage of brain blood vessels by astrocytic endfeet and ameliorates depressive-like behavior","volume":"257","author":"Azis","year":"2019","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2026.122376_bb0030","article-title":"Terazosin produces an antidepressant-like effect in mice exposed to chronic unpredictable mild stress behavioral alteration","volume":"822","author":"Bhatia","year":"2024","journal-title":"Neurosci. Lett."},{"issue":"11","key":"10.1016\/j.jad.2026.122376_bb0035","doi-asserted-by":"crossref","first-page":"6773","DOI":"10.1038\/s41380-021-01160-8","article-title":"Omega-3 polyunsaturated fatty acids protect against inflammation through production of LOX and CYP450 lipid mediators: relevance for major depression and for human hippocampal neurogenesis","volume":"26","author":"Borsini","year":"2021","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jad.2026.122376_bb0045","article-title":"The mouse forced swim test","volume":"59","author":"Can","year":"2012","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.jad.2026.122376_bb0050","article-title":"The tail suspension test","volume":"59","author":"Can","year":"2012","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.jad.2026.122376_bb0055","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1210\/er.2018-00084","article-title":"Melatonin as a hormone: new physiological and clinical insights","volume":"39","author":"Cipolla-Neto","year":"2018","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.jad.2026.122376_bb0060","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1242\/jcs.042341","article-title":"Determinants of aquaporin-4 assembly in orthogonal arrays revealed by live-cell single-molecule fluorescence imaging","volume":"122","author":"Crane","year":"2009","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.jad.2026.122376_bb0070","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2016.00008","article-title":"Fluoxetine requires the endfeet protein aquaporin-4 to enhance plasticity of astrocyte processes","volume":"10","author":"Di Benedetto","year":"2016","journal-title":"Front. Cell. Neurosci."},{"issue":"220","key":"10.1016\/j.jad.2026.122376_bb0080","article-title":"TNF-\u03b1\/TNFR1 activated astrocytes exacerbate depression-like behavior in CUMS mice","volume":"10","author":"Gao","year":"2024","journal-title":"Cell Death Discov."},{"issue":"9","key":"10.1016\/j.jad.2026.122376_bb0085","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.it.2020.07.007","article-title":"The role of astrocytes in CNS inflammation","volume":"41","author":"Giovannoni","year":"2020","journal-title":"Trends Immunol."},{"issue":"19","key":"10.1016\/j.jad.2026.122376_bb0090","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241914618","article-title":"The effects of chronic unpredictable mild stress and semi-pure diets on the brain, gut and adrenal medulla in C57BL6 mice","volume":"24","author":"Herselman","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.jad.2026.122376_bb0095","doi-asserted-by":"crossref","first-page":"3233","DOI":"10.15419\/bmrat.v6i6.550","article-title":"Centella asiatica prevents chronic unpredictable mild stress-induced behavioral changes in rats","volume":"6","author":"Jagadeesan","year":"2019","journal-title":"Biomed. Res. Ther."},{"issue":"3","key":"10.1016\/j.jad.2026.122376_bb0100","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1002\/ar.22641","article-title":"Quantitative analysis of histological staining and fluorescence using ImageJ","volume":"296","author":"Jensen","year":"2013","journal-title":"Anat Rec (Hoboken)."},{"issue":"1\u20132","key":"10.1016\/j.jad.2026.122376_bb0105","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.jad.2011.09.024","article-title":"Protein levels of \u03b2-catenin and activation state of glycogen synthase kinase-3\u03b2 in major depression. A study with postmortem prefrontal cortex","volume":"136","author":"Karege","year":"2012","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2026.122376_bb0110","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.neures.2009.03.002","article-title":"Activity-dependent glial swelling is impaired in aquaporin-4 knockout mice","volume":"64","author":"Kitaura","year":"2009","journal-title":"Neurosci. Res."},{"issue":"Pt 24","key":"10.1016\/j.jad.2026.122376_bb0115","doi-asserted-by":"crossref","first-page":"4029","DOI":"10.1242\/jcs.035758","article-title":"AQP4 knockout impairs proliferation, migration and neuronal differentiation of adult neural stem cells","volume":"121","author":"Kong","year":"2008","journal-title":"J. Cell Sci."},{"issue":"5","key":"10.1016\/j.jad.2026.122376_bb0120","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1038\/npp.2008.185","article-title":"Requirement of AQP4 for antidepressive efficiency of fluoxetine: implication in adult hippocampal neurogenesis","volume":"34","author":"Kong","year":"2009","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.jad.2026.122376_bb0125","article-title":"Aquaporin-4 knockout exacerbates corticosterone-induced depression by inhibiting astrocyte function and hippocampal neurogenesis","author":"Kong","year":"2016","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.jad.2026.122376_bb0130","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.bbi.2020.05.030","article-title":"Analysis of cerebrovascular dysfunction caused by chronic social defeat in mice","volume":"88","author":"Lehmann","year":"2020","journal-title":"Brain Behav. Immun."},{"issue":"9451","key":"10.1016\/j.jad.2026.122376_bb0135","doi-asserted-by":"crossref","first-page":"2106","DOI":"10.1016\/S0140-6736(04)17551-X","article-title":"A serum autoantibody marker of neuromyelitis optica: distinction from multiple sclerosis","volume":"364","author":"Lennon","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.jad.2026.122376_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2020.135485","article-title":"Protection of hUC-MSCs against neuronal complement C3a receptor-mediated NLRP3 activation in CUMS-induced mice","volume":"741","author":"Li","year":"2021","journal-title":"Neurosci. Lett."},{"issue":"16","key":"10.1016\/j.jad.2026.122376_bb0150","doi-asserted-by":"crossref","first-page":"3611","DOI":"10.1111\/bph.15178","article-title":"ARRIVE 2.0 and the British Journal of Pharmacology: Updated guidance for 2020","volume":"177","author":"Lilley","year":"2020","journal-title":"Br. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.jad.2026.122376_bb0155","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.bbr.2005.06.034","article-title":"Effect of chronic unpredictable mild stress on brain\u2013pancreas relative protein in rat brain and pancreas","volume":"165","author":"Lin","year":"2005","journal-title":"Behav. Brain Res."},{"issue":"5","key":"10.1016\/j.jad.2026.122376_bb0170","doi-asserted-by":"crossref","DOI":"10.1093\/ijnp\/pyu110","article-title":"PI3K\/AKT\/mTOR signaling-mediated neuropeptide VGF in the hippocampus of mice is involved in the rapid onset antidepressant-like effects of GLYX-13","volume":"18","author":"Lu","year":"2015","journal-title":"Int. J. Neuropsychopharmacol."},{"issue":"3","key":"10.1016\/j.jad.2026.122376_bb0175","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1111\/j.1600-0447.1993.tb03349.x","article-title":"Autoimmunity in depression: increased antiphospholipid autoantibodies","volume":"87","author":"Maes","year":"1993","journal-title":"Acta Psychiatr. Scand."},{"key":"10.1016\/j.jad.2026.122376_bb0180","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/72256","article-title":"Aquaporin-4 deletion in mice reduces brain edema after acute water intoxication and ischemic stroke","volume":"6","author":"Manley","year":"2000","journal-title":"Nat. Med."},{"issue":"12","key":"10.1016\/j.jad.2026.122376_bb0185","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1038\/s41593-017-0010-3","article-title":"Social stress induces neurovascular pathology promoting depression","volume":"20","author":"Menard","year":"2017","journal-title":"Nat. Neurosci."},{"issue":"5","key":"10.1016\/j.jad.2026.122376_bb0195","article-title":"TRIM32 deficiency impairs synaptic plasticity by excitatory-inhibitory imbalance via notch pathway","volume":"30","author":"Ntim","year":"2020","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.jad.2026.122376_bb0200","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/S1474-4422(12)70133-3","article-title":"Aquaporin 4 and neuromyelitis optica","volume":"11","author":"Papadopoulos","year":"2012","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.jad.2026.122376_bb0210","article-title":"The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research","volume":"16","author":"Percie","year":"2020","journal-title":"BMC Vet. Res."},{"issue":"3","key":"10.1016\/j.jad.2026.122376_bb0215","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1038\/s41380-019-0615-x","article-title":"Neuroplasticity in cognitive and psychological mechanisms of depression: an integrative model","volume":"25","author":"Price","year":"2020","journal-title":"Mol. Psychiatry"},{"issue":"11","key":"10.1016\/j.jad.2026.122376_bb0230","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1177\/0269881113497612","article-title":"Electroconvulsive seizure-induced changes in gene expression in the mouse hypothalamic paraventricular nucleus","volume":"27","author":"Sakaida","year":"2013","journal-title":"J. Psychopharmacol."},{"issue":"11","key":"10.1016\/j.jad.2026.122376_bb0240","article-title":"Microglia-derived interleukin-6 triggers astrocyte apoptosis in the hippocampus and mediates depression-like behavior","volume":"12","author":"Shen","year":"2025","journal-title":"Adv Sci (Weinh)"},{"key":"10.1016\/j.jad.2026.122376_bb0245","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1083\/jcb.201308118","article-title":"Aggregation state determines the localization and function of M1\u2013and M23\u2013aquaporin-4 in astrocytes","volume":"204","author":"Smith","year":"2014","journal-title":"J. Cell Biol."},{"issue":"4","key":"10.1016\/j.jad.2026.122376_bb0250","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.biopsych.2008.03.029","article-title":"DumanA postpartum model in rat: behavioral and gene expression changes induced by ovarian steroid deprivation","volume":"64","author":"Suda","year":"2008","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jad.2026.122376_bb0255","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.bbi.2017.10.025","article-title":"Depression and sterile inflammation: essential role of danger associated molecular patterns","volume":"72","author":"Tina","year":"2018","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.jad.2026.122376_bb0265","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2020.586321","article-title":"Levodopa improves cognitive function and the deficits of structural synaptic plasticity in hippocampus induced by global cerebral ischemia\/reperfusion injury in rats","volume":"14","author":"Wang","year":"2020","journal-title":"Front. Neurosci."},{"issue":"4","key":"10.1016\/j.jad.2026.122376_bb0270","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1007\/s00213-018-5147-6","article-title":"Chronic stress impairs the aquaporin-4-mediated glymphatic transport through glucocorticoid signaling","volume":"236","author":"Wei","year":"2019","journal-title":"Psychopharmacology"},{"issue":"3","key":"10.1016\/j.jad.2026.122376_bb0275","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s00213-016-4473-9","article-title":"Mechanism of depression as a risk factor in the development of Alzheimer's disease: the function of AQP4 and the glymphatic system","volume":"234","author":"Xia","year":"2017","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.jad.2026.122376_bb0280","doi-asserted-by":"crossref","DOI":"10.1038\/s41398-023-02614-z","article-title":"Melatonin alleviates depression-like behaviors and cognitive dysfunction in mice by regulating the circadian rhythm of AQP4 polarization","volume":"13","author":"Yao","year":"2023","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.jad.2026.122376_bb0290","article-title":"Beneficial effect of alkaloids from Sophora alopecuroides L. on CUMS induced depression model mice via modulating gut microbiota","volume":"11","author":"Zhang","year":"2021","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.jad.2026.122376_bb0295","doi-asserted-by":"crossref","first-page":"3425","DOI":"10.2147\/DDDT.S315060","article-title":"Network pharmacology and experimental evidence: PI3K\/AKT signaling pathway is involved in the antidepressive roles of Chaihu Shugan san","volume":"15","author":"Zhang","year":"2021","journal-title":"Drug Des. Devel. Ther."},{"issue":"30","key":"10.1016\/j.jad.2026.122376_bb0310","article-title":"AQP4 aggravates cognitive impairment in Sepsis-associated encephalopathy through inhibiting Nav1.6-mediated astrocyte autophagy","volume":"10","author":"Zhu","year":"2023","journal-title":"Adv Sci (Weinh)."},{"issue":"43","key":"10.1016\/j.jad.2026.122376_bb0315","doi-asserted-by":"crossref","first-page":"81698183","DOI":"10.1523\/JNEUROSCI.0401-22.2022","article-title":"AQP4-A25Q point mutation in mice depolymerizes orthogonal arrays of particles and decreases polarized expression of AQP4 protein in astrocytic endfeet at the blood\u2013brain barrier","volume":"42","author":"Zhu","year":"2022","journal-title":"J. Neurosci."}],"container-title":["Journal of Affective Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032726012292?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032726012292?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T18:04:34Z","timestamp":1793383474000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165032726012292"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":46,"alternative-id":["S0165032726012292"],"URL":"https:\/\/doi.org\/10.1016\/j.jad.2026.122376","relation":{},"ISSN":["0165-0327"],"issn-type":[{"value":"0165-0327","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Depolymerization of aquaporin-4 orthogonal array particles via the A25Q mutation does not cause behavioral deficits but confers resilience to chronic unpredictable mild stress","name":"articletitle","label":"Article Title"},{"value":"Journal of Affective Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jad.2026.122376","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"122376"}}