{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T01:42:26Z","timestamp":1774316546547,"version":"3.50.1"},"reference-count":63,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"A*STAR Biomedical Research Council, Singapore","award":["BMRC 04\/1\/36\/372"],"award-info":[{"award-number":["BMRC 04\/1\/36\/372"]}]},{"name":"NMRC Centre Grant and Clinical Individual Research","award":["NMRC\/CG\/013\/2013"],"award-info":[{"award-number":["NMRC\/CG\/013\/2013"]}]},{"name":"NMRC Centre Grant and Clinical Individual Research","award":["NMRC\/CG\/NUHS\/2010"],"award-info":[{"award-number":["NMRC\/CG\/NUHS\/2010"]}]},{"name":"NMRC Centre Grant and Clinical Individual Research","award":["NMRC\/CIRG\/1446\/2016"],"award-info":[{"award-number":["NMRC\/CIRG\/1446\/2016"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The American Journal of Geriatric Psychiatry"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1016\/j.jagp.2019.04.004","type":"journal-article","created":{"date-parts":[[2019,4,18]],"date-time":"2019-04-18T11:52:06Z","timestamp":1555588326000},"page":"948-959","source":"Crossref","is-referenced-by-count":17,"title":["Mechanisms Linking White Matter Lesions, Tract Integrity, and Depression in Alzheimer Disease"],"prefix":"10.1016","volume":"27","author":[{"given":"Chathuri","family":"Yatawara","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daryl","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kok Pin","family":"Ng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Russell","family":"Chander","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debby","family":"Ng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Ji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hee Youn","family":"Shim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saima","family":"Hilal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Narayanaswamy","family":"Venketasubramanian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nagaendran","family":"Kandiah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jagp.2019.04.004_bib0001","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.jad.2013.09.016","article-title":"Prevalence of minor depression in elderly persons with and without mild cognitive impairment: a systematic review","volume":"152","author":"Polyakova","year":"2014","journal-title":"J Affect Disord"},{"key":"10.1016\/j.jagp.2019.04.004_bib0002","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1176\/appi.ajp.2014.14050578","article-title":"Cerebral small vessel disease and association with higher incidence of depressive symptoms in a general elderly population: the AGES-Reykjavik Study","volume":"172","author":"van Sloten","year":"2015","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.jagp.2019.04.004_bib0003","doi-asserted-by":"crossref","first-page":"P320","DOI":"10.1093\/geronb\/58.6.P320","article-title":"Depressive symptoms and aging: the effects of illness and non-health-related events","volume":"58","author":"Fiske","year":"2003","journal-title":"J Gerontol B Psychol Sci Soc Sci"},{"key":"10.1016\/j.jagp.2019.04.004_bib0004","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.psc.2013.08.001","article-title":"What are the causes of late-life depression?","volume":"36","author":"Aziz","year":"2013","journal-title":"Psychiatr Clin North Am"},{"key":"10.1016\/j.jagp.2019.04.004_bib0005","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1001\/archpsyc.1997.01830220033006","article-title":"\u2018Vascular depression\u2019 hypothesis","volume":"54","author":"Alexopoulos","year":"1997","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.jagp.2019.04.004_bib0006","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1176\/appi.ajp.157.9.1499","article-title":"Cerebrovascular risk factors and 1-year depression outcome in older primary care patients","volume":"157","author":"Lyness","year":"2000","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.jagp.2019.04.004_bib0007","first-page":"5","article-title":"Cerebrovascular risk factors and later-life major depression: testing a small-vessel brain disease model","volume":"6","author":"Lyness","year":"1998","journal-title":"Am J Geriatr Psychiatry"},{"key":"10.1016\/j.jagp.2019.04.004_bib0008","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1136\/jnnp.2007.124651","article-title":"White matter hyperintensities in late life depression: a systematic review","volume":"79","author":"Herrmann","year":"2008","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.jagp.2019.04.004_bib0009","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1212\/WNL.0000000000000837","article-title":"Stroke subtype, vascular risk factors, and total MRI brain small-vessel disease burden","volume":"83","author":"Staals","year":"2014","journal-title":"Neurology"},{"key":"10.1016\/j.jagp.2019.04.004_bib0010","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1159\/000335497","article-title":"White matter hyperintensities and the course of depressive symptoms in elderly people with mild dementia","volume":"2","author":"Soennesyn","year":"2012","journal-title":"Dement Geriatr Cogn Dis Extra"},{"key":"10.1016\/j.jagp.2019.04.004_bib0011","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0006-3223(01)01160-X","article-title":"Evidence of white matter tract disruption in MRI hyperintensities","volume":"50","author":"Taylor","year":"2001","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.jagp.2019.04.004_bib0012","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1016\/j.neuroimage.2010.05.043","article-title":"Orientationally invariant indices of axon diameter and density from diffusion MRI","volume":"52","author":"Alexander","year":"2010","journal-title":"Neuroimage"},{"key":"10.1016\/j.jagp.2019.04.004_bib0013","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1503\/jpn.110180","article-title":"Is depression a disconnection syndrome? Meta-analysis of diffusion tensor imaging studies in patients with MDD","volume":"38","author":"Liao","year":"2013","journal-title":"J Psychiatry Neurosci"},{"key":"10.1016\/j.jagp.2019.04.004_bib0014","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1192\/bjp.bp.113.142109","article-title":"White matter integrity and late-life depression in community-dwelling individuals: diffusion tensor imaging study using tract-based spatial statistics","volume":"205","author":"Reppermund","year":"2014","journal-title":"Br J Psychiatry"},{"key":"10.1016\/j.jagp.2019.04.004_bib0015","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1038\/npp.2009.104","article-title":"Neurocircuitry of mood disorders","volume":"35","author":"Price","year":"2010","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.jagp.2019.04.004_bib0016","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1212\/WNL.0000000000001379","article-title":"Effects of vascular risk factors and APOE \u03b54 on white matter integrity and cognitive decline","volume":"84","author":"Wang","year":"2015","journal-title":"Neurology"},{"key":"10.1016\/j.jagp.2019.04.004_bib0017","doi-asserted-by":"crossref","first-page":"571","DOI":"10.3233\/JAD-2009-1077","article-title":"White matter microstructure in relation to education in aging and Alzheimer's disease","volume":"17","author":"Teipel","year":"2009","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.jagp.2019.04.004_bib0018","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1001\/archneur.56.3.338","article-title":"Prefrontal gray and white matter volumes in healthy aging and Alzheimer disease","volume":"56","author":"Salat","year":"1999","journal-title":"Arch Neurol"},{"key":"10.1016\/j.jagp.2019.04.004_bib0019","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1038\/mp.2010.90","article-title":"The APOE e 4 allele modulates brain white matter integrity in healthy adults","volume":"16","author":"Heise","year":"2011","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.jagp.2019.04.004_bib0020","first-page":"519","article-title":"Subclinical depression: a clinically relevant condition?","volume":"50","author":"Cuijpers","year":"2008","journal-title":"Tijdschr Psychiatr"},{"key":"10.1016\/j.jagp.2019.04.004_bib0021","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.jalz.2011.03.008","article-title":"The diagnosis of mild cognitive impairment due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease","volume":"7","author":"Albert","year":"2011","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.jagp.2019.04.004_bib0022","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.1212\/WNL.43.11.2412-a","article-title":"The Clinical Dementia Rating (CDR): current version and scoring rules","volume":"43","author":"Morris","year":"1993","journal-title":"Neurology"},{"key":"10.1016\/j.jagp.2019.04.004_bib0023","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1161\/CIRCULATIONAHA.107.699579","article-title":"General cardiovascular risk profile for use in primary care","volume":"117","author":"D'Agostino","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.jagp.2019.04.004_bib0024","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1111\/j.1532-5415.2005.53221.x","article-title":"The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment","volume":"53","author":"Nasreddine","year":"2005","journal-title":"J Am Geriatr Soc"},{"key":"10.1016\/j.jagp.2019.04.004_bib0025","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","article-title":"\u201cMini-mental state\u201d: a practical method for grading the cognitive state of patients for the clinician","volume":"12","author":"Folstein","year":"1975","journal-title":"J Psychiatr Res"},{"key":"10.1016\/j.jagp.2019.04.004_bib0026","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1300\/J018v05n01_09","article-title":"9\/Geriatric Depression Scale (GDS) recent evidence and development of a shorter violence","volume":"5","author":"Yesavage","year":"1986","journal-title":"Clin Gerontol"},{"key":"10.1016\/j.jagp.2019.04.004_bib0027","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1080\/13607863.2012.758231","article-title":"Usefulness of the Geriatric Depression Scale 15-item version among very old people with and without cognitive impairment","volume":"17","author":"Conradsson","year":"2013","journal-title":"Aging Ment Health"},{"key":"10.1016\/j.jagp.2019.04.004_bib0028","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1093\/ageing\/afp089","article-title":"Continued work employment and volunteerism and mental well-being of older adults: Singapore longitudinal ageing studies","volume":"38","author":"Schwingel","year":"2009","journal-title":"Age Ageing"},{"key":"10.1016\/j.jagp.2019.04.004_bib0029","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.pscychresns.2010.06.008","article-title":"Depression severity is correlated to the integrity of white matter fiber tracts in late-onset major depression","volume":"184","author":"Dalby","year":"2010","journal-title":"Psychiatry Res Neuroimaging"},{"key":"10.1016\/j.jagp.2019.04.004_bib0030","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1002\/gps.4129","article-title":"Diffusion tensor imaging studies in late\u2010life depression: systematic review and meta\u2010analysis","volume":"29","author":"Wen","year":"2014","journal-title":"Int J Geriatr Psychiatry"},{"key":"10.1016\/j.jagp.2019.04.004_bib0031","first-page":"135","article-title":"Cognitive impairment with and without depression history: an analysis of white matter microstructure","volume":"39","author":"Duffy","year":"2014","journal-title":"J Psychiatry Neurosci"},{"key":"10.1016\/j.jagp.2019.04.004_bib0032","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.neuroimage.2005.02.018","article-title":"Unified segmentation","volume":"26","author":"Ashburner","year":"2005","journal-title":"Neuroimage"},{"key":"10.1016\/j.jagp.2019.04.004_bib0033","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1097\/JGP.0b013e31824c0435","article-title":"Relationship between cognition, magnetic resonance white matter hyperintensities, and cardiovascular autonomic changes in late-life depression","volume":"20","author":"Vasudev","year":"2012","journal-title":"Am J Geriatr Psychiatry"},{"key":"10.1016\/j.jagp.2019.04.004_bib0034","doi-asserted-by":"crossref","DOI":"10.4061\/2011\/391783","article-title":"Validation of automated white matter hyperintensity segmentation","volume":"2011","author":"Smart","year":"2011","journal-title":"J Aging Res"},{"key":"10.1016\/j.jagp.2019.04.004_bib0035","doi-asserted-by":"crossref","first-page":"585","DOI":"10.3233\/JAD-160067","article-title":"The association between retinal neuronal layer and brain structure is disrupted in patients with cognitive impairment and Alzheimer's disease","volume":"54","author":"Liu","year":"2016","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.jagp.2019.04.004_bib0036","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1016\/j.neuroimage.2006.02.024","article-title":"Tract-based spatial statistics: voxelwise analysis of multi-subject diffusion data","volume":"31","author":"Smith","year":"2006","journal-title":"Neuroimage"},{"key":"10.1016\/j.jagp.2019.04.004_bib0037","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/s13195-017-0292-4","article-title":"Distinct white matter microstructural abnormalities and extracellular water increases relate to cognitive impairment in Alzheimer's disease with and without cerebrovascular disease","volume":"9","author":"Ji","year":"2017","journal-title":"Alzheimers Res Ther"},{"key":"10.1016\/j.jagp.2019.04.004_bib0038","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1016\/j.neuroimage.2010.05.049","article-title":"Atlas-guided tract reconstruction for automated and comprehensive examination of the white matter anatomy","volume":"52","author":"Zhang","year":"2010","journal-title":"Neuroimage"},{"key":"10.1016\/j.jagp.2019.04.004_bib0039","series-title":"Linear regression analysis","author":"Seber","year":"2012"},{"key":"10.1016\/j.jagp.2019.04.004_bib0040","series-title":"Introduction to mediation, moderation, and conditional process analysis: a regression-based approach","author":"Hayes","year":"2013"},{"key":"10.1016\/j.jagp.2019.04.004_bib0041","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.neuroimage.2010.02.072","article-title":"Microstructural correlations of white matter tracts in the human brain","volume":"51","author":"Wahl","year":"2010","journal-title":"Neuroimage"},{"key":"10.1016\/j.jagp.2019.04.004_bib0042","series-title":"Applied multiple regression\/correlation analysis for the behavioral sciences","author":"Cohen","year":"2013"},{"key":"10.1016\/j.jagp.2019.04.004_bib0043","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1080\/10543406.2011.607751","article-title":"On using the bootstrap for multiple comparisons","volume":"21","author":"Westfall","year":"2011","journal-title":"J Biopharm Stat"},{"key":"10.1016\/j.jagp.2019.04.004_bib0044","doi-asserted-by":"crossref","first-page":"323","DOI":"10.3200\/JOER.99.6.323-338","article-title":"Reporting structural equation modeling and confirmatory factor analysis results: a review","volume":"99","author":"Schreiber","year":"2006","journal-title":"J Educ Res"},{"key":"10.1016\/j.jagp.2019.04.004_bib0045","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1037\/1082-989X.7.4.422","article-title":"Mediation in experimental and nonexperimental studies: new procedures and recommendations","volume":"7","author":"Shrout","year":"2002","journal-title":"Psychol Methods"},{"key":"10.1016\/j.jagp.2019.04.004_bib0046","series-title":"Statistical power analysis for the behavioral sciences","author":"Cohen","year":"1988"},{"key":"10.1016\/j.jagp.2019.04.004_bib0047","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.jagp.2014.07.002","article-title":"White matter integrity and depressive symptoms in cerebral small vessel disease: the RUN DMC study","volume":"23","author":"van Uden","year":"2015","journal-title":"Am J Geriatr Psychiatry"},{"key":"10.1016\/j.jagp.2019.04.004_bib0048","doi-asserted-by":"crossref","first-page":"54","DOI":"10.3174\/ajnr.A3146","article-title":"FLAIR and diffusion MRI signals are independent predictors of white matter hyperintensities","volume":"34","author":"Maillard","year":"2013","journal-title":"AJNR Am J Neuroradiol"},{"key":"10.1016\/j.jagp.2019.04.004_bib0049","doi-asserted-by":"crossref","first-page":"9738","DOI":"10.1038\/srep09738","article-title":"Altered white matter integrity in individuals with cognitive vulnerability to depression: a tract-based spatial statistics study","volume":"5","author":"Xiao","year":"2015","journal-title":"Sci Rep"},{"key":"10.1016\/j.jagp.2019.04.004_bib0050","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1017\/S0033291713001980","article-title":"White-matter tract integrity in late-life depression: associations with severity and cognition","volume":"44","author":"Charlton","year":"2014","journal-title":"Psychol Med"},{"key":"10.1016\/j.jagp.2019.04.004_bib0051","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/j.cortex.2008.03.007","article-title":"Neuroimaging techniques offer new perspectives on callosal transfer and interhemispheric communication","volume":"44","author":"Doron","year":"2008","journal-title":"Cortex"},{"key":"10.1016\/j.jagp.2019.04.004_bib0052","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1038\/mp.2013.20","article-title":"The vascular depression hypothesis: mechanisms linking vascular disease with depression","volume":"18","author":"Taylor","year":"2013","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.jagp.2019.04.004_bib0053","doi-asserted-by":"crossref","first-page":"e65175","DOI":"10.1371\/journal.pone.0065175","article-title":"Associations between white matter hyperintensities and \u03b2 amyloid on integrity of projection, association, and limbic fiber tracts measured with diffusion tensor MRI","volume":"8","author":"Chao","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jagp.2019.04.004_bib0054","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1212\/WNL.0b013e3182a43e45","article-title":"Neuropathologic basis of white matter hyperintensity accumulation with advanced age","volume":"81","author":"Erten-Lyons","year":"2013","journal-title":"Neurology"},{"key":"10.1016\/j.jagp.2019.04.004_bib0055","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1016\/S0140-6736(05)66665-2","article-title":"Depression in the elderly","volume":"365","author":"Alexopoulos","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.jagp.2019.04.004_bib0056","doi-asserted-by":"crossref","DOI":"10.1100\/2012\/756357","article-title":"A review: inflammatory process in Alzheimer's disease, role of cytokines","volume":"2012","author":"Rubio-Perez","year":"2012","journal-title":"ScientificWorldJournal"},{"key":"10.1016\/j.jagp.2019.04.004_bib0057","doi-asserted-by":"crossref","first-page":"63","DOI":"10.3233\/JAD-142940","article-title":"Depressive symptoms and biomarkers of Alzheimer's disease in cognitively normal older adults","volume":"46","author":"Donovan","year":"2015","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.jagp.2019.04.004_bib0058","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/j.biopsych.2011.12.024","article-title":"Depressive symptoms in mild cognitive impairment predict greater atrophy in Alzheimer's disease-related regions","volume":"71","author":"Lee","year":"2012","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.jagp.2019.04.004_bib0059","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/j.jagp.2013.01.021","article-title":"The effect of subsyndromal symptoms of depression and white matter lesions on disability for individuals with mild cognitive impairment","volume":"21","author":"Mackin","year":"2013","journal-title":"Am J Geriatr Psychiatry"},{"key":"10.1016\/j.jagp.2019.04.004_bib0060","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.biopsych.2009.02.032","article-title":"Diffuse microstructural abnormalities of normal-appearing white matter in late life depression: a diffusion tensor imaging study","volume":"66","author":"Shimony","year":"2009","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.jagp.2019.04.004_bib0061","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/s00415-003-0992-5","article-title":"A study of the mechanisms of normal-appearing white matter damage in multiple sclerosis using diffusion tensor imaging","volume":"250","author":"Ciccarelli","year":"2003","journal-title":"J Neurol"},{"key":"10.1016\/j.jagp.2019.04.004_bib0062","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1097\/01.JGP.0000214558.63358.94","article-title":"White matter hyperintensities rather than lacunar infarcts are associated with depressive symptoms in older people: the LADIS study","volume":"14","author":"O'Brien","year":"2006","journal-title":"Am J Geriatr Psychiatry"},{"key":"10.1016\/j.jagp.2019.04.004_bib0063","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1212\/01.WNL.0000130530.55104.B5","article-title":"White matter lesions impair frontal lobe function regardless of their location","volume":"63","author":"Tullberg","year":"2004","journal-title":"Neurology"}],"container-title":["The American Journal of Geriatric Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1064748119303379?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1064748119303379?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,2]],"date-time":"2019-08-02T09:09:46Z","timestamp":1564736986000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1064748119303379"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":63,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["S1064748119303379"],"URL":"https:\/\/doi.org\/10.1016\/j.jagp.2019.04.004","relation":{},"ISSN":["1064-7481"],"issn-type":[{"value":"1064-7481","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9]]}}}