{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T18:32:28Z","timestamp":1793385148550,"version":"4.5.0"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Affective Disorders"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.jad.2026.122389","type":"journal-article","created":{"date-parts":[[2026,8,16]],"date-time":"2026-08-16T21:57:30Z","timestamp":1786917450000},"page":"122389","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Early metabolic and gut microbiota alterations during antipsychotic\u2011lithium treatment in acute bipolar mania: A prospective follow-up study"],"prefix":"10.1016","volume":"414","author":[{"given":"Xin","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Jian","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.jad.2026.122389_bb0005","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1080\/14740338.2020.1713091","article-title":"Update on weight-gain caused by antipsychotics: A systematic review and meta-analysis","volume":"19","author":"Barton","year":"2020","journal-title":"Expert Opin. Drug Saf."},{"issue":"6","key":"10.1016\/j.jad.2026.122389_bb0010","doi-asserted-by":"crossref","DOI":"10.1099\/mic.0.001568","article-title":"Pharmaco-psychiatry and gut microbiome: a systematic review of effects of psychotropic drugs for bipolar disorder","volume":"171","author":"Bui","year":"2025","journal-title":"Microbiology"},{"issue":"1","key":"10.1016\/j.jad.2026.122389_bb0020","doi-asserted-by":"crossref","DOI":"10.1192\/bjo.2022.619","article-title":"Association between antipsychotic medication and clinically relevant weight change: meta-analysis","volume":"9","author":"Campforts","year":"2023","journal-title":"BJPsych Open"},{"issue":"12","key":"10.1016\/j.jad.2026.122389_bb0025","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1016\/j.molmet.2016.10.003","article-title":"Gut microbiota and glucometabolic alterations in response to recurrent partial sleep deprivation in normal-weight young individuals","volume":"5","author":"Benedict","year":"2016","journal-title":"Mol. Metab."},{"issue":"9","key":"10.1016\/j.jad.2026.122389_bb0030","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms12091768","article-title":"The ambiguous correlation of Blautia with obesity: a systematic review","volume":"12","author":"Chanda","year":"2024","journal-title":"Microorganisms"},{"issue":"4","key":"10.1016\/j.jad.2026.122389_bb0035","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1080\/14737175.2016.1276284","article-title":"Is there a \u201cweight neutral\u201d second-generation antipsychotic for bipolar disorder?","volume":"17","author":"Fang","year":"2017","journal-title":"Expert. Rev. Neurother."},{"issue":"3","key":"10.1016\/j.jad.2026.122389_bb0040","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1002\/phar.1890","article-title":"Interaction between atypical antipsychotics and the gut microbiome in a bipolar disease cohort","volume":"37","author":"Flowers","year":"2017","journal-title":"Pharmacotherapy"},{"issue":"3","key":"10.1016\/j.jad.2026.122389_bb0045","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1590\/1516-4446-2020-0987","article-title":"The role of the microbiota-gut-brain axis in neuropsychiatric disorders","volume":"43","author":"Generoso","year":"2021","journal-title":"Brazilian Journal of Psychiatry"},{"issue":"1","key":"10.1016\/j.jad.2026.122389_bb0050","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s40345-016-0068-y","article-title":"Lithium side effects and toxicity: prevalence and management strategies","volume":"4","author":"Gitlin","year":"2016","journal-title":"Int J Bipolar Disord"},{"issue":"3","key":"10.1016\/j.jad.2026.122389_bb0055","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1080\/19490976.2017.1406584","article-title":"Low dietary fiber intake increases Collinsella abundance in the gut microbiota of overweight and obese pregnant women","volume":"9","author":"Gomez-Arango","year":"2018","journal-title":"Gut Microbes"},{"issue":"1","key":"10.1016\/j.jad.2026.122389_bb0060","doi-asserted-by":"crossref","first-page":"13073","DOI":"10.1038\/s41598-022-17417-3","article-title":"The abundance of Bifidobacterium in relation to visceral obesity and serum uric acid","volume":"12","author":"Gong","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jad.2026.122389_bb0065","doi-asserted-by":"crossref","first-page":"4477","DOI":"10.1038\/s41467-022-32015-7","article-title":"Oral administration of Blautia wexlerae ameliorates obesity and type 2 diabetes via metabolic remodeling of the gut microbiota","volume":"13","author":"Hosomi","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jad.2026.122389_bb0070","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2019.00098","article-title":"Current understanding of gut microbiota in mood disorders: an update of human studies","volume":"10","author":"Huang","year":"2019","journal-title":"Front. Genet."},{"issue":"6","key":"10.1016\/j.jad.2026.122389_bb0075","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1007\/s12072-019-09987-8","article-title":"Significant decrease in Faecalibacterium among gut microbiota in nonalcoholic fatty liver disease: A large BMI- and sex-matched population study","volume":"13","author":"Iino","year":"2019","journal-title":"Hepatol. Int."},{"issue":"15","key":"10.1016\/j.jad.2026.122389_bb0080","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1093\/bioinformatics\/btv183","article-title":"Power and sample-size estimation for microbiome studies using pairwise distances and PERMANOVA","volume":"31","author":"Kelly","year":"2015","journal-title":"Bioinformatics"},{"issue":"4","key":"10.1016\/j.jad.2026.122389_bb0085","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1176\/appi.focus.20230009","article-title":"The CANMAT and ISBD guidelines for the treatment of bipolar disorder: Summary and a 2023 update of evidence","volume":"21","author":"Keramatian","year":"2023","journal-title":"Focus"},{"issue":"12","key":"10.1016\/j.jad.2026.122389_bb0090","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0052078","article-title":"Hypothesis testing and power calculations for taxonomic-based human microbiome data","volume":"7","author":"La Rosa","year":"2012","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.jad.2026.122389_bb0095","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1093\/schbul\/sbac001","article-title":"Antipsychotic-induced weight gain: dose-response meta-analysis of randomized controlled trials","volume":"48","author":"Wu","year":"2022","journal-title":"Schizophr. Bull."},{"key":"10.1016\/j.jad.2026.122389_bb0100","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2025.1679119","article-title":"Characterization of the gut microbiota in people with different levels of obesity","volume":"16","author":"Li","year":"2025","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.jad.2026.122389_bb0105","article-title":"The burden of antipsychotic-induced weight gain and metabolic syndrome in children","volume":"12","author":"Libowitz","year":"2021","journal-title":"Front. Psychol."},{"issue":"1","key":"10.1016\/j.jad.2026.122389_bb0110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/YCO.0000000000000829","article-title":"Advances in the gut microbiome and mood disorders","volume":"36","author":"M\u00f6rkl","year":"2023","journal-title":"Curr. Opin. Psychiatry"},{"issue":"12","key":"10.1016\/j.jad.2026.122389_bb0115","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1001\/jamapsychiatry.2021.2573","article-title":"Perturbations in gut microbiota composition in psychiatric disorders: A review and meta-analysis","volume":"78","author":"Nikolova","year":"2021","journal-title":"JAMA Psychiatry"},{"issue":"1","key":"10.1016\/j.jad.2026.122389_bb0120","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1093\/schbul\/sbac133","article-title":"Evolutions of metabolic parameters following switches of psychotropic drugs: A longitudinal cohort study","volume":"49","author":"Piras","year":"2023","journal-title":"Schizophr. Bull."},{"issue":"1","key":"10.1016\/j.jad.2026.122389_bb0125","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.dsx.2018.08.008","article-title":"The effect of probiotic supplementation on glycemic control and lipid profile in patients with type 2 diabetes: a randomized placebo controlled trial","volume":"13","author":"Razmpoosh","year":"2019","journal-title":"Diabetes & Metabolic Syndrome"},{"key":"10.1016\/j.jad.2026.122389_bb0130","doi-asserted-by":"crossref","DOI":"10.1177\/20451253221096525","article-title":"Gut microbiome in schizophrenia and antipsychotic-induced metabolic alterations: a scoping review","volume":"12","author":"Singh","year":"2022","journal-title":"Ther. Adv. Psychopharmacol."},{"issue":"4","key":"10.1016\/j.jad.2026.122389_bb0135","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1093\/schbul\/sbaa191","article-title":"Does switching antipsychotics ameliorate weight gain in patients with severe mental illness? A systematic review and meta-analysis","volume":"47","author":"Siskind","year":"2021","journal-title":"Schizophr. Bull."},{"issue":"7","key":"10.1016\/j.jad.2026.122389_bb0140","doi-asserted-by":"crossref","DOI":"10.3390\/medicina57070678","article-title":"Differences in compositions of oral and fecal microbiota between patients with obesity and controls","volume":"57","author":"Stefura","year":"2021","journal-title":"Medicina"},{"issue":"9","key":"10.1016\/j.jad.2026.122389_bb0145","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1055\/a-1882-8423","article-title":"A systematic review and meta-analysis of metabolic syndrome prevalence in Chinese inpatients with bipolar disorder","volume":"54","author":"Tao","year":"2022","journal-title":"Horm. Metab. Res."},{"issue":"1","key":"10.1016\/j.jad.2026.122389_bb0150","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s12263-021-00703-6","article-title":"Gut microbiota in patients with obesity and metabolic disorders: a systematic review","volume":"17","author":"Xu","year":"2022","journal-title":"Genes Nutr."},{"issue":"8","key":"10.1016\/j.jad.2026.122389_bb0155","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1111\/bdi.13135","article-title":"Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) recommendations for the management of patients with bipolar disorder with mixed presentations","volume":"23","author":"Yatham","year":"2021","journal-title":"Bipolar Disord."},{"key":"10.1016\/j.jad.2026.122389_bb0160","doi-asserted-by":"crossref","DOI":"10.1155\/2023\/5127157","article-title":"The role of gut microbiota in various neurological and psychiatric disorders: an evidence mapping based on quantified evidence","volume":"2023","author":"Zang","year":"2023","journal-title":"Mediat. Inflamm."}],"container-title":["Journal of Affective Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032726012425?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032726012425?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T17:57:36Z","timestamp":1793383056000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165032726012425"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":31,"alternative-id":["S0165032726012425"],"URL":"https:\/\/doi.org\/10.1016\/j.jad.2026.122389","relation":{},"ISSN":["0165-0327"],"issn-type":[{"value":"0165-0327","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Early metabolic and gut microbiota alterations during antipsychotic\u2011lithium treatment in acute bipolar mania: A prospective follow-up study","name":"articletitle","label":"Article Title"},{"value":"Journal of Affective Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jad.2026.122389","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"122389"}}