{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:05:57Z","timestamp":1791497157676,"version":"4.3.4"},"reference-count":45,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004763","name":"Inner Mongolia Autonomous Region Natural Science Foundation","doi-asserted-by":"publisher","award":["2026SHZR0128"],"award-info":[{"award-number":["2026SHZR0128"]}],"id":[{"id":"10.13039\/501100004763","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2022ZD0211605"],"award-info":[{"award-number":["2022ZD0211605"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2021ZD0201805"],"award-info":[{"award-number":["2021ZD0201805"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["24JCYBJC00650"],"award-info":[{"award-number":["24JCYBJC00650"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["24ZXGZSY00060"],"award-info":[{"award-number":["24ZXGZSY00060"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017964","name":"Tianjin Municipal Health Commission","doi-asserted-by":"publisher","award":["TJYXZDXK-3-003C"],"award-info":[{"award-number":["TJYXZDXK-3-003C"]}],"id":[{"id":"10.13039\/100017964","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006606","name":"Natural Science Foundation of Tianjin Municipality","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006606","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019065","name":"Tianjin Municipal Science and Technology Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajgponline.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Geriatric Psychiatry"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.jagp.2026.01.017","type":"journal-article","created":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T23:23:29Z","timestamp":1769901809000},"page":"1247-1260","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Resting-State Cerebral Blood Flow and Its Disconnect From Functional Connectivity in Alzheimer's Disease Spectrum"],"prefix":"10.1016","volume":"34","author":[{"given":"Xiao","family":"Su","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baomin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caixia","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingzheng","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanxin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Che","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jagp.2026.01.017_bib0001","doi-asserted-by":"crossref","first-page":"5541","DOI":"10.2147\/IJN.S200490","article-title":"Alzheimer's disease: pathogenesis, diagnostics, and therapeutics","volume":"14","author":"Tiwari","year":"2019","journal-title":"Int J Nanomed"},{"key":"10.1016\/j.jagp.2026.01.017_bib0002","first-page":"e47","article-title":"Alzheimer\u2019s Association, 2014 Alzheimer\u2019s disease facts and figures","volume":"10","year":"2014","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.jagp.2026.01.017_bib0003","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.jalz.2011.03.008","article-title":"The diagnosis of mild cognitive impairment due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease","volume":"7","author":"Albert","year":"2011","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.jagp.2026.01.017_bib0004","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1093\/brain\/awv029","article-title":"Prevalence and prognosis of Alzheimer's disease at the mild cognitive impairment stage","volume":"138","author":"Vos","year":"2015","journal-title":"Brain"},{"key":"10.1016\/j.jagp.2026.01.017_bib0005","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s00401-006-0127-z","article-title":"Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry","volume":"112","author":"Braak","year":"2006","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.jagp.2026.01.017_bib0006","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1097\/NEN.0b013e318232a379","article-title":"Stages of the pathologic process in Alzheimer disease: age categories from 1 to 100 years","volume":"70","author":"Braak","year":"2011","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.1016\/j.jagp.2026.01.017_bib0007","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.1177\/0271678X19890830","article-title":"Neurovascular coupling preserved in a chronic mouse model of Alzheimer's disease: methodology is critical","volume":"40","author":"Sharp","year":"2020","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.jagp.2026.01.017_bib0008","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1007\/s11357-017-9980-z","article-title":"Demonstration of impaired neurovascular coupling responses in TG2576 mouse model of Alzheimer's disease using functional laser speckle contrast imaging","volume":"39","author":"Tarantini","year":"2017","journal-title":"Geroscience"},{"issue":"100","key":"10.1016\/j.jagp.2026.01.017_bib0009","first-page":"328","article-title":"Neurovascular coupling in the normal brain and in hypertension, stroke, and Alzheimer disease","volume":"2006","author":"Girouard","year":"1985","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.jagp.2026.01.017_bib0010","doi-asserted-by":"crossref","first-page":"4705","DOI":"10.1523\/JNEUROSCI.0169-12.2012","article-title":"Age-dependent rescue by simvastatin of Alzheimer's disease cerebrovascular and memory deficits","volume":"32","author":"Tong","year":"2012","journal-title":"J Neurosci"},{"key":"10.1016\/j.jagp.2026.01.017_bib0011","doi-asserted-by":"crossref","first-page":"8160","DOI":"10.1523\/JNEUROSCI.1140-20.2020","article-title":"tPA deficiency underlies neurovascular coupling dysfunction by amyloid-\u03b2","volume":"40","author":"Park","year":"2020","journal-title":"J Neurosci"},{"key":"10.1016\/j.jagp.2026.01.017_bib0012","doi-asserted-by":"crossref","first-page":"223","DOI":"10.3325\/cmj.2016.57.223","article-title":"New insights into coupling and uncoupling of cerebral blood flow and metabolism in the brain","volume":"57","author":"Venkat","year":"2016","journal-title":"Croat Med J"},{"key":"10.1016\/j.jagp.2026.01.017_bib0013","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1073\/pnas.1214900110","article-title":"Coupling of functional connectivity and regional cerebral blood flow reveals a physiological basis for network hubs of the human brain","volume":"110","author":"Liang","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jagp.2026.01.017_bib0014","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1002\/hbm.22241","article-title":"Overlapping and segregated resting-state functional connectivity in patients with major depressive disorder with and without childhood neglect","volume":"35","author":"Wang","year":"2014","journal-title":"Hum Brain Mapp"},{"key":"10.1016\/j.jagp.2026.01.017_bib0015","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1002\/hbm.22663","article-title":"The effects of antidepressant treatment on resting-state functional brain networks in patients with major depressive disorder","volume":"36","author":"Wang","year":"2015","journal-title":"Hum Brain Mapp"},{"key":"10.1016\/j.jagp.2026.01.017_bib0016","doi-asserted-by":"crossref","first-page":"9885","DOI":"10.1073\/pnas.1001414107","article-title":"Functional connectivity density mapping","volume":"107","author":"Tomasi","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jagp.2026.01.017_bib0017","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1093\/cercor\/bhq268","article-title":"Association between functional connectivity hubs and brain networks","volume":"21","author":"Tomasi","year":"2011","journal-title":"Cereb Cortex"},{"key":"10.1016\/j.jagp.2026.01.017_bib0018","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1159\/000492945","article-title":"The Precuneus: a witness for excessive a\u03b2 gathering in Alzheimer's Disease pathology","volume":"18","author":"Aghakhanyan","year":"2018","journal-title":"Neurodegener Dis"},{"key":"10.1016\/j.jagp.2026.01.017_bib0019","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/1750-1326-6-85","article-title":"Adult hippocampal neurogenesis and its role in Alzheimer's disease","volume":"6","author":"Mu","year":"2011","journal-title":"Mol Neurodegener"},{"key":"10.1016\/j.jagp.2026.01.017_bib0020","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1002\/ana.92","article-title":"Patterns of temporal lobe atrophy in semantic dementia and Alzheimer's disease","volume":"49","author":"Chan","year":"2001","journal-title":"Ann Neurol"},{"key":"10.1016\/j.jagp.2026.01.017_bib0021","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1093\/schbul\/sbx051","article-title":"Altered coupling between resting-state cerebral blood flow and functional connectivity in schizophrenia","volume":"43","author":"Zhu","year":"2017","journal-title":"Schizophr Bull"},{"key":"10.1016\/j.jagp.2026.01.017_bib0022","article-title":"Region-specific neurovascular decoupling associated with cognitive decline in Parkinson's disease","volume":"13","author":"Sa","year":"2021","journal-title":"Front Aging Neurosci"},{"key":"10.1016\/j.jagp.2026.01.017_bib0023","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.neuroscience.2022.12.001","article-title":"Sex difference in general cognition associated with coupling of whole-brain functional connectivity strength to cerebral blood flow changes during Alzheimer's disease progression","volume":"509","author":"Li","year":"2023","journal-title":"Neuroscience"},{"key":"10.1016\/j.jagp.2026.01.017_bib0024","doi-asserted-by":"crossref","first-page":"287","DOI":"10.3233\/JAD-230503","article-title":"Decoupling of regional cerebral blood flow and brain function along the Alzheimer's disease continuum","volume":"95","author":"Li","year":"2023","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.jagp.2026.01.017_bib0025","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1177\/070674371506001109","article-title":"Chronic pain, psychopathology, and DSM-5 somatic symptom disorder","volume":"60","author":"Klein","year":"2015","journal-title":"Can J Psychiatry"},{"key":"10.1016\/j.jagp.2026.01.017_bib0026","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/S1474-4422(14)70090-0","article-title":"Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria","volume":"13","author":"Dubois","year":"2014","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.jagp.2026.01.017_bib0027","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.1212\/WNL.43.11.2412-a","article-title":"The clinical dementia rating (CDR): current version and scoring rules","volume":"43","author":"Morris","year":"1993","journal-title":"Neurology"},{"key":"10.1016\/j.jagp.2026.01.017_bib0028","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","article-title":"\"Mini-mental state\". A practical method for grading the cognitive state of patients for the clinician","volume":"12","author":"Folstein","year":"1975","journal-title":"J Psychiatr Res"},{"key":"10.1016\/j.jagp.2026.01.017_bib0029","doi-asserted-by":"crossref","first-page":"e5900","DOI":"10.1002\/gps.5900","article-title":"A neuropsychological profile and its correlation with neuroimaging markers in patients with subcortical ischaemic vascular dementia","volume":"38","author":"Tian","year":"2023","journal-title":"Int J Geriatr Psychiatry"},{"key":"10.1016\/j.jagp.2026.01.017_bib0030","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/j.neuroimage.2008.09.036","article-title":"The impact of global signal regression on resting state correlations: are anti-correlated networks introduced?","volume":"44","author":"Murphy","year":"2009","journal-title":"Neuroimage"},{"key":"10.1016\/j.jagp.2026.01.017_bib0031","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.schres.2014.03.033","article-title":"Disrupted resting-state functional connectivity in minimally treated chronic schizophrenia","volume":"156","author":"Wang","year":"2014","journal-title":"Schizophr Res"},{"key":"10.1016\/j.jagp.2026.01.017_bib0032","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3389\/fncir.2019.00025","article-title":"Aberrant coupling between resting-state cerebral blood flow and functional connectivity in Wilson's disease","volume":"13","author":"Hu","year":"2019","journal-title":"Front Neural Circuits"},{"key":"10.1016\/j.jagp.2026.01.017_bib0033","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/nrn1387","article-title":"Neurovascular regulation in the normal brain and in Alzheimer's disease","volume":"5","author":"Iadecola","year":"2004","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.jagp.2026.01.017_bib0034","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1177\/0271678X231173175","article-title":"Calcium transients in nNOS neurons underlie distinct phases of the neurovascular response to barrel cortex activation in awake mice","volume":"43","author":"Ahn","year":"2023","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.jagp.2026.01.017_bib0035","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/j.bbadis.2015.10.023","article-title":"Attenuation of functional hyperemia to visual stimulation in mild Alzheimer's disease and its sensitivity to cholinesterase inhibition","volume":"1862","author":"Janik","year":"2016","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jagp.2026.01.017_bib0036","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.neuroimage.2011.06.070","article-title":"Impaired cerebral vasoreactivity to CO2 in Alzheimer's disease using BOLD fMRI","volume":"58","author":"Cantin","year":"2011","journal-title":"Neuroimage"},{"key":"10.1016\/j.jagp.2026.01.017_bib0037","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.neurobiolaging.2010.02.005","article-title":"Forebrain-dominant deficit in cerebrovascular reactivity in Alzheimer's disease","volume":"33","author":"Yezhuvath","year":"2012","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.jagp.2026.01.017_bib0038","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0006-8993(97)00122-4","article-title":"Decrease in parietal cerebral hemoglobin oxygenation during performance of a verbal fluency task in patients with Alzheimer's disease monitored by means of near-infrared spectroscopy (NIRS): correlation with simultaneous rCBF-PET measurements","volume":"755","author":"Hock","year":"1997","journal-title":"Brain Res"},{"key":"10.1016\/j.jagp.2026.01.017_bib0039","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1176\/ajp.155.6.785","article-title":"Increasing required neural response to expose abnormal brain function in mild versus moderate or severe Alzheimer's disease: PET study using parametric visual stimulation","volume":"155","author":"Mentis","year":"1998","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.jagp.2026.01.017_bib0040","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1212\/01.WNL.0000079052.01016.78","article-title":"Comparison of memory fMRI response among normal, MCI, and Alzheimer's patients","volume":"61","author":"Machulda","year":"2003","journal-title":"Neurology"},{"key":"10.1016\/j.jagp.2026.01.017_bib0041","first-page":"1869","article-title":"Functional MR imaging in Alzheimer's disease during memory encoding","volume":"21","author":"Rombouts","year":"2000","journal-title":"AJNR Am J Neuroradiol"},{"key":"10.1016\/j.jagp.2026.01.017_bib0042","doi-asserted-by":"crossref","first-page":"2909","DOI":"10.1007\/s11357-023-00841-2","article-title":"Amyloid beta accumulation in TgF344-AD rats is associated with reduced cerebral capillary endothelial Kir2.1 expression and neurovascular uncoupling","volume":"45","author":"Fang","year":"2023","journal-title":"Geroscience"},{"key":"10.1016\/j.jagp.2026.01.017_bib0043","doi-asserted-by":"crossref","first-page":"493","DOI":"10.2147\/CIA.S58879","article-title":"Pattern of cerebral hyperperfusion in Alzheimer's disease and amnestic mild cognitive impairment using voxel-based analysis of 3D arterial spin-labeling imaging: initial experience","volume":"9","author":"Ding","year":"2014","journal-title":"Clin Interv Aging"},{"key":"10.1016\/j.jagp.2026.01.017_bib0044","doi-asserted-by":"crossref","first-page":"5590","DOI":"10.1002\/alz.14072","article-title":"Neurovascular coupling, functional connectivity, and cerebrovascular endothelial extracellular vesicles as biomarkers of mild cognitive impairment","volume":"20","author":"Owens","year":"2024","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.jagp.2026.01.017_bib0045","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/S1053-8119(03)00287-8","article-title":"Semantic and episodic memory of music are subserved by distinct neural networks","volume":"20","author":"Platel","year":"2003","journal-title":"Neuroimage"}],"container-title":["The American Journal of Geriatric Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1064748126000382?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1064748126000382?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T19:40:31Z","timestamp":1787514031000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1064748126000382"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":45,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["S1064748126000382"],"URL":"https:\/\/doi.org\/10.1016\/j.jagp.2026.01.017","relation":{},"ISSN":["1064-7481"],"issn-type":[{"value":"1064-7481","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Resting-State Cerebral Blood Flow and Its Disconnect From Functional Connectivity in Alzheimer's Disease Spectrum","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Geriatric Psychiatry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jagp.2026.01.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 American Association for Geriatric Psychiatry. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}