{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T14:51:25Z","timestamp":1789829485484,"version":"4.0.1"},"reference-count":44,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5T32MH020004"],"award-info":[{"award-number":["5T32MH020004"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U19 AG024904"],"award-info":[{"award-number":["U19 AG024904"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014041","name":"Alzheimer&apos;s Disease Neuroimaging Initiative","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014041","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["W81XWH-12-2-0012"],"award-info":[{"award-number":["W81XWH-12-2-0012"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajgponline.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Geriatric Psychiatry"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.jagp.2025.04.207","type":"journal-article","created":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T11:21:00Z","timestamp":1744197660000},"page":"756-769","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Depressive Symptoms Correlate With Tau Accumulation Rates in Amyloid Positive Adults"],"prefix":"10.1016","volume":"33","author":[{"given":"Daniel","family":"Talmasov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aubrey S.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick J.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank A.","family":"Provenzano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick J.","family":"Lao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen S.","family":"Marder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey M.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jagp.2025.04.207_bib0001","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1212\/WNL.0b013e31828726f5","article-title":"Alzheimer disease in the United States (2010\u20132050) estimated using the 2010 census","volume":"80","author":"Hebert","year":"2013","journal-title":"Neurology"},{"key":"10.1016\/j.jagp.2025.04.207_bib0002","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1002\/gps.5556","article-title":"Prevalence of depression, anxiety, and apathy symptoms across dementia stages: a systematic review and meta-analysis","volume":"36","author":"Leung","year":"2021","journal-title":"Int J Geriat Psychiatry"},{"key":"10.1016\/j.jagp.2025.04.207_bib0003","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1001\/jamaneurol.2023.2309","article-title":"Association of early-, middle-, and late-life depression with incident dementia in a Danish cohort","volume":"80","author":"Elser","year":"2023","journal-title":"JAMA Neurol"},{"key":"10.1016\/j.jagp.2025.04.207_bib0004","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1003016","article-title":"The association of depression with subsequent dementia diagnosis: a Swedish nationwide cohort study from 1964 to 2016","volume":"17","author":"Holmquist","year":"2020","journal-title":"PLoS Med"},{"key":"10.1016\/j.jagp.2025.04.207_bib0005","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1002\/gps.4406","article-title":"Depressive symptoms increase the risk of progression to dementia in subjects with mild cognitive impairment: systematic review and meta-analysis","volume":"31","author":"Mourao","year":"2016","journal-title":"Int J Geriat Psychiatry"},{"key":"10.1016\/j.jagp.2025.04.207_bib0006","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.3233\/JAD-180564","article-title":"Depression and Alzheimer\u2019s disease biomarkers predict driving decline","volume":"66","author":"Babulal","year":"2018","journal-title":"JAD"},{"key":"10.1016\/j.jagp.2025.04.207_bib0007","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1001\/jamapsychiatry.2016.3162","article-title":"Prevalence of depression in patients with mild cognitive impairment: a systematic review and meta-analysis","volume":"74","author":"Ismail","year":"2017","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.jagp.2025.04.207_bib0008","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1002\/gps.5530","article-title":"Affective symptoms and regional cerebral tau burden in early-stage Alzheimer\u2019s disease","volume":"36","author":"Tommasi","year":"2021","journal-title":"Int J Geriat Psychiatry"},{"key":"10.1016\/j.jagp.2025.04.207_bib0009","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.3233\/JAD-191078","article-title":"Depression is associated with tau and not amyloid positron emission tomography in cognitively normal adults","volume":"74","author":"Babulal","year":"2020","journal-title":"J Alzheimer Dis"},{"key":"10.1016\/j.jagp.2025.04.207_bib0010","doi-asserted-by":"crossref","first-page":"975","DOI":"10.3233\/JAD-170001","article-title":"Depressive symptoms and tau accumulation in the inferior temporal lobe and entorhinal cortex in cognitively normal older adults: a pilot study","volume":"59","author":"Gatchel","year":"2017","journal-title":"J Alzheimer Dis"},{"key":"10.1016\/j.jagp.2025.04.207_bib0011","doi-asserted-by":"crossref","first-page":"5856","DOI":"10.1038\/s41380-020-0766-9","article-title":"Excess tau PET ligand retention in elderly patients with major depressive disorder","volume":"26","author":"Moriguchi","year":"2021","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.jagp.2025.04.207_bib0012","doi-asserted-by":"crossref","first-page":"249","DOI":"10.3233\/JAD-210232","article-title":"Association of midlife depressive symptoms with regional amyloid-\u03b2 and tau in the Framingham Heart Study","volume":"82","author":"Gonzales","year":"2021","journal-title":"J Alzheimer Dis"},{"key":"10.1016\/j.jagp.2025.04.207_bib0013","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1097\/JGP.0b013e31816029ec","article-title":"Increased neurofibrillary tangles in patients with Alzheimer disease with comorbid depression","volume":"16","author":"Rapp","year":"2008","journal-title":"Am J Geriatric Psychiatr"},{"key":"10.1016\/j.jagp.2025.04.207_bib0014","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1001\/archpsyc.63.2.161","article-title":"Increased hippocampal plaques and tangles in patients with Alzheimer disease with a lifetime history of major depression arch","volume":"63","author":"Rapp","year":"2006","journal-title":"Gen Psychiatry"},{"key":"10.1016\/j.jagp.2025.04.207_bib0015","doi-asserted-by":"crossref","first-page":"3805","DOI":"10.1093\/brain\/awaa327","article-title":"The accumulation rate of tau aggregates is higher in females and younger amyloid-positive subjects","volume":"143","author":"Smith","year":"2020","journal-title":"Brain"},{"key":"10.1016\/j.jagp.2025.04.207_bib0016","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1001\/jamaneurol.2023.4038","article-title":"ApoE4 and connectivity-mediated spreading of tau pathology at lower amyloid levels","volume":"80","author":"Steward","year":"2023","journal-title":"JAMA Neurol"},{"key":"10.1016\/j.jagp.2025.04.207_bib0017","doi-asserted-by":"crossref","first-page":"3136","DOI":"10.1093\/brain\/awaa248","article-title":"Predicting future rates of tau accumulation on PET","volume":"143","author":"Jack","year":"2020","journal-title":"Brain"},{"key":"10.1016\/j.jagp.2025.04.207_bib0018","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1093\/brain\/awad397","article-title":"Sex-specific modulation of amyloid-\u03b2 on tau phosphorylation underlies faster tangle accumulation in females","volume":"147","author":"Wang","year":"2024","journal-title":"Brain"},{"key":"10.1016\/j.jagp.2025.04.207_bib0019","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1093\/brain\/awy059","article-title":"Longitudinal tau PET in ageing and Alzheimer\u2019s disease","volume":"141","author":"Jack","year":"2018","journal-title":"Brain"},{"key":"10.1016\/j.jagp.2025.04.207_bib0020","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0022-3956(82)90033-4","article-title":"Development and validation of a geriatric depression screening scale: a preliminary report","volume":"17","author":"Yesavage","year":"1982","journal-title":"J Psychiatric Res"},{"key":"10.1016\/j.jagp.2025.04.207_bib0021","doi-asserted-by":"crossref","first-page":"P124","DOI":"10.1093\/geronj\/44.4.P124","article-title":"A correlation between the Geriatric Depression Scale long and short forms","volume":"44","author":"Alden","year":"1989","journal-title":"J Gerontol"},{"key":"10.1016\/j.jagp.2025.04.207_bib0022","doi-asserted-by":"crossref","first-page":"2308","DOI":"10.1212\/WNL.44.12.2308","article-title":"The Neuropsychiatric Inventory: comprehensive assessment of psychopathology in dementia","volume":"44","author":"Cummings","year":"1994","journal-title":"Neurology"},{"key":"10.1016\/j.jagp.2025.04.207_bib0023","unstructured":"Alzheimer\u2019s Disease Neuroimaging Initiative: Study documents Available athttps:\/\/adni.loni.usc.edu\/methods\/documents\/. Accessed February 1, 2024."},{"key":"10.1016\/j.jagp.2025.04.207_bib0024","unstructured":"Landau S, Ward TJ, Murphy A, et al.: Flortaucipir (AV-1451) processing methods 2024. Available at https:\/\/adni.bitbucket.io\/reference\/docs\/UCBERKELEYAV1451\/UCBERKELEY_AV1451_Methods_2021-01-14.pdf. Accessed October 10, 2023."},{"key":"10.1016\/j.jagp.2025.04.207_bib0025","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.jalz.2016.08.005","article-title":"Defining imaging biomarker cut points for brain aging and Alzheimer\u2019s disease","volume":"13","author":"Jack","year":"2017","journal-title":"Alzheimer Dement"},{"key":"10.1016\/j.jagp.2025.04.207_bib0026","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.1007\/s00259-021-05401-4","article-title":"A multicenter comparison of [18F]flortaucipir, [18F]RO948, and [18F]MK6240 tau PET tracers to detect a common target ROI for differential diagnosis","volume":"48","author":"Leuzy","year":"2021","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"10.1016\/j.jagp.2025.04.207_bib0027","unstructured":"Landau S, Jagust W: Florbetapir processing methods 2015. Available athttps:\/\/adni.bitbucket.io\/reference\/docs\/UCBERKELEYAV45\/ADNI_AV45_Methods_JagustLab_06.25.15.pdf. Accessed October 15, 2024."},{"key":"10.1016\/j.jagp.2025.04.207_bib0028","unstructured":"Landau S, Murphy A, Ward T, et al.: Florbetaben (FBB) processing methods 2021. Available at https:\/\/adni.bitbucket.io\/reference\/docs\/UCBERKELEYFBB\/UCBerkeley_FBB_Methods_11.15.2021.pdf. Accessed February 25, 2024."},{"key":"10.1016\/j.jagp.2025.04.207_bib0029","unstructured":"Holleran S, Ramakrishnan R: cufunctions, a package to facilitate statistical analyses in R 2021. Available at: http:\/\/biomath.net\/cufunctions.html. Accessed February 25, 2024."},{"key":"10.1016\/j.jagp.2025.04.207_bib0030","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/BF02294361","article-title":"Model selection and Akaike\u2019s Information criterion (AIC): the general theory and its analytical extensions","volume":"52","author":"Bozdogan","year":"1987","journal-title":"Psychometrika"},{"key":"10.1016\/j.jagp.2025.04.207_bib0031","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1093\/geront\/44.6.818","article-title":"Confirmatory factor analysis of the Geriatric Depression Scale","volume":"44","author":"Adams","year":"2004","journal-title":"The Gerontologist"},{"key":"10.1016\/j.jagp.2025.04.207_bib0032","article-title":"Specific depression dimensions are associated with a faster rate of cognitive decline in older adults","volume":"14","author":"Soleimani","year":"2022","journal-title":"Alzheimer\u2019s & Dementia\u202f: Diagnosis, Assessment & Disease Monitoring"},{"key":"10.1016\/j.jagp.2025.04.207_bib0033","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2019.8964","article-title":"Longitudinal association of depression symptoms with cognition and cortical amyloid among community-dwelling older adults","volume":"2","author":"Gatchel","year":"2019","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.jagp.2025.04.207_bib0034","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1111\/jgs.12600","article-title":"Depressive symptoms precede memory decline, but not vice versa, in non-demented older adults","volume":"62","author":"Zahodne","year":"2014","journal-title":"J Am Geriatr Soc"},{"key":"10.1016\/j.jagp.2025.04.207_bib0035","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1001\/jamaneurol.2021.1858","article-title":"Accuracy of tau positron emission tomography as a prognostic marker in preclinical and prodromal Alzheimer disease: A head-to-head comparison against amyloid positron emission tomography and magnetic resonance imaging","volume":"78","author":"Ossenkoppele","year":"2021","journal-title":"JAMA Neurol"},{"key":"10.1016\/j.jagp.2025.04.207_bib0036","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1136\/jnnp-2021-328623","article-title":"Tau-PET imaging predicts cognitive decline and brain atrophy progression in early Alzheimer\u2019s disease","volume":"93","author":"Lagarde","year":"2022","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.jagp.2025.04.207_bib0037","doi-asserted-by":"crossref","first-page":"eaau5732","DOI":"10.1126\/scitranslmed.aau5732","article-title":"Prospective longitudinal atrophy in Alzheimer\u2019s disease correlates with the intensity and topography of baseline tau-PET","volume":"12","author":"La Joie","year":"2020","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.jagp.2025.04.207_bib0038","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1017\/S1041610209990184","article-title":"Efficacy of SSRIs on cognition of Alzheimer\u2019s disease patients treated with cholinesterase inhibitors","volume":"22","author":"Rozzini","year":"2010","journal-title":"Int Psychogeriatr"},{"key":"10.1016\/j.jagp.2025.04.207_bib0039","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1001\/jamapsychiatry.2021.4363","article-title":"Associations between neuropsychiatric symptoms and neuropathological diagnoses of Alzheimer Disease and related dementias","volume":"79","author":"Devanand","year":"2022","journal-title":"JAMA Psychiat"},{"key":"10.1016\/j.jagp.2025.04.207_bib0040","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1038\/s41398-020-0839-1","article-title":"Depression\u2014An underrecognized target for prevention of dementia in Alzheimer\u2019s disease","volume":"10","author":"Dafsari","year":"2020","journal-title":"Transl Psychiatry"},{"key":"10.1016\/j.jagp.2025.04.207_bib0041","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/s41398-024-02739-9","article-title":"Association of amyloid-beta with depression or depressive symptoms in older adults without dementia: a systematic review and meta-analysis","volume":"14","author":"Twait","year":"2024","journal-title":"Transl Psychiatry"},{"key":"10.1016\/j.jagp.2025.04.207_bib0042","doi-asserted-by":"crossref","first-page":"e2898","DOI":"10.1002\/brb3.2898","article-title":"Lower cognitive function attenuates the convergence between self-ratings and observer ratings of depressive symptoms in late-life cognitive impairment","volume":"13","author":"Kwak","year":"2023","journal-title":"Brain Behavior"},{"key":"10.1016\/j.jagp.2025.04.207_bib0043","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.jtho.2020.12.008","article-title":"Statistical considerations for subgroup analyses","volume":"16","author":"Wang","year":"2021","journal-title":"J Thoracic Oncol"},{"key":"10.1016\/j.jagp.2025.04.207_bib0044","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.jclinepi.2003.08.009","article-title":"Subgroup analyses in randomized trials: risks of subgroup-specific analyses","volume":"57","author":"Brookes","year":"2004","journal-title":"J Clin Epidemiol"}],"container-title":["The American Journal of Geriatric Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1064748125003173?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1064748125003173?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T17:16:20Z","timestamp":1762362980000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1064748125003173"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":44,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["S1064748125003173"],"URL":"https:\/\/doi.org\/10.1016\/j.jagp.2025.04.207","relation":{},"ISSN":["1064-7481"],"issn-type":[{"value":"1064-7481","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Depressive Symptoms Correlate With Tau Accumulation Rates in Amyloid Positive Adults","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Geriatric Psychiatry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jagp.2025.04.207","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 American Association for Geriatric Psychiatry. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}