{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T22:46:04Z","timestamp":1792449964631,"version":"4.5.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of the American Dietetic Association"],"published-print":{"date-parts":[[2009,2]]},"DOI":"10.1016\/j.jada.2008.10.046","type":"journal-article","created":{"date-parts":[[2009,1,24]],"date-time":"2009-01-24T09:21:33Z","timestamp":1232788893000},"page":"313-318","source":"Crossref","is-referenced-by-count":38,"title":["Genetic Variants in Phosphatidylethanolamine N-methyltransferase and Methylenetetrahydrofolate Dehydrogenase Influence Biomarkers of Choline Metabolism When Folate Intake Is Restricted"],"prefix":"10.1016","volume":"109","author":[{"given":"Alexandre","family":"Ivanov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Nash-Barboza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Hinkis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie A.","family":"Caudill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jada.2008.10.046_bib1","series-title":"Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B-6, Folate, Vitamin B-12, Pantothenic Acid, Biotin and Choline","year":"1998"},{"key":"10.1016\/j.jada.2008.10.046_bib2","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1146\/annurev.nu.14.070194.001413","article-title":"Choline and human nutrition","volume":"14","author":"Zeisel","year":"1994","journal-title":"Annu Rev Nutr"},{"key":"10.1016\/j.jada.2008.10.046_bib3","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1096\/fasebj.5.7.2010061","article-title":"Choline, an essential nutrient for humans","volume":"5","author":"Zeisel","year":"1991","journal-title":"FASEB J"},{"key":"10.1016\/j.jada.2008.10.046_bib4","first-page":"1399","article-title":"Choline deficiency: A cause of hepatic steatosis during parenteral nutrition that can be reversed with intravenous choline supplementation","volume":"22","author":"Buchman","year":"1995","journal-title":"Hepatology"},{"key":"10.1016\/j.jada.2008.10.046_bib5","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.cmet.2006.03.007","article-title":"The ratio of phosphatidylcholine to phosphatidylethanolamine influences membrane integrity and steatohepatitis","volume":"3","author":"Li","year":"2006","journal-title":"Cell Metab"},{"key":"10.1016\/j.jada.2008.10.046_bib6","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1093\/ajcn\/80.1.163","article-title":"Elevated serum creatine phosphokinase in choline deficient humans: Mechanistic studies in C2C12 mouse myoblasts","volume":"80","author":"da Costa","year":"2004","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.jada.2008.10.046_bib7","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1111\/j.1471-4159.2004.02414.x","article-title":"Choline availability modulates human neuroblastoma cell proliferation and alters the methylation of the promoter region of the cyclic dependent kinase inhibitor 3 gene","volume":"89","author":"Niculescu","year":"2004","journal-title":"J Neurochem"},{"key":"10.1016\/j.jada.2008.10.046_bib8","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1096\/fj.01-0564fje","article-title":"Perturbations in choline metabolism cause neural tube defects in mouse embryos in vitro","volume":"16","author":"Fisher","year":"2002","journal-title":"FASEB J"},{"key":"10.1016\/j.jada.2008.10.046_bib9","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1093\/aje\/kwh187","article-title":"Periconceptional dietary intake of choline and betaine and neural tube defects in offspring","volume":"160","author":"Shaw","year":"2004","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.jada.2008.10.046_bib10","doi-asserted-by":"crossref","first-page":"S131","DOI":"10.1016\/j.jpeds.2006.06.065","article-title":"The fetal origins of memory: The role of dietary choline in optimal brain development","volume":"149","author":"Zeisel","year":"2006","journal-title":"J Pediatr"},{"key":"10.1016\/j.jada.2008.10.046_bib11","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1146\/annurev.nutr.26.061505.111156","article-title":"Choline: Critical role during fetal development and dietary requirements in adults","volume":"26","author":"Zeisel","year":"2006","journal-title":"Annu Rev Nutr"},{"key":"10.1016\/j.jada.2008.10.046_bib12","first-page":"3049","article-title":"Pregnancy and lactation are associated with diminished concentration of choline and its metabolites in rat liver","volume":"125","author":"Zeisel","year":"1995","journal-title":"J Nutr"},{"key":"10.1016\/j.jada.2008.10.046_bib13","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1093\/ajcn\/82.4.836","article-title":"Choline and homocysteine interrelations in umbilical cord and maternal plasma at delivery","volume":"82","author":"Molloy","year":"2005","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.jada.2008.10.046_bib14","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/S0005-2760(97)00108-2","article-title":"Phosphatidylethanolamine N-methyltransferase from liver","volume":"1348","author":"Vance","year":"1997","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jada.2008.10.046_bib15","doi-asserted-by":"crossref","first-page":"5952","DOI":"10.1074\/jbc.M212194200","article-title":"Plasma homocysteine is regulated by phospholipid methylation","volume":"278","author":"Noga","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jada.2008.10.046_bib16","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1093\/ajcn\/83.1.5","article-title":"Is it time to reevaluate methyl balance in humans?","volume":"83","author":"Stead","year":"2006","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.jada.2008.10.046_bib17","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1007\/s100380170035","article-title":"Identification of 197 genetic variations in six human methyltranferase genes in the Japanese population","volume":"46","author":"Saito","year":"2001","journal-title":"J Hum Genet"},{"key":"10.1016\/j.jada.2008.10.046_bib18","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1096\/fj.04-3580com","article-title":"Polymorphism of the PEMT gene and susceptibility to nonalcoholic fatty liver disease (NAFLD)","volume":"19","author":"Song","year":"2005","journal-title":"FASEB J"},{"key":"10.1016\/j.jada.2008.10.046_bib19","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1096\/fj.06-5734com","article-title":"Common genetic polymorphisms affect the human requirement for the nutrient choline","volume":"20","author":"da Costa","year":"2006","journal-title":"FASEB J"},{"key":"10.1016\/j.jada.2008.10.046_bib20","doi-asserted-by":"crossref","first-page":"2622","DOI":"10.1096\/fj.07-8227com","article-title":"Phosphatidylethanolamine N-methyltransferase (PEMT) gene expression is induced by estrogen in human and Mouse primary hepatocytes","volume":"21","author":"Resseguie","year":"2007","journal-title":"FASEB J"},{"key":"10.1016\/j.jada.2008.10.046_bib21","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/j.1399-0004.1998.tb02658.x","article-title":"Molecular genetic analysis of the gene encoding the trifunctional enzyme MTHFD (methylenetetrahydrofolate-dehydrogenase, methenyltetrahydrofolate-cyclohydrolase, formyltetrahydrofolate synthetase) in patients with neural tube defects","volume":"53","author":"Hol","year":"1998","journal-title":"Clin Gent"},{"key":"10.1016\/j.jada.2008.10.046_bib22","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1086\/344213","volume":"71","author":"Brody","year":"2002","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.jada.2008.10.046_bib23","doi-asserted-by":"crossref","first-page":"16025","DOI":"10.1073\/pnas.0504285102","article-title":"Genetic variation of folate-mediated one-carbon transfer pathway predicts susceptibility to choline deficiency in humans","volume":"102","author":"Kohlmeier","year":"2005","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.jada.2008.10.046_bib24","doi-asserted-by":"crossref","first-page":"2526","DOI":"10.1158\/1078-0432.CCR-06-2293","article-title":"Polymorphisms of MTHFD, plasma homocysteine levels, and risk of gastric cancer in a high-risk Chinese population","volume":"13","author":"Wang","year":"2007","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.jada.2008.10.046_bib25","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.jnutbio.2007.02.004","article-title":"Folate intake and the MTHFR C677T genotype influence choline status in young Mexican American women","volume":"19","author":"Abratte","year":"2008","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.jada.2008.10.046_bib26","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1093\/jn\/133.5.1272","article-title":"Methylenetetrahydrofolate reductase 677C\u2192T variant modulates folate status response to controlled folate intakes in young women","volume":"133","author":"Guinotte","year":"2003","journal-title":"J Nutr"},{"key":"10.1016\/j.jada.2008.10.046_bib27","series-title":"Folic Acid Metabolism in Health and Disease","first-page":"121","article-title":"Microbiological assay of folates","author":"Tamura","year":"1990"},{"key":"10.1016\/j.jada.2008.10.046_bib28","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1021\/jf960497p","article-title":"Food folate assay with protease, alpha amylase, and folate conjugase treatments","volume":"45","author":"Tamura","year":"1997","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.jada.2008.10.046_bib29","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/0889-1575(90)90020-M","article-title":"Adequacy of extraction techniques for determination of folates in foods and other biological materials","volume":"3","author":"Gregory","year":"1990","journal-title":"J Food Comp Anal"},{"key":"10.1016\/j.jada.2008.10.046_bib30","doi-asserted-by":"crossref","first-page":"4734","DOI":"10.1021\/ac025624x","article-title":"Quantification of choline and its metabolites in tissues and foods by liquid chromatography\/electrospray ionization-isotope dilution mass spectrometry","volume":"74","author":"Koc","year":"2002","journal-title":"Annal Chem"},{"key":"10.1016\/j.jada.2008.10.046_bib31","first-page":"549","article-title":"High performance liquid chromatograph method for rapid and accurate determination of homocysteine in plasma and serum","volume":"29","author":"Vester","year":"1991","journal-title":"Eur J Clin Chem Clin Biochem"},{"key":"10.1016\/j.jada.2008.10.046_bib32","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1093\/clinchem\/45.2.290","article-title":"Rapid and accurate HPLC assay for plasma total homocysteine and cysteine in a clinical laboratory setting","volume":"45","author":"Pfeiffer","year":"1999","journal-title":"Clin Chem"},{"key":"10.1016\/j.jada.2008.10.046_bib33","doi-asserted-by":"crossref","first-page":"12880","DOI":"10.1073\/pnas.94.24.12880","article-title":"Disruption of the murine gene encoding phosphatidylethanolamine N-methyltransferase","volume":"94","author":"Walkey","year":"1997","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.jada.2008.10.046_bib34","doi-asserted-by":"crossref","first-page":"27043","DOI":"10.1074\/jbc.273.42.27043","article-title":"Biochemical and evolutionary significance of phospholipid methylation","volume":"273","author":"Walkey","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jada.2008.10.046_bib35","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1194\/jlr.M300226-JLR200","article-title":"Insights into the requirement of phosphatidylcholine synthesis for liver function in mice","volume":"44","author":"Noga","year":"2003","journal-title":"J Lip Res"},{"key":"10.1016\/j.jada.2008.10.046_bib36","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1111\/j.1753-4887.2007.tb00308.x","article-title":"Personalized nutrition: Nutritional genomics as a potential tool for targeted medical nutrition therapy","volume":"65","author":"Vakili","year":"2007","journal-title":"Nutr Rev"},{"key":"10.1016\/j.jada.2008.10.046_bib37","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1016\/j.jada.2008.06.430","article-title":"Genetic and epigenetic contributions to human nutrition and health: Managing genome\u2013diet interactions","volume":"108","author":"Stover","year":"2008","journal-title":"J Am Diet Assoc"}],"container-title":["Journal of the American Dietetic Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002822308020397?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002822308020397?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,15]],"date-time":"2020-05-15T01:31:48Z","timestamp":1589506308000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002822308020397"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2]]},"references-count":37,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,2]]}},"alternative-id":["S0002822308020397"],"URL":"https:\/\/doi.org\/10.1016\/j.jada.2008.10.046","relation":{},"ISSN":["0002-8223"],"issn-type":[{"value":"0002-8223","type":"print"}],"subject":[],"published":{"date-parts":[[2009,2]]}}}