{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:17:48Z","timestamp":1790957868388,"version":"4.1.0"},"reference-count":72,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T00:00:00Z","timestamp":1712102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008248","name":"Department of Zoology, University of Otago","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008248","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002742","name":"Banaras Hindu University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002742","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018762","name":"CSIR-Structural Engineering Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018762","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100024215","name":"ICMR- National Institute of Virology","doi-asserted-by":"publisher","award":["5\/10\/FR\/29\/2019-RBMCH"],"award-info":[{"award-number":["5\/10\/FR\/29\/2019-RBMCH"]}],"id":[{"id":"10.13039\/501100024215","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006330","name":"Casappa","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006330","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015655","name":"Bose Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015655","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021073","name":"Indian Institute Of Petroleum, Council of Scientific and Industrial Research, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021073","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019967","name":"JRF Ortho","doi-asserted-by":"publisher","award":["09\/013(0899)\/2019-EMR-I"],"award-info":[{"award-number":["09\/013(0899)\/2019-EMR-I"]}],"id":[{"id":"10.13039\/100019967","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ayurveda and Integrative Medicine"],"published-print":{"date-parts":[[2024,7]]},"DOI":"10.1016\/j.jaim.2024.100930","type":"journal-article","created":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T03:22:05Z","timestamp":1723087325000},"page":"100930","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Shilajit mitigates chemotherapeutic drug-induced testicular toxicity: Study on testicular germ cell dynamics, steroidogenesis modulation, and Nrf-2\/Keap-1 signaling"],"prefix":"10.1016","volume":"15","author":[{"given":"Arti","family":"Rajpoot","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiran","family":"Yadav","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anupam","family":"Yadav","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9346-5074","authenticated-orcid":false,"given":"Raghav Kumar","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaim.2024.100930_bib1","series-title":"Developing sexual health programmes A framework for action","year":"2010"},{"key":"10.1016\/j.jaim.2024.100930_bib2","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0140-6736(20)32667-2","article-title":"Male infertility","volume":"397","author":"Agarwal","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.jaim.2024.100930_bib3","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.rbmo.2017.11.007","article-title":"Role of Withania somnifera (Ashwagandha) in the management of male infertility","volume":"36","author":"Sengupta","year":"2018","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.jaim.2024.100930_bib4","doi-asserted-by":"crossref","first-page":"150","DOI":"10.3109\/19396368.2015.1008071","article-title":"Oxidative status in testis and epididymal sperm parameters after acute and chronic stress by cold-water immersion in the adult rat","volume":"61","author":"Garc\u00eda-D\u00edaz","year":"2015","journal-title":"Syst Biol Reprod Med"},{"key":"10.1016\/j.jaim.2024.100930_bib5","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1016\/j.biopha.2016.10.097","article-title":"Paeoniflorin ameliorates renal function in cyclophosphamide-induced mice via AMPK suppressed inflammation and apoptosis","volume":"84","author":"Liu","year":"2016","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.jaim.2024.100930_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40425-018-0349-3","article-title":"Current landscape and future of dual anti-CTLA4 and PD-1\/PD-L1 blockade immunotherapy in cancer; lessons learned from clinical trials with melanoma and non-small cell lung cancer (NSCLC)","volume":"6","author":"Chae","year":"2018","journal-title":"J Immunother Cancer"},{"key":"10.1016\/j.jaim.2024.100930_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2020.152439","article-title":"LCZ696 (sacubitril\/valsartan) protects against cyclophosphamide-induced testicular toxicity in rats: role of neprilysin inhibition and lncRNA TUG1 in ameliorating apoptosis","volume":"437","author":"Salama","year":"2020","journal-title":"Toxicology"},{"key":"10.1016\/j.jaim.2024.100930_bib8","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/5758191","article-title":"Tribulus terrestris protects against male reproductive damage induced by cyclophosphamide in mice","volume":"2018","author":"Pavin","year":"2018","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.jaim.2024.100930_bib9","doi-asserted-by":"crossref","DOI":"10.1186\/s12906-022-03615-z","article-title":"Qiangjing tablets repair of blood-testis barrier dysfunction in rats via regulating oxidative stress and p38 MAPK pathway","volume":"22","author":"Li","year":"2022","journal-title":"BMC Complement Med Ther"},{"key":"10.1016\/j.jaim.2024.100930_bib10","doi-asserted-by":"crossref","DOI":"10.1111\/and.14071","article-title":"Cyclophosphamide suppresses spermatogenesis in the testis of mice through downregulation of miR-34b and miR-34c","volume":"53","author":"\u00d6zbilgin","year":"2021","journal-title":"Andrologia"},{"key":"10.1016\/j.jaim.2024.100930_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.112922","article-title":"Ethanolic extract of Moringa oleifera leaves alleviate cyclophosphamide-induced testicular toxicity by improving endocrine function and modulating cell specific gene expression in mouse testis","volume":"259","author":"Nayak","year":"2020","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.jaim.2024.100930_bib12","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1002\/pon.4990","article-title":"Infertility-related distress following cancer for women and men: a mixed method study","volume":"28","author":"Ussher","year":"2019","journal-title":"Psycho Oncol"},{"key":"10.1016\/j.jaim.2024.100930_bib13","doi-asserted-by":"crossref","DOI":"10.3390\/nu13082616","article-title":"Phycobiliproteins ameliorate gonadal toxicity in male mice treated with cyclophosphamide","volume":"13","author":"Brise\u00f1o-Bugar\u00edn","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.jaim.2024.100930_bib14","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1111\/and.12459","article-title":"Gallic acid protects against cyclophosphamide-induced toxicity in testis and epididymis of rats","volume":"48","author":"Oyagbemi","year":"2016","journal-title":"Andrologia"},{"key":"10.1016\/j.jaim.2024.100930_bib15","article-title":"Potential protective effects of antioxidants against cyclophosphamide-induced nephrotoxicity","volume":"2022","author":"Ayza","year":"2022","journal-title":"Internet J Nephrol"},{"key":"10.1016\/j.jaim.2024.100930_bib16","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1089\/jmf.2016.0010","article-title":"The human skeletal muscle transcriptome in response to oral shilajit supplementation","volume":"19","author":"Das","year":"2016","journal-title":"J Med Food"},{"key":"10.1016\/j.jaim.2024.100930_bib17","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1111\/and.12482","article-title":"Clinical evaluation of purified Shilajit on testosterone levels in healthy volunteers","volume":"48","author":"Pandit","year":"2016","journal-title":"Andrologia"},{"key":"10.1016\/j.jaim.2024.100930_bib18","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1002\/ptr.5018","article-title":"Safety and efficacy of shilajit (Mumie, Moomiyo)","volume":"28","author":"Stohs","year":"2014","journal-title":"Phytother Res"},{"key":"10.1016\/j.jaim.2024.100930_bib19","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1002\/ptr.2650090110","article-title":"Shilajit attenuates streptozotocin induced diabetes mellitus and decrease in pancreatic islet superoxide dismutase activity in rats","volume":"9","author":"Bhattacharya","year":"1995","journal-title":"Phytother Res"},{"key":"10.1016\/j.jaim.2024.100930_bib20","doi-asserted-by":"crossref","DOI":"10.1186\/s12970-019-0270-2","article-title":"The effects of Shilajit supplementation on fatigue-induced decreases in muscular strength and serum hydroxyproline levels","volume":"16","author":"Keller","year":"2019","journal-title":"J Int Soc Sports Nutr"},{"key":"10.1016\/j.jaim.2024.100930_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jep.2011.04.033","article-title":"Review on shilajit used in traditional Indian medicine","volume":"136","author":"Wilson","year":"2011","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.jaim.2024.100930_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtemb.2020.126574","article-title":"Cyclophosphamide induced oxidative stress, lipid per oxidation, apoptosis and histopathological changes in rats: protective role of boron","volume":"62","author":"Cengiz","year":"2020","journal-title":"J Trace Elem Med Biol"},{"key":"10.1016\/j.jaim.2024.100930_bib23","first-page":"1","article-title":"Mineral pitch induces apoptosis and inhibits proliferation via modulating reactive oxygen species in hepatic cancer cells","volume":"16","author":"Pant","year":"2016","journal-title":"BMC Compl Alternative Med"},{"key":"10.1016\/j.jaim.2024.100930_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.sjbs.2022.103393","article-title":"Shilajit potentiates the effect of chemotherapeutic drugs and mitigates metastasis induced liver and kidney damages in osteosarcoma rats","volume":"29","author":"Jambi","year":"2022","journal-title":"Saudi J Biol Sci"},{"key":"10.1016\/j.jaim.2024.100930_bib25","first-page":"93","article-title":"Male infertility: lifestyle and oriental remedies","volume":"56","author":"Mishra","year":"2012","journal-title":"Journal of Scientific Research"},{"key":"10.1016\/j.jaim.2024.100930_bib26","doi-asserted-by":"crossref","DOI":"10.1111\/and.13064","article-title":"Profertility effects of Shilajit on cadmium-induced infertility in male mice","volume":"50","author":"Mishra","year":"2018","journal-title":"Andrologia"},{"key":"10.1016\/j.jaim.2024.100930_bib27","first-page":"1","article-title":"Cardioprotective effect of Croton macrostachyus stem bark extract and solvent fractions on cyclophosphamide-induced cardiotoxicity in rats","volume":"2020","author":"Ayza","year":"2020","journal-title":"Evid base Compl Alternative Med"},{"key":"10.1016\/j.jaim.2024.100930_bib28","doi-asserted-by":"crossref","DOI":"10.1111\/and.13535","article-title":"Ameliorative effect of nerolidol on cyclophosphamide-induced gonadal toxicity in Swiss Albino mice: biochemical-, histological- and immunohistochemical-based evidences","volume":"52","author":"Iqubal","year":"2020","journal-title":"Andrologia"},{"key":"10.1016\/j.jaim.2024.100930_bib29","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.cca.2005.07.032","article-title":"Effect of squalene on cyclophosphamide-induced toxicity","volume":"364","author":"Senthilkumar","year":"2006","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.jaim.2024.100930_bib30","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.reprotox.2007.05.007","article-title":"Yukmijihwang-tang protects against cyclophosphamide-induced reproductive toxicity","volume":"24","author":"Oh","year":"2007","journal-title":"Reprod Toxicol"},{"key":"10.1016\/j.jaim.2024.100930_bib31","doi-asserted-by":"crossref","first-page":"599","DOI":"10.3390\/antiox8120599","article-title":"Effects of lespedeza bicolor extract on regulation of AMPK associated hepatic lipid metabolism in type 2 diabetic mice","volume":"8","author":"Kim","year":"2019","journal-title":"Antioxidants"},{"key":"10.1016\/j.jaim.2024.100930_bib32","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.etap.2014.12.014","article-title":"Zn(II)-curcumin protects against oxidative stress, deleterious changes in sperm parameters and histological alterations in a male mouse model of cyclophosphamide-induced reproductive damage","volume":"39","author":"Lu","year":"2015","journal-title":"Environ Toxicol Pharmacol"},{"key":"10.1016\/j.jaim.2024.100930_bib33","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.contraception.2009.01.001","article-title":"Reversible antifertility effect of aqueous rhizome extract of Curcuma longa L. in male laboratory mice","volume":"79","author":"Mishra","year":"2009","journal-title":"Contraception"},{"key":"10.1016\/j.jaim.2024.100930_bib34","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.bbrc.2017.10.089","article-title":"Standardized extract of Bacopa monnieri (CDRI-08): effect on germ cell dynamics and possible mechanisms of its beneficial action on spermatogenesis and sperm quality in male mice","volume":"494","author":"Patel","year":"2017","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jaim.2024.100930_bib35","series-title":"WHO laboratory manual for the examination and processing of human semen","year":"2010"},{"issue":"11","key":"10.1016\/j.jaim.2024.100930_bib36","doi-asserted-by":"crossref","first-page":"4425","DOI":"10.1073\/pnas.72.11.4425","article-title":"Chemical induction of sperm abnormalities in mice","volume":"72","author":"Wyrobek","year":"1975","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"10.1016\/j.jaim.2024.100930_bib37","first-page":"147","article-title":"Collection and physical examination of the ejaculate","volume":"1","author":"Zaneveld","year":"1977","journal-title":"Techniques of Human Andrology"},{"key":"10.1016\/j.jaim.2024.100930_bib38","doi-asserted-by":"crossref","first-page":"3333","DOI":"10.1016\/j.fct.2008.08.006","article-title":"Safety assessment of Syzygium aromaticum flower bud (clove) extract with respect to testicular function in mice","volume":"46","author":"Mishra","year":"2008","journal-title":"Food Chem Toxicol"},{"key":"10.1016\/j.jaim.2024.100930_bib39","first-page":"106","article-title":"Spermatogonial stem cells: assessing their survival and ability to produce differentiated cells","volume":"3","author":"Meistrich","year":"1993","journal-title":"Methods in Reproductive Toxicology"},{"key":"10.1016\/j.jaim.2024.100930_bib40","series-title":"Histological and histopathological evaluation of the testis","author":"Russell","year":"1990"},{"key":"10.1016\/j.jaim.2024.100930_bib41","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1002\/ar.22641","article-title":"Quantitative analysis of histological staining and fluorescence using ImageJ","volume":"296","author":"Jensen","year":"2013","journal-title":"Anat Rec"},{"key":"10.1016\/j.jaim.2024.100930_bib42","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Anal Biochem"},{"key":"10.1016\/j.jaim.2024.100930_bib43","first-page":"201","article-title":"A modified spectrophotometric assay of superoxide dismutase using nitrite formation by superoxide radicals","volume":"37","author":"Das","year":"2000","journal-title":"Indian J Biochem Biophys"},{"key":"10.1016\/j.jaim.2024.100930_bib44","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jaim.2024.100930_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.peptides.2022.170899","article-title":"Postnatal ontogeny of Neuromedin S and its receptors NMUR1 and NMUR2 expression in mouse testis","volume":"159","author":"Yadav","year":"2023","journal-title":"Peptides"},{"key":"10.1016\/j.jaim.2024.100930_bib46","doi-asserted-by":"crossref","DOI":"10.1111\/and.14196","article-title":"Protective effects of sinapic acid against cyclophosphamide-induced testicular toxicity via inhibiting oxidative stress, caspase-3 and NF-kB activity in BALB\/c mice","volume":"53","author":"Rezaei","year":"2021","journal-title":"Andrologia"},{"key":"10.1016\/j.jaim.2024.100930_bib47","first-page":"1","article-title":"ORIGINAL REPORT Crataegus monogyna aqueous extract ameliorates cyclophosphamide-induced toxicity in rat testis: stereological evidences","volume":"50","author":"Jalali","year":"2012","journal-title":"Acta Med Iran"},{"key":"10.1016\/j.jaim.2024.100930_bib48","doi-asserted-by":"crossref","first-page":"403","DOI":"10.29252\/ijrm.15.7.403","article-title":"Combined protective effect of zinc oxide nanoparticles and melatonin on cyclophosphamide-induced toxicity in testicular histology and sperm parameters in adult Wistar rats","volume":"15","author":"Torabi","year":"2017","journal-title":"Int J Reprod BioMed"},{"key":"10.1016\/j.jaim.2024.100930_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnim.2020.100109","article-title":"Antioxidant potential of garlic oil supplementation prevents cyclophosphamide-induced oxidative testicular damage and endocrine depletion in rats","volume":"18","author":"Ekeleme-Egedigwe","year":"2019","journal-title":"J Nutr Intermed Metab"},{"key":"10.1016\/j.jaim.2024.100930_bib50","doi-asserted-by":"crossref","first-page":"207","DOI":"10.4103\/0971-6580.97224","article-title":"Rutin ameliorates cyclophosphamide-induced reproductive toxicity in male rats","volume":"19","author":"Abarikwu","year":"2012","journal-title":"Toxicol Int"},{"key":"10.1016\/j.jaim.2024.100930_bib51","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.biopha.2018.02.068","article-title":"Crocin attenuates cyclophosphamide induced testicular toxicity by preserving glutathione redox system","volume":"101","author":"Potnuri","year":"2018","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.jaim.2024.100930_bib52","series-title":"Clinical evaluation of spermatogenic activity of processed Shilajit in oligospermia","first-page":"48","author":"Biswas","year":"2010"},{"key":"10.1016\/j.jaim.2024.100930_bib53","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1530\/REP-08-0247","article-title":"Intra-testicular injection of adenoviral constructs results in Sertoli cell-specific gene expression and disruption of the seminiferous epithelium","volume":"137","author":"Hooley","year":"2009","journal-title":"Reproduction"},{"key":"10.1016\/j.jaim.2024.100930_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2019.110053","article-title":"Automobile exhaust-derived PM2.5 induces blood-testis barrier damage through ROS-MAPK-Nrf2 pathway in sertoli cells of rats","volume":"189","author":"Liu","year":"2020","journal-title":"Ecotoxicol Environ Saf"},{"key":"10.1016\/j.jaim.2024.100930_bib55","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.semcdb.2021.06.016","article-title":"Sertoli cells as key drivers of testis function","volume":"121","author":"O\u2019Donnell","year":"2022","journal-title":"Semin Cell Dev Biol"},{"key":"10.1016\/j.jaim.2024.100930_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2019.110053","article-title":"Automobile exhaust-derived PM2.5 induces blood-testis barrier damage through ROS-MAPK-Nrf2 pathway in sertoli cells of rats","volume":"189","author":"Liu","year":"2020","journal-title":"Ecotoxicol Environ Saf"},{"key":"10.1016\/j.jaim.2024.100930_bib57","doi-asserted-by":"crossref","DOI":"10.1111\/and.14575","article-title":"Sub-chronic restraint stress exposure in adult rats: an insight into possible inhibitory mechanism on testicular function in relation to germ cell dynamics","volume":"54","author":"Yadav","year":"2022","journal-title":"Andrologia"},{"key":"10.1016\/j.jaim.2024.100930_bib58","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.ecoenv.2018.12.034","article-title":"Prepubertal exposure to perfluorononanoic acid interferes with spermatogenesis and steroidogenesis in male mice","volume":"170","author":"Singh","year":"2019","journal-title":"Ecotoxicol Environ Saf"},{"key":"10.1016\/j.jaim.2024.100930_bib59","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1210\/me.2010-0030","article-title":"Regulation of sertoli-germ cell adhesion and sperm release by fsh and nonclassical testosterone signaling","volume":"25","author":"Shupe","year":"2011","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.jaim.2024.100930_bib60","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1038\/s41556-020-00603-8","article-title":"Apoptosis in the fetal testis eliminates developmentally defective germ cell clones","volume":"22","author":"Nguyen","year":"2020","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.jaim.2024.100930_bib61","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s00418-020-01900-x","article-title":"Global changes in epigenomes during mouse spermatogenesis: possible relation to germ cell apoptosis","volume":"154","author":"Koji","year":"2020","journal-title":"Histochem Cell Biol"},{"key":"10.1016\/j.jaim.2024.100930_bib62","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s00210-019-01741-z","article-title":"Protective effect of chrysin on cyclophosphamide-induced hepatotoxicity and nephrotoxicity via the inhibition of oxidative stress, inflammation, and apoptosis","volume":"393","author":"Temel","year":"2020","journal-title":"Naunyn-Schmiedeberg\u2019s Arch Pharmacol"},{"key":"10.1016\/j.jaim.2024.100930_bib63","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1080\/17425255.2017.1277205","article-title":"The mechanisms of cyclophosphamide-induced testicular toxicity and the protective agents","volume":"13","author":"Ghobadi","year":"2017","journal-title":"Expet Opin Drug Metabol Toxicol"},{"key":"10.1016\/j.jaim.2024.100930_bib64","doi-asserted-by":"crossref","first-page":"3","DOI":"10.4103\/1008-682X.165946","article-title":"Regulation of epithelial function, differentiation, and remodeling in the epididymis","volume":"18","author":"Breton","year":"2016","journal-title":"Asian J Androl"},{"key":"10.1016\/j.jaim.2024.100930_bib65","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1002\/ptr.4756","article-title":"Astragalus membranaceus ameliorates reproductive toxicity induced by cyclophosphamide in male mice","volume":"26","author":"Kim","year":"2012","journal-title":"Phytother Res"},{"key":"10.1016\/j.jaim.2024.100930_bib66","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/BF00256565","article-title":"Review article: structure and function of the epididymis transport of spermatozoa","volume":"14","author":"Cosentino","year":"1986","journal-title":"Urol Res"},{"key":"10.1016\/j.jaim.2024.100930_bib67","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1093\/humupd\/dmw015","article-title":"The human epididymis: its function in sperm maturation","volume":"22","author":"Sullivan","year":"2016","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.jaim.2024.100930_bib68","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.jep.2006.03.039","article-title":"The spermatogenic and ovogenic effects of chronically administered Shilajit to rats","volume":"107","author":"Park","year":"2006","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.jaim.2024.100930_bib69","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110781","article-title":"Protective effects of bee bread on testicular oxidative stress, NF-\u03baB-mediated inflammation, apoptosis and lactate transport decline in obese male rats","volume":"131","author":"Suleiman","year":"2020","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.jaim.2024.100930_bib70","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118192","article-title":"Protective role of wogonin against cadmium induced testicular toxicity: involvement of antioxidant, anti-inflammatory and anti-apoptotic pathways","volume":"258","author":"Yu","year":"2020","journal-title":"Life Sci"},{"key":"10.1016\/j.jaim.2024.100930_bib71","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/1813798","article-title":"Polysaccharides from hemp seed protect against cyclophosphamide-induced intestinal oxidative damage via Nrf2-Keap1 signaling pathway in mice","volume":"2020","author":"Xue","year":"2020","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.jaim.2024.100930_bib72","doi-asserted-by":"crossref","first-page":"4264","DOI":"10.3390\/nu14204264","article-title":"Antioxidative and energy metabolism-improving effects of Maca polysaccharide on cyclophosphamide-induced hepatotoxicity mice via metabolomic analysis and Keap1-Nrf2 pathway","volume":"14","author":"Fei","year":"2022","journal-title":"Nutrients"}],"container-title":["Journal of Ayurveda and Integrative Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0975947624000457?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0975947624000457?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T23:13:59Z","timestamp":1725059639000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0975947624000457"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":72,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["S0975947624000457"],"URL":"https:\/\/doi.org\/10.1016\/j.jaim.2024.100930","relation":{},"ISSN":["0975-9476"],"issn-type":[{"value":"0975-9476","type":"print"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Shilajit mitigates chemotherapeutic drug-induced testicular toxicity: Study on testicular germ cell dynamics, steroidogenesis modulation, and Nrf-2\/Keap-1 signaling","name":"articletitle","label":"Article Title"},{"value":"Journal of Ayurveda and Integrative Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaim.2024.100930","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V. on behalf of Institute of Transdisciplinary Health Sciences and Technology and World Ayurveda Foundation","name":"copyright","label":"Copyright"}],"article-number":"100930"}}