{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T18:28:34Z","timestamp":1786991314107,"version":"build-2736575974"},"reference-count":32,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,8,7]],"date-time":"2018-08-07T00:00:00Z","timestamp":1533600000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research (ICMR), New Delhi","doi-asserted-by":"publisher","award":["45\/9\/2007\/BMS\/TRM"],"award-info":[{"award-number":["45\/9\/2007\/BMS\/TRM"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board, Department of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Government of India","award":["SB\/YS\/LS-241\/2013"],"award-info":[{"award-number":["SB\/YS\/LS-241\/2013"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ayurveda and Integrative Medicine"],"published-print":{"date-parts":[[2020,7]]},"DOI":"10.1016\/j.jaim.2018.05.009","type":"journal-article","created":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T09:34:09Z","timestamp":1540287249000},"page":"281-286","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Bioassay guided fractionation of Cyclea peltata using in\u00a0vitro RAW 264.7\u00a0cell culture, antioxidant assays and isolation of bioactive compound tetrandrine"],"prefix":"10.1016","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9507-021X","authenticated-orcid":false,"given":"V.J.","family":"Shine","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.I.","family":"Anuja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.R.","family":"Suja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gopan","family":"Raj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.G.","family":"Latha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaim.2018.05.009_bib1","first-page":"1","article-title":"Use of Menispermaceae family plants in folk medicine of Bangladesh","volume":"4","author":"Jahan","year":"2010","journal-title":"Adv Nat Appl Sci"},{"key":"10.1016\/j.jaim.2018.05.009_bib2","series-title":"The legacy of Charaka","first-page":"365","author":"Valiathan","year":"2003"},{"key":"10.1016\/j.jaim.2018.05.009_bib3","first-page":"65","article-title":"Ethnobotanical studies in Cannanore district, Kerala state (India)","volume":"2","author":"Ramachandran","year":"1981","journal-title":"J\u00a0Econ Taxon"},{"key":"10.1016\/j.jaim.2018.05.009_bib4","first-page":"161","article-title":"Ethnobotanical notes on certain medicinal plants among some Garo people around Balphakram Sanctuary in Meghalaya","volume":"22","author":"Kumar","year":"1980","journal-title":"Bull Bot Sur Ind"},{"key":"10.1016\/j.jaim.2018.05.009_bib5","first-page":"277","volume":"Second volume","author":"Varier","year":"2007"},{"key":"10.1016\/j.jaim.2018.05.009_bib6","first-page":"210","article-title":"Chromatographic study on the glycosides of Aerva lanata L","volume":"9","author":"Yamunadevi","year":"2011","journal-title":"Chin J Nat Med"},{"key":"10.1016\/j.jaim.2018.05.009_bib7","first-page":"237","article-title":"Cyclea peltata (Menispermaceae)","volume":"vol. 2","author":"Rastogi","year":"1999"},{"key":"10.1016\/j.jaim.2018.05.009_bib8","first-page":"63","article-title":"Medicinal and aromatic plants of India","volume":"vol. XII","author":"Reddi","year":"2005"},{"key":"10.1016\/j.jaim.2018.05.009_bib9","first-page":"319","volume":"vol. 2","author":"Anonymous","year":"2004"},{"key":"10.1016\/j.jaim.2018.05.009_bib10","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1211\/0022357023330","article-title":"The plasma glucose lowering action of tetrandrine in strptozotocin-induced diabetic rats","volume":"56","author":"Chen","year":"2004","journal-title":"J\u00a0Pharm Pharmacol"},{"key":"10.1016\/j.jaim.2018.05.009_bib11","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/0192-0561(89)90086-6","article-title":"Anti-inflammatory and immuno-suppressive properties of the bis-benzylisoquinolines: in\u00a0vitro comparisons of tetrandrine and berbamine","volume":"11","author":"Li","year":"1989","journal-title":"Int J Immunopharm"},{"key":"10.1016\/j.jaim.2018.05.009_bib12","first-page":"1086","article-title":"Cardiovascular pharmacological effects of bisbenzylisoquinoline alkaloid derivatives","volume":"23","author":"Qian","year":"2002","journal-title":"Acta Pharmacol Sin"},{"key":"10.1016\/j.jaim.2018.05.009_bib13","first-page":"1107","article-title":"Pharmacological actions of tetrandrine in inflammatory pulmonary diseases","volume":"23","author":"Xie","year":"2002","journal-title":"Acta Pharmacol Sin"},{"key":"10.1016\/j.jaim.2018.05.009_bib14","doi-asserted-by":"crossref","first-page":"39","DOI":"10.4103\/0250-474X.62235","article-title":"Comparetive phytochemical investigation of the source of Ayurvedic drug patha: a chromatographic fingerprinting analysis","author":"Hullatti","year":"2010","journal-title":"Ind J Pharmacu Sci"},{"key":"10.1016\/j.jaim.2018.05.009_bib15","series-title":"Phytochemical methods. A guide to modern technique of plant analysis","first-page":"9","author":"Harborne","year":"1984"},{"issue":"2","key":"10.1016\/j.jaim.2018.05.009_bib16","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.jep.2009.04.039","article-title":"Gastric antisecretory and antiulcer activities of C.\u00a0peltata (Lam.) Hook. f. & Thoms. in rats","volume":"125","author":"Shine","year":"2009","journal-title":"J\u00a0Ethnopharmacol"},{"key":"10.1016\/j.jaim.2018.05.009_bib17","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for lipid peroxidation in animal tissueby thiobarbituric acid reaction","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Anal Biochem"},{"key":"10.1016\/j.jaim.2018.05.009_bib18","doi-asserted-by":"crossref","first-page":"6049","DOI":"10.1016\/S0021-9258(18)63504-5","article-title":"Superoxide dismutase. An enzymatic function for erythrocuprein (hemocuprein)","volume":"25","author":"McCord","year":"1969","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jaim.2018.05.009_bib19","first-page":"169","article-title":"Free radical scavenging activity of curcuminoids","volume":"46","author":"Sreejayan","year":"1996","journal-title":"Drug Res"},{"key":"10.1016\/j.jaim.2018.05.009_bib20","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.jep.2004.01.019","article-title":"Evaluation of hepatoprotective effects of Helminthostachys zeylanica (L.) Hook against carbon tetrachloride-induced liver damage in Wistar rats","volume":"92","author":"Suja","year":"2004","journal-title":"J\u00a0Ethnopharmacol"},{"key":"10.1016\/j.jaim.2018.05.009_bib21","doi-asserted-by":"crossref","first-page":"23","DOI":"10.3746\/pnf.2013.18.1.023","article-title":"Anti-inflammatory effect of oyster shell extract in LPS-stimulated Raw 264.7 cells","volume":"18","author":"Lee","year":"2013","journal-title":"Prev Nutr food Sci"},{"key":"10.1016\/j.jaim.2018.05.009_bib22","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/978-1-59745-364-6_11","article-title":"In\u00a0vitro assays for cyclooxygenase activity and inhibitor characterization","volume":"644","author":"Walker","year":"2010","journal-title":"Meth Mol Biol"},{"key":"10.1016\/j.jaim.2018.05.009_bib23","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/0076-6879(81)71055-3","article-title":"Lipoxygenase from soya bean","volume":"71","author":"Axelrod","year":"1981","journal-title":"Meth Enzymol"},{"issue":"3","key":"10.1016\/j.jaim.2018.05.009_bib24","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/1523-1747.ep12506462","article-title":"Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker","volume":"78","author":"Bradley","year":"1982","journal-title":"J\u00a0Invest Dermatol"},{"issue":"8","key":"10.1016\/j.jaim.2018.05.009_bib25","first-page":"1970","article-title":"Antiproliferative activity of gamma-interferon combined with lipopolysaccharide on murine adenocarcinoma: dependence on an L-arginine metabolism with production of nitrite and citrulline","volume":"49","author":"Lepoivre","year":"1989","journal-title":"Cancer Res"},{"issue":"2","key":"10.1016\/j.jaim.2018.05.009_bib26","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S2221-1691(14)60223-9","article-title":"Ameliorative effect of alkaloid extract of Cyclea peltata (Poir.) Hook. f. & Thoms. roots (ACP) on APAP\/CCl4 induced liver toxicity in Wistar rats and in\u00a0vitro free radical scavenging property","volume":"4","author":"Shine","year":"2014","journal-title":"Asian Pac J Trop Biomed"},{"key":"10.1016\/j.jaim.2018.05.009_bib27","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/nature05485","article-title":"Inflammation and metabolic disorders","volume":"444","author":"Hotamisligil","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.jaim.2018.05.009_bib28","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.intimp.2017.05.021","article-title":"Xanthotoxin suppresses LPS-induced expression of iNOS, COX-2, TNF-\u03b1, and IL-6 via AP-1, NF-\u03baB, and JAK-STAT inactivation in RAW 264.7 macrophages","volume":"49","author":"Lee","year":"2017","journal-title":"Int Immunopharm"},{"issue":"2","key":"10.1016\/j.jaim.2018.05.009_bib29","first-page":"141","article-title":"Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa: a review of preclinical and clinical research, alternative medicine review","volume":"14","author":"Jurenka","year":"2009","journal-title":"J\u00a0of Clinic Therapeu"},{"issue":"2","key":"10.1016\/j.jaim.2018.05.009_bib30","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.intimp.2014.04.004","article-title":"Geniposide suppresses LPS-induced nitric oxide, PGE2 and inflammatory cytokine by downregulating NF-kappaB, MAPK and AP-1 signaling pathways in macrophages","volume":"20","author":"Shi","year":"2014","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.jaim.2018.05.009_bib31","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1001\/jama.296.13.jed60058","article-title":"COX-2 inhibitors, other NSAIDs, and Cardiovascular risk: the seduction of Common sense","volume":"296","author":"Graham","year":"2006","journal-title":"JAMA"},{"issue":"4","key":"10.1016\/j.jaim.2018.05.009_bib32","first-page":"1","article-title":"Anti-inflammatory drugs, kidney function, and exercise","volume":"11","author":"Farquhar","year":"1997","journal-title":"Sports Science Exchange"}],"container-title":["Journal of Ayurveda and Integrative Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0975947617306113?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0975947617306113?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T06:13:31Z","timestamp":1760854411000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0975947617306113"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["S0975947617306113"],"URL":"https:\/\/doi.org\/10.1016\/j.jaim.2018.05.009","relation":{},"ISSN":["0975-9476"],"issn-type":[{"value":"0975-9476","type":"print"}],"subject":[],"published":{"date-parts":[[2020,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bioassay guided fractionation of Cyclea peltata using in\u00a0vitro RAW 264.7\u00a0cell culture, antioxidant assays and isolation of bioactive compound tetrandrine","name":"articletitle","label":"Article Title"},{"value":"Journal of Ayurveda and Integrative Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaim.2018.05.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Transdisciplinary University, Bangalore and World Ayurveda Foundation. Publishing Services by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}