{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T01:38:55Z","timestamp":1792633135737,"version":"4.5.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Affective Disorders"],"published-print":{"date-parts":[[2027,1]]},"DOI":"10.1016\/j.jad.2026.122573","type":"journal-article","created":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T06:30:03Z","timestamp":1790922603000},"page":"122573","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Proteins from platelet-enriched preparations as candidate biomarkers for major depressive disorder: An exploratory proteomic study"],"prefix":"10.1016","volume":"416","author":[{"given":"Lu","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ZiMeng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HaoBo","family":"Leng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DaoRan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"TianQi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ZhiQiang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GuoFu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haitao","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CaiLi","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jad.2026.122573_bb0005","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.jadohealth.2020.12.138","article-title":"Clinician recognition of first episode psychosis","volume":"69","author":"Albin","year":"2021","journal-title":"J. Adolesc. Health"},{"key":"10.1016\/j.jad.2026.122573_bb0010","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s12953-014-0049-y","article-title":"Serum peptidome based biomarkers searching for monitoring minimal residual disease in adult acute lymphocytic leukemia","volume":"12","author":"Bai","year":"2014","journal-title":"Proteome Sci."},{"key":"10.1016\/j.jad.2026.122573_bb0015","doi-asserted-by":"crossref","first-page":"4597","DOI":"10.1038\/s41598-019-40788-z","article-title":"Complement component 1q subcomponent binding protein in the brain of the rat","volume":"9","author":"Barna","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jad.2026.122573_bb0020","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.4103\/NRR.NRR-D-24-01459","article-title":"Mitochondrial damage-associated molecular patterns: neuroimmunomodulators in central nervous system pathophysiology","volume":"21","author":"Brooks","year":"2025","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.jad.2026.122573_bb0025","first-page":"21","article-title":"Relationship of mean platelet volume to MDD: a retrospective study","volume":"29","author":"Cai","year":"2017","journal-title":"Shanghai Arch. Psychiatry"},{"key":"10.1016\/j.jad.2026.122573_bb0030","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.jpsychires.2011.11.016","article-title":"Association of mean platelet volume with DSM-IV major depression in a large community-based population: the MELEN study","volume":"46","author":"Canan","year":"2012","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.jad.2026.122573_bb0035","doi-asserted-by":"crossref","first-page":"2597","DOI":"10.1093\/brain\/awx218","article-title":"WDR81 mutations cause extreme microcephaly and impair mitotic progression in human fibroblasts and Drosophila neural stem cells","volume":"140","author":"Cavallin","year":"2017","journal-title":"Brain J. Neurol."},{"key":"10.1016\/j.jad.2026.122573_bb0040","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.pharmthera.2008.10.004","article-title":"Unfaithful neurotransmitter transporters: focus on serotonin uptake and implications for antidepressant efficacy","volume":"121","author":"Daws","year":"2009","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.jad.2026.122573_bb0045","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.pharmthera.2011.03.013","article-title":"Ontogeny and regulation of the serotonin transporter: providing insights into human disorders","volume":"131","author":"Daws","year":"2011","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.jad.2026.122573_bb0050","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s12991-020-00281-8","article-title":"The prevalence of depression among patients with tuberculosis: a systematic review and meta-analysis","volume":"19","author":"Duko","year":"2020","journal-title":"Ann. Gen. Psychiatry"},{"key":"10.1016\/j.jad.2026.122573_bb0055","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.genhosppsych.2007.06.002","article-title":"Major depression in individuals with chronic medical disorders: prevalence, correlates and association with health resource utilization, lost productivity and functional disability","volume":"29","author":"Egede","year":"2007","journal-title":"Gen. Hosp. Psychiatry"},{"key":"10.1016\/j.jad.2026.122573_bb0060","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.ajhg.2017.08.015","article-title":"Biallelic C1QBP mutations cause severe neonatal-, childhood-, or later-onset cardiomyopathy associated with combined respiratory-chain deficiencies","volume":"101","author":"Feichtinger","year":"2017","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.jad.2026.122573_bb0065","first-page":"1517","article-title":"Depression is the leading cause of disability around the world","volume":"317","author":"Friedrich","year":"2017","journal-title":"JAMA"},{"key":"10.1016\/j.jad.2026.122573_bb0070","series-title":"Encyclopedia of Clinical Neuropsychology","first-page":"2410","article-title":"Structured clinical interview for DSM-IV (SCID-I\/SCID-II)","author":"Gorgens","year":"2011"},{"key":"10.1016\/j.jad.2026.122573_bb0075","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.ejpn.2012.08.005","article-title":"Regulated granule trafficking in platelets and neurons: a common molecular machinery","volume":"17","author":"Goubau","year":"2013","journal-title":"Eur. J. Paediatr. Neurol."},{"key":"10.1016\/j.jad.2026.122573_bb0080","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1101\/gr.126110.111","article-title":"Homozygosity mapping and targeted genomic sequencing reveal the gene responsible for cerebellar hypoplasia and quadrupedal locomotion in a consanguineous kindred","volume":"21","author":"Gulsuner","year":"2011","journal-title":"Genome Res."},{"key":"10.1016\/j.jad.2026.122573_bb0085","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.mito.2013.05.005","article-title":"Mitochondrial respiration in blood platelets of depressive patients","volume":"13","author":"Hroudov\u00e1","year":"2013","journal-title":"Mitochondrion"},{"key":"10.1016\/j.jad.2026.122573_bb0090","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.jad.2012.12.001","article-title":"What does the HAMD mean?","volume":"148","author":"Leucht","year":"2013","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2026.122573_bb0095","article-title":"Mitochondrial damage-associated molecular patterns (mtDAMPs) in stress-related psychiatric disorders","volume":"132","author":"Lindqvist","year":"2021","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.jad.2026.122573_bb0100","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1083\/jcb.201608039","article-title":"The BEACH-containing protein WDR81 coordinates p62 and LC3C to promote aggrephagy","volume":"216","author":"Liu","year":"2017","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.jad.2026.122573_bb0105","doi-asserted-by":"crossref","first-page":"19992","DOI":"10.1038\/s41598-022-23374-8","article-title":"Identification of noninvasive diagnostic biomarkers for ectopic pregnancy using data-independent acquisition (DIA)proteomics: a pilot study","volume":"12","author":"Ma","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jad.2026.122573_bb0110","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.1016\/S0140-6736(18)31948-2","article-title":"Depression","volume":"392","author":"Malhi","year":"2018","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.jad.2026.122573_bb0115","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1038\/s41593-017-0010-3","article-title":"Social stress induces neurovascular pathology promoting depression","volume":"20","author":"Menard","year":"2017","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.jad.2026.122573_bb0120","doi-asserted-by":"crossref","first-page":"6035","DOI":"10.1007\/s12035-019-1505-6","article-title":"Prions strongly reduce NMDA receptor S-nitrosylation levels at pre-symptomatic and terminal stages of prion diseases","volume":"56","author":"Meneghetti","year":"2019","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.jad.2026.122573_bb0125","doi-asserted-by":"crossref","first-page":"3802","DOI":"10.1128\/MCB.01368-10","article-title":"DDX60, a DEXD\/H box helicase, is a novel antiviral factor promoting RIG-I-like receptor-mediated signaling\u25bf","volume":"31","author":"Miyashita","year":"2011","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.jad.2026.122573_bb0130","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2016.00200","article-title":"Accessory factors of cytoplasmic viral RNA sensors required for antiviral innate immune response","volume":"7","author":"Oshiumi","year":"2016","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jad.2026.122573_bb0135","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/nrdp.2016.65","article-title":"Major depressive disorder","volume":"2","author":"Otte","year":"2016","journal-title":"Nat. Rev. Dis. Primers."},{"key":"10.1016\/j.jad.2026.122573_bb0140","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1182\/blood-2014-09-598722","article-title":"Autophagy is induced upon platelet activation and is essential for hemostasis and thrombosis","volume":"126","author":"Ouseph","year":"2015","journal-title":"Blood"},{"key":"10.1016\/j.jad.2026.122573_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.psychres.2021.114216","article-title":"Potential usefulness of complete blood count parameters and inflammatory ratios as simple biomarkers of depression and suicide risk in drug-naive, adolescents with major depressive disorder","volume":"305","author":"Puangsri","year":"2021","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.jad.2026.122573_bb0150","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1038\/s41577-020-0288-3","article-title":"RIG-I-like receptors: their regulation and roles in RNA sensing","volume":"20","author":"Rehwinkel","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jad.2026.122573_bb0155","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1001\/jamapsychiatry.2017.1713","article-title":"Association of neural and emotional impacts of reward prediction errors with major depression","volume":"74","author":"Rutledge","year":"2017","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.jad.2026.122573_bb0160","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1177\/02698811221104058","article-title":"Systematic review and meta-analysis of augmentation and combination treatments for early-stage treatment-resistant depression","volume":"37","author":"Scott","year":"2023","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.jad.2026.122573_bb0165","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1016\/j.cmet.2022.09.022","article-title":"Vps37a regulates hepatic glucose production by controlling glucagon receptor localization to endosomes","volume":"34","author":"Sekar","year":"2022","journal-title":"Cell Metab."},{"key":"10.1016\/j.jad.2026.122573_bb0170","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1002\/jez.2554","article-title":"Cardiovascular serotonergic system: evolution, receptors, transporter, and function","volume":"337","author":"Soslau","year":"2022","journal-title":"J. Exp. Zool. A Ecol. Integr. Physiol."},{"key":"10.1016\/j.jad.2026.122573_bb0175","doi-asserted-by":"crossref","first-page":"1089236","DOI":"10.1155\/2024\/1089236","article-title":"Peripheral blood mononuclear cell biomarkers for major depressive disorder: a transcriptomic approach","volume":"2024","author":"Sun","year":"2024","journal-title":"Depress. Anxiety"},{"key":"10.1016\/j.jad.2026.122573_bb0180","author":"The Platelet Web - Systems Biology Workbench"},{"key":"10.1016\/j.jad.2026.122573_bb0185","doi-asserted-by":"crossref","DOI":"10.3390\/cells12020245","article-title":"A multi-trait association analysis of brain disorders and platelet traits identifies novel susceptibility loci for major depression, Alzheimer\u2019s and Parkinson\u2019s disease","volume":"12","author":"Tirozzi","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.jad.2026.122573_bb0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.virusres.2021.198658","article-title":"DEAD\/H-box helicases:anti-viral and pro-viral roles during infections","volume":"309","author":"Ullah","year":"2022","journal-title":"Virus Res."},{"key":"10.1016\/j.jad.2026.122573_bb0195","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1038\/s41380-018-0307-y","article-title":"WDR81 regulates adult hippocampal neurogenesis through endosomal SARA-TGF\u03b2 signaling","volume":"26","author":"Wang","year":"2021","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jad.2026.122573_bb0200","doi-asserted-by":"crossref","DOI":"10.1038\/s41380-026-03732-y","article-title":"Mitochondrial-inflammation crosstalk in major depressive disorder: molecular mechanisms and therapeutic implications","author":"Wang","year":"2026","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jad.2026.122573_bb0205","year":"2021","journal-title":"Depression [Internet]"},{"key":"10.1016\/j.jad.2026.122573_bb0210","article-title":"Lactobacillus plantarum-derived postbiotics prevent Salmonella-induced neurological dysfunctions by modulating gut-brain axis in mice","volume":"9","author":"Wu","year":"2022","journal-title":"Front. Nutr."},{"key":"10.1016\/j.jad.2026.122573_bb0215","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13358","article-title":"Platelet biomarkers for a descending cognitive function: a proteomic approach","volume":"20","author":"Yu","year":"2021","journal-title":"Aging Cell"},{"key":"10.1016\/j.jad.2026.122573_bb0220","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.pnpbp.2014.03.004","article-title":"Platelet 5-HT(1A) receptor correlates with major depressive disorder in drug-free patients","volume":"53","author":"Zhang","year":"2014","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"}],"container-title":["Journal of Affective Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032726014266?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032726014266?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:47:28Z","timestamp":1792630048000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165032726014266"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,1]]},"references-count":44,"alternative-id":["S0165032726014266"],"URL":"https:\/\/doi.org\/10.1016\/j.jad.2026.122573","relation":{},"ISSN":["0165-0327"],"issn-type":[{"value":"0165-0327","type":"print"}],"subject":[],"published":{"date-parts":[[2027,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Proteins from platelet-enriched preparations as candidate biomarkers for major depressive disorder: An exploratory proteomic study","name":"articletitle","label":"Article Title"},{"value":"Journal of Affective Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jad.2026.122573","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"122573"}}