{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T03:23:04Z","timestamp":1777605784113,"version":"3.51.4"},"reference-count":14,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100007543","name":"Agence Nationale de S\u00e9curit\u00e9 du M\u00e9dicament et des Produits de Sant\u00e9","doi-asserted-by":"publisher","award":["2011-001844-31"],"award-info":[{"award-number":["2011-001844-31"]}],"id":[{"id":"10.13039\/501100007543","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009242","name":"DGOS","doi-asserted-by":"publisher","award":["PHRC 10-VC\/ASAP"],"award-info":[{"award-number":["PHRC 10-VC\/ASAP"]}],"id":[{"id":"10.13039\/501100009242","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014630","name":"Minist\u00e8re des Solidarit\u00e9s et de la Sant\u00e9","doi-asserted-by":"publisher","award":["A81216-27"],"award-info":[{"award-number":["A81216-27"]}],"id":[{"id":"10.13039\/501100014630","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajgponline.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Geriatric Psychiatry"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.jagp.2025.04.214","type":"journal-article","created":{"date-parts":[[2025,5,3]],"date-time":"2025-05-03T11:55:22Z","timestamp":1746273322000},"page":"962-973","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Affective Symptoms and Amyloid Plaques: Antidepressant Response and Clinical Outcome Associated With Brain Amyloid Load in a 2-Year Cohort of Nondemented Older Adults With Depression\u2014The ASAP Study"],"prefix":"10.1016","volume":"33","author":[{"given":"Thomas","family":"Desmidt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria-Joao","family":"Santiago-Ribeiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel","family":"Robert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Blanc","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandrine Louchart","family":"de la Chapelle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renaud","family":"David","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Vandel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soumia","family":"Benbrika","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoire","family":"Leroy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florence","family":"Lejeune","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Andersson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurent","family":"Barantin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Val\u00e9rie","family":"Gissot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johnny","family":"Vercouillie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Arlicot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wissam","family":"El-Hage","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agn\u00e8s","family":"Caille","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"Camus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jagp.2025.04.214_bib0001","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.jagp.2015.12.003","article-title":"Amyloid hypothesis: is there a role for antiamyloid treatment in late-life depression?","volume":"24","author":"Mahgoub","year":"2016","journal-title":"Am J Geriatr Psychiatry"},{"key":"10.1016\/j.jagp.2025.04.214_bib0002","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1038\/s41398-023-02464-9","article-title":"Biological factors influencing depression in later life: role of aging processes and treatment implications","volume":"13","author":"Szymkowicz","year":"2023","journal-title":"Transl Psychiatry"},{"key":"10.1016\/j.jagp.2025.04.214_bib0003","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/j.biopsych.2020.06.017","article-title":"Late-life depression is associated with reduced cortical amyloid burden: findings from the Alzheimer\u2019s Disease Neuroimaging Initiative Depression Project","volume":"89","author":"Mackin","year":"2021","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.jagp.2025.04.214_bib0004","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1001\/jamapsychiatry.2024.4305","article-title":"Depressive symptoms and amyloid pathology","volume":"82","author":"Wiels","year":"2025","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.jagp.2025.04.214_bib0005","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.jagp.2020.09.019","article-title":"Preliminary evidence that cortical amyloid burden predicts poor response to antidepressant medication treatment in cognitively intact individuals with late-life depression","volume":"29","author":"Taylor","year":"2021","journal-title":"Am J Geriatr Psychiatry"},{"key":"10.1016\/j.jagp.2025.04.214_bib0006","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1017\/S003329172200397X","article-title":"Antidepressant medications in dementia: evidence and potential mechanisms of treatment-resistance","volume":"53","author":"Costello","year":"2023","journal-title":"Psychol Med"},{"key":"10.1016\/j.jagp.2025.04.214_bib0007","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1161\/01.CIR.97.18.1837","article-title":"Prediction of coronary heart disease using risk factor categories","volume":"97","author":"Wilson","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.jagp.2025.04.214_bib0008","doi-asserted-by":"crossref","first-page":"913","DOI":"10.2967\/jnumed.109.069088","article-title":"In vivo imaging of amyloid deposition in Alzheimer disease using the radioligand 18F-AV-45 (florbetapir [corrected] F 18","volume":"51","author":"Wong","year":"2010","journal-title":"J Nucl Med"},{"key":"10.1016\/j.jagp.2025.04.214_bib0009","first-page":"525","article-title":"The neurobiology of apathy in depression and neurocognitive impairment in older adults: a review of epidemiological, clinical, neuropsychological and biological research transl","volume":"12","author":"Steffens","year":"2022","journal-title":"Psychiatry"},{"key":"10.1016\/j.jagp.2025.04.214_bib0010","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s13550-017-0273-4","article-title":"Beta-amyloid deposition in patients with major depressive disorder with differing levels of treatment resistance: a pilot study","volume":"7","author":"Li","year":"2017","journal-title":"EJNMMI Res"},{"key":"10.1016\/j.jagp.2025.04.214_bib0011","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/s41398-021-01539-9","article-title":"Positron emission tomography imaging of serotonin degeneration and beta-amyloid deposition in late-life depression evaluated with multi-modal partial least squares","volume":"11","author":"Smith","year":"2021","journal-title":"Transl Psychiatry"},{"key":"10.1016\/j.jagp.2025.04.214_bib0012","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2021.108447","article-title":"Molecular imaging of the serotonin transporter availability and occupancy by antidepressant treatment in late-life depression","volume":"194","author":"Smith","year":"2021","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.jagp.2025.04.214_bib0013","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1038\/s41380-024-02710-6","article-title":"Predicting treatment outcomes in major depressive disorder using brain magnetic resonance imaging: a meta-analysis","volume":"30","author":"Long","year":"2024","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.jagp.2025.04.214_bib0014","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1186\/s12916-016-0720-5","article-title":"Vascular depression consensus report\u2014a critical update","volume":"14","author":"Aizenstein","year":"2016","journal-title":"BMC Med"}],"container-title":["The American Journal of Geriatric Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1064748125003331?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1064748125003331?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T11:27:09Z","timestamp":1774870029000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1064748125003331"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":14,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["S1064748125003331"],"URL":"https:\/\/doi.org\/10.1016\/j.jagp.2025.04.214","relation":{},"ISSN":["1064-7481"],"issn-type":[{"value":"1064-7481","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Affective Symptoms and Amyloid Plaques: Antidepressant Response and Clinical Outcome Associated With Brain Amyloid Load in a 2-Year Cohort of Nondemented Older Adults With Depression\u2014The ASAP Study","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Geriatric Psychiatry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jagp.2025.04.214","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 American Association for Geriatric Psychiatry. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}