{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T21:40:05Z","timestamp":1758836405861,"version":"3.44.0"},"reference-count":51,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T00:00:00Z","timestamp":1740960000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ayurveda and Integrative Medicine"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.jaim.2025.101152","type":"journal-article","created":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T09:44:28Z","timestamp":1753350268000},"page":"101152","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Swarna Bhasma reduces the blood concentration of tumor-specific signatures and protects from hepatocellular damages in Ehrlich ascites mice model"],"prefix":"10.1016","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8023-8390","authenticated-orcid":false,"given":"Namrata","family":"Joshi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9915-607X","authenticated-orcid":false,"given":"Pankaj","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8166-1860","authenticated-orcid":false,"given":"Shiwakshi","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Remya","family":"Jayakumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4827-8581","authenticated-orcid":false,"given":"Anand","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5356-8134","authenticated-orcid":false,"given":"V.","family":"Harsha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manoj Kumar","family":"Dash","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaim.2025.101152_bib1","first-page":"1","article-title":"History of the growing burden of cancer in India: from antiquity to the 21st century","volume":"5","author":"Smith","year":"2019","journal-title":"J Glob Oncol"},{"key":"10.1016\/j.jaim.2025.101152_bib2","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/306346","article-title":"Cancer, inflammation, and insights from ayurveda","volume":"2012","author":"Sumantran","year":"2012","journal-title":"Evidence-Based Complement Altern Med"},{"key":"10.1016\/j.jaim.2025.101152_bib3","first-page":"85","article-title":"Global burden of cancer","volume":"79","author":"Ma","year":"2006","journal-title":"Yale J Biol Med"},{"key":"10.1016\/j.jaim.2025.101152_bib4","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1200\/GO.20.00122","article-title":"Cancer statistics, 2020: report from national cancer Registry programme, India","author":"Mathur","year":"2020","journal-title":"JCO Glob Oncol"},{"key":"10.1016\/j.jaim.2025.101152_bib5","first-page":"209","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.jaim.2025.101152_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2023.116290","article-title":"Exploring the multifunctional roles of quantum dots for unlocking the future of biology and medicine","volume":"232","author":"Ali","year":"2023","journal-title":"Environ Res"},{"key":"10.1016\/j.jaim.2025.101152_bib7","doi-asserted-by":"crossref","first-page":"2342","DOI":"10.1002\/2211-5463.13713","article-title":"Ayurvedic preparations of Raudra Rasa inhibit agonist-mediated platelet activation and restrict thrombogenicity without affecting cell viability","volume":"13","author":"Chaurasia","year":"2023","journal-title":"FEBS Open Bio"},{"key":"10.1016\/j.jaim.2025.101152_bib8","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.950109","article-title":"Exploring the recent trends in perturbing the cellular signaling pathways in cancer by natural products","volume":"13","author":"Rahman","year":"2022","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.jaim.2025.101152_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaim.2023.100823","article-title":"Pharmaceutical characterization and exploration of Arkeshwara rasa in MDA-MB-231 cells","volume":"15","author":"Jayakumar","year":"2024","journal-title":"J Ayurveda Integr Med"},{"key":"10.1016\/j.jaim.2025.101152_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.hermed.2021.100490","article-title":"Ayurvedic supportive therapy in the management of breast cancer","volume":"29","author":"Dash","year":"2021","journal-title":"J Herb Med"},{"key":"10.1016\/j.jaim.2025.101152_bib11","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1385\/BTER:109:3:231","article-title":"Bhasmas: unique Ayurvedic metallic-herbal preparations, chemical characterization","volume":"109","author":"Kumar","year":"2006","journal-title":"Biol Trace Elem Res"},{"key":"10.1016\/j.jaim.2025.101152_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaim.2023.100864","article-title":"Characterization of lead sulfide obtained from Naga Bhasma","volume":"15","author":"Dash","year":"2024","journal-title":"J Ayurveda Integr Med"},{"key":"10.1016\/j.jaim.2025.101152_bib13","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2022.952297","article-title":"Development of new bioactive molecules to treat breast and lung cancer with natural myricetin and its derivatives: a computational and SAR approach","volume":"12","author":"Akash","year":"2022","journal-title":"Front Cell Infect Microbiol"},{"year":"2003","series-title":"Ver.1.0 (AFI e-book. Ayurvedic formulary of India-rasendrasara sangraha","key":"10.1016\/j.jaim.2025.101152_bib14"},{"first-page":"374","year":"2014","series-title":"Rasatarangini","key":"10.1016\/j.jaim.2025.101152_bib15"},{"key":"10.1016\/j.jaim.2025.101152_bib16","doi-asserted-by":"crossref","first-page":"181","DOI":"10.2147\/IJN.S219042","article-title":"New approaches in breast cancer therapy through green nanotechnology and nano-ayurvedic medicine \u2013 pre-clinical and pilot human clinical investigations","volume":"15","author":"Khoobchandani","year":"2020","journal-title":"Int J Nanomed"},{"key":"10.1016\/j.jaim.2025.101152_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-021-96224-8","article-title":"Green nanotechnology of MGF-AuNPs for immunomodulatory intervention in prostate cancer therapy","volume":"11","author":"Khoobchandani","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.jaim.2025.101152_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2019.112388","article-title":"Physicochemical characterization of Suvarna Bhasma, its toxicity profiling in rat and behavioural assessment in zebrafish model","volume":"249","author":"Biswas","year":"2020","journal-title":"J Ethnopharmacol"},{"first-page":"362","year":"2014","series-title":"Rasatarangini","key":"10.1016\/j.jaim.2025.101152_bib19"},{"key":"10.1016\/j.jaim.2025.101152_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.adcanc.2022.100029","article-title":"Ehrlich Ascites carcinoma mice model for studying liver inflammation and fibrosis","volume":"4","author":"Sannappa Gowda","year":"2022","journal-title":"Adv Cancer Biol - Metastasis"},{"key":"10.1016\/j.jaim.2025.101152_bib21","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.835027","article-title":"ST08 altered NF-\u03baB pathway in breast cancer cells in vitro as revealed by miRNA-mRNA analysis and enhanced the effect of cisplatin on tumour reduction in EAC mouse model","volume":"12","author":"Nirgude","year":"2022","journal-title":"Front Oncol"},{"key":"10.1016\/j.jaim.2025.101152_bib22","doi-asserted-by":"crossref","first-page":"27","DOI":"10.4103\/0976-0105.177703","article-title":"A simple practice guide for dose conversion between animals and human","volume":"7","author":"Nair","year":"2016","journal-title":"J Basic Clin Pharm"},{"key":"10.1016\/j.jaim.2025.101152_bib23","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jare.2010.02.002","article-title":"Gold nanoparticles: optical properties and implementations in cancer diagnosis and photothermal therapy","volume":"1","author":"Huang","year":"2010","journal-title":"J Adv Res"},{"key":"10.1016\/j.jaim.2025.101152_bib24","first-page":"1","article-title":"Toxicity of nanoparticles and an overview of current experimental models","volume":"20","author":"Bahadar","year":"2016","journal-title":"Iran Biomed J"},{"key":"10.1016\/j.jaim.2025.101152_bib25","doi-asserted-by":"crossref","first-page":"10644","DOI":"10.1021\/la0513712","article-title":"Biocompatibility of gold nanoparticles and their endocytotic fate inside the cellular compartment: a microscopic overview","volume":"21","author":"Shukla","year":"2005","journal-title":"Langmuir"},{"key":"10.1016\/j.jaim.2025.101152_bib26","article-title":"The potential impact of ayurvedic traditional bhasma on SARS-CoV- 2- induced pathogenesis","volume":"9","author":"Kumar","year":"2022","journal-title":"Curr Tradit Med"},{"issue":"1","key":"10.1016\/j.jaim.2025.101152_bib27","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1515\/jcim-2020-0390","article-title":"Transmission modes of COVID-19 disease pandemic in the light of ancient wisdom of Ayurveda medicine : a review","volume":"19","author":"Joshi","year":"2021","journal-title":"J.Complement Integr Med"},{"key":"10.1016\/j.jaim.2025.101152_bib28","doi-asserted-by":"crossref","first-page":"4648","DOI":"10.1073\/pnas.85.13.4648","article-title":"Carcinoembryonic antigen is anchored to membranes by covalent attachment to a glycosylphosphatidylinositol moiety: identification of the ethanolamine linkage site","volume":"85","author":"Hefta","year":"1988","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaim.2025.101152_bib29","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0065-2571(00)00013-3","article-title":"The enhanced permeability and retention (EPR) effect in tumor vasculature: the key role of tumor-selective macromolecular drug targeting","volume":"41","author":"Maeda","year":"2001","journal-title":"Adv Enzym Regul"},{"key":"10.1016\/j.jaim.2025.101152_bib30","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1023\/A:1016486910719","article-title":"Long-circulating poly(ethylene glycol)-modified gelatin nanoparticles for intracellular delivery","volume":"19","author":"Kaul","year":"2002","journal-title":"Pharm Res"},{"key":"10.1016\/j.jaim.2025.101152_bib31","doi-asserted-by":"crossref","first-page":"12716","DOI":"10.1016\/S0021-9258(18)37812-8","article-title":"Evidence for carboxyl-terminal processing and glycolipid-anchoring of human carcinoembryonic antigen","volume":"263","author":"Takami","year":"1988","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jaim.2025.101152_bib32","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1002\/jcla.1860050510","article-title":"Carcinoembryonic antigen gene family: molecular biology and clinical perspectives","volume":"5","author":"Thompson","year":"1991","journal-title":"J Clin Lab Anal"},{"key":"10.1016\/j.jaim.2025.101152_bib33","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/0092-8674(89)90970-7","article-title":"Carcinoembryonic antigen, a human tumor marker, functions as an intercellular adhesion molecule","volume":"57","author":"Benchimol","year":"1989","journal-title":"Cell"},{"key":"10.1016\/j.jaim.2025.101152_bib34","doi-asserted-by":"crossref","unstructured":"Oikawa S, Inuzuka C, Kuroki M, Matsuoka Y, Kosaki G, Nakazato H. Cell adhesion activity of non-specific cross-reacting antigen (NCA) and carcinoembryonic antigen (CEA) expressed on CHO cell surface: Homophilic and heterophilic adhesion. Biochem Biophys Res Commun n.d.;164:Pages 39-45. https:\/\/doi.org\/10.1016\/0006-291x(89)91679-3.","DOI":"10.1016\/0006-291X(89)91679-3"},{"key":"10.1016\/j.jaim.2025.101152_bib35","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.actbio.2022.12.054","article-title":"Gold nanoparticles inhibit tumor growth via targeting the Warburg effect in a c-Myc-dependent way","volume":"158","author":"Sun","year":"2023","journal-title":"Acta Biomater"},{"key":"10.1016\/j.jaim.2025.101152_bib36","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1038\/nri3834","article-title":"Regulation of tumour necrosis factor signalling: live or let die","volume":"15","author":"Brenner","year":"2015","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jaim.2025.101152_bib37","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1016\/j.cellsig.2012.02.006","article-title":"Signal transduction by tumor necrosis factor receptors","volume":"24","author":"Cabal-Hierro","year":"2012","journal-title":"Cell Signal"},{"key":"10.1016\/j.jaim.2025.101152_bib38","first-page":"25","article-title":"Monoclonal antibodies specific for murine p55 and p75 tumor necrosis factor receptors: identification of a novel in vivo role for p75 By kathleen C. F. Sheehan, J. Keith Pinckard, Cora D. Arthur","volume":"181","author":"Sheehan","year":"1995","journal-title":"In Vitro"},{"key":"10.1016\/j.jaim.2025.101152_bib39","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0044529","article-title":"Mac-2 binding protein is a novel E-selectin ligand expressed by breast cancer cells","volume":"7","author":"Shirure","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jaim.2025.101152_bib40","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1182\/blood.V83.1.113.113","article-title":"Interleukin-6 (IL-6) as an anti-inflammatory cytokine: induction of circulating IL-1 receptor antagonist and soluble tumor necrosis factor receptor p55","volume":"83","author":"Tilg","year":"1994","journal-title":"Blood"},{"key":"10.1016\/j.jaim.2025.101152_bib41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/sdata.2018.289","article-title":"A protein-protein interaction map of the TNF-induced NF-\u03baB signal transduction pathway","volume":"5","author":"Van Quickelberghe","year":"2018","journal-title":"Sci Data"},{"key":"10.1016\/j.jaim.2025.101152_bib42","doi-asserted-by":"crossref","first-page":"11553","DOI":"10.1007\/s13277-016-5098-7","article-title":"Role of interleukin-6 in cancer progression and therapeutic resistance","volume":"37","author":"Kumari","year":"2016","journal-title":"Tumour Biol J Int Soc Oncodevelopmental Biol Med"},{"key":"10.1016\/j.jaim.2025.101152_bib43","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1002\/ijc.33247","article-title":"Site-specific metastasis: a cooperation between cancer cells and the metastatic microenvironment","volume":"148","author":"Izraely","year":"2021","journal-title":"Int J Cancer"},{"key":"10.1016\/j.jaim.2025.101152_bib44","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0001826","article-title":"CD44v4 is a major E-selectin ligand that mediates breast cancer cell transendothelial migration","volume":"3","author":"Zen","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.jaim.2025.101152_bib45","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.cbpa.2014.10.011","article-title":"TNFR1-activated NF-\u03baB signal transduction: regulation by the ubiquitin\/proteasome system","volume":"23","author":"Wertz","year":"2014","journal-title":"Curr Opin Chem Biol"},{"key":"10.1016\/j.jaim.2025.101152_bib46","article-title":"Elevated AST\/ALT ratio is associated with all-cause mortality and cancer incident","volume":"36","author":"Chen","year":"2022","journal-title":"J Clin Lab Anal"},{"key":"10.1016\/j.jaim.2025.101152_bib47","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.3748\/wjg.v9.i7.1618","article-title":"Fatty metamorphosis of the liver in patients with breast cancer: possible associated factors","volume":"9","author":"Chu","year":"2003","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.jaim.2025.101152_bib48","article-title":"Gold compounds and the anticancer immune response","volume":"12","author":"Zhou","year":"2021","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.jaim.2025.101152_bib49","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1191\/0269216302pm593oa","article-title":"Loss of weight and loss of appetite in advanced cancer: a problem for the patient, the carer, or the health professional?","volume":"16","author":"Poole","year":"2002","journal-title":"Palliat Med"},{"key":"10.1016\/j.jaim.2025.101152_bib50","doi-asserted-by":"crossref","first-page":"3650","DOI":"10.4238\/2015.April.17.15","article-title":"Effects of silver nanoparticles and gold nanoparticles on IL-2, IL-6, and TNF-\u03b1 production via MAPK pathway in leukemic cell lines","volume":"14","author":"Parnsamut","year":"2015","journal-title":"Genet Mol Res"},{"key":"10.1016\/j.jaim.2025.101152_bib51","doi-asserted-by":"crossref","first-page":"74","DOI":"10.4103\/2141-9248.126619","article-title":"An evaluation of hepatotoxicity in breast cancer patients receiving injection doxorubicin","volume":"4","author":"Damodar","year":"2014","journal-title":"Ann Med Health Sci Res"}],"container-title":["Journal of Ayurveda and Integrative Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0975947625000282?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0975947625000282?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T21:08:58Z","timestamp":1758834538000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0975947625000282"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":51,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["S0975947625000282"],"URL":"https:\/\/doi.org\/10.1016\/j.jaim.2025.101152","relation":{},"ISSN":["0975-9476"],"issn-type":[{"type":"print","value":"0975-9476"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Swarna Bhasma reduces the blood concentration of tumor-specific signatures and protects from hepatocellular damages in Ehrlich ascites mice model","name":"articletitle","label":"Article Title"},{"value":"Journal of Ayurveda and Integrative Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaim.2025.101152","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V. on behalf of Institute of Transdisciplinary Health Science and Technology and World Ayurveda Foundation.","name":"copyright","label":"Copyright"}],"article-number":"101152"}}