{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T13:02:09Z","timestamp":1762606929933,"version":"3.37.3"},"reference-count":40,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["N01MH90001"],"award-info":[{"award-number":["N01MH90001"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The American Journal of Geriatric Psychiatry"],"published-print":{"date-parts":[[2017,7]]},"DOI":"10.1016\/j.jagp.2017.01.016","type":"journal-article","created":{"date-parts":[[2017,1,30]],"date-time":"2017-01-30T14:17:33Z","timestamp":1485785853000},"page":"708-716","source":"Crossref","is-referenced-by-count":14,"title":["Lack of Early Improvement with Antipsychotics is a Marker for Subsequent Nonresponse in Behavioral and Psychological Symptoms of Dementia: Analysis of CATIE-AD Data"],"prefix":"10.1016","volume":"25","author":[{"given":"Kazunari","family":"Yoshida","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"Roberts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takefumi","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barry","family":"Lebowitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne","family":"Reeves","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Howard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayuki","family":"Abe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaru","family":"Mimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Uchida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jagp.2017.01.016_bib0010","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1001\/archpsyc.1997.01830150083012","article-title":"The course of psychopathologic features in mild to moderate Alzheimer disease","volume":"54","author":"Devanand","year":"1997","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.jagp.2017.01.016_bib0015","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.jamda.2011.12.059","article-title":"Efficacy and feasibility of nonpharmacological interventions for neuropsychiatric symptoms of dementia in long term care: a systematic review","volume":"13","author":"Seitz","year":"2012","journal-title":"J Am Med Dir Assoc"},{"key":"10.1016\/j.jagp.2017.01.016_bib0020","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1002\/gps.4452","article-title":"Psychotropic use and associated neuropsychiatric symptoms among patients with dementia in the USA","volume":"32","author":"Maust","year":"2017","journal-title":"Int J Geriatr Psychiatry"},{"key":"10.1016\/j.jagp.2017.01.016_bib0025","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1176\/appi.ajp.2008.07111779","article-title":"Clinical symptom responses to atypical antipsychotic medications in Alzheimer's disease: phase 1 outcomes from the CATIE-AD effectiveness trial","volume":"165","author":"Sultzer","year":"2008","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.jagp.2017.01.016_bib0030","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1097\/01.JGP.0000200589.01396.6d","article-title":"Efficacy and adverse effects of atypical antipsychotics for dementia: meta-analysis of randomized, placebo-controlled trials","volume":"14","author":"Schneider","year":"2006","journal-title":"Am J Geriatr Psychiatry"},{"issue":"1","key":"10.1016\/j.jagp.2017.01.016_bib0035","article-title":"The effectiveness of atypical antipsychotics for the treatment of aggression and psychosis in Alzheimer's disease","author":"Ballard","year":"2006","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.jagp.2017.01.016_bib0040","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1001\/jamapsychiatry.2014.3018","article-title":"Antipsychotics, other psychotropics, and the risk of death in patients with dementia","volume":"72","author":"Maust","year":"2015","journal-title":"JAMA Psychiatry"},{"author":"U.S. Food and Drug Administration","key":"10.1016\/j.jagp.2017.01.016_bib0045"},{"author":"American Psychiatric Association","key":"10.1016\/j.jagp.2017.01.016_bib0050"},{"key":"10.1016\/j.jagp.2017.01.016_bib0055","doi-asserted-by":"crossref","first-page":"397","DOI":"10.4088\/JCP.08r04171","article-title":"Increased antipsychotic sensitivity in elderly patients: evidence and mechanisms","volume":"70","author":"Uchida","year":"2009","journal-title":"J Clin Psychiatry"},{"key":"10.1016\/j.jagp.2017.01.016_bib0060","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/j.pnpbp.2009.04.023","article-title":"Dosing of antipsychotics in schizophrenia across the life-spectrum","volume":"33","author":"Uchida","year":"2009","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.jagp.2017.01.016_bib0065","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.schres.2008.02.021","article-title":"Predicting response to atypical antipsychotics based on early response in the treatment of schizophrenia","volume":"102","author":"Kinon","year":"2008","journal-title":"Schizophr Res"},{"key":"10.1016\/j.jagp.2017.01.016_bib0070","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1176\/appi.ajp.160.11.2063","article-title":"Early prediction of antipsychotic response in schizophrenia","volume":"160","author":"Correll","year":"2003","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.jagp.2017.01.016_bib0075","doi-asserted-by":"crossref","first-page":"344","DOI":"10.4088\/JCP.07m03780","article-title":"Early improvement in the first 2 weeks as a predictor of treatment outcome in patients with major depressive disorder: a meta-analysis including 6562 patients","volume":"70","author":"Szegedi","year":"2009","journal-title":"J Clin Psychiatry"},{"key":"10.1016\/j.jagp.2017.01.016_bib0080","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1093\/schbul\/sbm134","article-title":"Clinical, functional, and economic ramifications of early nonresponse to antipsychotics in the naturalistic treatment of schizophrenia","volume":"34","author":"Ascher-Svanum","year":"2008","journal-title":"Schizophr Bull"},{"year":"2012","author":"Taylor","series-title":"The Maudsley Prescribing Guidelines in Psychiatry","key":"10.1016\/j.jagp.2017.01.016_bib0085"},{"key":"10.1016\/j.jagp.2017.01.016_bib0090","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.jad.2009.04.014","article-title":"Early improvement is a predictor of treatment outcome in patients with mild major, minor or subsyndromal depression","volume":"120","author":"Tadi\u0107","year":"2010","journal-title":"J Affect Disord"},{"key":"10.1016\/j.jagp.2017.01.016_bib0095","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1093\/oxfordjournals.schbul.a006991","article-title":"Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE): Alzheimer's disease trial","volume":"29","author":"Schneider","year":"2003","journal-title":"Schizophr Bull"},{"key":"10.1016\/j.jagp.2017.01.016_bib0100","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1097\/00019442-200111000-00004","article-title":"National Institute of Mental Health Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE): Alzheimer disease trial methodology","volume":"9","author":"Schneider","year":"2001","journal-title":"Am J Geriatr Psychiatry"},{"year":"1997","author":"First","series-title":"User's Guide for the Structured Clinical Interview for DSM-IV Axis I Disorders SCID-I: Clinician Version","key":"10.1016\/j.jagp.2017.01.016_bib0105"},{"key":"10.1016\/j.jagp.2017.01.016_bib0110","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1212\/WNL.34.7.939","article-title":"Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease","volume":"34","author":"McKhann","year":"1984","journal-title":"Neurology"},{"key":"10.1016\/j.jagp.2017.01.016_bib0115","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1093\/geronj\/39.2.194","article-title":"The Brief Psychiatric Rating Scale (BPRS) in geropsychiatric research. II. Representative profile patterns","volume":"39","author":"Beller","year":"1984","journal-title":"J Gerontol"},{"key":"10.1016\/j.jagp.2017.01.016_bib0120","doi-asserted-by":"crossref","first-page":"2308","DOI":"10.1212\/WNL.44.12.2308","article-title":"The Neuropsychiatric Inventory: comprehensive assessment of psychopathology in dementia","volume":"44","author":"Cummings","year":"1994","journal-title":"Neurology"},{"key":"10.1016\/j.jagp.2017.01.016_bib0125","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1002\/gps.4265","article-title":"Cognitive phenotype of psychotic symptoms in Alzheimer's disease: evidence for impaired visuoperceptual function in the misidentification subtype","volume":"30","author":"Reeves","year":"2015","journal-title":"Int J Geriatr Psychiatry"},{"key":"10.1016\/j.jagp.2017.01.016_bib0130","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1097\/00019442-200307000-00003","article-title":"Psychotic symptoms in Alzheimer disease: evidence for subtypes","volume":"11","author":"Cook","year":"2003","journal-title":"Am J Geriatr Psychiatry"},{"key":"10.1016\/j.jagp.2017.01.016_bib0135","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1002\/gps.2607","article-title":"Determining the minimum clinically important differences for outcomes in the DOMINO trial","volume":"26","author":"Howard","year":"2010","journal-title":"Int J Geriatr Psychiatry"},{"key":"10.1016\/j.jagp.2017.01.016_bib0140","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1001\/jama.2014.13128","article-title":"Minimal clinically important difference: defining what really matters to patients","volume":"312","author":"McGlothlin","year":"2014","journal-title":"JAMA"},{"year":"1987","author":"Rubin","series-title":"Multiple Imputation for Nonresponse in Surveys","key":"10.1016\/j.jagp.2017.01.016_bib0145"},{"key":"10.1016\/j.jagp.2017.01.016_bib0150","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1097\/JCP.0b013e3182214aad","article-title":"Dopamine D2 receptor occupancy and clinical effects","volume":"31","author":"Uchida","year":"2011","journal-title":"J Clin Psychopharmacol"},{"key":"10.1016\/j.jagp.2017.01.016_bib0155","doi-asserted-by":"crossref","first-page":"352","DOI":"10.4088\/JCP.v68n0301","article-title":"Early prediction of antipsychotic nonresponse among patients with schizophrenia","volume":"68","author":"Leucht","year":"2007","journal-title":"J Clin Psychiatry"},{"key":"10.1016\/j.jagp.2017.01.016_bib0160","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1038\/sj.npp.1300341","article-title":"Onset and early behavioral effects of pharmacologically different antidepressants andplacebo in depression","volume":"29","author":"Katz","year":"2003","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.jagp.2017.01.016_bib0165","doi-asserted-by":"crossref","first-page":"413","DOI":"10.4088\/JCP.v64n0410","article-title":"Early improvement under mirtazapine and paroxetine predicts later stable response and remission with high sensitivity in patients with major depression","volume":"64","author":"Szegedi","year":"2003","journal-title":"J Clin Psychiatry"},{"key":"10.1016\/j.jagp.2017.01.016_bib0170","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1093\/schbul\/13.2.261","article-title":"The positive and negative syndrome scale (PANSS) for schizophrenia","volume":"13","author":"Kay","year":"1987","journal-title":"Schizophr Bull"},{"key":"10.1016\/j.jagp.2017.01.016_bib0175","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.schres.2006.03.027","article-title":"A double-blind comparison of risperidone, quetiapine and placebo in patients with schizophrenia experiencing an acute exacerbation requiring hospitalization","volume":"85","author":"Potkin","year":"2006","journal-title":"Schizophr Res"},{"key":"10.1016\/j.jagp.2017.01.016_bib0180","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/j.euroneuro.2012.11.004","article-title":"Equipercentile linking of the BPRS and the PANSS","volume":"23","author":"Leucht","year":"2013","journal-title":"Eur Neuropsychopharmacol"},{"key":"10.1016\/j.jagp.2017.01.016_bib0185","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1192\/bjp.bp.113.128710","article-title":"Prescription of antipsychotics in people with dementia","volume":"205","author":"Ballard","year":"2014","journal-title":"Br J Psychiatry"},{"key":"10.1016\/j.jagp.2017.01.016_bib0190","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.arr.2011.07.002","article-title":"Systematic appraisal of dementia guidelines for the management of behavioural and psychological symptoms","volume":"11","author":"Azermai","year":"2012","journal-title":"Ageing Res Rev"},{"key":"10.1016\/j.jagp.2017.01.016_bib0195","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1001\/jama.2012.7422","article-title":"CMS seeks to reduce antipsychotic use in nursing home residents with dementia","volume":"308","author":"Mitka","year":"2012","journal-title":"JAMA"},{"key":"10.1016\/j.jagp.2017.01.016_bib0200","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.schres.2015.11.003","article-title":"A review of genetic alterations in the serotonin pathway and their correlation with psychotic diseases and response to atypical antipsychotics","volume":"170","author":"Baou","year":"2016","journal-title":"Schizophr Res"},{"key":"10.1016\/j.jagp.2017.01.016_bib0205","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1056\/NEJMsr1203730","article-title":"The prevention and treatment of missing data in clinical trials","volume":"367","author":"Little","year":"2012","journal-title":"N Engl J Med"}],"container-title":["The American Journal of Geriatric Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1064748117300337?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1064748117300337?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,9]],"date-time":"2019-08-09T14:41:14Z","timestamp":1565361674000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1064748117300337"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7]]},"references-count":40,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["S1064748117300337"],"URL":"https:\/\/doi.org\/10.1016\/j.jagp.2017.01.016","relation":{},"ISSN":["1064-7481"],"issn-type":[{"type":"print","value":"1064-7481"}],"subject":[],"published":{"date-parts":[[2017,7]]}}}