{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:22:00Z","timestamp":1790806920635,"version":"4.1.0"},"reference-count":25,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,4,26]],"date-time":"2022-04-26T00:00:00Z","timestamp":1650931200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["ajgponline.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Geriatric Psychiatry"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1016\/j.jagp.2022.03.007","type":"journal-article","created":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T21:37:48Z","timestamp":1650490668000},"page":"1096-1107","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Symptom Severity Mixity in Older-Age Bipolar Disorder: Analyses From the Global Aging and Geriatric Experiments in Bipolar Disorder Database (GAGE-BD)"],"prefix":"10.1016","volume":"30","author":[{"given":"Lisa T.","family":"Eyler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farren B.S.","family":"Briggs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annemiek","family":"Dols","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soham","family":"Rej","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osvaldo P.","family":"Almeida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra J.M.","family":"Beunders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilary P.","family":"Blumberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brent P.","family":"Forester","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regan E.","family":"Patrick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orestes V.","family":"Forlenza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariel","family":"Gildengers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Jimenez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduard","family":"Vieta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benoit H.","family":"Mulsant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigfried","family":"Schouws","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine P.G.","family":"Paans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Strejilevich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Sutherland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shangying","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha","family":"Sajatovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jagp.2022.03.007_bib0001","series-title":"Diagnostic and Statistical Manual of Mental Disorders","year":"2013"},{"key":"10.1016\/j.jagp.2022.03.007_bib0002","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1176\/appi.ajp.2012.12030301","article-title":"Bipolar mixed states: an international society for bipolar disorders task force report of symptom structure, course of illness, and diagnosis","volume":"170","author":"Swann","year":"2013","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.jagp.2022.03.007_bib0003","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1017\/S1041610202008517","article-title":"Bipolar disorder: similarities and differences between patients with illness onset before and after 65 years of age","volume":"14","author":"Almeida","year":"2002","journal-title":"Int Psychogeriatr"},{"key":"10.1016\/j.jagp.2022.03.007_bib0004","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1111\/j.1399-5618.2006.00278.x","article-title":"Diagnostic subtypes of bipolar disorder in older versus younger adults","volume":"8","author":"Kessing","year":"2006","journal-title":"Bipolar Disord"},{"key":"10.1016\/j.jagp.2022.03.007_bib0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4068\/cmj.2017.53.1.1","article-title":"Mixed states in bipolar disorder: etiology, pathogenesis and treatment","volume":"53","author":"Muneer","year":"2017","journal-title":"Chonnam Med J"},{"issue":"Suppl 1","key":"10.1016\/j.jagp.2022.03.007_bib0006","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1016\/j.sleep.2009.07.004","article-title":"Sleep and its disorders in aging populations","volume":"10","author":"Ancoli-Israel","year":"2009","journal-title":"Sleep Med"},{"key":"10.1016\/j.jagp.2022.03.007_bib0007","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1097\/WCO.0000000000000028","article-title":"Depression in the elderly: brain correlates, neuropsychological findings, and role of vascular lesion load","volume":"26","author":"Vu","year":"2013","journal-title":"Curr Opin Neurol"},{"key":"10.1016\/j.jagp.2022.03.007_bib0008","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.maturitas.2011.07.005","article-title":"The role of white matter damage in late onset bipolar disorder","volume":"70","author":"Besga","year":"2011","journal-title":"Maturitas"},{"key":"10.1016\/j.jagp.2022.03.007_bib0009","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1111\/bdi.12795","article-title":"The Global Aging & Geriatric Experiments in Bipolar Disorder Database (GAGE-BD) project: understanding older-age bipolar disorder by combining multiple datasets","volume":"21","author":"Sajatovic","year":"2019","journal-title":"Bipolar Disord"},{"issue":"2","key":"10.1016\/j.jagp.2022.03.007_bib0010","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1111\/bdi.13119","article-title":"Bipolar symptoms, somatic burden, and functioning in older-age bipolar disorder: analyses from the Global Aging & Geriatric Experiments in Bipolar Disorder Database project","volume":"24","author":"Sajatovic","year":"2022","journal-title":"Bipolar Disord"},{"key":"10.1016\/j.jagp.2022.03.007_bib0011","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1192\/bjp.133.5.429","article-title":"A rating scale for mania: reliability, validity and sensitivity","volume":"133","author":"Young","year":"1978","journal-title":"Br J Psychiatry"},{"key":"10.1016\/j.jagp.2022.03.007_bib0012","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1136\/jnnp.23.1.56","article-title":"A rating scale for depression","volume":"23","author":"Hamilton","year":"1960","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.jagp.2022.03.007_bib0013","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1192\/bjp.134.4.382","article-title":"A new depression scale designed to be sensitive to change","volume":"134","author":"Montgomery","year":"1979","journal-title":"Br J Psychiatry"},{"key":"10.1016\/j.jagp.2022.03.007_bib0014","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.jad.2013.04.028","article-title":"Severity classification on the Hamilton Depression Rating Scale","volume":"150","author":"Zimmerman","year":"2013","journal-title":"J Affect Disord"},{"key":"10.1016\/j.jagp.2022.03.007_bib0015","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1161\/01.STR.29.3.618","article-title":"The Sunnybrook Stroke Study: a prospective study of depressive symptoms and functional outcome","volume":"29","author":"Herrmann","year":"1998","journal-title":"Stroke."},{"key":"10.1016\/j.jagp.2022.03.007_bib0016","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1111\/j.1399-5618.2009.00726.x","article-title":"The International Society for Bipolar Disorders (ISBD) task force report on the nomenclature of course and outcome in bipolar disorders","volume":"11","author":"Tohen","year":"2009","journal-title":"Bipolar Disord"},{"key":"10.1016\/j.jagp.2022.03.007_bib0017","series-title":"Outcome Assessment in Clinical Practice","article-title":"Global assessment of functioning (GAF) Scale","author":"Spitzer","year":"1996"},{"key":"10.1016\/j.jagp.2022.03.007_bib0018","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1590\/1516-4446-2012-1693","article-title":"Bipolar disorder prevalence: a systematic review and meta-analysis of the literature","volume":"37","author":"Clemente","year":"2015","journal-title":"Braz J Psychiatry"},{"key":"10.1016\/j.jagp.2022.03.007_bib0019","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.jad.2014.09.026","article-title":"The prevalence and illness characteristics of DSM-5-defined \u201cmixed feature specifier\u201d in adults with major depressive disorder and bipolar disorder: results from the International Mood Disorders Collaborative Project","volume":"172","author":"McIntyre","year":"2015","journal-title":"J Affect Disord"},{"key":"10.1016\/j.jagp.2022.03.007_bib0020","doi-asserted-by":"crossref","first-page":"e1773","DOI":"10.1002\/mpr.1773","article-title":"The prevalence and diagnostic classification of mixed features in patients with major depressive episodes: a multicenter study based on the DSM-5","volume":"28","author":"Shim","year":"2019","journal-title":"Int J Methods Psychiatr Res"},{"key":"10.1016\/j.jagp.2022.03.007_bib0021","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.jpsychires.2021.08.013","article-title":"Predictors of psychosocial functioning in euthymic patients with bipolar disorder: a model selection approach","volume":"143","author":"Tsapekos","year":"2021","journal-title":"J Psychiatr Res"},{"key":"10.1016\/j.jagp.2022.03.007_bib0022","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1001\/archpsyc.62.10.1089","article-title":"Mixed hypomania in 908 patients with bipolar disorder evaluated prospectively in the Stanley Foundation Bipolar Treatment Network: a sex-specific phenomenon","volume":"62","author":"Suppes","year":"2005","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.jagp.2022.03.007_bib0023","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1176\/appi.ajp.160.12.2099","article-title":"The McLean-Harvard first-episode mania study: prediction of recovery and first recurrence","volume":"160","author":"Tohen","year":"2003","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.jagp.2022.03.007_bib0024","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.jad.2007.06.011","article-title":"The empirical redefinition of the psychometric criteria for remission in bipolar disorder","volume":"106","author":"Berk","year":"2008","journal-title":"J Affect Disord"},{"key":"10.1016\/j.jagp.2022.03.007_bib0025","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.euroneuro.2021.03.008","article-title":"Bipolar disorder cohort studies: crucial, but underfunded","volume":"47","author":"Vieta","year":"2021","journal-title":"Eur Neuropsychopharmacol"}],"container-title":["The American Journal of Geriatric Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S106474812200392X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S106474812200392X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T04:33:30Z","timestamp":1761021210000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S106474812200392X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":25,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["S106474812200392X"],"URL":"https:\/\/doi.org\/10.1016\/j.jagp.2022.03.007","relation":{},"ISSN":["1064-7481"],"issn-type":[{"value":"1064-7481","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Symptom Severity Mixity in Older-Age Bipolar Disorder: Analyses From the Global Aging and Geriatric Experiments in Bipolar Disorder Database (GAGE-BD)","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Geriatric Psychiatry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jagp.2022.03.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc. on behalf of American Association for Geriatric Psychiatry.","name":"copyright","label":"Copyright"}]}}