{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T18:14:45Z","timestamp":1776104085863,"version":"3.50.1"},"reference-count":29,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,11,26]],"date-time":"2016-11-26T00:00:00Z","timestamp":1480118400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"SPP School of Pharmacy and Technology Management"},{"name":"SVKM's NMIMS"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ayurveda and Integrative Medicine"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1016\/j.jaim.2017.02.005","type":"journal-article","created":{"date-parts":[[2017,10,11]],"date-time":"2017-10-11T06:15:40Z","timestamp":1507702540000},"page":"27-37","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"title":["A nutraceutical combination of Cinnamomum cassia & Nigella sativa for Type 1 diabetes mellitus"],"prefix":"10.1016","volume":"9","author":[{"given":"Ginpreet","family":"Kaur","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mihir","family":"Invally","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed Kamil","family":"Khan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priyanka","family":"Jadhav","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaim.2017.02.005_bib1","first-page":"24","article-title":"Antioxidative potential of herbal hypoglycemic agents in diabetes: an overview","volume":"3","author":"Chandra","year":"2004","journal-title":"SFRR Indian Bull"},{"issue":"1","key":"10.1016\/j.jaim.2017.02.005_bib2","first-page":"27","article-title":"Potential antidiabetic, hypolipidaemic and antioxidant effects of Xanthosoma sagittifolium extract in alloxan induced diabetic rats","volume":"5","author":"Shajeela","year":"2013","journal-title":"Int J Pharm Sci"},{"issue":"10","key":"10.1016\/j.jaim.2017.02.005_bib3","first-page":"990","article-title":"Consensus guidelines for the management of insulin-dependent (type 1) diabetes, European IDDM Policy Group 1993.","volume":"10","year":"1993","journal-title":"Diabet Med."},{"issue":"5","key":"10.1016\/j.jaim.2017.02.005_bib4","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1177\/1932296816645121","article-title":"Registry of youth Onset diabetes in India (YDR): rationale, recruitment, and current status","volume":"10","author":"Praveen","year":"2016","journal-title":"J\u00a0Diabetes Sci Technol"},{"key":"10.1016\/j.jaim.2017.02.005_bib5","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0944-7113(11)80059-0","article-title":"Antidiabetic plants and their active constituents","volume":"2","author":"Marles","year":"1995","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jaim.2017.02.005_bib6","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1017\/S0007114598001718","article-title":"Traditional plant treatments for diabetes mellitus: pharmaceutical foods","volume":"80","author":"Day","year":"1998","journal-title":"Br J Nutr"},{"key":"10.1016\/j.jaim.2017.02.005_bib7","series-title":"Traditional medicine. WHO fact sheet No. 134","author":"World Health Organization","year":"2003"},{"issue":"2","key":"10.1016\/j.jaim.2017.02.005_bib8","doi-asserted-by":"crossref","first-page":"S291","DOI":"10.1016\/S2221-1691(11)60175-5","article-title":"Current status of Indian medicinal plants with antidiabetic potential: a review","volume":"1","author":"Patel","year":"2011","journal-title":"Asian Pac J Trop Biomed"},{"issue":"1","key":"10.1016\/j.jaim.2017.02.005_bib9","first-page":"980","article-title":"Immunomodulatory effect of Nigella sativa oil in the disease process of type 1 diabetic rats","volume":"4","author":"Afaf","year":"2014","journal-title":"Res J Pharm Biol Chem Sci"},{"issue":"2","key":"10.1016\/j.jaim.2017.02.005_bib10","first-page":"1","article-title":"Nigella sativa L: a review of therapeutic applications","volume":"4","author":"Ilaiyaraja","year":"2010","journal-title":"J\u00a0Herb Med Toxicol"},{"issue":"2","key":"10.1016\/j.jaim.2017.02.005_bib11","doi-asserted-by":"crossref","first-page":"73","DOI":"10.4103\/0974-8490.94719","article-title":"Effects of Cinnamomum zeylanicum (Ceylon cinnamon) on blood glucose and lipids in a diabetic and healthy rat model","volume":"4","author":"Ranasinghe","year":"2012","journal-title":"Pharmacogn Res"},{"issue":"5","key":"10.1016\/j.jaim.2017.02.005_bib12","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1111\/j.1472-8206.2004.00275.x","article-title":"Nigella sativa seed extracts enhances glucose-induced insulin release from rat-isolated Langerhans islets","volume":"18","author":"Rchid","year":"2004","journal-title":"Fundam Clin Pharmacol"},{"key":"10.1016\/j.jaim.2017.02.005_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0113486","article-title":"Nigella sativa improves glycemic control and ameliorates oxidative in patients with type 2 diabetes mellitus: placebo controlled participant blinded clinical trial","volume":"10","author":"Kaatabi","year":"2015","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.jaim.2017.02.005_bib14","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1177\/193229681000400324","article-title":"Cinnamon: potential role in the prevention of insulin resistance, metabolic syndrome, and type 2 diabetes","volume":"4","author":"Qin","year":"2012","journal-title":"J\u00a0Diabetes Sci Technol"},{"key":"10.1016\/j.jaim.2017.02.005_bib15","series-title":"Practical pharmacognosy","first-page":"149","author":"Khandelwal","year":"2006"},{"issue":"10","key":"10.1016\/j.jaim.2017.02.005_bib16","first-page":"1212","article-title":"Cinnamomum cassia: an implication of serotonin reuptake inhibition in animal models of depression","volume":"30","author":"Wahid","year":"2015","journal-title":"Nat Prod Res"},{"issue":"1","key":"10.1016\/j.jaim.2017.02.005_bib17","first-page":"67","article-title":"Nigella sativa seed decreases endothelial dysfunction in streptozotocin-induced diabetic rat aorta","volume":"6","author":"Abbasali","year":"2016","journal-title":"Phytomed"},{"key":"10.1016\/j.jaim.2017.02.005_bib18","first-page":"796","article-title":"\u03b1-glucosidase inhibitory activity of curcumin and its Comparison with combinatorial extract consisting of curcumin with piperine and quercetin","volume":"3","author":"Patel","year":"2011","journal-title":"Pharmacol online"},{"key":"10.1016\/j.jaim.2017.02.005_bib19","series-title":"OECD Guidelines for testing of chemicals","article-title":"Acute oral toxicity test method","author":"OECD","year":"2001"},{"key":"10.1016\/j.jaim.2017.02.005_bib20","first-page":"181","article-title":"Streptozotocin-induced type 1 diabetes in rodents as a model for studying mitochondrial mechanisms of diabetic \u03b2 cell glucotoxicity","volume":"8","author":"Wu","year":"2015","journal-title":"Diabetes Metab Syndr Obes"},{"key":"10.1016\/j.jaim.2017.02.005_bib21","doi-asserted-by":"crossref","first-page":"957283","DOI":"10.5402\/2012\/957283","article-title":"Amelioration of obesity, glucose intolerance, and oxidative stress in high-fat diet and low-dose streptozotocin-induced diabetic rats by combination consisting of \u201ccurcumin with piperine and quercetin\u201d","volume":"2012","author":"Kaur","year":"2012","journal-title":"ISRN Pharmacol"},{"key":"10.1016\/j.jaim.2017.02.005_bib22","doi-asserted-by":"crossref","first-page":"2492107","DOI":"10.1155\/2016\/2492107","article-title":"Nigella sativa relieves the altered insulin receptor signaling in streptozotocin-induced diabetic rats fed with a high-fat diet","volume":"2016","author":"Balbaa","year":"2016","journal-title":"Oxidative Med Cell Longev"},{"issue":"9","key":"10.1016\/j.jaim.2017.02.005_bib23","first-page":"1","article-title":"Cytological and Histochemical Studies in Rat Liver and Pancreas during progression of streptozotocin induced diabetes and possible protection of certain natural antioxidants","volume":"2","author":"Hanaa","year":"2012","journal-title":"J\u00a0Nutr Food Sci"},{"issue":"1\u20132","key":"10.1016\/j.jaim.2017.02.005_bib24","first-page":"96","article-title":"Antidiabetic activity of Nigella sativa seed extract in cultured pancreatic \u03b2-cells, skeletal muscle cells, and adipocytes","volume":"46","author":"Ali","year":"2008","journal-title":"Pharm Biol"},{"key":"10.1016\/j.jaim.2017.02.005_bib25","first-page":"39","article-title":"Mechanism of action of Anti-diabetic property of Cinnamic acid, a principal active ingredient from the bark of Cinnamomum cassia","volume":"9","author":"Tandon","year":"2013","journal-title":"Int J Ther App"},{"key":"10.1016\/j.jaim.2017.02.005_bib26","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1111\/j.1463-1326.2009.01094.x","article-title":"The potential of cinnamon to reduce blood glucose levels in patients with type-2 diabetes and insulin resistance","volume":"11","author":"Kirkham","year":"2009","journal-title":"Diabetes, Obes Metabolism"},{"issue":"8","key":"10.1016\/j.jaim.2017.02.005_bib27","first-page":"1","article-title":"20-HETE and EETs in diabetic nephropathy: a novel mechanistic pathway","volume":"8","author":"Stephanie","year":"2013","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.jaim.2017.02.005_bib28","doi-asserted-by":"crossref","first-page":"164","DOI":"10.2337\/diacare.28.1.164","article-title":"Diabetic nephropathy: diagnosis, prevention, and treatment","volume":"28","author":"Gross","year":"2005","journal-title":"Diabetes Care"},{"issue":"1","key":"10.1016\/j.jaim.2017.02.005_bib29","first-page":"82","article-title":"Protective effects of herbal antioxidants on diabetic kidney disease","volume":"19","author":"Nasri","year":"2014","journal-title":"J\u00a0Res Med Sci"}],"container-title":["Journal of Ayurveda and Integrative Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0975947616304454?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0975947616304454?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,8,27]],"date-time":"2018-08-27T03:53:25Z","timestamp":1535342005000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0975947616304454"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["S0975947616304454"],"URL":"https:\/\/doi.org\/10.1016\/j.jaim.2017.02.005","relation":{},"ISSN":["0975-9476"],"issn-type":[{"value":"0975-9476","type":"print"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A nutraceutical combination of Cinnamomum cassia & Nigella sativa for Type 1 diabetes mellitus","name":"articletitle","label":"Article Title"},{"value":"Journal of Ayurveda and Integrative Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaim.2017.02.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Transdisciplinary University, Bangalore and World Ayurveda Foundation. Publishing Services by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}