{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T04:23:59Z","timestamp":1793939039747,"version":"4.8.0"},"reference-count":142,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1RF1AG072637-01"],"award-info":[{"award-number":["1RF1AG072637-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P01AG003991"],"award-info":[{"award-number":["P01AG003991"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P01AG026276"],"award-info":[{"award-number":["P01AG026276"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 AG066444"],"award-info":[{"award-number":["P30 AG066444"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG056466"],"award-info":[{"award-number":["R01AG056466"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG067428"],"award-info":[{"award-number":["R01AG067428"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG068183"],"award-info":[{"award-number":["R01AG068183"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG074302"],"award-info":[{"award-number":["R01AG074302"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U19 AG024904"],"award-info":[{"award-number":["U19 AG024904"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U19 AG032438"],"award-info":[{"award-number":["U19 AG032438"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajgponline.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Geriatric Psychiatry"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1016\/j.jagp.2023.06.001","type":"journal-article","created":{"date-parts":[[2023,6,11]],"date-time":"2023-06-11T12:43:16Z","timestamp":1686487396000},"page":"853-866","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":107,"title":["Neuroinflammation: A Modifiable Pathway Linking Obesity, Alzheimer's disease, and Depression"],"prefix":"10.1016","volume":"31","author":[{"given":"Maria","family":"Ly","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary Z.","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Mian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Austin","family":"Cramer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Somayeh","family":"Meysami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Merrill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amjad","family":"Samara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah A.","family":"Eisenstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"Hershey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ganesh M.","family":"Babulal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric J.","family":"Lenze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C.","family":"Morris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tammie L.S.","family":"Benzinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyrus A.","family":"Raji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jagp.2023.06.001_bib0001","doi-asserted-by":"crossref","first-page":"313","DOI":"10.14283\/jpad.2021.15","article-title":"The epidemiology of Alzheimer's disease modifiable risk factors and prevention","volume":"8","author":"Zhang","year":"2021","journal-title":"J Prev Alzheimer's Dis"},{"key":"10.1016\/j.jagp.2023.06.001_bib0002","unstructured":"Patterson C: World alzheimer report 2018. 2018;"},{"key":"10.1016\/j.jagp.2023.06.001_bib0003","doi-asserted-by":"crossref","unstructured":"2023 Alzheimer's disease facts and figures. Alzheimers Dement 2023; 19:1598-1695","DOI":"10.1002\/alz.13016"},{"key":"10.1016\/j.jagp.2023.06.001_bib0004","author":"Gotlib","year":"2008","journal-title":"Handbook of depression"},{"key":"10.1016\/j.jagp.2023.06.001_bib0005","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1590\/1516-4446-2020-0650","article-title":"Prevalence and correlates of major depressive disorder: a systematic review","volume":"42","author":"Guti\u00e9rrez-Rojas","year":"2020","journal-title":"Braz J Psychiatry"},{"key":"10.1016\/j.jagp.2023.06.001_bib0006","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-018-21243-x","article-title":"Prevalence of depression in the community from 30 countries between 1994 and 2014","volume":"8","author":"Lim","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.jagp.2023.06.001_bib0007","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1002\/gps.4204","article-title":"Subsyndromal depression among older adults in the USA: prevalence, comorbidity, and risk for new-onset psychiatric disorders in late life","volume":"30","author":"Laborde-Lahoz","year":"2015","journal-title":"Int J Geriatr Psychiatry"},{"key":"10.1016\/j.jagp.2023.06.001_bib0008","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1002\/gps.5119","article-title":"Prevalence of depressive symptoms and its associated factors among healthy community-dwelling older adults living in Australia and the United States","volume":"34","author":"Mohebbi","year":"2019","journal-title":"Int J Geriatr Psychiatry"},{"key":"10.1016\/j.jagp.2023.06.001_bib0009","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1016\/j.jacc.2015.07.050","article-title":"Food Consumption and its impact on cardiovascular disease: importance of solutions focused on the globalized food system: a report from the workshop convened by the world heart federation","volume":"66","author":"Anand","year":"2015","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jagp.2023.06.001_bib0010","series-title":"Prevalence of overweight, obesity, and severe obesity among adults aged 20 and over: United States, 1960\u20131962 through 2017\u20132018","author":"Fryar","year":"2020"},{"key":"10.1016\/j.jagp.2023.06.001_bib0011","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1001\/archgenpsychiatry.2011.1481","article-title":"Midlife vs late-life depressive symptoms and risk of dementia: differential effects for Alzheimer disease and vascular dementia","volume":"69","author":"Barnes","year":"2012","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.jagp.2023.06.001_bib0012","doi-asserted-by":"crossref","first-page":"345","DOI":"10.31887\/DCNS.2008.10.3\/mabutters","article-title":"Pathways linking late-life depression to persistent cognitive impairment and dementia","volume":"10","author":"Butters","year":"2008","journal-title":"Dialogues Clin Neurosci"},{"key":"10.1016\/j.jagp.2023.06.001_bib0013","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1016\/j.jagp.2016.04.004","article-title":"Mood changes in cognitively normal older adults are linked to alzheimer disease biomarker levels","volume":"24","author":"Babulal","year":"2016","journal-title":"Am J Geriatr Psychiatry"},{"key":"10.1016\/j.jagp.2023.06.001_bib0014","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.orcp.2016.07.003","article-title":"The interface of depression and obesity","volume":"11","author":"Jantaratnotai","year":"2017","journal-title":"Obes Res Clin Pract"},{"key":"10.1016\/j.jagp.2023.06.001_bib0015","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1002\/gps.1040","article-title":"Obesity and depressive symptoms in Chinese elderly","volume":"19","author":"Li","year":"2004","journal-title":"Int J Geriatr Psychiatry"},{"key":"10.1016\/j.jagp.2023.06.001_bib0016","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s13098-020-00526-2","article-title":"Depressive symptoms and metabolic syndrome components among older Chinese adults","volume":"12","author":"Liu","year":"2020","journal-title":"Diabetol Metab Syndr"},{"key":"10.1016\/j.jagp.2023.06.001_bib0017","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.18632\/aging.102738","article-title":"Late-life obesity is a protective factor for prodromal Alzheimer's disease: a longitudinal study","volume":"12","author":"Sun","year":"2020","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.jagp.2023.06.001_bib0018","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2010\/289645","article-title":"Chronic inflammation in obesity and the metabolic syndrome","author":"Monteiro","year":"2010","journal-title":"Mediators Inflamm"},{"key":"10.1016\/j.jagp.2023.06.001_bib0019","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1017\/S0007114520000380","article-title":"Microbial dysbiosis-induced obesity: role of gut microbiota in homoeostasis of energy metabolism","volume":"123","author":"Amabebe","year":"2020","journal-title":"Br J Nutr"},{"key":"10.1016\/j.jagp.2023.06.001_bib0020","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s11892-018-1104-3","article-title":"Gut microbiome in obesity, metabolic syndrome, and diabetes","volume":"18","author":"Chen","year":"2018","journal-title":"Curr Diab Rep"},{"key":"10.1016\/j.jagp.2023.06.001_bib0021","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1042\/CS20191313","article-title":"Inflammation: major denominator of obesity, Type 2 diabetes and Alzheimer's disease-like pathology?","volume":"134","author":"Kac\u00ed\u0159ov\u00e1","year":"2020","journal-title":"Clin Sci (Lond)"},{"key":"10.1016\/j.jagp.2023.06.001_bib0022","doi-asserted-by":"crossref","first-page":"718","DOI":"10.2337\/db08-1098","article-title":"Reduced adipose tissue oxygenation in human obesity: evidence for rarefaction, macrophage chemotaxis, and inflammation without an angiogenic response","volume":"58","author":"Pasarica","year":"2009","journal-title":"Diabetes"},{"key":"10.1016\/j.jagp.2023.06.001_bib0023","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s40279-013-0023-3","article-title":"Effects of exercise training on chronic inflammation in obesity: current evidence and potential mechanisms","volume":"43","author":"You","year":"2013","journal-title":"Sports Med"},{"key":"10.1016\/j.jagp.2023.06.001_bib0024","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1381\/096089206777346600","article-title":"Adipocyte size and liability to cell death","volume":"16","author":"Monteiro","year":"2006","journal-title":"Obes Surg"},{"key":"10.1016\/j.jagp.2023.06.001_bib0025","doi-asserted-by":"crossref","first-page":"461","DOI":"10.5114\/ceji.2020.103418","article-title":"Obesity and chronic inflammation crosslinking","volume":"45","author":"Artemniak-Wojtowicz","year":"2020","journal-title":"Cent Eur J Immunol"},{"key":"10.1016\/j.jagp.2023.06.001_bib0026","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1172\/JCI200319451","article-title":"Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance","volume":"112","author":"Xu","year":"2003","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jagp.2023.06.001_bib0027","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1467-789X.2009.00623.x","article-title":"Subcutaneous and visceral adipose tissue: structural and functional differences","volume":"11","author":"Ibrahim","year":"2010","journal-title":"Obes Rev"},{"key":"10.1016\/j.jagp.2023.06.001_bib0028","doi-asserted-by":"crossref","first-page":"2487","DOI":"10.1007\/s00125-013-3023-9","article-title":"Obesity phenotype is related to NLRP3 inflammasome activity and immunological profile of visceral adipose tissue","volume":"56","author":"Esser","year":"2013","journal-title":"Diabetologia"},{"key":"10.1016\/j.jagp.2023.06.001_bib0029","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/678159","article-title":"Obesity and inflammation: epidemiology, risk factors, and markers of inflammation","volume":"2013","author":"Rodr\u00edguez-Hern\u00e1ndez","year":"2013","journal-title":"Int J Endocrinol"},{"key":"10.1016\/j.jagp.2023.06.001_bib0030","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.1253\/circj.CJ-11-1184","article-title":"Chronic inflammation links cardiovascular, metabolic and renal diseases","volume":"75","author":"Manabe","year":"2011","journal-title":"Circ J"},{"key":"10.1016\/j.jagp.2023.06.001_bib0031","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2019.10456","article-title":"Associations of chronic inflammation, insulin resistance, and severe obesity with mortality, myocardial infarction, cancer, and chronic pulmonary disease","volume":"2","author":"Wiebe","year":"2019","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.jagp.2023.06.001_bib0032","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1016\/j.dsx.2019.01.041","article-title":"How the association between obesity and inflammation may lead to insulin resistance and cancer","volume":"13","author":"Amin","year":"2019","journal-title":"Diabetes Metab Syndr"},{"key":"10.1016\/j.jagp.2023.06.001_bib0033","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.3389\/fphys.2019.01607","article-title":"Chronic adipose tissue inflammation linking obesity to insulin resistance and type 2 diabetes","volume":"10","author":"Zatterale","year":"2019","journal-title":"Front Physiol"},{"key":"10.1016\/j.jagp.2023.06.001_bib0034","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.hgmx.2016.06.011","article-title":"Low-grade inflammation and its relation to obesity and chronic degenerative diseases","volume":"80","author":"Pantoja-Mel\u00e9ndez","year":"2017","journal-title":"Revista M\u00e9dica Hospital Gen M\u00e9xico"},{"key":"10.1016\/j.jagp.2023.06.001_bib0035","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1038\/s41591-019-0675-0","article-title":"Chronic inflammation in the etiology of disease across the life span","volume":"25","author":"Furman","year":"2019","journal-title":"Nat Med"},{"key":"10.1016\/j.jagp.2023.06.001_bib0036","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ijerph17114135","article-title":"Chronic inflammation in the context of everyday life: dietary changes as mitigating factors","volume":"17","author":"Margin\u0103","year":"2020","journal-title":"Int J Environ Res Public Health"},{"key":"10.1016\/j.jagp.2023.06.001_bib0037","doi-asserted-by":"crossref","first-page":"2837","DOI":"10.2147\/NDT.S177973","article-title":"Neuroprogression: the hidden mechanism of depression","volume":"14","author":"Ruiz","year":"2018","journal-title":"Neuropsychiatr Dis Treat"},{"key":"10.1016\/j.jagp.2023.06.001_bib0038","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.brainres.2009.05.032","article-title":"Modifiers of cognitive function and brain structure in middle-aged and elderly individuals with type 2 diabetes mellitus","volume":"1280","author":"Bruehl","year":"2009","journal-title":"Brain Res"},{"key":"10.1016\/j.jagp.2023.06.001_bib0039","doi-asserted-by":"crossref","first-page":"140","DOI":"10.3389\/fendo.2019.00140","article-title":"Molecular mechanisms underlying obesity-induced hypothalamic inflammation and insulin resistance: pivotal role of resistin\/TLR4 Pathways","volume":"10","author":"Benomar","year":"2019","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.jagp.2023.06.001_bib0040","doi-asserted-by":"crossref","first-page":"69","DOI":"10.4049\/jimmunol.2100567","article-title":"High-fat diet-induced obesity alters dendritic cell homeostasis by enhancing mitochondrial fatty acid oxidation","volume":"209","author":"Chen","year":"2022","journal-title":"J Immunol"},{"key":"10.1016\/j.jagp.2023.06.001_bib0041","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/cells10113164","article-title":"High-fat, western-style diet, systemic inflammation, and gut microbiota: a narrative review","volume":"10","author":"Malesza","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.jagp.2023.06.001_bib0042","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1172\/JCI59660","article-title":"Obesity is associated with hypothalamic injury in rodents and humans","volume":"122","author":"Thaler","year":"2012","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jagp.2023.06.001_bib0043","doi-asserted-by":"crossref","first-page":"83","DOI":"10.3389\/fgene.2019.00083","article-title":"Transcriptomic analysis of high fat diet fed mouse brain cortex","volume":"10","author":"Yoon","year":"2019","journal-title":"Front Genet"},{"key":"10.1016\/j.jagp.2023.06.001_bib0044","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.14336\/AD.2019.0102","article-title":"AMPK signaling regulates the age-related decline of hippocampal neurogenesis","volume":"10","author":"Wang","year":"2019","journal-title":"Aging Dis"},{"key":"10.1016\/j.jagp.2023.06.001_bib0045","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1002\/hipo.20470","article-title":"Diet-induced insulin resistance impairs hippocampal synaptic plasticity and cognition in middle-aged rats","volume":"18","author":"Stranahan","year":"2008","journal-title":"Hippocampus"},{"key":"10.1016\/j.jagp.2023.06.001_bib0046","doi-asserted-by":"crossref","first-page":"399","DOI":"10.3389\/fnagi.2017.00399","article-title":"Blood-brain barrier dysfunction precedes cognitive decline and neurodegeneration in diabetic insulin resistant mouse model: an implication for causal link","volume":"9","author":"Takechi","year":"2017","journal-title":"Front Aging Neurosci"},{"key":"10.1016\/j.jagp.2023.06.001_bib0047","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1159\/000343211","article-title":"Aging-related changes in blood-brain barrier integrity and the effect of dietary fat","volume":"12","author":"Takechi","year":"2013","journal-title":"Neurodegener Dis"},{"key":"10.1016\/j.jagp.2023.06.001_bib0048","doi-asserted-by":"crossref","first-page":"207","DOI":"10.3233\/JAD-2010-091414","article-title":"The effects of a high-energy diet on hippocampal function and blood-brain barrier integrity in the rat","volume":"21","author":"Kanoski","year":"2010","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.jagp.2023.06.001_bib0049","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/7854_2018_54","article-title":"Hypothalamic integration of the endocrine signaling related to food intake","volume":"43","author":"Klockars","year":"2019","journal-title":"Curr Top Behav Neurosci"},{"key":"10.1016\/j.jagp.2023.06.001_bib0050","doi-asserted-by":"crossref","first-page":"98","DOI":"10.18632\/aging.100431","article-title":"Inflammatory cause of metabolic syndrome via brain stress and NF-\u03baB","volume":"4","author":"Cai","year":"2012","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.jagp.2023.06.001_bib0051","doi-asserted-by":"crossref","first-page":"70","DOI":"10.3389\/fncel.2013.00070","article-title":"Microglia and synapse interactions: fine tuning neural circuits and candidate molecules","volume":"7","author":"Miyamoto","year":"2013","journal-title":"Front Cell Neurosci"},{"key":"10.1016\/j.jagp.2023.06.001_bib0052","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.nbd.2005.11.002","article-title":"Redox proteomics identification of oxidatively modified hippocampal proteins in mild cognitive impairment: insights into the development of Alzheimer's disease","volume":"22","author":"Butterfield","year":"2006","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.jagp.2023.06.001_bib0053","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1093\/jnen\/60.8.759","article-title":"Oxidative damage is the earliest event in Alzheimer disease","volume":"60","author":"Nunomura","year":"2001","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.1016\/j.jagp.2023.06.001_bib0054","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.pnpbp.2010.05.004","article-title":"A review on the oxidative and nitrosative stress (O&NS) pathways in major depression and their possible contribution to the (neuro)degenerative processes in that illness","volume":"35","author":"Maes","year":"2011","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.jagp.2023.06.001_bib0055","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.psyneuen.2014.09.025","article-title":"Is depression associated with increased oxidative stress? A systematic review and meta-analysis","volume":"51","author":"Black","year":"2015","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.jagp.2023.06.001_bib0056","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1038\/srep00799","article-title":"Obesity-induced endoplasmic reticulum stress causes chronic inflammation in adipose tissue","volume":"2","author":"Kawasaki","year":"2012","journal-title":"Sci Rep"},{"key":"10.1016\/j.jagp.2023.06.001_bib0057","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.lfs.2017.11.019","article-title":"Mitochondrial dysfunction in obesity","volume":"192","author":"de Mello","year":"2018","journal-title":"Life Sci"},{"key":"10.1016\/j.jagp.2023.06.001_bib0058","doi-asserted-by":"crossref","first-page":"2502","DOI":"10.1093\/hmg\/ddy154","article-title":"Mutant APP and amyloid beta-induced defective autophagy, mitophagy, mitochondrial structural and functional changes and synaptic damage in hippocampal neurons from Alzheimer's disease","volume":"27","author":"Reddy","year":"2018","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.jagp.2023.06.001_bib0059","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1111\/j.1471-4159.2010.06865.x","article-title":"High fat diet increases hippocampal oxidative stress and cognitive impairment in aged mice: implications for decreased Nrf2 signaling","volume":"114","author":"Morrison","year":"2010","journal-title":"J Neurochem"},{"key":"10.1016\/j.jagp.2023.06.001_bib0060","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1159\/000342020","article-title":"Axonal transport and mitochondrial dysfunction in Alzheimer's disease","volume":"12","author":"Riemer","year":"2013","journal-title":"Neurodegener Dis"},{"key":"10.1016\/j.jagp.2023.06.001_bib0061","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.arr.2004.05.002","article-title":"Reactive oxygen species and synaptic plasticity in the aging hippocampus","volume":"3","author":"Serrano","year":"2004","journal-title":"Ageing Res Rev"},{"key":"10.1016\/j.jagp.2023.06.001_bib0062","doi-asserted-by":"crossref","first-page":"3117","DOI":"10.3390\/ijms12053117","article-title":"Inflammation, oxidative stress, and obesity","volume":"12","author":"Fern\u00e1ndez-S\u00e1nchez","year":"2011","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jagp.2023.06.001_bib0063","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1007\/s13105-012-0154-2","article-title":"Oxidative stress and inflammation interactions in human obesity","volume":"68","author":"Bondia-Pons","year":"2012","journal-title":"J Physiol Biochem"},{"key":"10.1016\/j.jagp.2023.06.001_bib0064","doi-asserted-by":"crossref","first-page":"270","DOI":"10.3389\/fncel.2017.00270","article-title":"Microglia: an interface between the loss of neuroplasticity and depression","volume":"11","author":"Singhal","year":"2017","journal-title":"Front Cell Neurosci"},{"key":"10.1016\/j.jagp.2023.06.001_bib0065","doi-asserted-by":"crossref","first-page":"79","DOI":"10.5507\/bp.2018.015","article-title":"M1\/M2 macrophage polarization in human obese adipose tissue","volume":"162","author":"Chylikova","year":"2018","journal-title":"Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub"},{"key":"10.1016\/j.jagp.2023.06.001_bib0066","doi-asserted-by":"crossref","first-page":"8354","DOI":"10.1523\/JNEUROSCI.0616-08.2008","article-title":"Microglial dysfunction and defective beta-amyloid clearance pathways in aging Alzheimer's disease mice","volume":"28","author":"Hickman","year":"2008","journal-title":"J Neurosci"},{"key":"10.1016\/j.jagp.2023.06.001_bib0067","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nature21029","article-title":"Neurotoxic reactive astrocytes are induced by activated microglia","volume":"541","author":"Liddelow","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.jagp.2023.06.001_bib0068","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/1742-2094-8-94","article-title":"Severe depression is associated with increased microglial quinolinic acid in subregions of the anterior cingulate gyrus: evidence for an immune-modulated glutamatergic neurotransmission?","volume":"8","author":"Steiner","year":"2011","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.jagp.2023.06.001_bib0069","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.bbi.2014.05.007","article-title":"Evidence for increased microglial priming and macrophage recruitment in the dorsal anterior cingulate white matter of depressed suicides","volume":"42","author":"Torres-Platas","year":"2014","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.jagp.2023.06.001_bib0070","doi-asserted-by":"crossref","first-page":"306","DOI":"10.3389\/fncel.2018.00306","article-title":"Switching of the microglial activation phenotype is a possible treatment for depression disorder","volume":"12","author":"Zhang","year":"2018","journal-title":"Front Cell Neurosci"},{"key":"10.1016\/j.jagp.2023.06.001_bib0071","doi-asserted-by":"crossref","first-page":"480","DOI":"10.2337\/dc12-1442","article-title":"A systematic review and meta-analysis of the association between depression and insulin resistance","volume":"36","author":"Kan","year":"2013","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jagp.2023.06.001_bib0072","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1038\/oby.2012.19","article-title":"Obesity, insulin resistance, and Alzheimer's disease","volume":"20","author":"Hildreth","year":"2012","journal-title":"Obesity (Silver Spring)"},{"key":"10.1016\/j.jagp.2023.06.001_bib0073","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.tibs.2016.10.009","article-title":"Stressed and inflamed, can GSK3 be blamed?","volume":"42","author":"Jope","year":"2017","journal-title":"Trends Biochem Sci"},{"key":"10.1016\/j.jagp.2023.06.001_bib0074","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3389\/fpsyt.2019.00057","article-title":"Insulin resistance as a shared pathogenic mechanism between depression and type 2 diabetes","volume":"10","author":"Lyra","year":"2019","journal-title":"Front Psychiatry"},{"key":"10.1016\/j.jagp.2023.06.001_bib0075","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/neu.2019.17","article-title":"Inflammation, insulin resistance and neuroprogression in depression","volume":"32","author":"Leonard","year":"2020","journal-title":"Acta Neuropsychiatr"},{"key":"10.1016\/j.jagp.2023.06.001_bib0076","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.bbi.2014.04.001","article-title":"Obesity and neuroinflammation: a pathway to cognitive impairment","volume":"42","author":"Miller","year":"2014","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.jagp.2023.06.001_bib0077","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.cobeha.2016.05.004","article-title":"Eirini CSaPDAaANM: obesity, inflammation and cognition","volume":"9","year":"2016","journal-title":"Curr Opin Behav Sci"},{"key":"10.1016\/j.jagp.2023.06.001_bib0078","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1093\/gerona\/glt013","article-title":"Frailty and incident dementia","volume":"68","author":"Gray","year":"2013","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"10.1016\/j.jagp.2023.06.001_bib0079","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1038\/s41366-018-0211-1","article-title":"Perceived weight discrimination and risk of incident dementia","volume":"43","author":"Sutin","year":"2019","journal-title":"Int J Obes (Lond)"},{"key":"10.1016\/j.jagp.2023.06.001_bib0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpsychores.2019.109793","article-title":"Perceived weight discrimination and performance in five domains of cognitive function","volume":"131","author":"Sutin","year":"2020","journal-title":"J Psychosom Res"},{"key":"10.1016\/j.jagp.2023.06.001_bib0081","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1007\/s00415-004-0316-4","article-title":"Weight loss, nutritional status and physical activity in patients with Alzheimer's disease. A controlled study","volume":"251","author":"Wang","year":"2004","journal-title":"J Neurol"},{"key":"10.1016\/j.jagp.2023.06.001_bib0082","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1017\/S0029665112002753","article-title":"Weight loss and Alzheimer's disease: temporal and aetiologic connections","volume":"72","author":"Sergi","year":"2013","journal-title":"Proc Nutr Soc"},{"key":"10.1016\/j.jagp.2023.06.001_bib0083","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0151710","article-title":"Weight loss predicts progression of mild cognitive impairment to Alzheimer's Disease","volume":"11","author":"Cova","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.jagp.2023.06.001_bib0084","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1093\/gerona\/glac234","article-title":"Plasma leptin is associated with amyloid CSF biomarkers and Alzheimer's disease diagnosis in cognitively impaired patients","volume":"78","author":"Lilamand","year":"2023","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"10.1016\/j.jagp.2023.06.001_bib0085","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s10571-015-0282-7","article-title":"Leptin dysfunction and Alzheimer's disease: evidence from cellular, animal, and human studies","volume":"36","author":"McGuire","year":"2016","journal-title":"Cell Mol Neurobiol"},{"key":"10.1016\/j.jagp.2023.06.001_bib0086","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/j.jagp.2016.05.004","article-title":"Appetite and weight loss symptoms in late-life depression predict dementia outcomes","volume":"24","author":"Saha","year":"2016","journal-title":"Am J Geriatr Psychiatry"},{"key":"10.1016\/j.jagp.2023.06.001_bib0087","first-page":"640","article-title":"Evaluating and treating unintentional weight loss in the elderly","volume":"65","author":"Huffman","year":"2002","journal-title":"Am Fam Phys"},{"key":"10.1016\/j.jagp.2023.06.001_bib0088","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.atherosclerosis.2015.11.029","article-title":"Apolipoprotein E4 association with metabolic syndrome depends on body fatness","volume":"245","author":"Torres-Perez","year":"2016","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.jagp.2023.06.001_bib0089","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0108605","article-title":"The apolipoprotein E polymorphism rs7412 associates with body fatness independently of plasma lipids in middle aged men","volume":"9","author":"Tejedor","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jagp.2023.06.001_bib0090","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1038\/oby.2003.201","article-title":"Obesity modulates the association among APOE genotype, insulin, and glucose in men","volume":"11","author":"Elosua","year":"2003","journal-title":"Obes Res"},{"key":"10.1016\/j.jagp.2023.06.001_bib0091","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.jstrokecerebrovasdis.2011.06.020","article-title":"Apolipoprotein epsilon 4 allele modifies waist-to-hip ratio effects on cognition and brain structure","volume":"22","author":"Zade","year":"2013","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"10.1016\/j.jagp.2023.06.001_bib0092","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/S0006-3223(03)00608-5","article-title":"Depression and obesity","volume":"54","author":"Stunkard","year":"2003","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.jagp.2023.06.001_bib0093","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1038\/sj.ijo.0802204","article-title":"Prospective association between obesity and depression: evidence from the Alameda County Study","volume":"27","author":"Roberts","year":"2003","journal-title":"Int J Obes Relat Metab Disord"},{"key":"10.1016\/j.jagp.2023.06.001_bib0094","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1093\/aje\/152.2.163","article-title":"Are the obese at greater risk for depression?","volume":"152","author":"Roberts","year":"2000","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.jagp.2023.06.001_bib0095","doi-asserted-by":"crossref","first-page":"15","DOI":"10.2337\/diaspect.23.1.15","article-title":"Depression among adults with diabetes: prevalence, impact, and treatment options","volume":"23","author":"de Groot","year":"2010","journal-title":"Diabetes Spectr"},{"key":"10.1016\/j.jagp.2023.06.001_bib0096","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1001\/archgenpsychiatry.2010.2","article-title":"Overweight, obesity, and depression: a systematic review and meta-analysis of longitudinal studies","volume":"67","author":"Luppino","year":"2010","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.jagp.2023.06.001_bib0097","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0157240","article-title":"Prospective associations between depression and obesity for adolescent males and females- A systematic review and meta-analysis of longitudinal studies","volume":"11","author":"Mannan","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.jagp.2023.06.001_bib0098","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1136\/archdischild-2017-314608","article-title":"Is obesity associated with depression in children? Systematic review and meta-analysis","volume":"104","author":"Sutaria","year":"2019","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.jagp.2023.06.001_bib0099","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.jad.2018.04.102","article-title":"Depression and metabolic syndrome in the older population: a review of evidence","volume":"237","author":"Repousi","year":"2018","journal-title":"J Affect Disord"},{"key":"10.1016\/j.jagp.2023.06.001_bib0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.psyneuen.2019.104443","article-title":"Inflammatory and metabolic disturbances are associated with more severe trajectories of late-life depression","volume":"110","author":"de la Torre-Luque","year":"2019","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.jagp.2023.06.001_bib0101","doi-asserted-by":"crossref","DOI":"10.1016\/j.archger.2021.104603","article-title":"Frailty measures in immuno-metabolic subtypes of late-life depression; a two-year prospective study","volume":"99","author":"Kokkeler","year":"2022","journal-title":"Arch Gerontol Geriatr"},{"key":"10.1016\/j.jagp.2023.06.001_bib0102","doi-asserted-by":"crossref","first-page":"533","DOI":"10.2174\/1570159X15666171123201142","article-title":"Imaging the role of inflammation in mood and anxiety-related disorders","volume":"16","author":"Felger","year":"2018","journal-title":"Curr Neuropharmacol"},{"key":"10.1016\/j.jagp.2023.06.001_bib0103","first-page":"1","article-title":"The complex relationship between depression and progression to incident cognitive impairment across race and ethnicity","volume":"12","author":"Babulal","year":"2022","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.jagp.2023.06.001_bib0104","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1046\/j.1467-789X.2002.00065.x","article-title":"Asians are different from Caucasians and from each other in their body mass index\/body fat per cent relationship","volume":"3","author":"Deurenberg","year":"2002","journal-title":"Obes Rev"},{"key":"10.1016\/j.jagp.2023.06.001_bib0105","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1056\/NEJMoa1010679","article-title":"Association between body-mass index and risk of death in more than 1 million Asians","volume":"364","author":"Zheng","year":"2011","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jagp.2023.06.001_bib0106","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s12991-021-00375-x","article-title":"Prevalence and determinants of depression among old age: a systematic review and meta-analysis","volume":"20","author":"Zenebe","year":"2021","journal-title":"Ann Gen Psychiatry"},{"key":"10.1016\/j.jagp.2023.06.001_bib0107","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2020.1606","article-title":"Association of race and ethnicity with late-life depression severity, symptom burden, and care","volume":"3","author":"Vyas","year":"2020","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.jagp.2023.06.001_bib0108","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1001\/jamaneurol.2022.0976","article-title":"Risk factors associated with alzheimer disease and related dementias by sex and race and ethnicity in the US","volume":"79","author":"Nianogo","year":"2022","journal-title":"JAMA Neurol"},{"key":"10.1016\/j.jagp.2023.06.001_bib0109","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.freeradbiomed.2006.12.005","article-title":"Alternate day calorie restriction improves clinical findings and reduces markers of oxidative stress and inflammation in overweight adults with moderate asthma","volume":"42","author":"Johnson","year":"2007","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.jagp.2023.06.001_bib0110","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1210\/jc.2003-031310","article-title":"Effects of hypocaloric diet and exercise training on inflammation and adipocyte lipolysis in obese postmenopausal women","volume":"89","author":"You","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jagp.2023.06.001_bib0111","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1007\/s11695-008-9626-4","article-title":"In morbid obesity, metabolic abnormalities and adhesion molecules correlate with visceral fat, not with subcutaneous fat: effect of weight loss through surgery","volume":"19","author":"Pontiroli","year":"2009","journal-title":"Obes Surg"},{"key":"10.1016\/j.jagp.2023.06.001_bib0112","doi-asserted-by":"crossref","first-page":"3028","DOI":"10.1007\/s11695-018-3320-y","article-title":"The Impact of obesity and metabolic surgery on chronic inflammation","volume":"28","author":"Chiappetta","year":"2018","journal-title":"Obes Surg"},{"key":"10.1016\/j.jagp.2023.06.001_bib0113","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1007\/s11695-007-9140-0","article-title":"Gastric bypass surgery is associated with reduced inflammation and less depression: a preliminary investigation","volume":"17","author":"Emery","year":"2007","journal-title":"Obes Surg"},{"key":"10.1016\/j.jagp.2023.06.001_bib0114","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1111\/j.1532-5415.2010.02903.x","article-title":"Physical activity over the life course and its association with cognitive performance and impairment in old age","volume":"58","author":"Middleton","year":"2010","journal-title":"J Am Geriatr Soc"},{"key":"10.1016\/j.jagp.2023.06.001_bib0115","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s00592-011-0278-9","article-title":"Effects of exercise on inflammation markers in type 2 diabetic subjects","volume":"48","author":"Hopps","year":"2011","journal-title":"Acta Diabetol"},{"key":"10.1016\/j.jagp.2023.06.001_bib0116","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1111\/bpa.12255","article-title":"Voluntary running attenuates memory loss, decreases neuropathological changes and induces neurogenesis in a mouse model of Alzheimer's disease","volume":"26","author":"Tapia-Rojas","year":"2016","journal-title":"Brain Pathol"},{"key":"10.1016\/j.jagp.2023.06.001_bib0117","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1249\/MSS.0000000000002242","article-title":"Exercise intensity and recovery on circulating brain-derived neurotrophic factor","volume":"52","author":"Reycraft","year":"2020","journal-title":"Med Sci Sports Exerc"},{"key":"10.1016\/j.jagp.2023.06.001_bib0118","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1177\/02698811211069110","article-title":"Modulation of microglial activation by antidepressants","volume":"36","author":"Mariani","year":"2022","journal-title":"J Psychopharmacol"},{"key":"10.1016\/j.jagp.2023.06.001_bib0119","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2021.136044","article-title":"Lithium: a therapeutic option in Alzheimer's disease and its prodromal stages?","volume":"760","author":"Haussmann","year":"2021","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.jagp.2023.06.001_bib0120","doi-asserted-by":"crossref","first-page":"403","DOI":"10.3233\/JAD-150437","article-title":"Lithium as a treatment for Alzheimer's disease: a systematic review and meta-analysis","volume":"48","author":"Matsunaga","year":"2015","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.jagp.2023.06.001_bib0121","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1002\/biof.1597","article-title":"The effects of statins on microglial cells to protect against neurodegenerative disorders: a mechanistic review","volume":"46","author":"Bagheri","year":"2020","journal-title":"Biofactors"},{"key":"10.1016\/j.jagp.2023.06.001_bib0122","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1007\/s11011-017-0021-5","article-title":"The beneficial effects of HMG-CoA reductase inhibitors in the processes of neurodegeneration","volume":"32","author":"Saeedi","year":"2017","journal-title":"Metab Brain Dis"},{"key":"10.1016\/j.jagp.2023.06.001_bib0123","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1007\/s00228-022-03363-6","article-title":"Pharmacotherapy of Alzheimer's disease: an overview of systematic reviews","volume":"78","author":"Majidazar","year":"2022","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1016\/j.jagp.2023.06.001_bib0124","doi-asserted-by":"crossref","first-page":"83","DOI":"10.3389\/fnagi.2018.00083","article-title":"NSAID exposure and risk of Alzheimer's disease: an updated meta-analysis from cohort studies","volume":"10","author":"Zhang","year":"2018","journal-title":"Front Aging Neurosci"},{"key":"10.1016\/j.jagp.2023.06.001_bib0125","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1212\/01.wnl.0000311269.57716.63","article-title":"Protective effects of NSAIDs on the development of Alzheimer disease","volume":"70","author":"Vlad","year":"2008","journal-title":"Neurology"},{"key":"10.1016\/j.jagp.2023.06.001_bib0126","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.neurobiolaging.2006.03.013","article-title":"NSAIDs and Alzheimer disease: epidemiological, animal model and clinical studies","volume":"28","author":"McGeer","year":"2007","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.jagp.2023.06.001_bib0127","doi-asserted-by":"crossref","first-page":"2819","DOI":"10.1001\/jama.289.21.2819","article-title":"Effects of rofecoxib or naproxen vs placebo on Alzheimer disease progression: a randomized controlled trial","volume":"289","author":"Aisen","year":"2003","journal-title":"JAMA"},{"key":"10.1016\/j.jagp.2023.06.001_bib0128","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.biopsych.2020.03.007","article-title":"Translocator protein distribution volume predicts reduction of symptoms during open-label trial of celecoxib in major depressive disorder","volume":"88","author":"Attwells","year":"2020","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.jagp.2023.06.001_bib0129","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1016\/S2215-0366(20)30255-8","article-title":"Neuroinflammation in psychiatric disorders: PET imaging and promising new targets","volume":"7","author":"Meyer","year":"2020","journal-title":"Lancet Psychiatry"},{"key":"10.1016\/j.jagp.2023.06.001_bib0130","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/sj.bjp.0705667","article-title":"Cannabinoids and neuroinflammation","volume":"141","author":"Walter","year":"2004","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.jagp.2023.06.001_bib0131","doi-asserted-by":"crossref","first-page":"3152","DOI":"10.1093\/brain\/awp239","article-title":"Microglial CB2 cannabinoid receptors are neuroprotective in Huntington's disease excitotoxicity","volume":"132","author":"Palazuelos","year":"2009","journal-title":"Brain"},{"key":"10.1016\/j.jagp.2023.06.001_bib0132","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0129618","article-title":"Cannabinoid CB2 receptors in a mouse model of A\u03b2 amyloidosis: immunohistochemical analysis and suitability as a PET biomarker of neuroinflammation","volume":"10","author":"Savonenko","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jagp.2023.06.001_bib0133","doi-asserted-by":"crossref","first-page":"53S","DOI":"10.2967\/jnumed.121.263199","article-title":"Cyclooxygenases as potential pet imaging biomarkers to explore neuroinflammation in dementia","volume":"63","author":"Kenou","year":"2022","journal-title":"J Nucl Med"},{"key":"10.1016\/j.jagp.2023.06.001_bib0134","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/bs.pmbts.2019.04.005","article-title":"Development of brain PET imaging agents: strategies for imaging neuroinflammation in Alzheimer's disease","volume":"165","author":"Janssen","year":"2019","journal-title":"Prog Mol Biol Transl Sci"},{"key":"10.1016\/j.jagp.2023.06.001_bib0135","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1002\/jmri.27438","article-title":"Arterial spin labeling applications in pediatric and adult neurologic disorders","volume":"55","author":"Bambach","year":"2022","journal-title":"J Magn Reson Imaging"},{"key":"10.1016\/j.jagp.2023.06.001_bib0136","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2967\/jnumed.109.065680","article-title":"Radioisotopic imaging of neuroinflammation","volume":"51","author":"Winkeler","year":"2010","journal-title":"J Nucl Med"},{"key":"10.1016\/j.jagp.2023.06.001_bib0137","doi-asserted-by":"crossref","first-page":"9576","DOI":"10.1038\/s41598-018-27839-7","article-title":"Chemical exchange saturation transfer MRI shows low cerebral 2-deoxy-D-glucose uptake in a model of Alzheimer's disease","volume":"8","author":"Tolomeo","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.jagp.2023.06.001_bib0138","doi-asserted-by":"crossref","DOI":"10.1016\/j.nicl.2019.101767","article-title":"Quantification of white matter cellularity and damage in preclinical and early symptomatic Alzheimer's disease","volume":"22","author":"Wang","year":"2019","journal-title":"Neuroimage Clin"},{"key":"10.1016\/j.jagp.2023.06.001_bib0139","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.jneuroim.2016.10.002","article-title":"A new imaging modality to non-invasively assess multiple sclerosis pathology","volume":"304","author":"Cross","year":"2017","journal-title":"J Neuroimmunol"},{"key":"10.1016\/j.jagp.2023.06.001_bib0140","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.neuroimage.2005.03.042","article-title":"Composite hindered and restricted model of diffusion (CHARMED) MR imaging of the human brain","volume":"27","author":"Assaf","year":"2005","journal-title":"Neuroimage"},{"key":"10.1016\/j.jagp.2023.06.001_bib0141","doi-asserted-by":"crossref","first-page":"464","DOI":"10.3389\/fnhum.2019.00464","article-title":"Neuroinflammation and white matter alterations in obesity assessed by diffusion basis spectrum imaging","volume":"13","author":"Samara","year":"2019","journal-title":"Front Hum Neurosci"},{"key":"10.1016\/j.jagp.2023.06.001_bib0142","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.3233\/JAD-201242","article-title":"Obesity and white matter neuroinflammation related edema in Alzheimer's disease dementia biomarker negative cognitively normal individuals","volume":"79","author":"Ly","year":"2021","journal-title":"J Alzheimers Dis"}],"container-title":["The American Journal of Geriatric Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1064748123003184?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1064748123003184?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T04:35:11Z","timestamp":1761021311000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1064748123003184"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":142,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["S1064748123003184"],"URL":"https:\/\/doi.org\/10.1016\/j.jagp.2023.06.001","relation":{},"ISSN":["1064-7481"],"issn-type":[{"value":"1064-7481","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neuroinflammation: A Modifiable Pathway Linking Obesity, Alzheimer's disease, and Depression","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Geriatric Psychiatry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jagp.2023.06.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 American Association for Geriatric Psychiatry. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}