{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T12:18:15Z","timestamp":1769084295034,"version":"3.49.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000025","name":"NIMH","doi-asserted-by":"publisher","award":["R03 MH 095917"],"award-info":[{"award-number":["R03 MH 095917"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"NIMH","doi-asserted-by":"publisher","award":["R01 MH54846"],"award-info":[{"award-number":["R01 MH54846"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"NIMH","doi-asserted-by":"publisher","award":["K24 MH70027"],"award-info":[{"award-number":["K24 MH70027"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Duke University BIRCWH","award":["K12 HD043446"],"award-info":[{"award-number":["K12 HD043446"]}]},{"name":"Duke Claude A. Pepper Center","award":["2P30 AG028716-08"],"award-info":[{"award-number":["2P30 AG028716-08"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The American Journal of Geriatric Psychiatry"],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1016\/j.jagp.2015.03.001","type":"journal-article","created":{"date-parts":[[2015,3,12]],"date-time":"2015-03-12T17:31:39Z","timestamp":1426181499000},"page":"42-49","source":"Crossref","is-referenced-by-count":20,"title":["Late-life Depression Modifies the Association Between Cerebral White Matter Hyperintensities and Functional Decline Among Older Adults"],"prefix":"10.1016","volume":"24","author":[{"given":"Celia F.","family":"Hybels","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carl F.","family":"Pieper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martha E.","family":"Payne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David C.","family":"Steffens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jagp.2015.03.001_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00019442-200401000-00001","article-title":"Depression and frailty: the need for multidisciplinary research","volume":"12","author":"Katz","year":"2004","journal-title":"Am J Geriatr Psychiatry"},{"key":"10.1016\/j.jagp.2015.03.001_bib2","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1097\/00019442-200105000-00003","article-title":"Depression and disability in late life: directions for future research","volume":"9","author":"Bruce","year":"2001","journal-title":"Am J Geriatr Psychiatry"},{"key":"10.1016\/j.jagp.2015.03.001_bib3","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1176\/ajp.153.7.877","article-title":"Disability in geriatric depression","volume":"153","author":"Alexopoulos","year":"1996","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.jagp.2015.03.001_bib4","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1001\/archpsyc.1997.01830220033006","article-title":"'Vascular depression' hypothesis","volume":"54","author":"Alexopoulos","year":"1997","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.jagp.2015.03.001_bib5","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1176\/ajp.154.4.497","article-title":"MRI-defined vascular depression","volume":"154","author":"Krishnan","year":"1997","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.jagp.2015.03.001_bib6","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/S0006-3223(98)00084-5","article-title":"Structural neuroimaging and mood\u00a0disorders: recent findings, implications for classification, and future directions","volume":"43","author":"Steffens","year":"1998","journal-title":"Soc Biol Psychiatry"},{"key":"10.1016\/j.jagp.2015.03.001_bib7","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1001\/archpsyc.60.11.1090","article-title":"White matter hyperintensity progression and late-life depression outcomes","volume":"60","author":"Taylor","year":"2003","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.jagp.2015.03.001_bib8","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1097\/JGP.0b013e318048a1a0","article-title":"Longitudinal magnetic resonance imaging vascular changes, apolipoprotein E genotype, and development of dementia in the Neurocognitive Outcomes of Depression in the Elderly Study","volume":"15","author":"Steffens","year":"2007","journal-title":"Am J Geriatr Psychiatry"},{"key":"10.1016\/j.jagp.2015.03.001_bib9","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1111\/j.1532-5415.2011.03490.x","article-title":"White matter lesions on rain magnetic resonance imaging scan and 5-year cognitive decline: the Honolulu-Asia-Aging Study","volume":"59","author":"Inaba","year":"2011","journal-title":"J\u00a0Am Geriatr Soc"},{"key":"10.1016\/j.jagp.2015.03.001_bib10","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1001\/archneurol.2007.23","article-title":"Magnetic resonance imaging white matter hyperintensities and brain volume in the prediction of mild cognitive impairment and dementia","volume":"65","author":"Smith","year":"2008","journal-title":"Arch Neurol"},{"key":"10.1016\/j.jagp.2015.03.001_bib11","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1001\/archneurol.2010.284","article-title":"Longitudinal changes in white matter disease and cognition in the first year of the Alzheimer Disease Neuroimaging Initiative","volume":"67","author":"Carmichael","year":"2010","journal-title":"Arch Neurol"},{"key":"10.1016\/j.jagp.2015.03.001_bib12","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1111\/j.1532-5415.2006.00798.x","article-title":"Leukoaraiosis predicts hidden global functioning impairment in nondisabled older people: The LADIS (Leukoaraiosis and Disability in the Elderly) Study","volume":"54","author":"Pantoni","year":"2006","journal-title":"J\u00a0Am Geriatr Soc"},{"key":"10.1016\/j.jagp.2015.03.001_bib13","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1159\/000337815","article-title":"White matter hyperintensities are an independent predictor of physical decline in community-dwelling older people","volume":"58","author":"Zheng","year":"2012","journal-title":"Gerontology"},{"key":"10.1016\/j.jagp.2015.03.001_bib14","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1212\/WNL.54.6.1277","article-title":"White matter abnormalaties in mobility-imapired older persons","volume":"54","author":"Guttmann","year":"2000","journal-title":"Neurology"},{"key":"10.1016\/j.jagp.2015.03.001_bib15","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1212\/01.wnl.0000305959.46197.e6","article-title":"Association of gait and balance disorders with age-related white matter changes: the LADIS Study","volume":"70","author":"Baezner","year":"2008","journal-title":"Neurology"},{"key":"10.1016\/j.jagp.2015.03.001_bib16","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1136\/jnnp.2008.154633","article-title":"Deep frontal and periventricular age related white matter changes but not basal ganglia and infratentorial hyperintensities are associated with falls: cross-sectional results from the LADIS study","volume":"80","author":"Blahak","year":"2009","journal-title":"J\u00a0Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.jagp.2015.03.001_bib17","doi-asserted-by":"crossref","first-page":"e546","DOI":"10.1161\/STROKEAHA.109.558122","article-title":"White matter lesions predispose to falls in older people","volume":"40","author":"Masdeu","year":"2009","journal-title":"Stroke"},{"key":"10.1016\/j.jagp.2015.03.001_bib18","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1111\/j.1532-5415.2005.53214.x","article-title":"Subclinical brain magnetic resonance imaging abnormalities predict physical functional decline in high-functioning older adults","volume":"53","author":"Rosano","year":"2005","journal-title":"J\u00a0Am Geriatr Soc"},{"key":"10.1016\/j.jagp.2015.03.001_bib19","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1161\/STROKEAHA.108.524355","article-title":"Cerebral white matter lesions, gait, and the risk of incident falls","volume":"40","author":"Srikanth","year":"2009","journal-title":"Stroke"},{"key":"10.1016\/j.jagp.2015.03.001_bib20","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1111\/j.1532-5415.2009.02699.x","article-title":"White matter hyperintensities predict functional decline in voiding, mobility, amd cognition in older adults","volume":"58","author":"Wakefield","year":"2010","journal-title":"J\u00a0Am Geriatr Soc"},{"key":"10.1016\/j.jagp.2015.03.001_bib21","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1080\/13607863.2012.692767","article-title":"Vascular depression: an early warning sign of frailty","volume":"17","author":"Paulson","year":"2013","journal-title":"Aging Ment Health"},{"key":"10.1016\/j.jagp.2015.03.001_bib22","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1093\/gerona\/glt072","article-title":"Rapid buildup of brain white matter hyperintensities over 4 years linked to ambulatory blood pressure, mobility, cognition, and depression in old persons","volume":"68","author":"Wolfson","year":"2013","journal-title":"J\u00a0Gerontol Med Sci"},{"key":"10.1016\/j.jagp.2015.03.001_bib23","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1001\/archinte.167.1.81","article-title":"Risk of rapid global functional decline in elderly patients with severe cerebral age-related white matter changes","volume":"167","author":"Inzatari","year":"2007","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.jagp.2015.03.001_bib24","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/0022-3956(91)90024-5","article-title":"Subjective social support and depressive symptoms in major depression: separate phenomena or epiphenomena","volume":"25","author":"Blazer","year":"1991","journal-title":"J\u00a0Psychiatr Res"},{"key":"10.1016\/j.jagp.2015.03.001_bib25","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1177\/014662167700100306","article-title":"The CES-D scale: a self-report depression scale for research in the general population","volume":"1","author":"Radloff","year":"1977","journal-title":"Appl Psychol Meas"},{"key":"10.1016\/j.jagp.2015.03.001_bib26","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1001\/archpsyc.1981.01780290015001","article-title":"National Institute of Mental Health Diagnostic Interview Schedule: its history, characteristics, and validity","volume":"38","author":"Robins","year":"1981","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.jagp.2015.03.001_bib27","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1093\/geront\/10.1_Part_1.20","article-title":"Progress in development of the index of ADL","volume":"10","author":"Katz","year":"1970","journal-title":"Gerontologist"},{"key":"10.1016\/j.jagp.2015.03.001_bib28","series-title":"Multidimensional Functional Assessment of Older Adults: The Duke Older Americans Resources and Services Procedures","author":"Fillenbaum","year":"1988"},{"key":"10.1016\/j.jagp.2015.03.001_bib29","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1093\/geronj\/21.4.556","article-title":"A\u00a0Guttman health scale for the aged","volume":"21","author":"Rosow","year":"1966","journal-title":"J\u00a0Gerontol"},{"key":"10.1016\/j.jagp.2015.03.001_bib30","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","article-title":"Mini-mental state: a practical method for grading the cognitive state of patients for clinicians","volume":"12","author":"Folstein","year":"1975","journal-title":"J\u00a0Psychiatr Res"},{"key":"10.1016\/j.jagp.2015.03.001_bib31","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0925-4927(02)00009-4","article-title":"Development of a semi-automatic method for quantification of MRI gray and white matter lesions in geriatric subjects","volume":"115","author":"Payne","year":"2002","journal-title":"Psychiatry Res"},{"key":"10.1016\/j.jagp.2015.03.001_bib32","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1097\/EDE.0b013e318127181b","article-title":"Four types of effect modification: a classification based on directed acyclic graphs","volume":"18","author":"VanderWeele","year":"2007","journal-title":"Epidemiology"},{"key":"10.1016\/j.jagp.2015.03.001_bib33","series-title":"Modern Epidemiology","author":"Rothman","year":"2008"},{"key":"10.1016\/j.jagp.2015.03.001_bib34","series-title":"An Introduction to the Bootstrap: CRC Monographs on Statistics and Applied Probability 57","author":"Efron","year":"1994"},{"key":"10.1016\/j.jagp.2015.03.001_bib35","unstructured":"Miller D: Bootstrap 101: Obtain robust confidence intervals for any statistic, in Proceedings of the Twenty-Ninth Annual SAS Users Group International Conference, paper 193\u201329. Edited by SAS Institute. Cary, NC, SAS Institute, 2004, pp"},{"key":"10.1016\/j.jagp.2015.03.001_bib36","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1017\/S1041610214000829","article-title":"Vascular lesions and functional limitations among older adults: does depression make a difference?","volume":"26","author":"Hybels","year":"2014","journal-title":"Int Psychogeriatr"},{"key":"10.1016\/j.jagp.2015.03.001_bib37","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.jad.2011.11.002","article-title":"The influence of subcortical ischemic lesions on cognitive function and quality of life in late life depression","volume":"136","author":"Kang","year":"2012","journal-title":"J\u00a0Affect Disord"},{"key":"10.1016\/j.jagp.2015.03.001_bib38","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.jpsychires.2012.01.011","article-title":"Vascular depression prevalence and epidemiology in the United States","volume":"46","author":"Gonzalez","year":"2012","journal-title":"J\u00a0Psychiatr Res"},{"key":"10.1016\/j.jagp.2015.03.001_bib39","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.archger.2005.06.001","article-title":"Effects of cognitive function on functional decline among community-dwelling non-disabled older Japanese","volume":"42","author":"Ishizaki","year":"2006","journal-title":"Arch Gerontol Geriatr"},{"key":"10.1016\/j.jagp.2015.03.001_bib40","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1161\/01.STR.0000150668.58689.f2","article-title":"Anatomical mapping of white matter hyperintensities (WMH) exploring the relationship between periventricular WMH, deep WMH, and total WMH burden","volume":"36","author":"DeCarli","year":"2005","journal-title":"Stroke"}],"container-title":["The American Journal of Geriatric Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S106474811500113X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S106474811500113X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,21]],"date-time":"2019-08-21T22:41:29Z","timestamp":1566427289000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S106474811500113X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["S106474811500113X"],"URL":"https:\/\/doi.org\/10.1016\/j.jagp.2015.03.001","relation":{},"ISSN":["1064-7481"],"issn-type":[{"value":"1064-7481","type":"print"}],"subject":[],"published":{"date-parts":[[2016,1]]}}}