{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T04:55:45Z","timestamp":1790830545124,"version":"4.1.0"},"reference-count":63,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100015956","name":"Special Project for Research and Development in Key areas of Guangdong Province","doi-asserted-by":"publisher","award":["2023B0303020001"],"award-info":[{"award-number":["2023B0303020001"]}],"id":[{"id":"10.13039\/501100015956","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004000","name":"Guangzhou Municipal Science and Technology Program key projects","doi-asserted-by":"publisher","award":["2025A03J3357"],"award-info":[{"award-number":["2025A03J3357"]}],"id":[{"id":"10.13039\/501100004000","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82301688"],"award-info":[{"award-number":["82301688"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023A1515011383"],"award-info":[{"award-number":["2023A1515011383"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2025A1515010507"],"award-info":[{"award-number":["2025A1515010507"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2025YFC3410005"],"award-info":[{"award-number":["2025YFC3410005"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2025YFC3410000"],"award-info":[{"award-number":["2025YFC3410000"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009659","name":"Guangzhou Medical University","doi-asserted-by":"publisher","award":["2024SRP200"],"award-info":[{"award-number":["2024SRP200"]}],"id":[{"id":"10.13039\/100009659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Affective Disorders"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.jad.2026.122465","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T15:14:28Z","timestamp":1788362068000},"page":"122465","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Compensatory neurochemical adaptation in first-episode, drug-na\u00efve depression: Integrating cortical and systemic metabolism using multivoxel 1H-MRS"],"prefix":"10.1016","volume":"415","author":[{"given":"Shuyun","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengchun","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangda","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hehua","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhendong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhang","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingping","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingxin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junlu","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jad.2026.122465_bb0005","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1176\/appi.ajp.2014.14010067","article-title":"Glutamate metabolism in major depressive disorder","volume":"171","author":"Abdallah","year":"2014","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jad.2026.122465_bb0010","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1002\/nbm.2937","article-title":"Improved efficiency on editing MRS of lactate and \u03b3-aminobutyric acid by inclusion of frequency offset corrected inversion pulses at high fields","volume":"26","author":"Arteaga de Castro","year":"2013","journal-title":"NMR Biomed."},{"key":"10.1016\/j.jad.2026.122465_bb0015","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1111\/j.1471-4159.2006.03913.x","article-title":"The glutamate\/GABA-glutamine cycle: aspects of transport, neurotransmitter homeostasis and ammonia transfer","volume":"98","author":"Bak","year":"2006","journal-title":"J. Neurochem."},{"key":"10.1016\/j.jad.2026.122465_bb0020","doi-asserted-by":"crossref","first-page":"5013","DOI":"10.1038\/s41380-025-03083-0","article-title":"Evidence of bidirectional relationship between type 2 diabetes and depression; a Mendelian randomization study","volume":"30","author":"Bala","year":"2025","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jad.2026.122465_bb0025","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1002\/nbm.1940060114","article-title":"Quantitation of proton NMR spectra of the human brain using tissue water as an internal concentration reference","volume":"6","author":"Barker","year":"1993","journal-title":"NMR Biomed."},{"key":"10.1016\/j.jad.2026.122465_bb0030","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.nic.2012.10.002","article-title":"Brain proton magnetic resonance spectroscopy: introduction and overview","volume":"23","author":"Bertholdo","year":"2013","journal-title":"Neuroimaging Clin. N. Am."},{"key":"10.1016\/j.jad.2026.122465_bb0035","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/j.neuroimage.2013.07.062","article-title":"On the use of Cram\u00e9r-Rao minimum variance bounds for the design of magnetic resonance spectroscopy experiments","volume":"83","author":"Bolliger","year":"2013","journal-title":"Neuroimage"},{"key":"10.1016\/j.jad.2026.122465_bb0040","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.euroneuro.2023.03.007","article-title":"Associations between individual depressive symptoms and immunometabolic characteristics in major depression","volume":"71","author":"Chae","year":"2023","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.jad.2026.122465_bb0045","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1109\/TCI.2023.3267623","article-title":"Magnetic resonance spectroscopy deep learning denoising using few in vivo data","volume":"9","author":"Chen","year":"2023","journal-title":"IEEE Trans. Comput. Imaging"},{"key":"10.1016\/j.jad.2026.122465_bb0050","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1109\/TBME.2024.3354123","article-title":"Magnetic resonance spectroscopy quantification aided by deep estimations of imperfection factors and macromolecular signal","volume":"71","author":"Chen","year":"2024","journal-title":"IEEE Trans. Biomed. Eng."},{"key":"10.1016\/j.jad.2026.122465_bb0055","article-title":"CloudBrain-MRS: an intelligent cloud computing platform for in vivo magnetic resonance spectroscopy preprocessing, quantification, and analysis","volume":"358","author":"Chen","year":"2024","journal-title":"J. Magn. Reson. (San Diego, Calif.\u202f: 1997)"},{"key":"10.1016\/j.jad.2026.122465_bb0060","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/s41398-023-02580-6","article-title":"Triangulating brain alterations in anorexia nervosa: a multimodal investigation of magnetic resonance spectroscopy, morphometry and blood-based biomarkers","volume":"13","author":"Doose","year":"2023","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.jad.2026.122465_bb0065","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.neuron.2019.03.013","article-title":"Altered connectivity in depression: GABA and glutamate neurotransmitter deficits and reversal by novel treatments","volume":"102","author":"Duman","year":"2019","journal-title":"Neuron"},{"key":"10.1016\/j.jad.2026.122465_bb0070","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/jmrb.1993.1055","article-title":"Absolute quantitation of water and metabolites in the human brain. I. Compartments and water","volume":"102","author":"Ernst","year":"1993","journal-title":"J. Magn. Reson. B"},{"key":"10.1016\/j.jad.2026.122465_bb0075","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.jad.2016.10.019","article-title":"The 52 symptoms of major depression: lack of content overlap among seven common depression scales","volume":"208","author":"Fried","year":"2017","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2026.122465_bb0080","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1002\/mrm.20901","article-title":"Use of tissue water as a concentration reference for proton spectroscopic imaging","volume":"55","author":"Gasparovic","year":"2006","journal-title":"Magn. Reson. Med."},{"key":"10.1016\/j.jad.2026.122465_bb0085","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1002\/nbm.3575","article-title":"Regional distributions of brain glutamate and glutamine in normal subjects","volume":"29","author":"Goryawala","year":"2016","journal-title":"NMR Biomed."},{"key":"10.1016\/j.jad.2026.122465_bb0090","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1136\/jnnp.23.1.56","article-title":"A rating scale for depression","volume":"23","author":"Hamilton","year":"1960","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.jad.2026.122465_bb0095","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1038\/mp.2011.23","article-title":"Discovering imaging endophenotypes for major depression","volume":"16","author":"Hasler","year":"2011","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jad.2026.122465_bb0100","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/s41398-019-0500-z","article-title":"Association between prefrontal glutamine levels and neuroticism determined using proton magnetic resonance spectroscopy","volume":"9","author":"Hasler","year":"2019","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.jad.2026.122465_bb0105","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s12991-025-00580-y","article-title":"The relationship among hopelessness, suicide risk, body mass index and eating motivations in major depressive disorder comorbid with obesity: a case-control study","volume":"24","author":"Helvac\u0131 \u00c7elik","year":"2025","journal-title":"Ann. General Psychiatry"},{"key":"10.1016\/j.jad.2026.122465_bb0110","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0017514","article-title":"Scaling of brain metabolism with a fixed energy budget per neuron: implications for neuronal activity, plasticity and evolution","volume":"6","author":"Herculano-Houzel","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.jad.2026.122465_bb0115","article-title":"Association of thyroid function with abnormal lipid metabolism in young patients with first-episode and drug na\u00efve major depressive disorder","volume":"14","author":"Hu","year":"2023","journal-title":"Front. Psychol."},{"key":"10.1016\/j.jad.2026.122465_bb0120","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1002\/oby.22557","article-title":"Obesity tissue: composition, energy expenditure, and energy content in adult humans","volume":"27","author":"Hwaung","year":"2019","journal-title":"Obesity"},{"key":"10.1016\/j.jad.2026.122465_bb0125","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s00406-022-01415-7","article-title":"Association of high BMI with subclinical hypothyroidism in young, first-episode and drug-na\u00efve patients with major depressive disorder: a large-scale cross-sectional study","volume":"273","author":"Kang","year":"2023","journal-title":"Eur. Arch. Psychiatry Clin. Neurosci."},{"key":"10.1016\/j.jad.2026.122465_bb0130","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.biopsych.2006.10.001","article-title":"Overweight and obesity affect treatment response in major depression","volume":"62","author":"Kloiber","year":"2007","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jad.2026.122465_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.jfma.2025.10.039","article-title":"Anterior cingulate cortex-related functional dysconnectivity in adolescents with major depressive disorder with and without severe loneliness","author":"Ko","year":"2025","journal-title":"J. Formos. Med. Assoc. = Taiwan yi zhi"},{"key":"10.1016\/j.jad.2026.122465_bb0140","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.jad.2014.02.039","article-title":"Both body weight and BMI predicts improvement in symptom and functioning for patients with major depressive disorder","volume":"161","author":"Lin","year":"2014","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2026.122465_bb0145","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.jad.2023.06.064","article-title":"Association between body mass index and suicide attempts in Chinese patients of a hospital in Shanxi district with first-episode drug-na\u00efve major depressive disorder","volume":"339","author":"Liu","year":"2023","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2026.122465_bb0150","article-title":"The prevalence of underweight and obesity in Chinese children and adolescents with major depressive disorder and relationship with suicidal ideation and attempted suicide","volume":"14","author":"Liu","year":"2023","journal-title":"Front. Psychol."},{"key":"10.1016\/j.jad.2026.122465_bb0155","doi-asserted-by":"crossref","DOI":"10.1155\/da\/6648190","article-title":"Association between body mass index and comorbid anxiety in first-episode and drug na\u00efve patients with major depressive disorder","volume":"2025","author":"Liu","year":"2025","journal-title":"Depress. Anxiety"},{"key":"10.1016\/j.jad.2026.122465_bb0160","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1001\/archgenpsychiatry.2010.2","article-title":"Overweight, obesity, and depression: a systematic review and meta-analysis of longitudinal studies","volume":"67","author":"Luppino","year":"2010","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.jad.2026.122465_bb0165","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.neubiorev.2011.05.014","article-title":"Region and state specific glutamate downregulation in major depressive disorder: a meta-analysis of (1)H-MRS findings","volume":"36","author":"Luykx","year":"2012","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.jad.2026.122465_bb0170","first-page":"60","article-title":"Detection of glutamate alterations in the human brain using (1)H-MRS: comparison of STEAM and sLASER at 7 T","volume":"8","author":"Marsman","year":"2017","journal-title":"Front. Psychol."},{"key":"10.1016\/j.jad.2026.122465_bb0175","doi-asserted-by":"crossref","DOI":"10.1038\/s41572-023-00454-1","article-title":"Major depressive disorder","volume":"9","author":"Marx","year":"2023","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.jad.2026.122465_bb0180","doi-asserted-by":"crossref","first-page":"2428","DOI":"10.1038\/npp.2012.101","article-title":"Increased glutamate levels in the medial prefrontal cortex in patients with postpartum depression","volume":"37","author":"McEwen","year":"2012","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.jad.2026.122465_bb0185","article-title":"Obesity, inflammation, and depression in adolescents","volume":"14","author":"McLachlan","year":"2023","journal-title":"Front. Psychol."},{"key":"10.1016\/j.jad.2026.122465_bb0190","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1038\/mp.2015.86","article-title":"Polygenic dissection of major depression clinical heterogeneity","volume":"21","author":"Milaneschi","year":"2016","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jad.2026.122465_bb0195","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/s41380-018-0017-5","article-title":"Depression and obesity: evidence of shared biological mechanisms","volume":"24","author":"Milaneschi","year":"2019","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jad.2026.122465_bb0200","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1038\/s41380-018-0252-9","article-title":"Glutamatergic neurometabolite levels in major depressive disorder: a systematic review and meta-analysis of proton magnetic resonance spectroscopy studies","volume":"24","author":"Moriguchi","year":"2019","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jad.2026.122465_bb0205","doi-asserted-by":"crossref","first-page":"9","DOI":"10.21037\/qims-20-517","article-title":"Repeatability of proton magnetic resonance spectroscopy of the brain at 7 T: effect of scan time on semi-localized by adiabatic selective refocusing and short-echo time stimulated echo acquisition mode scans and their comparison","volume":"11","author":"Okada","year":"2021","journal-title":"Quant. Imaging Med. Surg."},{"key":"10.1016\/j.jad.2026.122465_bb0210","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.psyneuen.2014.10.001","article-title":"Obesity and major depression: Body-mass index (BMI) is associated with a severe course of disease and specific neurostructural alterations","volume":"51","author":"Opel","year":"2015","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.jad.2026.122465_bb0215","doi-asserted-by":"crossref","first-page":"5588","DOI":"10.1073\/pnas.0501703102","article-title":"The contribution of GABA to glutamate\/glutamine cycling and energy metabolism in the rat cortex in vivo","volume":"102","author":"Patel","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jad.2026.122465_bb0220","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1002\/mrm.1910300604","article-title":"Estimation of metabolite concentrations from localized in vivo proton NMR spectra","volume":"30","author":"Provencher","year":"1993","journal-title":"Magn. Reson. Med."},{"key":"10.1016\/j.jad.2026.122465_bb0225","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1001\/jamapsychiatry.2022.3384","article-title":"Evaluation of prefrontal \u03b3-aminobutyric acid and glutamate levels in individuals with major depressive disorder using proton magnetic resonance spectroscopy","volume":"79","author":"Ritter","year":"2022","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.jad.2026.122465_bb0230","article-title":"Glutamate and GABA homeostasis and neurometabolism in major depressive disorder","volume":"12","author":"Sarawagi","year":"2021","journal-title":"Front. Psychol."},{"key":"10.1016\/j.jad.2026.122465_bb0235","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1038\/mp.2016.60","article-title":"Cortical abnormalities in adults and adolescents with major depression based on brain scans from 20 cohorts worldwide in the ENIGMA Major Depressive Disorder Working Group","volume":"22","author":"Schmaal","year":"2017","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jad.2026.122465_bb0240","doi-asserted-by":"crossref","first-page":"3337","DOI":"10.1002\/hbm.23244","article-title":"Brain GABA levels across psychiatric disorders: a systematic literature review and meta-analysis of (1) H-MRS studies","volume":"37","author":"Sch\u00fcr","year":"2016","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.jad.2026.122465_bb0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2024.167561","article-title":"Depression and obesity: focus on factors and mechanistic links","volume":"1871","author":"Selman","year":"2025","journal-title":"Biochim. Biophys. Acta Mol. basis Dis."},{"key":"10.1016\/j.jad.2026.122465_bb0250","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.4088\/JCP.09r05346blu","article-title":"Antidepressants and body weight: a comprehensive review and meta-analysis","volume":"71","author":"Serretti","year":"2010","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.jad.2026.122465_bb0255","doi-asserted-by":"crossref","DOI":"10.1016\/j.jad.2025.119889","article-title":"Body mass index mediates the relationship between depression and triglyceride levels: evidence from a large national cohort","volume":"390","author":"Shah","year":"2025","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2026.122465_bb0260","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1038\/nature01616","article-title":"Turning on and off recurrent balanced cortical activity","volume":"423","author":"Shu","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.jad.2026.122465_bb0265","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1111\/j.1365-2265.2004.02074.x","article-title":"Proton magnetic resonance spectroscopy and single photon emission computed tomography study of the brain in asymptomatic young hyperlipidaemic Asian Indians in North India show early abnormalities","volume":"61","author":"Sinha","year":"2004","journal-title":"Clin. Endocrinol."},{"key":"10.1016\/j.jad.2026.122465_bb0270","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1017\/S1461145712000272","article-title":"Early increase in marker of neuronal integrity with antidepressant treatment of major depression: 1H-magnetic resonance spectroscopy of N-acetyl-aspartate","volume":"15","author":"Taylor","year":"2012","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.jad.2026.122465_bb0275","series-title":"World Mental Health Report: Transforming Mental Health for All: Executive Summary","author":"World Health Organization","year":"2022"},{"key":"10.1016\/j.jad.2026.122465_bb0280","article-title":"The Brain-Gut Health Initiative (BIGHI): a prospective cohort on psychiatric disorders in China","volume":"9","author":"Wu","year":"2026","journal-title":"Research (Wash D C)"},{"key":"10.1016\/j.jad.2026.122465_bb0285","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.jad.2020.11.059","article-title":"The association of body mass index (BMI) with treatment outcomes in patients with major depressive disorder","volume":"281","author":"Xiao","year":"2021","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2026.122465_bb0290","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1192\/bjp.2024.69","article-title":"Global, regional and national burdens of depression in adolescents and young adults aged 10\u201324\u00a0years, from 1990 to 2019: findings from the 2019 Global Burden of Disease study","volume":"225","author":"Yang","year":"2024","journal-title":"Br. J. Psychiatry J. Ment. Sci."},{"key":"10.1016\/j.jad.2026.122465_bb0295","article-title":"Decreased medial prefrontal cortex glutamate levels in perimenopausal women","volume":"12","author":"Yap","year":"2021","journal-title":"Front. Psychol."},{"key":"10.1016\/j.jad.2026.122465_bb0300","doi-asserted-by":"crossref","first-page":"3363","DOI":"10.1016\/j.neuron.2025.07.018","article-title":"Optimized deep brain stimulation for anterior cingulate cortex inhibition produces antidepressant-like effects in mice","volume":"113","author":"Yuan","year":"2025","journal-title":"Neuron"},{"key":"10.1016\/j.jad.2026.122465_bb0305","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.jad.2022.06.024","article-title":"Correlation between cognitive deficits and dorsolateral prefrontal cortex functional connectivity in first-episode depression","volume":"312","author":"Zhang","year":"2022","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2026.122465_bb0310","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.jpsychires.2024.07.054","article-title":"Change in the global burden of depression from 1990\u20132019 and its prediction for 2030","volume":"178","author":"Zhang","year":"2024","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.jad.2026.122465_bb0315","first-page":"83","article-title":"Predictive values of body mass index and waist circumference for risk factors of certain related diseases in Chinese adults\u2014study on optimal cut-off points of body mass index and waist circumference in Chinese adults","volume":"15","author":"Zhou","year":"2002","journal-title":"Biomed. Environ. Sci."}],"container-title":["Journal of Affective Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032726013182?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032726013182?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T04:01:45Z","timestamp":1790827305000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165032726013182"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":63,"alternative-id":["S0165032726013182"],"URL":"https:\/\/doi.org\/10.1016\/j.jad.2026.122465","relation":{},"ISSN":["0165-0327"],"issn-type":[{"value":"0165-0327","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Compensatory neurochemical adaptation in first-episode, drug-na\u00efve depression: Integrating cortical and systemic metabolism using multivoxel 1H-MRS","name":"articletitle","label":"Article Title"},{"value":"Journal of Affective Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jad.2026.122465","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"122465"}}