{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T20:09:44Z","timestamp":1762459784171,"version":"build-2065373602"},"reference-count":71,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajgponline.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Geriatric Psychiatry"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1016\/j.jagp.2019.07.008","type":"journal-article","created":{"date-parts":[[2019,7,19]],"date-time":"2019-07-19T19:59:52Z","timestamp":1563566392000},"page":"1360-1371","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Relationships Between Executive Control Circuit Activity, Amyloid Burden, and Education in Cognitively Healthy Older Adults"],"prefix":"10.1016","volume":"27","author":[{"given":"Helmet T.","family":"Karim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dana L.","family":"Tudorascu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie C.","family":"Price","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Lopresti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chester","family":"Mathis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Klunk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beth E.","family":"Snitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Howard J.","family":"Aizenstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jagp.2019.07.008_bib0001","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1126\/science.1072994","article-title":"The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics","volume":"297","author":"Hardy","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.jagp.2019.07.008_bib0002","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/0896-6273(91)90052-2","article-title":"The molecular pathology of Alzheimer's disease","volume":"6","author":"Selkoe","year":"1991","journal-title":"Neuron"},{"key":"10.1016\/j.jagp.2019.07.008_bib0003","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1126\/science.1141736","article-title":"Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model","volume":"316","author":"Roberson","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.jagp.2019.07.008_bib0004","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/1750-1326-9-51","article-title":"Models of beta-amyloid induced Tau-pathology: the long and \u201cfolded\u201d road to understand the mechanism","volume":"9","author":"Stancu","year":"2014","journal-title":"Mol Neurodegener"},{"key":"10.1016\/j.jagp.2019.07.008_bib0005","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1056\/NEJMoa1202753","article-title":"Clinical and biomarker changes in dominantly inherited Alzheimer's disease","volume":"367","author":"Bateman","year":"2012","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jagp.2019.07.008_bib0006","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/S1474-4422(12)70227-2","article-title":"Florbetapir PET analysis of amyloid-beta deposition in the presenilin 1 E280A autosomal dominant Alzheimer's disease kindred: a cross-sectional study","volume":"11","author":"Fleisher","year":"2012","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.jagp.2019.07.008_bib0007","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S1474-4422(12)70291-0","article-title":"Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers","volume":"12","author":"Jack","year":"2013","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.jagp.2019.07.008_bib0008","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1212\/WNL.0b013e31828ab35d","article-title":"Meta-analysis of amyloid-cognition relations in cognitively normal older adults","volume":"80","author":"Hedden","year":"2013","journal-title":"Neurology"},{"key":"10.1016\/j.jagp.2019.07.008_bib0009","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1001\/archneur.64.3.noc60123","article-title":"Cerebrospinal fluid tau\/beta-amyloid(42) ratio as a prediction of cognitive decline in nondemented older adults","volume":"64","author":"Fagan","year":"2007","journal-title":"Arch Neurol"},{"key":"10.1016\/j.jagp.2019.07.008_bib0010","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1002\/ana.23650","article-title":"Amyloid deposition, hypometabolism, and longitudinal cognitive decline","volume":"72","author":"Landau","year":"2012","journal-title":"Ann Neurol"},{"key":"10.1016\/j.jagp.2019.07.008_bib0011","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1093\/brain\/awt286","article-title":"Effect of amyloid on memory and non-memory decline from preclinical to clinical Alzheimer's disease","volume":"137","author":"Lim","year":"2014","journal-title":"Brain"},{"key":"10.1016\/j.jagp.2019.07.008_bib0012","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1212\/WNL.0b013e3181d3e3e9","article-title":"Longitudinal cognitive decline is associated with fibrillar amyloid-beta measured by [11C]PiB","volume":"74","author":"Resnick","year":"2010","journal-title":"Neurology"},{"key":"10.1016\/j.jagp.2019.07.008_bib0013","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1001\/jamaneurol.2014.2031","article-title":"Synergistic effect of beta-amyloid and neurodegeneration on cognitive decline in clinically normal individuals","volume":"71","author":"Mormino","year":"2014","journal-title":"JAMA Neurol"},{"key":"10.1016\/j.jagp.2019.07.008_bib0014","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1001\/jamaneurol.2013.182","article-title":"Selective worsening of brain injury biomarker abnormalities in cognitively normal elderly persons with beta-amyloidosis","volume":"70","author":"Knopman","year":"2013","journal-title":"JAMA Neurol"},{"key":"10.1016\/j.jagp.2019.07.008_bib0015","doi-asserted-by":"crossref","first-page":"12686","DOI":"10.1523\/JNEUROSCI.3189-09.2009","article-title":"Disruption of functional connectivity in clinically normal older adults harboring amyloid burden","volume":"29","author":"Hedden","year":"2009","journal-title":"J Neurosci"},{"key":"10.1016\/j.jagp.2019.07.008_bib0016","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.biopsych.2009.08.024","article-title":"Amyloid plaques disrupt resting state default mode network connectivity in cognitively normal elderly","volume":"67","author":"Sheline","year":"2010","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.jagp.2019.07.008_bib0017","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.1093\/cercor\/bhr025","article-title":"Relationships between beta-amyloid and functional connectivity in different components of the default mode network in aging","volume":"21","author":"Mormino","year":"2011","journal-title":"Cereb Cortex"},{"key":"10.1016\/j.jagp.2019.07.008_bib0018","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1038\/nn.3806","article-title":"Neural compensation in older people with brain amyloid-beta deposition","volume":"17","author":"Elman","year":"2014","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.jagp.2019.07.008_bib0019","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1093\/brain\/awm133","article-title":"Abeta amyloid deposition in the language system and how the brain responds","volume":"130","author":"Nelissen","year":"2007","journal-title":"Brain"},{"key":"10.1016\/j.jagp.2019.07.008_bib0020","doi-asserted-by":"crossref","first-page":"3327","DOI":"10.1093\/brain\/awu271","article-title":"Regional amyloid burden and intrinsic connectivity networks in cognitively normal elderly subjects","volume":"137","author":"Lim","year":"2014","journal-title":"Brain"},{"key":"10.1016\/j.jagp.2019.07.008_bib0021","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1093\/brain\/awv326","article-title":"Is amyloid-beta harmful to the brain? Insights from human imaging studies","volume":"139","author":"Jagust","year":"2016","journal-title":"Brain"},{"key":"10.1016\/j.jagp.2019.07.008_bib0022","doi-asserted-by":"crossref","first-page":"2514","DOI":"10.1002\/hbm.22788","article-title":"The effect of beta-amyloid on face processing in young and old adults: a multivariate analysis of the BOLD signal","volume":"36","author":"Rieck","year":"2015","journal-title":"Hum Brain Mapp"},{"key":"10.1016\/j.jagp.2019.07.008_bib0023","doi-asserted-by":"crossref","first-page":"2776","DOI":"10.1016\/j.neuropsychologia.2011.06.006","article-title":"Face-name associative memory performance is related to amyloid burden in normal elderly","volume":"49","author":"Rentz","year":"2011","journal-title":"Neuropsychologia"},{"key":"10.1016\/j.jagp.2019.07.008_bib0024","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/S1474-4422(12)70191-6","article-title":"Cognitive reserve in ageing and Alzheimer's disease","volume":"11","author":"Stern","year":"2012","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.jagp.2019.07.008_bib0025","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.tics.2013.08.012","article-title":"Efficiency, capacity, compensation, maintenance, plasticity: emerging concepts in cognitive reserve","volume":"17","author":"Barulli","year":"2013","journal-title":"Trends Cogn Sci"},{"key":"10.1016\/j.jagp.2019.07.008_bib0026","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1002\/ana.25123","article-title":"Person-specific contribution of neuropathologies to cognitive loss in old age","volume":"83","author":"Boyle","year":"2018","journal-title":"Ann Neurol"},{"key":"10.1016\/j.jagp.2019.07.008_bib0027","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1093\/geronj\/33.2.232","article-title":"The role of memory in the age decline in digit-symbol substitution performance","volume":"33","author":"Salthouse","year":"1978","journal-title":"J Gerontol"},{"key":"10.1016\/j.jagp.2019.07.008_bib0028","doi-asserted-by":"crossref","first-page":"3436","DOI":"10.1016\/j.neuroimage.2009.11.019","article-title":"Executive control function, brain activation and white matter hyperintensities in older adults","volume":"49","author":"Venkatraman","year":"2010","journal-title":"Neuroimage"},{"key":"10.1016\/j.jagp.2019.07.008_bib0029","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1037\/0894-4105.19.4.520","article-title":"Cognitive impairment in preclinical Alzheimer's disease: a meta-analysis","volume":"19","author":"Backman","year":"2005","journal-title":"Neuropsychology"},{"key":"10.1016\/j.jagp.2019.07.008_bib0030","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.dadm.2016.09.002","article-title":"Cognitive impairment and decline in cognitively normal older adults with high amyloid-beta: a meta-analysis","volume":"6","author":"Baker","year":"2017","journal-title":"Alzheimers Dement (Amst)"},{"key":"10.1016\/j.jagp.2019.07.008_bib0031","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0022-3956(82)90033-4","article-title":"Development and validation of a geriatric depression screening scale: a preliminary report","volume":"17","author":"Yesavage","year":"1982","journal-title":"J Psychiatr Res"},{"year":"2000","series-title":"Mini-Mental State Examination: MMSE user's guide","author":"Folstein","key":"10.1016\/j.jagp.2019.07.008_bib0032"},{"key":"10.1016\/j.jagp.2019.07.008_bib0033","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.1212\/WNL.43.12.2457","article-title":"The consortium to establish a registry for Alzheimer's disease (CERAD)","volume":"43","author":"Morris","year":"1993","journal-title":"Neurology"},{"key":"10.1016\/j.jagp.2019.07.008_bib0034","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0010-9452(87)80019-9","article-title":"Normal rates of forgetting of verbal and non-verbal material in Alzheimer's disease","volume":"23","author":"Becker","year":"1987","journal-title":"Cortex"},{"year":"2006","series-title":"A Compendium of Neuropsychological Tests: Administration, Norms, and Commentary","author":"Strauss","key":"10.1016\/j.jagp.2019.07.008_bib0035"},{"year":"1981","series-title":"WAIS-R Manual: Wechsler Adult Intelligence Scale-Revised","author":"Wechsler","key":"10.1016\/j.jagp.2019.07.008_bib0036"},{"key":"10.1016\/j.jagp.2019.07.008_bib0037","unstructured":"Golden CJ: A manual for the clinical and experimental use of the Stroop color and word test. 1978;"},{"year":"1994","series-title":"Clock Drawing: A Neuropsychological Analysis","author":"Freedman","key":"10.1016\/j.jagp.2019.07.008_bib0038"},{"key":"10.1016\/j.jagp.2019.07.008_bib0039","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1136\/jnnp.2004.045567","article-title":"Neuropsychological characteristics of mild cognitive impairment subgroups","volume":"77","author":"Lopez","year":"2006","journal-title":"J Neurol Neurosurg Psychiatry"},{"year":"2001","series-title":"Boston Naming Test","author":"Kaplan","key":"10.1016\/j.jagp.2019.07.008_bib0040"},{"key":"10.1016\/j.jagp.2019.07.008_bib0041","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1080\/01688638408401227","article-title":"Base rate data for the WAIS-R: test-retest stability and VIQ-PIQ differences","volume":"6","author":"Matarazzo","year":"1984","journal-title":"J Clin Neuropsychol"},{"year":"2002","series-title":"E-Prime: User's guide","author":"Schneider","key":"10.1016\/j.jagp.2019.07.008_bib0042"},{"key":"10.1016\/j.jagp.2019.07.008_bib0043","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/S0969-8051(00)00132-3","article-title":"Radiotracer synthesis from [(11)C]-iodomethane: a remarkably simple captive solvent method","volume":"27","author":"Wilson","year":"2000","journal-title":"Nucl Med Biol"},{"key":"10.1016\/j.jagp.2019.07.008_bib0044","doi-asserted-by":"crossref","first-page":"14770","DOI":"10.1523\/JNEUROSCI.3669-09.2009","article-title":"Basal cerebral metabolism may modulate the cognitive effects of Abeta in mild cognitive impairment: an example of brain reserve","volume":"29","author":"Cohen","year":"2009","journal-title":"J Neurosci"},{"key":"10.1016\/j.jagp.2019.07.008_bib0045","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1097\/00004728-199307000-00004","article-title":"MRI-PET registration with automated algorithm","volume":"17","author":"Woods","year":"1993","journal-title":"J Comput Assist Tomogr"},{"key":"10.1016\/j.jagp.2019.07.008_bib0046","first-page":"1959","article-title":"Simplified quantification of Pittsburgh Compound B amyloid imaging PET studies: a comparative analysis","volume":"46","author":"Lopresti","year":"2005","journal-title":"J Nucl Med"},{"key":"10.1016\/j.jagp.2019.07.008_bib0047","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1097\/00004647-199607000-00016","article-title":"MR-based correction of brain PET measurements for heterogeneous gray matter radioactivity distribution","volume":"16","author":"Meltzer","year":"1996","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.jagp.2019.07.008_bib0048","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0006-8993(98)00909-3","article-title":"Reduced binding of [18F]altanserin to serotonin type 2A receptors in aging: persistence of effect after partial volume correction","volume":"813","author":"Meltzer","year":"1998","journal-title":"Brain Res"},{"key":"10.1016\/j.jagp.2019.07.008_bib0049","first-page":"1842","article-title":"Does cerebral blood flow decline in healthy aging? A PET study with partial-volume correction","volume":"41","author":"Meltzer","year":"2000","journal-title":"J Nucl Med"},{"key":"10.1016\/j.jagp.2019.07.008_bib0050","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1038\/sj.jcbfm.9600146","article-title":"Kinetic modeling of amyloid binding in humans using PET imaging and Pittsburgh Compound-B","volume":"25","author":"Price","year":"2005","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.jagp.2019.07.008_bib0051","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.neuroimage.2013.01.015","article-title":"Classification of amyloid-positivity in controls: comparison of visual read and quantitative approaches","volume":"71","author":"Cohen","year":"2013","journal-title":"Neuroimage"},{"key":"10.1016\/j.jagp.2019.07.008_bib0052","unstructured":"Ashburner J, Barnes G, Chen C-c, et al: SPM12 Manual The FIL Methods Group (and honorary members). 2014;"},{"key":"10.1016\/j.jagp.2019.07.008_bib0053","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1002\/hbm.10062","article-title":"Fast robust automated brain extraction","volume":"17","author":"Smith","year":"2002","journal-title":"Hum Brain Mapp"},{"year":"2006","series-title":"ITK-SNaP Integration","author":"Yushkevich","key":"10.1016\/j.jagp.2019.07.008_bib0054"},{"key":"10.1016\/j.jagp.2019.07.008_bib0055","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.pscychresns.2006.09.003","article-title":"A fully automated method for quantifying and localizing white matter hyperintensities on MR images","volume":"148","author":"Wu","year":"2006","journal-title":"Psychiatry Res"},{"key":"10.1016\/j.jagp.2019.07.008_bib0056","series-title":"R: A Language and Environment for Statistical Computing","first-page":"2014","author":"Team","year":"2013"},{"key":"10.1016\/j.jagp.2019.07.008_bib0057","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/hbm.1058","article-title":"Nonparametric permutation tests for functional neuroimaging: a primer with examples","volume":"15","author":"Nichols","year":"2002","journal-title":"Hum Brain Mapp"},{"key":"10.1016\/j.jagp.2019.07.008_bib0058","doi-asserted-by":"crossref","first-page":"7900","DOI":"10.1073\/pnas.1602413113","article-title":"Cluster failure: why fMRI inferences for spatial extent have inflated false-positive rates","volume":"113","author":"Eklund","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jagp.2019.07.008_bib0059","doi-asserted-by":"crossref","first-page":"e68910","DOI":"10.1371\/journal.pone.0068910","article-title":"BrainNet Viewer: a network visualization tool for human brain connectomics","volume":"8","author":"Xia","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jagp.2019.07.008_bib0060","unstructured":"Cui X, Li J, Song X: xjview: a viewing program for SPM. Retreived from www.alivelearn.net\/xjview8, 2011"},{"key":"10.1016\/j.jagp.2019.07.008_bib0061","doi-asserted-by":"crossref","first-page":"13040","DOI":"10.1073\/pnas.0905267106","article-title":"Correspondence of the brain's functional architecture during activation and rest","volume":"106","author":"Smith","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jagp.2019.07.008_bib0062","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1111\/rssc.12295","article-title":"Bayesian log\u2010Gaussian Cox process regression: applications to meta\u2010analysis of neuroimaging working memory studies","volume":"68","author":"Samartsidis","year":"2018","journal-title":"J R Stat Soc"},{"key":"10.1016\/j.jagp.2019.07.008_bib0063","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1093\/cercor\/bhr255","article-title":"Abeta Deposition in aging is associated with increases in brain activation during successful memory encoding","volume":"22","author":"Mormino","year":"2012","journal-title":"Cereb Cortex"},{"key":"10.1016\/j.jagp.2019.07.008_bib0064","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1002\/hbm.20131","article-title":"N-back working memory paradigm: a meta-analysis of normative functional neuroimaging studies","volume":"25","author":"Owen","year":"2005","journal-title":"Hum Brain Mapp"},{"key":"10.1016\/j.jagp.2019.07.008_bib0065","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.neuroimage.2012.06.062","article-title":"Abnormal insula functional network is associated with episodic memory decline in amnestic mild cognitive impairment","volume":"63","author":"Xie","year":"2012","journal-title":"Neuroimage"},{"key":"10.1016\/j.jagp.2019.07.008_bib0066","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.neuroimage.2008.11.024","article-title":"Functional imaging studies of episodic memory in Alzheimer's disease: a quantitative meta-analysis","volume":"45","author":"Schwindt","year":"2009","journal-title":"Neuroimage"},{"key":"10.1016\/j.jagp.2019.07.008_bib0067","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.neuron.2009.07.003","article-title":"Amyloid deposition is associated with impaired default network function in older persons without dementia","volume":"63","author":"Sperling","year":"2009","journal-title":"Neuron"},{"key":"10.1016\/j.jagp.2019.07.008_bib0068","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1093\/brain\/awv007","article-title":"Amyloid-beta deposition in mild cognitive impairment is associated with increased hippocampal activity, atrophy and clinical progression","volume":"138","author":"Huijbers","year":"2015","journal-title":"Brain"},{"key":"10.1016\/j.jagp.2019.07.008_bib0069","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1093\/brain\/awv001","article-title":"Where is hippocampal activity in the cascade of Alzheimer's disease biomarkers?","volume":"138","author":"Aizenstein","year":"2015","journal-title":"Brain"},{"key":"10.1016\/j.jagp.2019.07.008_bib0070","doi-asserted-by":"crossref","first-page":"6174","DOI":"10.1523\/JNEUROSCI.0730-07.2007","article-title":"Amyloid deposition begins in the striatum of presenilin-1 mutation carriers from two unrelated pedigrees","volume":"27","author":"Klunk","year":"2007","journal-title":"J Neurosci"},{"key":"10.1016\/j.jagp.2019.07.008_bib0071","doi-asserted-by":"crossref","first-page":"2202","DOI":"10.1016\/j.neuropsychologia.2013.07.017","article-title":"Cognitive aging in persons with minimal amyloid-beta and white matter hyperintensities","volume":"51","author":"Nebes","year":"2013","journal-title":"Neuropsychologia"}],"container-title":["The American Journal of Geriatric Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1064748119304373?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1064748119304373?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T04:29:09Z","timestamp":1761020949000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1064748119304373"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":71,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["S1064748119304373"],"URL":"https:\/\/doi.org\/10.1016\/j.jagp.2019.07.008","relation":{},"ISSN":["1064-7481"],"issn-type":[{"type":"print","value":"1064-7481"}],"subject":[],"published":{"date-parts":[[2019,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Relationships Between Executive Control Circuit Activity, Amyloid Burden, and Education in Cognitively Healthy Older Adults","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Geriatric Psychiatry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jagp.2019.07.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 American Association for Geriatric Psychiatry. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}